LOCUS       NM_024639               4811 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 322 (ZNF322), transcript variant
            2, mRNA.
ACCESSION   NM_024639
VERSION     NM_024639.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4811)
  AUTHORS   Huang,S.H., Hsieh,H.C., Shieh,J.M., Su,W.C. and Wang,Y.C.
  TITLE     Downregulation of microRNA-326 enhances ZNF322A expression,
            transcriptional activity and tumorigenic effects in lung cancer
  JOURNAL   Biofactors 50 (1), 214-227 (2024)
   PUBMED   37647209
  REMARK    GeneRIF: Downregulation of microRNA-326 enhances ZNF322A
            expression, transcriptional activity and tumorigenic effects in
            lung cancer.
REFERENCE   2  (bases 1 to 4811)
  AUTHORS   Lin,C.C., Kuo,I.Y., Wu,L.T., Kuan,W.H., Liao,S.Y., Jen,J.,
            Yang,Y.E., Tang,C.W., Chen,Y.R. and Wang,Y.C.
  TITLE     Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances
            neo-angiogenesis to promote lung cancer progression
  JOURNAL   Theranostics 10 (22), 10001-10015 (2020)
   PUBMED   32929330
  REMARK    GeneRIF: Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis
            enhances neo-angiogenesis to promote lung cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4811)
  AUTHORS   Cheung,C.H.Y., Hsu,C.L., Lin,T.Y., Chen,W.T., Wang,Y.C., Huang,H.C.
            and Juan,H.F.
  TITLE     ZNF322A-mediated protein phosphorylation induces autophagosome
            formation through modulation of IRS1-AKT glucose uptake and
            HSP-elicited UPR in lung cancer
  JOURNAL   J Biomed Sci 27 (1), 75 (2020)
   PUBMED   32576196
  REMARK    GeneRIF: ZNF322A-mediated protein phosphorylation induces
            autophagosome formation through modulation of IRS1-AKT glucose
            uptake and HSP-elicited UPR in lung cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4811)
  AUTHORS   Liao,S.Y., Kuo,I.Y., Chen,Y.T., Liao,P.C., Liu,Y.F., Wu,H.Y.,
            Lai,W.W. and Wang,Y.C.
  TITLE     AKT-mediated phosphorylation enhances protein stability and
            transcription activity of ZNF322A to promote lung cancer
            progression
  JOURNAL   Oncogene 38 (41), 6723-6736 (2019)
   PUBMED   31399647
  REMARK    GeneRIF: results reveal a new mechanism of AKT signaling in
            promoting ZNF322A protein stability and transcriptional activity in
            lung cancer cell, xenograft, and clinical models
REFERENCE   5  (bases 1 to 4811)
  AUTHORS   Jen,J., Liu,C.Y., Chen,Y.T., Wu,L.T., Shieh,Y.C., Lai,W.W. and
            Wang,Y.C.
  TITLE     Oncogenic zinc finger protein ZNF322A promotes stem cell-like
            properties in lung cancer through transcriptional suppression of
            c-Myc expression
  JOURNAL   Cell Death Differ 26 (7), 1283-1298 (2019)
   PUBMED   30258097
  REMARK    GeneRIF: The ZNF322A-centered transcriptome promotes lung
            tumorigenesis and ZNF322A acts as a transcription suppressor of
            c-Myc to maintain lung cancer stem cell-like properties by shifting
            metabolism towards oxidative phosphorylation.
REFERENCE   6  (bases 1 to 4811)
  AUTHORS   Liao,S.Y., Chiang,C.W., Hsu,C.H., Chen,Y.T., Jen,J., Juan,H.F.,
            Lai,W.W. and Wang,Y.C.
  TITLE     CK1delta/GSK3beta/FBXW7alpha axis promotes degradation of the
            ZNF322A oncoprotein to suppress lung cancer progression
  JOURNAL   Oncogene 36 (41), 5722-5733 (2017)
   PUBMED   28581525
  REMARK    GeneRIF: Our results reveal a new mechanism of ZNF322A oncoprotein
            destruction regulated by the CK1delta/GSK3beta/FBXW7a axis.
            Deregulation of this signaling axis results in ZNF322A
            overexpression and promotes cancer progression
REFERENCE   7  (bases 1 to 4811)
  AUTHORS   Jen,J., Lin,L.L., Chen,H.T., Liao,S.Y., Lo,F.Y., Tang,Y.A.,
            Su,W.C., Salgia,R., Hsu,C.L., Huang,H.C., Juan,H.F. and Wang,Y.C.
