LOCUS       NM_032433               4716 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 333 (ZNF333), transcript variant
            1, mRNA.
ACCESSION   NM_032433
VERSION     NM_032433.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4716)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4716)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4716)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 4716)
  AUTHORS   Jing,Z., Liu,Y., Dong,M., Hu,S. and Huang,S.
  TITLE     Identification of the DNA binding element of the human ZNF333
            protein
  JOURNAL   J Biochem Mol Biol 37 (6), 663-670 (2004)
   PUBMED   15607024
  REMARK    GeneRIF: ZNF333 recognized the specific DNA core binding sequence
            ATAAT
REFERENCE   5  (bases 1 to 4716)
  AUTHORS   Tian,Y., Breedveld,G.J., Huang,S., Oostra,B.A., Heutink,P. and
            Lo,W.H.
  TITLE     Characterization of ZNF333, a novel double KRAB domain containing
            zinc finger gene on human chromosome 19p13.1
  JOURNAL   Biochim Biophys Acta 1577 (1), 121-125 (2002)
   PUBMED   12151103
  REMARK    GeneRIF: dna sequence analysis of ZNF333 gene located on chromosome
            19p13.1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA103403.1, AF372702.1 and AC090427.2.
            
            On Nov 23, 2018 this sequence version replaced NM_032433.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF372702.1, SRR1660807.180877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292530.11/ ENSP00000292530.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DA103403.1         9-70
            63-4122             AF372702.1         10-4069
            4123-4713           AF372702.1         4071-4661
            4714-4716           AC090427.2         71865-71867
FEATURES             Location/Qualifiers
     source          1..4716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..4716
                     /gene="ZNF333"
                     /note="zinc finger protein 333"
                     /db_xref="GeneID:84449"
                     /db_xref="HGNC:HGNC:15624"
                     /db_xref="MIM:611811"
     exon            1..103
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            104..147
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2142
                     /gene="ZNF333"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 333 isoform 1"
                     /protein_id="NP_115809.1"
                     /db_xref="CCDS:CCDS12316.1"
                     /db_xref="GeneID:84449"
                     /db_xref="HGNC:HGNC:15624"
                     /db_xref="MIM:611811"
                     /translation="MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGT
                     PPCKPSCVSQLGQRAEPKATERGILRATGVAWESQLKPEELPSMQDLLEEASSRDMQM
                     GPGLFLRMQLVPSIEERETPLTREDRPALQEPPWSLGCTGLKAAMQIQRVVIPVPTLG
                     HRNPWVARDSAVPARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWV
                     FLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEP
                     QCQPQEAIPSQDTFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAG
                     EASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRHEKTHTAEK
                     CFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPY
                     ECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYEC
                     NQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQE
                     CGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCE
                     KAFRHSSSLTVHKRTHVGRETIRNGSLPLSMSHPYCGPLAN"
