LOCUS       NM_001353824            4767 bp    mRNA    linear   PRI 21-NOV-2024
DEFINITION  Homo sapiens zinc finger protein 334 (ZNF334), transcript variant
            15, mRNA.
ACCESSION   NM_001353824 XM_017027936
VERSION     NM_001353824.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4767)
  AUTHORS   Yang,B., Tang,H., Wang,N., Gu,J. and Wang,Q.
  TITLE     Targeted DNA demethylation of the ZNF334 promoter inhibits
            colorectal cancer growth
  JOURNAL   Cell Death Dis 14 (3), 210 (2023)
   PUBMED   36966142
  REMARK    GeneRIF: Targeted DNA demethylation of the ZNF334 promoter inhibits
            colorectal cancer growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4767)
  AUTHORS   Sun,D., Gan,X., Liu,L., Yang,Y., Ding,D., Li,W., Jiang,J., Ding,W.,
            Zhao,L., Hou,G., Yu,J., Wang,J., Yang,F., Yuan,S. and Zhou,W.
  TITLE     DNA hypermethylation modification promotes the development of
            hepatocellular carcinoma by depressing the tumor suppressor gene
            ZNF334
  JOURNAL   Cell Death Dis 13 (5), 446 (2022)
   PUBMED   35534462
  REMARK    GeneRIF: DNA hypermethylation modification promotes the development
            of hepatocellular carcinoma by depressing the tumor suppressor gene
            ZNF334.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4767)
  AUTHORS   Cheng,Z., Yu,R., Li,L., Mu,J., Gong,Y., Wu,F., Liu,Y., Zhou,X.,
            Zeng,X., Wu,Y., Sun,R. and Xiang,T.
  TITLE     Disruption of ZNF334 promotes triple-negative breast carcinoma
            malignancy through the SFRP1/ Wnt/beta-catenin signaling axis
  JOURNAL   Cell Mol Life Sci 79 (5), 280 (2022)
   PUBMED   35507080
  REMARK    GeneRIF: Disruption of ZNF334 promotes triple-negative breast
            carcinoma malignancy through the SFRP1/ Wnt/beta-catenin signaling
            axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4767)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4767)
  AUTHORS   Henc,I., Soroczynska-Cybula,M., Bryl,E. and Witkowski,J.M.
  TITLE     The in vitro modulatory effect of TNFalpha on the mRNA expression
            and protein levels of zinc finger protein ZNF334 in CD4(+)
            lymphocytes of healthy people
  JOURNAL   Acta Biochim Pol 62 (1), 113-117 (2015)
   PUBMED   25738173
  REMARK    GeneRIF: results obtained in vitro for helper lymphocytes of
            healthy individuals seem to mimic the regulatory effect of TNFalpha
            on the expression of ZNF334 in the cells of RA patients
REFERENCE   6  (bases 1 to 4767)
  AUTHORS   Soroczynska-Cybula,M., Bryl,E., Smolenska,Z. and Witkowski,J.M.
  TITLE     Varying expression of four genes sharing a common regulatory
            sequence may differentiate rheumatoid arthritis from ageing effects
            on the CD4(+) lymphocytes
  JOURNAL   Immunology 132 (1), 78-86 (2011)
   PUBMED   20738421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034424.9 and AL354745.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001353824.1.
            
            Summary: This gene encodes a member of the C2H2 zinc finger family.
