LOCUS       NM_014487               1891 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 330 (ZNF330), transcript variant
            1, mRNA.
ACCESSION   NM_014487
VERSION     NM_014487.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Sanchez-Brinas,A., Duran-Ruiz,C., Astola,A., Arroyo,M.M.,
            Raposo,F.G., Valle,A. and Bolivar,J.
  TITLE     ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell
            cycle and proliferation in response to heat shock in HEK293 cells
  JOURNAL   Biol Direct 18 (1), 26 (2023)
   PUBMED   37254218
  REMARK    GeneRIF: ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates
            cell cycle and proliferation in response to heat shock in HEK293
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1891)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1891)
  AUTHORS   de Melo,I.S., Jimenez-Nunez,M.D., Iglesias,C., Campos-Caro,A.,
            Moreno-Sanchez,D., Ruiz,F.A. and Bolivar,J.
  TITLE     NOA36 protein contains a highly conserved nucleolar localization
            signal capable of directing functional proteins to the nucleolus,
            in mammalian cells
  JOURNAL   PLoS One 8 (3), e59065 (2013)
   PUBMED   23516598
  REMARK    GeneRIF: NOA36 protein contains a highly conserved nucleolar
            localization signal capable of directing functional proteins to the
            nucleolus, in mammalian cells.
REFERENCE   6  (bases 1 to 1891)
  AUTHORS   de Melo,I.S., Iglesias,C., Benitez-Rondan,A., Medina,F.,
            Martinez-Barbera,J.P. and Bolivar,J.
  TITLE     NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic
            activity in human cells
  JOURNAL   Biochim Biophys Acta 1793 (12), 1876-1885 (2009)
   PUBMED   19895853
  REMARK    GeneRIF: NOA36/ZNF330 is translocated from the mitochondria to the
            cytoplasm when apoptosis is induced and that it contributes to
            cytochrome c release.
REFERENCE   7  (bases 1 to 1891)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   8  (bases 1 to 1891)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 1891)
  AUTHORS   Bolivar,J., Garcia-Cozar,F.J., Astola,A., Iglesias,C., Pendon,C.
            and Valdivia,M.M.
  TITLE     Genomic structure and chromosome location of the human gene
            encoding the zinc finger autoantigen ZNF330
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 234-238 (2001)
   PUBMED   11528117
REFERENCE   10 (bases 1 to 1891)
  AUTHORS   Bolivar,J., Diaz,I., Iglesias,C. and Valdivia,M.M.
  TITLE     Molecular cloning of a zinc finger autoantigen transiently
            associated with interphase nucleolus and mitotic centromeres and
            midbodies. Orthologous proteins with nine CXXC motifs highly
            conserved from nematodes to humans
  JOURNAL   J Biol Chem 274 (51), 36456-36464 (1999)
   PUBMED   10593942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU532661.1, AK223609.1, BC004421.1, AK002106.1 and AJ006591.2.
            
            On Nov 23, 2018 this sequence version replaced NM_014487.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.87237.1,
                                           SRR3476690.971316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262990.9/ ENSP00000262990.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BU532661.1         12-52
            42-769              AK223609.1         1-728
            770-790             BC004421.1         754-774
            791-1557            AK223609.1         750-1516
            1558-1880           AK002106.1         1515-1837
            1881-1891           AJ006591.2         1833-1843
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..1891
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="zinc finger protein 330"
                     /db_xref="GeneID:27309"
                     /db_xref="HGNC:HGNC:15462"
                     /db_xref="MIM:609550"
     exon            1..214
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            215..340
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1183
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar cysteine-rich protein; zinc finger autoantigen