     exon            148..271
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            272..367
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            368..450
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            451..567
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            568..655
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            656..744
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            745..871
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1044
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..4716
                     /gene="ZNF333"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF333"
                     /note="hexamer: ATTACA"
     polyA_site      2552
                     /gene="ZNF333"
                     /note="major polyA site"
     regulatory      3746..3751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF333"
                     /note="hexamer: AATATA"
     polyA_site      3777
                     /gene="ZNF333"
                     /note="major polyA site"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF333"
                     /note="hexamer: AATAAA"
     polyA_site      4716
                     /gene="ZNF333"
ORIGIN      
        1 aagcggaagt gcgcgcggcg gcggccgacg gcggctgagc tgtgctgcgc ggcgcggcgc
       61 ggtgcggcac ggcacggtgg gagtgtctcc ggctggcttg cagggagaac accgactgag
      121 acctcaaacc ctggctccag tgtcatggaa tccgtcacct ttgaggatgt ggccgtggag
      181 ttcatccagg agtgggcatt gctggacagc gcacggagga gcctgtgcaa atacaggatg
      241 cttgaccagt gcaggaccct ggcctccagg ggaactccac catgcaaacc cagttgtgtc
      301 tcccagctgg ggcaaagagc agagccaaag gcaacagaac gagggattct ccgtgccaca
      361 ggtgttgcct gggaatctca acttaaaccc gaagagttgc cttctatgca ggatcttttg
      421 gaagaagcat cctccaggga catgcaaatg gggccggggc tgttcctgag gatgcagctg
      481 gtgccctcca tagaagagag ggagacacca ttgactcgag aggaccggcc agctctccag
      541 gagccgcctt ggtctctggg atgcacggga ctgaaggccg ctatgcagat tcagagggtg
      601 gtgataccag tgcctactct gggccaccgc aacccatggg tggccaggga ttctgctgtg
      661 cctgcacgtg accctgcctg gcttcaggag gacaaagtgg aggaagaagc tatggctcct
      721 gggctgccaa ccgcctgttc acaggaacca gtcacctttg cagatgtggc tgtggtgttc
      781 accccagaag aatgggtgtt tctggactct actcagagga gcctgtatag agatgtgatg
      841 ctggagaact acaggaacct ggcctctgtg gctgatcaac tgtgcaaacc caatgcgttg
      901 tcttatttgg aagaaagagg agagcagtgg accactgaca ggggcgtcct ctcagacacc
      961 tgtgcagaac ctcagtgtca accccaagag gcaattccta gccaagatac ttttacagag
     1021 atcctgtcca ttgatgtgaa aggggagcaa cctcagcctg gagaaaaact ctataaatat
     1081 aatgaacttg agaaaccttt taacagcatt gaaccacttt tccagtacca gagaattcat
     1141 gctggagagg catcctgtga atgtcaagag attagaaatt ccttcttcca gagtgcccac
     1201 ctaattgtgc ccgagaaaat ccgtagtggg gataaatcct atgcatgtaa caaatgtgaa
     1261 aaatccttca gatacagctc tgaccttatc aggcatgaga agactcatac tgcagagaag
     1321 tgctttgact gtcaagaatg tgggcaagcc ttcaaatatt cctcgaatct ccggcgacac
     1381 atgagaaccc ataccggaga gaagccattt gaatgtagtc agtgtgggaa aaccttcacg
     1441 aggaacttta acctgatttt gcaccagaga aaccacacag gagagaagcc ctacgagtgt
     1501 aaagattgtg ggaaagcctt caatcagcca tcatccctca ggagccacgt gagaactcac
     1561 actggagaga agccctttga atgcagccag tgtgggaaag ccttcaggga acactcttca
     1621 ctgaagacac atctgcgaac ccataccaga gagaaaccat atgaatgcaa ccagtgtggc
     1681 aagcccttcc ggacgagcac tcatctgaac gtgcacaaga ggatacacac aggggagaaa
     1741 ctgtatgagt gcgcgacttg cggtcaggtc ttgagtcgtc tttcaaccct gaagagtcac
     1801 atgcgaactc acactggaga gaagccctat gtgtgccagg aatgtgggcg agccttcagt
