LOCUS       NM_182976               9729 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 326 (ZNF326), transcript variant
            1, mRNA.
ACCESSION   NM_182976
VERSION     NM_182976.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9729)
  AUTHORS   Xu,Y., Qin,Y., Cui,J.X. and Xu,J.
  TITLE     MicroRNA-136-5p regulates gemcitabine resistance in pancreatic
            cancer via down-regulating ZNF32
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (20), 10472-10482 (2020)
   PUBMED   33155203
  REMARK    GeneRIF: MicroRNA-136-5p regulates gemcitabine resistance in
            pancreatic cancer via down-regulating ZNF32.
REFERENCE   2  (bases 1 to 9729)
  AUTHORS   Deng,C., Zhang,B., Zhang,Y., Xu,X., Xiong,D., Chen,X. and Wu,J.
  TITLE     A long non-coding RNA OLBC15 promotes triple-negative breast cancer
            progression via enhancing ZNF326 degradation
  JOURNAL   J Clin Lab Anal 34 (8), e23304 (2020)
   PUBMED   32329931
  REMARK    GeneRIF: A long non-coding RNA OLBC15 promotes triple-negative
            breast cancer progression via enhancing ZNF326 degradation.
REFERENCE   3  (bases 1 to 9729)
  AUTHORS   Wang,M., Han,Q., Su,Z. and Yu,X.
  TITLE     Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and
            HDAC7 and its Clinicopathologic Significance in Glioma
  JOURNAL   Lab Med 51 (4), 377-384 (2020)
   PUBMED   31930344
  REMARK    GeneRIF: Transcription Factor ZNF326 Upregulates the Expression of
            ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
REFERENCE   4  (bases 1 to 9729)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9729)
  AUTHORS   Yu,X., Wang,M., Wu,J., Han,Q. and Zhang,X.
  TITLE     ZNF326 promotes malignant phenotype of glioma by up-regulating
            HDAC7 expression and activating Wnt pathway
  JOURNAL   J Exp Clin Cancer Res 38 (1), 40 (2019)
   PUBMED   30691485
  REMARK    GeneRIF: High ZNF326 expression is associated with glioma.
            Erratum:[J Exp Clin Cancer Res. 2020 Jan 16;39(1):14. doi:
            10.1186/s13046-020-1526-z.. PMID: 31941535]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9729)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 9729)
  AUTHORS   Close,P., East,P., Dirac-Svejstrup,A.B., Hartmann,H., Heron,M.,
            Maslen,S., Chariot,A., Soding,J., Skehel,M. and Svejstrup,J.Q.
  TITLE     DBIRD complex integrates alternative mRNA splicing with RNA
            polymerase II transcript elongation
  JOURNAL   Nature 484 (7394), 386-389 (2012)
   PUBMED   22446626
  REMARK    GeneRIF: data indicate that the DBIRD complex (consisting of DBC1
            and ZNF326) acts at the interface between mRNP particles and
            RNAPII, integrating transcript elongation with the regulation of
            alternative splicing
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 9729)
  AUTHORS   Liou,Y.J., Chen,C.H., Cheng,C.Y., Chen,S.Y., Chen,T.J., Yu,Y.W.,
            Nian,F.S., Tsai,S.J. and Hong,C.J.