            The encoded protein contains a Krueppel-associated box, fourteen
            C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding
            domains. Decreased expression of this gene may be a marker for
            rheumatoid arthritis. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, Jul 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3841984.1,
                                           SRR18074969.3207644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267750, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692313.1/ ENSP00000510334.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1020              AL034424.9         731-1750            c
            1021-1079           AL034424.9         273-331             c
            1080-1206           AL354745.11        6240-6366           c
            1207-1299           AL354745.11        5840-5932           c
            1300-4767           AL354745.11        1256-4723           c
FEATURES             Location/Qualifiers
     source          1..4767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4767
                     /gene="ZNF334"
                     /note="zinc finger protein 334"
                     /db_xref="GeneID:55713"
                     /db_xref="HGNC:HGNC:15806"
                     /db_xref="MIM:621017"
     exon            1..1020
                     /gene="ZNF334"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1079
                     /gene="ZNF334"
                     /inference="alignment:Splign:2.1.0"
     CDS             1059..3101
                     /gene="ZNF334"
                     /note="isoform a is encoded by transcript variant 15"
                     /codon_start=1
                     /product="zinc finger protein 334 isoform a"
                     /protein_id="NP_001340753.1"
                     /db_xref="CCDS:CCDS33480.1"
                     /db_xref="GeneID:55713"
                     /db_xref="HGNC:HGNC:15806"
                     /db_xref="MIM:621017"
                     /translation="MKMKKFQIPVSFQDLTVNFTQEEWQQLDPAQRLLYRDVMLENYS
                     NLVSVGYHVSKPDVIFKLEQGEEPWIVEEFSNQNYPDIDDALEKNKEIQDKHLTQTVF
                     FSNKTLITERENVFGKTLNLGMNSVPSRKMPYKCNPGGNSLKTNSEVIVAKKSKENRK
                     IPDGYSGFGKHEKSHLGMKKYRYNPMRKASNQNENLILHQNIQILKQPFDYNKCGKTF
                     FKRAILITQKGRQTERKPNECNECRKTFSKRSTLIVHQRIHTGEKPYVCSDCRKTFRV
                     KTSLTRHRRIHTGERPYECSECRKTFIDKSALIVHQKIHGGEKSYECNECGKTFFRKS
                     ALAEHFRSHTGEKPYECKECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTFFCQSAL
                     TAHQRIHTGEKPYECSECEKTFFCQSALNVHRRSHTGEKPYECSQCGKFLCTKSALIA
                     HQITHRGKKSYECNECGKFFCHKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCK
                     RMNTKENLYECSEHGHAVSKNSHLIVHQRTIWERPYECNECGRTYCRKSALTHHQRTH
                     TGQRPYECNECGKTFCQKFSFVEHQRTHTGEKPYECNECGKSFCHKSAFRVHRRIHTG
                     EKPYECNQCGKTYRRLWTLTEHQKIHTGEKPYECNKCEKTFRHKSNFLLHQKSHKE"
     exon            1080..1206
                     /gene="ZNF334"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1299
                     /gene="ZNF334"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..4767
                     /gene="ZNF334"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3284..3289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF334"