     1861 gagccctcat ccctcaggaa acatgcaagg actcacagtg gcaagaagcc ctatgcatgc
     1921 caggaatgcg ggcgagcctt tggtcagtct tcacatctta ttgtacatgt gagaacacac
     1981 agtgccggga gaccctatca atgtaatcag tgtgagaaag ccttcaggca cagctcctca
     2041 ctcactgtac acaaaagaac ccatgtggga agagagacca ttaggaatgg cagcctgcct
     2101 ttatccatgt ctcatccata ctgtgggccc cttgctaatt aacttccatt ttgtaaaaat
     2161 ataaacacat ggggctatga ctttccctcg taatactcct ttagctgcat cctgtgtttc
     2221 aatgtataat attttcattt tggtttaatt gtaagtattg tcttaacctc cattatcgtt
     2281 tattctttga cccatctatt atttggaatt agatttttca aaactaatat gtggatatat
     2341 tttcatagag gtataatgac ttatagtgaa atgcatacat ctgaagtgta cagttggatg
     2401 agtttgacag atgcatacat gcatgtaacc accaccccat tccagatata gaatgtttct
     2461 atctctctgg aaggttcctg catgttatat ggctatttct tagttgcctt tttgttgttg
     2521 gtttctaatt taattacatg gtgagaagag tatgtggcct ctttgttact gagtcatagg
     2581 tatttgctga gatttgctat taggtctggt gtggcttatt cttctagctg ccaacccaaa
     2641 ttaccccttc ctccttagaa aagaacctgg gttttctgtt cagattggca gtgtgcacta
     2701 ttaaaaagct tccatctccc ggctgggcac ggtggctcat gcctctaatc ccagcacttt
     2761 gggaggctga ggctggggga tcacctgagg tcaggagttc gagatcagcc tggccaacat
     2821 ggtgaaatcc cctctctact aaaaatataa aaattagcca agtttggtgg catgcacctg
     2881 taatcccagc tacttgggag gctgaggcag gagaattctt tgaacccagg aggcagaggt
     2941 tgcagtgagc cgagattgcg ccactgcact ccagcctggg caacagagtg aaactctgtc
     3001 tcaaaaataa taataataaa aaaaagcttc catctcccag cccttcttgc aagcaagggc
     3061 aggccatttc ctccggtcct ggctagtatg aatatgagaa gtcactggat gtgactctgg
     3121 ggaagatatt gtgttcaggg atggtttcat gtagccacat ctctccactt cttgcctttt
     3181 ggacaagtag acatgatttc tagacctaga ggagccctcc tgtgaccata agggtaaaag
     3241 ccgcaagcta agaagagggt ggccggaagt cataaccatc ttgcttctgt aatctaaaaa
     3301 atatttagga tagatttaat agaattggca tatttatgtg attgcagcag ccctggacta
     3361 tttatttctg gatgtcccat acatgaaaaa tatgcacttc ttactggtac agttttcttt
     3421 tgtttgtttt tgtttttggt gggaggttta tttcacctga atataattcc taactgatgc
     3481 acttagtata tgtcagtttt tataaatgct tcatggatgg ttgaaatcaa tgtattgtat
     3541 tctacaaatg tctgctagat caagcaaatg tgtttaaaaa ccatctacac atttataaat
     3601 gttgatctgt gatctagcat ttattgagag aggtatgtta aactctccca ccatgattat
     3661 gtattgctga aaaatctttg tcattctgtc agtttttaaa tttatgtata tacatacata
     3721 tatatgtttt gaagcaatga aattaaatat agatactgac attttttaca tttccaacaa
     3781 attgttactt ttattcttat aaagtgatca tccttttccc tattactgaa cattcaacca
     3841 ttcattgtaa tgatagtaaa tacttattta gagtttacta ttaatagata gtagccactg
     3901 cctgaagctt tgcatctttt aatttagtcc tcacactgac actttgaggt atgtactgtt
     3961 atccccaatt cccagatgag gaagctgagg cccagcaagt taaggtgggc tatcaaagtc
     4021 atctgggtgg catgtgacag gcctgactct ctctacagtg gcagacccag gggactagtc
     4081 tccattttta cttgttcttt tttttttttt tttttttttt ttggttttaa agttctctta
     4141 ggtataactt acataaacgt taataaatct tagggtacac cttggtgaat tttgtatatg
     4201 tctataccca ccacggtctc catcaaaata ttttatcgtc ccagaaattt cccttgggcc
     4261 ccacctcatc ctcaaaggtt atcactattc tgatgtctat caccatagat ttgtttttcc
     4321 tgttcatgta aatggaacca taaacagccc tcttgtgtct gttttcttca cttaatatag
     4381 tgtcattgag atttatctat gttgtattat cagtagttta tgctttttaa ttgctgtgta
     4441 atagtccata gtctgaatat accacaattt aaaaattcta ttctgtttac aaacatttga
     4501 gttctgtcct ccaggttcat ccatgttatc acaaatgaca gaatttcctt cctcatcaag
     4561 gctgaatagt attccattgt gtagatatac cacattttct ttatccattc atccaccgat
     4621 ggacagttag gttgattcca tatcttggct attgtgaata atcctgcagg ttttattgtt
     4681 atgaataaag ctgctgtgaa tgttcttgtt aagtca
//
