LOCUS       NM_001079906            4065 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 331 (ZNF331), transcript variant
            4, mRNA.
ACCESSION   NM_001079906 XM_001134239 XM_001134339
VERSION     NM_001079906.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Nie,C., Han,X., Wei,R., Leonteva,A., Hong,J., Du,X., Wang,J.,
            Zhu,L., Zhao,Y., Xue,Y., Zhou,H. and Tian,W.
  TITLE     Association of ZNF331 and WIF1 methylation in peripheral blood
            leukocytes with the risk and prognosis of gastric cancer
  JOURNAL   BMC Cancer 21 (1), 551 (2021)
   PUBMED   33992091
  REMARK    GeneRIF: Association of ZNF331 and WIF1 methylation in peripheral
            blood leukocytes with the risk and prognosis of gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Vedeld,H.M., Nesbakken,A., Lothe,R.A. and Lind,G.E.
  TITLE     Re-assessing ZNF331 as a DNA methylation biomarker for colorectal
            cancer
  JOURNAL   Clin Epigenetics 10, 70 (2018)
   PUBMED   29854011
  REMARK    GeneRIF: Study have showed the potential of promoter methylation of
            ZNF331 as a biomarker for colorectal cancer detection. Further data
            provide evidence indicating a trend towards poorer prognosis for
            patients with ZNF331 methylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Daelemans,C., Ritchie,M.E., Smits,G., Abu-Amero,S., Sudbery,I.M.,
            Forrest,M.S., Campino,S., Clark,T.G., Stanier,P., Kwiatkowski,D.,
            Deloukas,P., Dermitzakis,E.T., Tavare,S., Moore,G.E. and Dunham,I.
  TITLE     High-throughput analysis of candidate imprinted genes and
            allele-specific gene expression in the human term placenta
  JOURNAL   BMC Genet 11, 25 (2010)
   PUBMED   20403199
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   McHale,C.M., Zhang,L., Lan,Q., Li,G., Hubbard,A.E., Forrest,M.S.,
            Vermeulen,R., Chen,J., Shen,M., Rappaport,S.M., Yin,S., Smith,M.T.
            and Rothman,N.
  TITLE     Changes in the peripheral blood transcriptome associated with
            occupational benzene exposure identified by cross-comparison on two
            microarray platforms
  JOURNAL   Genomics 93 (4), 343-349 (2009)
   PUBMED   19162166
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Pollard,K.S., Serre,D., Wang,X., Tao,H., Grundberg,E., Hudson,T.J.,
            Clark,A.G. and Frazer,K.
  TITLE     A genome-wide approach to identifying novel-imprinted genes
  JOURNAL   Hum Genet 122 (6), 625-634 (2008)
   PUBMED   17955261
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Forrest,M.S., Lan,Q., Hubbard,A.E., Zhang,L., Vermeulen,R.,
            Zhao,X., Li,G., Wu,Y.Y., Shen,M., Yin,S., Chanock,S.J., Rothman,N.
            and Smith,M.T.
  TITLE     Discovery of novel biomarkers by microarray analysis of peripheral
            blood mononuclear cell gene expression in benzene-exposed workers
  JOURNAL   Environ Health Perspect 113 (6), 801-807 (2005)
   PUBMED   15929907
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Meiboom,M., Murua Escobar,H., Pentimalli,F., Fusco,A., Belge,G. and
            Bullerdiek,J.
  TITLE     A 3.4-kbp transcript of ZNF331 is solely expressed in follicular
            thyroid adenomas
  JOURNAL   Cytogenet Genome Res 101 (2), 113-117 (2003)
   PUBMED   14610350
  REMARK    GeneRIF: Unique expression of a 3.4-kbp transcript of ZNF331 is
            described in thyroid adenoma cell lines with 19q13 aberrations.
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Wu,H., Zhang,S., Qiu,W., Zhang,G., Xia,Q., Xiao,C., Huang,X.,
            Huang,M., Agen,P., Fan,T., Yang,J. and Milunsky,A.
  TITLE     Isolation, characterization, and mapping of a novel human KRAB zinc
            finger protein encoding gene ZNF463
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 190-193 (2001)
   PUBMED   11267678
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Rippe,V., Belge,G., Meiboom,M., Kazmierczak,B., Fusco,A. and
            Bullerdiek,J.
  TITLE     A KRAB zinc finger protein gene is the potential target of 19q13
            translocation in benign thyroid tumors
  JOURNAL   Genes Chromosomes Cancer 26 (3), 229-236 (1999)
   PUBMED   10502321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF057584.1, AF412402.1,
            AC011487.5 and CR749560.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001079906.1.
            
            Summary: This gene encodes a zinc finger protein containing a KRAB
            (Kruppel-associated box) domain found in transcriptional
            repressors. This gene may be methylated and silenced in cancer
            cells. This gene is located within a differentially methylated
            region (DMR) and shows allele-specific expression in placenta.
            Alternative splicing and the use of alternative promoters results
            in multiple transcript variants encoding the same protein.