  TITLE     Convergent evidence from mouse and human studies suggests the
            involvement of zinc finger protein 326 gene in antidepressant
            treatment response
  JOURNAL   PLoS One 7 (5), e32984 (2012)
   PUBMED   22666313
  REMARK    GeneRIF: involvement of the Zfp326 and ZNF326 genes in
            antidepressant treatment response
REFERENCE   9  (bases 1 to 9729)
  AUTHORS   Stein,J.L., Hua,X., Morra,J.H., Lee,S., Hibar,D.P., Ho,A.J.,
            Leow,A.D., Toga,A.W., Sul,J.H., Kang,H.M., Eskin,E., Saykin,A.J.,
            Shen,L., Foroud,T., Pankratz,N., Huentelman,M.J., Craig,D.W.,
            Gerber,J.D., Allen,A.N., Corneveaux,J.J., Stephan,D.A., Webster,J.,
            DeChairo,B.M., Potkin,S.G., Jack,C.R. Jr., Weiner,M.W. and
            Thompson,P.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide analysis reveals novel genes influencing temporal lobe
            structure with relevance to neurodegeneration in Alzheimer's
            disease
  JOURNAL   Neuroimage 51 (2), 542-554 (2010)
   PUBMED   20197096
REFERENCE   10 (bases 1 to 9729)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN299618.1, BC090866.2, AK303707.1, AL161797.10 and BU676987.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182976.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.120816.1,
                                           SRR1803613.166355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340281.9/ ENSP00000340796.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CN299618.1         26-40
            16-1558             BC090866.2         1-1543
            1559-2012           AK303707.1         1037-1490
            2013-9286           AL161797.10        15955-23228
            9287-9727           BU676987.1         13-453              c
            9728-9729           AL161797.10        23670-23671
FEATURES             Location/Qualifiers
     source          1..9729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..9729
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="zinc finger protein 326"
                     /db_xref="GeneID:284695"
                     /db_xref="HGNC:HGNC:14104"
                     /db_xref="MIM:614601"
     exon            1..164
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1897
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ZNF-protein interacting with nuclear mRNPs and DBC1; DBIRD
                     complex subunit ZNF326; zinc finger protein interacting
                     with mRNPs and DBC1"
                     /codon_start=1
                     /product="DBIRD complex subunit ZNF326 isoform 1"
                     /protein_id="NP_892021.1"
                     /db_xref="CCDS:CCDS727.1"
                     /db_xref="GeneID:284695"
                     /db_xref="HGNC:HGNC:14104"
                     /db_xref="MIM:614601"
                     /translation="MDFEDDYTHSACRNTYQGFNGMDRDYGPGSYGGMDRDYGHGSYG
                     GQRSMDSYLNQSYGMDNHSGGGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNEPEQSR
                     FGGSYGGRFESSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSF
                     SSPHMKPAPVGSRGRGTPAYPESTFGSRNYDAFGGPSTGRGRGRGHMGDFGSIHRPGI
                     VVDYQNKSTNVTVAAARGIKRKMMQPFNKPSGTFIKKPKLAKPMEKISLSKSPTKTDP
                     KNEEEEKRRIEARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESS
                     SHQETLDHIQKQTKFDKVVMEFLHECMVNKFKKTSIRKQQTNNQTEVVKIIEKDVMEG