  TITLE     Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin,
            cyclin D1 and p53 to promote tumor growth and metastasis in lung
            cancer
  JOURNAL   Oncogene 35 (18), 2357-2369 (2016)
   PUBMED   26279304
  REMARK    GeneRIF: ZNF322A overexpression transcriptionally dysregulates
            genes involved in cell growth and motility therefore contributes to
            lung tumorigenesis and poor prognosis
            Erratum:[Oncogene. 2017 Aug;36(31):4526. doi: 10.1038/onc.2017.77..
            PMID: 28368404]
REFERENCE   8  (bases 1 to 4811)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 4811)
  AUTHORS   Li,Y., Wang,Y., Zhang,C., Yuan,W., Wang,J., Zhu,C., Chen,L.,
            Huang,W., Zeng,W., Wu,X. and Liu,M.
  TITLE     ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein,
            regulates transcriptional activation in MAPK signaling pathways
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1383-1392 (2004)
   PUBMED   15555580
  REMARK    GeneRIF: These results suggest that ZNF322 is a member of the
            zinc-finger transcription factor family and may act as a positive
            regulator in gene transcription mediated by the MAPK signaling
            pathways.
REFERENCE   10 (bases 1 to 4811)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX474628.1, AK290038.1 and AL513548.8.
            
            On Nov 22, 2018 this sequence version replaced NM_024639.4.
            
            Summary: ZNF322A is a member of the zinc-finger transcription
            factor family and may regulate transcriptional activation in MAPK
            (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed
            15555580]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.241668.1,
                                           SRR1803615.87429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415922.7/ ENSP00000418897.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               BX474628.1         11-279
            270-1900            AK290038.1         1-1631
            1901-4811           AL513548.8         48869-51779         c
FEATURES             Location/Qualifiers
     source          1..4811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..4811
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /note="zinc finger protein 322"
                     /db_xref="GeneID:79692"
                     /db_xref="HGNC:HGNC:23640"
                     /db_xref="MIM:610847"
     exon            1..306
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /inference="alignment:Splign:2.1.0"
     exon            307..395
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /inference="alignment:Splign:2.1.0"
     exon            396..465
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /inference="alignment:Splign:2.1.0"
     exon            466..4811
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..1849
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /note="HLA complex group 12; zinc finger protein 489; zinc
                     finger protein 388; zinc finger protein 322A"
                     /codon_start=1
                     /product="zinc finger protein 322"
                     /protein_id="NP_078915.2"
                     /db_xref="CCDS:CCDS4617.1"
                     /db_xref="GeneID:79692"
                     /db_xref="HGNC:HGNC:23640"
                     /db_xref="MIM:610847"
                     /translation="MYTSEEKCNQRTQKRKIYNVCPRKGKKIFIHMHEIIQIDGHIYQ