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (4, also known as e) differs in
            the 5' UTR compared to variant 1. All variants encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.95845.1,
                                           SRR1803617.230043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 20403199
            MANE Ensembl match     :: ENST00000449416.6/ ENSP00000393817.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BF057584.1         67-81
            16-613              AF412402.1         1-598
            614-2457            AC011487.5         65562-67405         c
            2458-4065           CR749560.1         3446-5053
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..4065
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="zinc finger protein 331"
                     /db_xref="GeneID:55422"
                     /db_xref="HGNC:HGNC:15489"
                     /db_xref="MIM:606043"
     exon            1..152
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     exon            153..219
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     exon            220..283
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     exon            284..365
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1748
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="zinc finger protein 463; KRAB zinc finger protein;
                     C2H2-like zinc finger protein rearranged in thyroid
                     adenomas; zinc finger protein 361"
                     /codon_start=1
                     /product="zinc finger protein 331"
                     /protein_id="NP_001073375.1"
                     /db_xref="CCDS:CCDS33102.1"
                     /db_xref="GeneID:55422"
                     /db_xref="HGNC:HGNC:15489"
                     /db_xref="MIM:606043"
                     /translation="MAQGLVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVS
                     LDLESAYENKSLPTEKNIHEIRASKRNSDRRSKSLGRNWICEGTLERPQRSRGRYVNQ
                     MIINYVKRPATREGTPPRTHQRHHKENSFECKDCGKAFSRGYQLSQHQKIHTGEKPYE
                     CKECKKAFRWGNQLTQHQKIHTGEKPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECK
                     DCGKAFRRGDELTQHQRFHTGEKDYECKDCGKTFSRVYKLIQHKRIHSGEKPYECKDC
                     GKAFICGSSLIQHKRIHTGEKPYECQECGKAFTRVNYLTQHQKIHTGEKPHECKECGK
                     AFRWGSSLVKHERIHTGEKPYKCTECGKAFNCGYHLTQHERIHTGETPYKCKECGKAF
                     IYGSSLVKHERIHTGVKPYGCTECGKSFSHGHQLTQHQKTHSGAKSYECKECGKACNH
                     LNHLREHQRIHNS"
     exon            366..492
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     exon            493..4065
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="hexamer: AATAAA"
     polyA_site      1877
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="major polyA site"
     regulatory      3340..3345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="major polyA site"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="ZNF331"
                     /gene_synonym="RITA; ZNF361; ZNF463"
                     /note="major polyA site"
ORIGIN      
        1 gcacttgcgt gggagtacga ggctgacgcg gcggccctgt ccccgtaact gtgacacggg
       61 tgcacgcgag cgtcattggg ggcgatgggg gccgtgctgg gtgcgcgttt gcaccagtga
      121 cgcagccgct gcatctccgc cagtccgcgc aggccagcat ccttcagaaa aagcatcccc
      181 gaggaggaag acgaatcgtt aaacatctga aagggtcagg ccagcatcct tcagaaaaag
      241 catccccgag gaggaagacg aatcgttaaa catcttaggt cagctctagc ctctcggaat
      301 ttgtcttctt cagtggaaac cccgagaaga ctgatcagtt cttcagttct aaaacaatgg
      361 cccagggttt ggtgacgttc gccgacgtag ccatagactt ttctcaggag gagtgggcct
      421 gtctgaactc tgctcagagg gacctgtact gggacgtgat gctggagaac tacagtaact
      481 tggtctcact ggatttggag tcagcatatg aaaataagag tttacctaca gaaaaaaaca
      541 ttcatgaaat aagggcttcc aaaaggaatt cagatagaag aagtaaatcc cttggccgta
      601 actggatatg tgaaggtacg cttgaaagac cacagcgctc cagagggagg tatgtcaatc
      661 agatgatcat caattatgtc aaaagacctg ctactagaga aggcacccct cctagaacac
      721 atcagagaca tcataaggag aattcctttg aatgtaagga ctgtgggaag gcctttagtc