                     VTVDDHMMKVETVHCSACSVYIPALHSSVQQHLKSPDHIKGKQAYKEQIKRESVLTAT
                     SILNNPIVKARYERFVKGENPFEIQDHSQDQQIEGDEEDEEKIDEPIEEEEDEDEEEE
                     AEEVGEVEEVEEVEEVREGGIEGEGNIQGVGEGGEVGVVGEVEGVGEVEEVEELEEET
                     AKEEPADFPVEQPEEN"
     exon            165..209
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            210..245
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            246..357
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            358..763
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            764..962
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1074
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1222
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1322
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1453
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1549
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..9729
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="major polyA site"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="hexamer: AATACA"
     polyA_site      2731
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="major polyA site"
     regulatory      7763..7768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="hexamer: AATAAA"
     polyA_site      7784
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
     regulatory      9709..9714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
                     /note="hexamer: AATAAA"
     polyA_site      9729
                     /gene="ZNF326"
                     /gene_synonym="dJ871E2.1; ZAN75; Zfp326; ZIRD"
ORIGIN      
        1 agcctcgctg tggcctgcgg ctcccgggct ggtagcgcgc cgctctcggt cgcgcggagt
       61 gatcgtgtgg aatcgcgggt cgcggacgct cgccgccggc catagctcag cctagcgccg
      121 ccaaggccga cggccctcag cctctgccat ggacttcgag gacgattaca cacactccgc
      181 ctgcaggaat acttatcagg gctttaatgg aatggatcgt gattatggcc ctggatctta
      241 tggagggatg gatcgtgact atggccatgg atcctatggg ggtcagagat ccatggattc
      301 ctacctaaac cagtcatatg gcatggacaa tcacagtggt ggtggtgggg gtagcaggtt
      361 tggaccttat gagtcttacg actccaggtc ttctctgggt gggcgagatc tgtacagatc
      421 tggctatggt tttaatgaac ccgaacaaag ccgcttcgga ggtagttatg gtggtcgatt
      481 tgagagctcc taccggaata gccttgactc tttcggaggt agaaaccagg gcgggtctag
      541 ctgggaagca ccttactccc gttcaaaatt gaggcctggg tttatggagg acagaggaag
      601 agagaattac tcttcctaca gcagtttttc ttcaccccat atgaagcctg cacctgtagg
      661 ctctcggggg agaggaacgc ctgcttatcc tgaaagtacg tttggaagca gaaactatga
      721 tgcttttgga ggaccatcaa caggcagagg ccgaggccga ggacatatgg gtgattttgg
      781 aagcattcat agacccggaa ttgttgttga ctatcaaaac aaatccacca atgtgacagt
      841 tgctgctgca agaggaataa agagaaaaat gatgcagcca tttaataagc ccagtggaac
      901 ctttatcaag aaacccaaac tagcaaaacc tatggagaag ataagcctca gcaaatcacc
      961 cacaaaaact gatcctaaaa atgaagagga agaaaagcgg cgaattgagg ctcggcgaga
     1021 gaaacaaagg cgcagaagag aaaaaaacag tgagaaatac ggagatggat acagaatggc
     1081 atttacatgt tcattttgta aatttcgaac atttgaagaa aaagatattg aactgcatct
     1141 ggaaagttct tcacatcagg aaacattaga tcatatacag aaacaaacta aatttgataa
     1201 agtagttatg gagtttttgc atgagtgtat ggtgaataaa ttcaagaaaa catctattcg
     1261 taagcaacag acaaataatc aaacagaagt agttaaaata attgaaaaag atgttatgga
     1321 aggtgttact gtagatgatc acatgatgaa ggtagagaca gttcattgca gcgcttgcag
     1381 tgtttatatc cctgctttac atagttcagt tcagcagcac ttaaaatctc ctgatcatat