                     CLECKQNFCENLALIMCERTHTGEKPYKCDMCEKTFVQSSDLTSHQRIHNYEKPYKCS
                     KCEKSFWHHLALSGHQRTHAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSEC
                     DKCFSRSTNLIRHRRTHTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEK
                     SYRHRSAFIVHKRVHTGEKPYKCGACEKCFGQKSDLIVHQRVHTGEKPYKCLECMRSF
                     TRSANLIRHQATHTHTFKCLEYEKSFNCSSDLIVHQRIHMEEKPHQWSACESGFLLGM
                     DFVAQQKMRTQTEELHYKYTVCDKSFHQSSALLQHQTVHIGEKPFVCNVSEKGLELSP
                     PHASEASQMS"
     regulatory      4785..4790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /note="hexamer: AATAAA"
     polyA_site      4811
                     /gene="ZNF322"
                     /gene_synonym="HCG12; ZNF322A; ZNF388; ZNF489"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgcgc cggcctcttc ccagccagct tgaaagggtt tgcgtagccg gccttgtggg
       61 cccttgaagc gctctgttaa agcgctctgt gggcggcctg gccccaactc ctctagtcta
      121 ggcgcacgaa gggagttgct cctaggtctt gtccgtgccg ggttcgcttt tctttccttc
      181 ccgaagcctg gcccttagat ctactatcgc agagtctgcg gccgccagga agcccagatt
      241 cgagtgtccg gagagtaacc ggaagtgctg tccccaggcc taggggcggc gccggcggct
      301 gccagggaga ggcaagaatt gagtgttgtg aatagttctg aactagagac cttttgaaac
      361 caaaaggaag atggtcttga gtctttcttg ttacgaatgc tatcttcttt gagaagtcaa
      421 attgtcagga tcaggaatgt atgttttctt ccatctggat tctagggttg gaaataccaa
      481 gtaaggaatt aacatatatg atgctggaaa cttgtagagg ctcatgattg aaaggcctga
      541 aacagatgta tcttccaagt tcttatcaag aaaatgactg tgagggcaac gatgggtcaa
      601 gaagaccagc ggaaaactcc ctaggagaga gccatagaaa atgtacactt cagaagagaa
      661 atgtaatcag agaactcaaa aaaggaaaat atataatgta tgccctcgga agggtaaaaa
      721 gatttttatt catatgcatg agattattca gatagatggt catatatacc agtgccttga
      781 atgcaagcaa aacttctgtg aaaacttagc tcttattatg tgtgagagaa cccatactgg
      841 ggagaaacct tataaatgtg atatgtgtga gaaaaccttt gtccaaagct cagatcttac
      901 ttcacaccag aggatccaca attacgagaa accttataaa tgtagcaaat gtgagaagag
      961 cttttggcat cacttagcgc tttcaggaca tcagagaaca catgcaggta aaaaattcta
     1021 tacatgtgac atttgtggca agaattttgg tcagagttct gatctgcttg tccaccagcg
     1081 aagccatact ggcgagaaac catatctatg tagtgagtgt gacaaatgct tcagtagaag
     1141 tacaaacctc ataaggcatc gaagaactca cacaggtgag aaaccattta agtgtctcga
     1201 gtgtgaaaaa gcttttagtg ggaaatcaga tcttattagc caccagagaa ctcacactgg
     1261 ggaaaggccc tacaaatgta ataagtgtga gaaaagttac cgacaccgtt cagccttcat
     1321 tgtacataaa agagttcata ctggggagaa gccctataag tgtggtgcct gtgaaaaatg
     1381 ctttggccag aaatcagacc ttatcgtgca ccagagagtc cacacaggtg agaagccgta
     1441 taaatgcctg gaatgtatga gaagttttac tcggagtgcc aacctaatta ggcaccaggc
     1501 aactcacact cacactttta aatgccttga atatgaaaaa agctttaact gtagctcaga
     1561 tcttattgta catcagagaa ttcacatgga agagaaacca catcagtggt ctgcgtgtga
     1621 gagtggcttc ctcctaggaa tggactttgt tgcccaacag aaaatgagaa ctcaaacaga
     1681 ggagctacac tataaataca ctgtatgtga taaaagcttc caccagagtt cagcccttct
     1741 tcaacatcag acagtacaca ttggtgaaaa accgtttgtc tgtaatgtga gtgaaaaagg
     1801 tcttgagctt agccctcccc atgcgtcaga agcctcacag atgtcttgac caggcgagaa
     1861 gctgtaatac caatattaaa aattatttat gtatcagaga actcattaag atgaggacaa
     1921 atctcagact ttgctcagag ctcagaattc agtggggacc agagagcctg caattggaaa
     1981 tatgagaaat tctttgccca gagagctgcc ctaacagaac acttcatcct cactccaacg
     2041 agaaatctac agatgcccag aggttttgaa aacttaccgt ctgagctcaa atttgatcac