      781 gtggctatca acttagtcaa catcagaaaa tccatactgg tgagaaacct tatgaatgta
      841 aagaatgtaa gaaggccttc cgttggggca atcagcttac tcaacatcaa aaaattcata
      901 ctggggagaa gccctacgaa tgtaaagact gtgggaaggc ttttcgatgg ggctcaagcc
      961 tcgttattca taagaggatt catactggtg aaaaacccta tgaatgtaaa gactgtggaa
     1021 aggcctttcg gcgtggtgat gagctcactc agcaccagag attccacact ggggagaaag
     1081 actacgaatg caaagactgt gggaagacct ttagccgtgt gtataaactt attcagcaca
     1141 agagaattca tagtggggag aagccttacg agtgtaaaga ctgtgggaag gcttttattt
     1201 gtggttcaag cctcattcag cataaaagaa ttcacacagg tgagaaaccc tatgaatgtc
     1261 aagaatgtgg gaaggccttt actcgagtca attaccttac tcagcatcag aagatccaca
     1321 ccggtgagaa gcctcacgaa tgtaaggagt gtgggaaggc ctttcgctgg ggttcgagcc
     1381 tcgttaagca cgagaggata catacgggcg agaagccgta caagtgcaca gaatgtggga
     1441 aggccttcaa ttgtggctat cacctcactc agcacgagag aatccacaca ggcgaaaccc
     1501 cgtataaatg taaggagtgt gggaaggctt tcatttatgg atcgagcctc gtgaaacatg
     1561 agagaattca taccggggtg aaaccctatg ggtgtacaga atgtgggaag agctttagtc
     1621 acggccatca gcttacacaa catcagaaaa cgcacagtgg ggcgaaatcc tacgaatgta
     1681 aggagtgcgg gaaggcatgt aaccacctaa accatctccg agaacatcag aggatccaca
     1741 acagttgaag agccttttga acgcagtagc ccgctcgtat ctatggtttc gctttccaca
     1801 gtttgttacc tgcagtcaac tgcagttcaa aaatattaaa tggaaaattc cagaaataaa
     1861 gaattttaag tctcaaatgg tgtgcccttc tgagtagcgt gatgaaatct ctcgctgtcc
     1921 ggctccagcc ggccggggat gtgagtcatc ccttggtcca gcacatccac gctgtatacg
     1981 ccacccaccc tgctagtgac ttagtagccg tcttggtgat cagatcaact atcccagcat
     2041 cacagtgcct gtgcccaagc agtcctcact ttgcttaaca gtggccccag agagcaggag
     2101 tagtgatgct ggtgattcgg atatgccaaa gagaagccac aaagtgcttc cttttaaatg
     2161 aaaaggtgaa agttctcaac ttaaaaaaga aaagaaaaaa atcatatact gaggttgcta
     2221 agatctacat gacaataaga tattttggga gagagatacg ttcacataat tttattacat
     2281 atattgttac aattgttcta ttttgttagt tactgttggt aatctcttac tgtgcctaat
     2341 ttataaatta aactttagat atgtatgtac aggaaaaaat gtagtatata gtatcgtata
     2401 tatgtacagg aaaaaaacgt actatctgtg gtttcaggtg tccactgcgg gtcttcaaac
     2461 gtacccccct caggtgagag gggactgctg tacaaagaat ataggaaggc ctctagacta
     2521 catccattcc ttcctcaaca ggaggaaaat tcctggtaca gtttaacgta aggcttcact
     2581 gatcactgtt gtttttgttt ttgtttttgt ttttttgaga cagagtctca ctcttgccca
     2641 ggctggagtg cagtggcacg gtcttggctc actgcaacct ccacctccca ggttccagca
     2701 attctcctgc ctcagcctcc ccagtagctg ggattacaga catgcaccac cacacctggc
     2761 taatttttgt atttttagta gagacagttt tcaccatgtt gtccaggctg gtctcaactc
     2821 ctgacctcag gtgatccacc caccttgccc tcccaaagtg ctaggattac aggcgtgagc
     2881 cactgcacct agcccactga tcactcttct gcttacagaa tatcagaagt cattctagag
     2941 gcaaatttga agagtggaaa aatcactttt tctgaatgat cttgtttttg gtgtagatgt
     3001 ttttattgtg tgggttagtt taatgaatac ataaagacta ccagtaccat tctgtcttta
     3061 ctccgtggca tctgtggaat aaccctgcta atgtaacacg tgagaaagcc tttggtcatg
     3121 ccacccactc taccagttgt ccccaccatc ccccgccctc ctccctgtga gacactgggc
     3181 caaaggctca ctacccctgt gcgttgtcca gcacacagac actatgtgca ttatttgtac
     3241 ataaggataa tcacatctac ctgagactgc tatcatggaa attaaatgtt tggtacatgt
     3301 aaagtctttg aaagtgtaac tggaatattg tgtaatttta ataaataata actattgttg
     3361 tttttatgat cattactacc atttgtgttg ccattagtga atttttacaa gaaaactccc
     3421 tgtgggtgca atgagtctgg aaaagaccat tgagtcttct agaagaaaac attaagagat
     3481 tattggcaca gccgtgggtt acgcaatgat ttcttagtac acaaaacaca gcaaacataa
     3541 aaagttgtta cacttcatca aaagtacaaa gttctgttca tcaaatgatg ctgttaagat
     3601 agggaaaaga caagaaacag gactggaaga agatgtttgc tctaaggtac acctgacaaa
     3661 ggaactctca tagaaaatat aaagaatccc tcaagttgaa aaaaaaatca atttaaaggg
     3721 gagaaaactt cagcacgtct caacagaaga ccaccaaatg gccaataagt aagtgaaaat
     3781 gtattcaatg tcattgctcc tcaaggaact gtagagtaaa accacaatgt gctgtcactc
     3841 tagacagtca ccaggatgat taaatttaaa tcacaataac aaggctgatt tcagatgtct
     3901 caccacaaag aaggaggata agggagcgag gtgatggata tgttaattag cttgatttaa
     3961 tccttccaca ttgtatacat gtatcagaac atcacattgt actccatcaa tataatacaa
     4021 ttattatttg tcaatcaaat attaataaaa tcaaagatga gcagg
//