     1441 caaagggaag caggcttata aggaacaaat aaaaagagag agtgtcttga ctgctacaag
     1501 cattttaaat aatccaatag tgaaggcgcg atatgaacgt tttgttaagg gtgagaatcc
     1561 ttttgaaatt caagaccatt ctcaggatca gcaaatagaa ggagatgagg aggatgaaga
     1621 gaagattgat gaacctattg aagaagagga ggatgaagat gaggaagaag aagcagagga
     1681 agtgggggaa gtagaggaag tggaagaagt agaggaagtg agagaaggag gaatagaggg
     1741 cgagggaaat atacagggag taggggaagg aggggaagta ggggtagtgg gagaagtaga
     1801 gggagtgggg gaagtagagg aagtagagga attagaggaa gagacagcaa aggaagaacc
     1861 tgctgacttc cctgttgagc aacctgaaga aaattaaata taaggtatta gatttaaaag
     1921 gagctttaca tttcggttct aatgtaaaaa agggtaagaa atttaatagc ttaaaatatg
     1981 aattaacacc catgttgcat gcattccaca tattaaaatt tgttttatat aatttctaaa
     2041 tgtttaacat ttgtttaata aaatgaaggc aaaactattt tagtttagtt tttatagcta
     2101 ccagacttag atccgataaa ttgtttgtat aatttttaag cttaattttt attactttat
     2161 tggtgttaag gataacaaat gtgtattgtt agtatatcta ttctaatcat tttatcttaa
     2221 atgctgctct tgggagtgaa tattcaagtg tgcatcaatt ttttgaatac ttaccctgga
     2281 agatataaac tgggcaagta ttttgtgctc tgtgtatttt tttactgcat tagacattga
     2341 atagtaattt gcgttaagat acgcttaaag gctctttgtg accatgtttc cctttgtagc
     2401 aataaaatgt tttttacgaa aactttctcc ctggattagc agtttaaatg aaacagagtt
     2461 catcaatgaa atgagtattt aaaataaaaa tttgccttaa tgtatcagtt cagctcacaa
     2521 gtattttaag atgattgaga agacttgaat taaagaaaaa aaaattctca atcatatttt
     2581 taaaatataa gactaaaatt gtttttaaaa cacatttcaa atagaagtga gtttgaactg
     2641 accttattta tactcttttt aagtttgttc cttttccctg tgcctgtgtc aaatcttcaa
     2701 gtcttgctga aaatacattt gatacaaagt tttctgtagt tgtgttagtt cttttgtcat
     2761 gtctgttttt ggctgaagaa ccaagaagca gacttttctt ttaaaagaat tatttctctt
     2821 tcaaatattt ctatcctttt taaaaaattc ctttttatgg cttatatacc tacatattta
     2881 aaaagagaac atgagcttga tagaggatct attcttaaat aatttatttt caaacaaccg
     2941 tctatgtcac taaaaagtag tgctcttatt tttttcaatc tttactgtgg cctcttttga
     3001 gagtagggtc cgtagttttt tttttttttc ttttttggga cagggtttca ctctgtcacc
     3061 caggctggag tgcagtgtag cctcaacctc ctgggctcaa gcgatcctcc aacttagcct
     3121 cccaagtagc tgggactgtt aagtgtgagc caccatgccc agctaatttt tgtagttttt
     3181 gtagagacag ggttttacca tgttgtccag gctggttttg aactcctggg ctcaagtgac
     3241 ctgtctgtct tggcctccca cagtgctggg attgcaggtg tgagccacca tgcctggcat
     3301 agggggctgt atttcagtga aattagaaaa gttttgaggc atcgaatgga taaatggatg
     3361 gatatatcaa attgtaaggt attaagtggg tgaatgtatg gacatttgta gaatcccaca
     3421 gataatttat ctttttgtgt aaaataaggc ttttaaaact agactttctg aaccaataca
     3481 gttttttttt tttgaggtga actaggtttg cctagcttta agctagcaat atctgataga
     3541 tacttgcatc taattttagg gatttggtgc caaataagag aagggtagtt gaagactaga
     3601 taaatttgga tactatctag gagtctgtat ttacttagca ggcttttgaa agccgttttg
     3661 cttaggagtt caaattttaa ggataatagg acttgttacc ctcttatttc tcctttattt
     3721 ttaaaaatat ttgtggaagg gctaaggtaa aagaataata aattcctcta ggttattagt
     3781 atttggttct tctgatacta agctgagtga ttttttttaa aacaatgtct ctggtagtct
     3841 gattgagata tgaaactttt gggaagaaaa ccattatgta acaagaatcc tatgtaacaa
     3901 ctgggtaaat gttttagaat gagagatagg aaagaacatc taaatagtac ttttttgtgg
     3961 gacgcatgag cctttataca gcctagctaa tttgcaaggt aatgataaat aaaagtgtat
     4021 tttgttactg tgcttaattc agaaattcaa attcatgtat ttcctattgg ataatttgta
     4081 ggcgggcagt ttactttata gtcaggttag tttttgtgat ccttagtgtt tatatttgca
     4141 ttgcttttgt aataaggatg tatataagat cttaaacgcc tttcaacttc tgttttcaag