                     /note="hexamer: AATAAA"
     polyA_site      3316
                     /gene="ZNF334"
                     /note="major polyA site"
     regulatory      4413..4418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF334"
                     /note="hexamer: AATAAA"
     polyA_site      4431
                     /gene="ZNF334"
                     /note="major polyA site"
     regulatory      4743..4748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF334"
                     /note="hexamer: AGTAAA"
     regulatory      4747..4752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF334"
                     /note="hexamer: AAGAAA"
     polyA_site      4760
                     /gene="ZNF334"
     polyA_site      4767
                     /gene="ZNF334"
ORIGIN      
        1 aggctcttcc gggtgagggt cctgcagccc gtgaatccct ggtcccgccg agacttggac
       61 ctggtgcgaa ctggaggcga agcgggtgca cccacaacct ataggaaggg ctggcggcga
      121 gctctgagca ctcgggcgtc ggagggaacg gtggggccgg gcggagcggg cctcgggtct
      181 gcggagggtg gacgcgcgct ctccctgtct ttggagggag ggtttcctgt ggtcgggagg
      241 cgaggcagcc agggcaggat tgggctcctg acctgcaggc cacgggcgag ctctctctag
      301 ggccctgatt tgcccgaaga aggcgcttgg tgaaggtgaa aggtttacgc atccaagtag
      361 ctagaacctc tttccagaac ttctgctgat gcacttagtc ttgcagccat tgattattat
      421 agctcagcaa agttcagttc aactttcgga agaaggatgt gagctggaat gggcagggtc
      481 aagatttgac aggaaaagac acttcactgg aggtatctgc gagagtcctg ggttggaggg
      541 aaggagtact ggttataaat aaggaaatga tgtcttcatc acttcctaaa cacatacatg
      601 tcattcccta ccatctccac cctctgttta ttcagagctg caccaaccat gttcatcacc
      661 tcacctggga tttactgagt ttacccctta cagagctaca cgataggggt aaaggaaaga
      721 ctaaaaacca atttatctta tattaaaatt acgacttagt aaatattttt ttcagtaatg
      781 cagtttgcta gtgacagatc caataactga attctggtcc tttgagtacc aggtcagggc
      841 ttttgtcatc taccacattt acgttaccta ccacaagaag tttcttagta aaaggtcctc
      901 ttgtgaaact gcagctaagg gaaaccaaac tgtcaaaaag acaaacacct taaagcactt
      961 tcattcattc tctctggatt ctgtcatctc aagtggctaa acacattagt aggaaaacag
     1021 ctctgctttc aacactcttg gccctttctc aagagaacat gaaaatgaaa aaatttcaga
     1081 taccagtttc attccaggac ctgactgtga acttcaccca agaggaatgg cagcaactgg
     1141 accctgctca gaggctcctg tacagggatg tgatgctgga gaactacagc aacttggtct
     1201 ctgtggggta tcatgttagc aaaccagatg tgattttcaa attggagcaa ggagaagagc
     1261 catggatagt ggaggaattc tcaaatcaga actacccaga cattgatgat gccttagaga
     1321 agaacaagga aatccaagat aaacatttga cacaaactgt attcttcagc aacaaaacac
     1381 tgattacaga aagagagaat gtatttggga aaacacttaa tctgggcatg aatagtgttc
     1441 cctcaagaaa aatgccctat aaatgtaatc caggaggaaa cagtttgaaa actaattcag
     1501 aagtaattgt tgcaaagaaa agcaaagaaa acagaaagat tcctgatgga tacagtggat
     1561 ttgggaagca tgagaaaagt catttgggaa tgaaaaaata cagatacaat ccaatgagga
     1621 aagccagcaa tcaaaacgaa aatcttattc tgcaccagaa cattcagatt ttgaaacaac
     1681 cgtttgacta taataaatgt gggaaaacct tcttcaagag ggcaattctc attacacaaa
     1741 aggggagaca gactgaaagg aaaccaaatg aatgtaatga atgtaggaaa accttttcta
     1801 agagatctac cctcattgta catcagagaa ttcatacagg ggagaaaccg tatgtttgta
     1861 gtgattgtag gaaaactttt cgtgtgaaga caagcctcac tcgacaccga agaattcata
     1921 ctggagagag accctatgaa tgcagtgaat gcaggaaaac cttcattgac aaatctgccc
     1981 ttattgtaca ccagaaaatt catggagggg agaaatccta tgagtgtaat gaatgtggaa
     2041 agaccttttt tcggaagtca gccctggctg aacatttcag gtcacacaca ggggagaagc