     2101 tcacaagagg attcatacaa gtgggaaacc ttagaaatgc actgagtgtg agagagcttt
     2161 ctactaatgc tcagcccttc tcgttgtaag agaattcaca ccggagaaca actttttaaa
     2221 tgccttcagt gtcagttgtg ctgcagacag tatgaacatc tcattggacc tcagaaaacc
     2281 caccctgggg agaagcccca gcaagtgtga aaaaagcttc taacaaaact ctgacttacc
     2341 catcagagaa gccatactgg tgaaaaattg tatatttgtc ttaagtatgg caaaagcatt
     2401 cgttggagag ccttacttgg gtttgcaccc aaaaaaaaaa acccaatctg aggaaagact
     2461 gcaagtgtct gaatgaagag tgcttgtcaa tgatcaactc ttgtggtaca tcagggaact
     2521 cacataggtg aaaaaaccca tacttacctt gagtctgaga aaacctttgg tagaagctcc
     2581 tgtcttatca ggccccaaaa aacctgttct gcagtgagag atttaattgt gggtgagaat
     2641 ctatgtacat ataatatgta tgagaagact gttctcatag ttagttgact catatggtag
     2701 agaggacttt acatgaaatc agtatgaaaa tagtttttta gatacccaga agcttgttct
     2761 gggagaagct agggtgggtc agagtagacc tgatgggtaa ctcaggtaaa gatgcttttc
     2821 ttttatctga actacttaat gattgcttta cttttacttt ttaaaaaatt cagaaatcca
     2881 ataaaggaaa ggacggtaac cttatgatag aaggtgtggc atgtgttact gttgggggaa
     2941 aggagtatat tgactttgcc ttggttgata tttttatgct tgtctaggat gggactagag
     3001 tgttgatagt aacatggcag ccttttgctg gcagtgaaat gaacttaaga agctagggag
     3061 tagctatcct agatcaaaac tctcctaata gtttttcctt tgcaggacca atcttataaa
     3121 gaaacagcat actcagcttt ttacttagtg tcagttgagg catactctca aaagtttttt
     3181 cccctaaaat atctttcaag ttattactgg tatttgaaat ttcaagttta gaaattcatt
     3241 tctttttaac tcaaagtgca aatttcatat aatgattatg atggttttag tgtccatatt
     3301 tttgtggctt cacttatcat ctctttcagc agtagctacc cacagtcagc tcctagtaaa
     3361 atggctacag gaaaactgaa agaaaagttt aagcctgagt aggcatagag taaaaaatgc
     3421 ataatgatgc attattaata taagagtaag gcttttttta ttttgagtat cctaactcca
     3481 aacctagtgt tcttttcact ccattatcct gctgtttata gcaaatcaag acccataatg
     3541 atacgtcttt catttatttc agttctgcca aggaaagaga aaataccttt taatcccagg
     3601 gaaaggattg caatcaccac attataaggt atatggcgtg gaatgcagaa ttctaaatac
     3661 tagaagggaa aagtagttgg cagattcatc agaggcttaa ggataagtac ttgtttccaa
     3721 tttaaaagta taattaggat tgtctttaat gttctctaga aatactataa ttaatctaga
     3781 gatctatcaa tggtcacatc tcagtttttt tcttccctga gattcaaaga cgtgtaatac
     3841 caatacttca gattcctata gtatttggga ctttgtagac tagtgaatag atactttgtt
     3901 gctagtccaa atcctctgat tttggtttga tttgtcctag cagatccctg aacttcagag
     3961 agtattgcca tttggattca tggagttggc gaactgctac actgctacct tgtgtatggc
     4021 tctaagcttt gatcctaatg actggttgat gatcatgata atattagggc cagtgaatat
     4081 agctcatagt gataataagg attctagggt attttttttt cttttagaaa aagatcctgg
     4141 aagtttattt gatctgacat gtttttgtaa tatttagaaa tagctcttgt atcataaaaa
     4201 gttgcccagt ataagacaca caagatgtat tttttttctc tggtgaaaat catgcctatc
     4261 actagtatat gtttgacatt tgtagtatac ttaaaatagt attgggtgtg aggcatggtg
     4321 gtgatgaaaa gtagtcctta cggctacttg ttagtcatta gagagaacat ggagaagggg
     4381 tcaaagttgg tatcattaac agggcaatga cttgaccctt ctttcaactg atcttactgg
     4441 tagttgtctc tagtttttaa gtaaattaat gatggaccat cccccaaaca gagaactatg
     4501 ggggtatgaa acaaggctga aggcttttaa ccatgggaga aaaaggtgtt ggtattattc
     4561 atatagcata acctgaggtt ggagaggacc acttgggagc ctgtaaccaa aactagaagg
     4621 taacttctgg gatggacgga ggttcccttg aagcagtgcc aacctaaatc tacctcaggt
     4681 aagtagttag attaactttt tcaagatttc agaccaaaca agacaacttg tattcagttg
     4741 atgtattcct atgctttaat gtttttgttt gcccttaatt attaaataaa catttgttct
     4801 gaaaaactcc a
//