     4201 tatcacttgt tttctctatt acaaagtgag atacatagtt ctaaataacc aaagaaattt
     4261 atttataacc tacacagttg tttcagctcc atgcctaggg actatcctgt attattcgct
     4321 ttttatcact ttctacctac agtctaccaa aaagtctgtc tgttctactt ccaaaattta
     4381 tctgccgact cttctacctc cactgcaacc aacccagttc aagtcatgat aatttcttgt
     4441 taactaatct tgattccacc cttaccatga tagattcagt tttctacaca agtataagct
     4501 tttaaaaatg taattcagat gatgttaatc tcatgctttt tttttttttg tacctataca
     4561 gttagaactc cttatcatgt tgatcagact ggcctagctt tacaacttta tatcatatac
     4621 cattcttacc agccataatg gccttttgtt acttttttga tgagttcttt cctacaaaga
     4681 cctttgcatt ttcttattct atagcctata cccatcagct ttccttggct gattcttcat
     4741 ccttcaggtc accttaaatg ttagaaaagg ggagtagttc taaaatgttt gtagaaacga
     4801 ggatttgggg gtaccaacct agattttact agagcatatt ctttggaggt gttctttttt
     4861 tctacttttt tttttttttt ctttaggttc tgtctttgtc atgcaggctg gaattcagtg
     4921 gcacgatcat ggcttactgc agctttgacc tcctgggctc aagcggtcgt cccgccttag
     4981 cctcccaagt agctgggacc acagacgtgc accatcacac tcagctaata ttttttttgt
     5041 agagatgggg tcttgctttg ttgcccaggc tagtcttgaa ctcctggaca caagcagtcc
     5101 tcccacctca gcttcccaaa gtgctagaat tacaggcatg agccaccacg cctatcctgg
     5161 aggtgatata tttttaacaa atatctcaca tgattttgaa ggtagtggtc agtgattgca
     5221 ctttgaggac attcataggg ccctcataca aatttctggt gcctgtaact cttcccctat
     5281 caaggcagga gtttccgccc ttttgaatat aaacataggt ttgggggatt cttcataata
     5341 ctttctgaaa gcactggaat ctataacaga cctgtgggag tcagaaaatg gggacttttc
     5401 ccccctcatt taatacttac aactatattg gtaagttagt aggagtagta attttcccat
     5461 ataataagcc cactcttgta catgtagaaa cagagaaaag aactacaaag gtaaatgtta
     5521 gtgcatgttg aaatgtattt aagaactctg tttttgttgg caagattgtt cttattgtag
     5581 aagtggatat tatcagatta ttttagatgt tattcaacat ttgatttatt taccaaattg
     5641 tccttacttt gaatataagc aaactttttt attgtggtaa agtatacata gcataaaatt
     5701 accattctaa tcatttttta atgtaccatt tagtggcatt aattacaagc aacctttttt
     5761 tttttttttt gagacatagc ctcactctgt cacccaggct ggagttcagt ggcactatct
     5821 cagctcactg caatctctgc ttcctgggtt caagcgattc ttgtgcctca gccctcccga
     5881 gtaactggga ttacaggcac acaccaccat gcccagctaa tttttttgta tttttaatag
     5941 agatggggtt tcattatatt ggttaggttg gtcttgaact cctgacctca agtgatctgc
     6001 ctgccttggc ctcccaaagt gctgggatta taggcatgag ccaccgcgtc tggcatacaa
     6061 acttttgatt acagtttgac acctgttgat ggacagaaaa tggagtaacc gtccaggcag
     6121 gaatgttcta gtctgtgtga cagttacagt tcattttata aataaacaat tgactttttt
     6181 tggtagttat ggtccctacc ctcagtgctg tatctctatt tggtattcaa acaaatccag
     6241 ggaatctgca aggctgaagg gcagattctt ggcaatggta aattcagtag gtcctgccac
     6301 catttgaggc ctcctcggag acagccatac tagtctaatc tcttcttgac tttcccttct
     6361 tctttcccag tcctctaatt cccagaggtc tgttgtgaat tctaatgctt tcagaaaata
     6421 ttacggagaa tcccacaatg ataaaatttc ccagtttttg ttttaaaaca aagttgaaaa
     6481 atattatatt aggggtcagg gtgaggtgct gttgatggtg acagatggcc cccttggcga
     6541 cagggaagta tgaaatagca tggagtgtgg aagggtacta tgggtagctt atttattaga
     6601 tcagtataaa gtatagattt aagagagtta gattaaaatg gcatgcttga ttcaagtcat
     6661 taaattctaa agttctatta aaattgtaga ggagatacaa taatacaaat ttcagcaata
     6721 aggatagatt tataatcaca ctaggaagac aagaagggtg ctgtgaaata tttctagaag
     6781 atacaaaaca aggaattaga tcttggtgaa accaagagag ccaaggaact gacagccaca
     6841 tgccgatgat aattaaagaa ttacctccag ttgtagagac agctctgaga tggggtgtct
     6901 gtagtgtgct aagccagatt tttgaaggac tagatagtta ttctggtctc tgactcagag