     2101 cttacgaatg caaggaatgt ggaaatgcct tcagcaagaa atcgtatctt gttgtacatc
     2161 aaagaactca cagaggagag aagccaaatg aatgtaagga atgtgggaaa accttcttct
     2221 gtcagtcagc ccttactgcg catcagagaa ttcacacagg ggaaaaaccc tatgaatgta
     2281 gtgaatgtga gaaaaccttc ttttgtcaat ctgccctcaa tgtgcatcga agaagtcata
     2341 caggagagaa gccctatgaa tgcagtcaat gtggaaaatt tttatgtacg aaatcagccc
     2401 tcattgcaca tcagataact catagaggaa agaagtctta tgaatgtaat gaatgtggga
     2461 aatttttctg ccataagtca acactcacta tacatcagag aacacacaca ggagagaaac
     2521 atggtgtgtt taataaatgt ggtagaatct ccattgtgaa gtcaaactgc agtcagtgta
     2581 agagaatgaa cacaaaggag aatctttatg agtgtagtga acatgggcat gccgtcagca
     2641 aaaactcaca cctcattgta catcagagaa ctatatggga gagaccatat gaatgcaatg
     2701 aatgtgggag aacctactgc aggaagtcag ccctgactca ccatcagaga acacacacag
     2761 gacagagacc ctatgagtgt aatgaatgtg ggaaaacctt ctgtcagaag ttctcctttg
     2821 ttgaacatca gcgaactcac actggggaga aaccatatga atgtaatgaa tgtgggaaat
     2881 ccttctgcca taagtcagcc ttcagagtcc atagaagaat tcacacagga gagaaaccat
     2941 atgaatgtaa tcaatgtggg aaaacctacc gtcgcctgtg gactctcact gaacatcaga
     3001 aaatacacac aggagagaaa ccttatgaat gtaacaaatg tgagaaaaca tttcgccaca
     3061 aatcaaactt tcttttacat cagaaatccc acaaggaata agttccaaca aagtaataaa
     3121 ttccaacaaa gcaacaaatc aaataactta cacaatgcta aactgtgagt atgtatagag
     3181 gagtaaaatc ttataaatgt aatgaatatg gaaaattttt ctgccataag tcaaccctca
     3241 atgtaacatc agagaaatca tgtaggaaag aaataatttg tttaataaat gtattattca
     3301 ttgtgaacta tgaaaatatt caacagcaat tcaaaggtta tgccaaatgt gcctcccttt
     3361 taaaataatg aaacaaacat tgtttaagtt aaattgttac ttggttcctc cccacagtgt
     3421 tacttgatag tgtatgttac gaggtgtgag gatctgacct tcatttcaaa tcaataccat
     3481 tgtttgatag ttgagtaagt tacagtttct caatttatgg tgtattttca gatttggcag
     3541 attttttgtt gtctgctaac tccatagtct tctagtagtg gactgtatac ctttatctgc
     3601 aaaggtgaca actcaggaga actaaccatt gtactctatg cacccatggt aattataccc
     3661 caggtgagca ttttgtaaag ctgagccagt gaaagccctt cctaagacct ttctaatgga
     3721 agataggcac aggataacta gttcatgatc ctgaagcttt cagctaagtc aagaagacgg
     3781 caattgcagt aggaaaaaca tgggaaaata agcattcttg aacaacaaag agaatttgga
     3841 tgatggttga atccaaaaag tgtttatttc tctggtttta gtattctgta atatccactc
     3901 aaccccatct accagtggtt tatgtcaatt agtatgtttt caaaaatctc ttggatttcc
     3961 taatcaacat gttcattaga ggtattgttt agaagtcact gatcaaattc tgagaacaaa
     4021 aggcgcctgg gatgctgatt aggattacat tatatggata tatatgatga ggtaggattg
     4081 ccacttttat ggggttattg ggaaatgttt acctttcaag ttctgatttc catgagtggg
     4141 attttcccta tacccattcc tagcttctct gccacattat gcattctgcc ccaggcatga
     4201 ggaagtgggc ttatctagtt ggtaagatag tgatgggtaa ctgggtttgc tcagctgaac
     4261 tccctcttca ttgtgggctg acctgcaagt ataatttctt gtcacagata ttgcctgtga
     4321 ttggtaaatt ggtctaattc tgtcattcag ctaattggcc cattagctga atggtcacac
     4381 taagttgcat cctccaactc aatttgatca gtaataaaag tttcatcctg ccccctgtct
     4441 gctacttaat tttttatcgt ttagatgggg ggaaattgtg ctatttattt ggggcccttc
     4501 agagaaccca atatgaacat gatttatcta tttattcagt ttttatgtcc ttcaggacag
     4561 ataaatgtat gtatacacac atatacatgt gttaatatat gtaagtatat acatatgttt
     4621 aaatgtatgt gtatgtgtat actgatcttg ctcttttcct gtgaaatgta ttaatagtca
     4681 cttcaaagat ttggttgcta ttgtgaaaga aattaagtta cctttcactt tgaaactaat
     4741 agagtaaaga aaaacaaaaa tacctaa
//