                     330; nucleolar autoantigen 36"
                     /codon_start=1
                     /product="zinc finger protein 330 isoform 1"
                     /protein_id="NP_055302.1"
                     /db_xref="CCDS:CCDS3754.1"
                     /db_xref="GeneID:27309"
                     /db_xref="HGNC:HGNC:15462"
                     /db_xref="MIM:609550"
                     /translation="MPKKKTGARKKAENRREREKQLRASRSTIDLAKHPCNASMECDK
                     CQRRQKNRAFCYFCNSVQKLPICAQCGKTKCMMKSSDCVIKHAGVYSTGLAMVGAICD
                     FCEAWVCHGRKCLSTHACACPLTDAECVECERGVWDHGGRIFSCSFCHNFLCEDDQFE
                     HQASCQVLEAETFKCVSCNRLGQHSCLRCKACFCDDHTRSKVFKQEKGKQPPCPKCGH
                     ETQETKDLSMSTRSLKFGRQTGGEEGDGASGYDAYWKNLSSDKYGDTSYHDEEEDEYE
                     AEDDEEEEDEGRKDSDTESSDLFTNLNLGRTYASGYAHYEEQEN"
     exon            341..360
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            361..431
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            432..511
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            512..638
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            639..743
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            744..790
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            791..908
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1891
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="hexamer: ATTAAA"
     polyA_site      1677
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="major polyA site"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="ZNF330"
                     /gene_synonym="HSA6591; NOA36"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcgtaa aaggacgtcc ggtccgtctc ctagtgtccg gaatcggctg tcagcctccc
       61 tggctgttag taccttcttt cccggagtcc tggtccacga gttggattta ctgctgtcgc
      121 gggtgggcct cacgccattc cctgtccctc ggccccctga gtgagtccgg tctcccggcg
      181 aaagtgagcg aggtttgccc ggagcgcgca cgaggggaaa atgcctaaaa aaaagactgg
      241 tgcgaggaag aaggctgaga accgccgaga acgtgaaaaa caactaagag catcaagaag
      301 cactatagat ttagctaaac atccatgtaa tgcctcaatg gaatgtgaca agtgtcagag
      361 gcggcagaag aatagagcat tttgctactt ttgtaattct gtacagaagt taccaatttg
      421 tgcacagtgt gggaaaacaa agtgcatgat gaagtcttca gactgtgtca taaagcatgc
      481 tggtgtatac agtactggcc ttgcaatggt gggtgcaata tgtgacttct gtgaagcttg
      541 ggtttgccat ggtaggaaat gtctcagtac acatgcttgt gcctgccctc ttaccgatgc
      601 tgagtgtgtt gaatgtgaac gaggcgtgtg ggaccatgga ggcagaatat tcagttgttc
      661 tttttgccat aactttctct gtgaagatga tcaatttgag catcaagcca gctgccaggt
      721 tttagaggca gaaacattta aatgtgtttc atgcaatcgg cttggtcagc actcatgtct
      781 ccgttgtaag gcttgtttct gtgatgatca tacaaggagc aaagtgttta agcaagaaaa
      841 aggaaaacag cctccttgtc ctaaatgtgg gcatgaaact caggagacta aggaccttag
      901 catgtcaaca cgctccctga aatttggcag gcagactgga ggtgaagagg gagatggagc
      961 ttctgggtat gatgcttatt ggaagaacct ttcatctgat aagtatggtg ataccagcta
     1021 ccacgatgag gaggaggatg agtatgaagc agaggatgat gaagaggaag aagatgaagg
     1081 cagaaaggat tcagatactg agtcatcaga tttgtttact aatttgaatt taggaaggac
     1141 ctatgctagt ggctatgctc actatgagga acaagagaac taggggagct gctctggtgg
     1201 ccgtgtgtga gaggagcagg agtgagtgtg tgtgcttgat gaattgtgtg tggttgttca
     1261 aaagtacctt agccacttag ccttgtgcag aagactagtt acacttaatg ggccaagcaa
     1321 tagggtgtag cgtttttata gaactgataa tcaggcttat ggcataagaa aaatgagttt
     1381 caaatttaag atgtttattg atcgaagcaa ttgaagtatc atggattgga ttgttactga
     1441 tttcagtaaa gtatgttttg ccaattagat acatatatac aagataaagg aataggatgg
     1501 taatatattt gtttgaaatt aaattactgt ttttattaaa aaatactgct tcattgggct
     1561 gattttgtaa aatgtaatga gtaaaatgaa ttactgtatt tttcctttta tgtccacaga
     1621 atgagagtca tatgttgtta tattctaaat tttcattaaa tattcatgtc accttgagtt
     1681 gtcatgataa gtatgtttta gtatttgact tattcttctc tttcttcaca atgtatgtcc
     1741 tcagtggtac ctattattga tgccttaaat gtattgataa ggtgactagt tagccatttt
     1801 tcagagatac agtatcagaa atagtattat tacagaagct ttacccagga cattttattt
     1861 ctctttgaat aaatctatta tttcacttaa a
//