     6961 ctgctggtcc acagaattcc tctaagctaa agctgtaaca caatttgatg tttgccaaat
     7021 aaggtgagac tcacagagta tatgtgcaga gcatataatg cagagcatac aaataggggc
     7081 catcgaagtg tggcaatgcc ctaggtatat tgtgattacc acaaggagct ttattcctca
     7141 tacttagaaa acaagcacac aaagaaaaat ctgccagctg tctatttccc aattttcctt
     7201 ctgactgttc ctttctcctt cctcacacaa ttaaaatgct aggtttcctg taatcgcaat
     7261 cttcagggaa tttttcactc aagcccagaa aataaactcc agataatgat actgagaaat
     7321 ttattggttg gaaaactgct atctacaggc cttccactac ctatttctta gtagatttta
     7381 catttttaaa gggttgtaga acaccaaaac aatatatgac agatactgtg tttgggcctt
     7441 aaagcctacc ctttatataa aaagtttgtt gactcctagg ctctcatttg caagtagaca
     7501 aatgagaaac agcaaatatt taaggaaaag agcaacatga aaaatacaca gcaaacttaa
     7561 caagcagaaa gaattcctgg ggaaacaatt cagggggaaa aaatgaccaa gtataattag
     7621 tattatatgg aataataatt actactactt ataatagttt catatgtaat cctcatcata
     7681 ttatatgtca taatcttcaa atattttaga ggttattgta ctaattttaa aaatgcaagt
     7741 tgctataaag aagtatcttg gaaataaaca gttgtgaaaa taaactctgt tttaggctga
     7801 ttagttgaat aaacatggct gagaatcaaa ttactgagct agaattttga gctgaagata
     7861 cttccagagc ttacaagaaa agataaaaaa gatggaagtt acagtaaaag acatagatgt
     7921 atctcttaaa gacatagaaa acccagaaca ccatctgttt aaaaattaaa cttcatgaga
     7981 ttaagagcca tatgtataga gaattcacca ttgaataccc tgcatatatc acagtgccag
     8041 gtaaatacta tgcaataaat atttttgaat gtatgtatgt atgttacagt ataaatatat
     8101 agaggagttc cagaaagtga aaaaagaagt gaagaatagg aaaaaaaaaa aaatcttctg
     8161 atgaaagatt catattagaa gtctccagtg ctgagcaaaa acaatgaaaa agtcatgcag
     8221 gatgaatact gacaaaatat gtgtaatccc aagcttagaa aaatctcaaa atgtctaaag
     8281 agaaacagtg tacctataag gggaaaagaa tcacattggt ctcagacttg tcatctgttc
     8341 gttggagtgc tacaacatac tgctattttt gaagttctga gggagaactg ttttgaattt
     8401 agacttctat cttgagtgaa actgtcaaga gtaagggcac agcaaggaca ttctaccaat
     8461 tttagaacat gcaaggattt cagaaattaa ctcataaaac acaacctgca cggcatggta
     8521 tcaaattatg taaagaaaaa cttggtaaac aagaaattgt caaatttata atcatagcta
     8581 cgtatttgaa cacagcgctt agaaattgtc agataaagag ttcaaaatag aggaaacatt
     8641 ttgaattata tagtgcacaa attttaatag ctatagaata tttgttttca aatgccatga
     8701 aaaaatgacc atgaagcaaa aaccacaata tttttttgtt tgttgatagg taggaattca
     8761 gggtccatcc tgtcatcaca atgcaatgaa acaaaaaatt agcaagtgga tagcaataaa
     8821 tcaattttta aaaatcagac aaaagaaaac actgtccttg taatgcttgc atttaaaagg
     8881 aaataaaaac ttatgaaaga gaatctttat tttatttaag cagttctaga ttatacaaaa
     8941 tgttgaaaca tctcaatttg gtctctgagg ctagcataat ccttattcca gaaaattgtt
     9001 catcaaagat agctatagac cagtctcact tacgaacaaa tgtaatttgt tgaaactggt
     9061 catgttgaaa aaacatgacc aattaaatat cccaaaataa tgtgtcatgg tagagtaggg
     9121 tttatctgaa aactgcaaca tgacgattat gtaactcaat cctttaggaa atttattact
     9181 ttaacttaaa aaaaaatacc ataagcttga tagatgctcg aaaaacattt cctaagattg
     9241 aacacattcc agatttaaat ttttcaggct gagaatagaa taaagccttt gtaacttggc
     9301 taaggactag gaaggtcttc cagaaagctt catcaaacat ctgcattcaa gtcaggatta
     9361 agacaataat gactgttgcc tatgcaacaa tcatttaacc ctaagaaata gaagtattag
     9421 gaagagaaaa catagtcctt attttgagca gtgtgattgt agagacaaac atccaagaga
     9481 aacagttgaa aaactattag aaatgacaaa aggtagtttt gtttaatagt tcaccatgaa
     9541 aatctgtact atatagaaaa tctgtatata gaatatagca ttggccaatt ggaaatgtaa
     9601 tttgaaaatc ccatttgcag caaaacttgg aactgtatac tgtctaagaa taaacaatgg
     9661 gaaaaatgca aaatccttat gaggaaaatg atacatttta atggaggaaa taaaatgcct
     9721 gaataaaca
//
