LOCUS       NM_001351774            6331 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 320 (ZNF320), transcript variant
            3, mRNA.
ACCESSION   NM_001351774 XM_017026394
VERSION     NM_001351774.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6331)
  AUTHORS   Zhen,J., Ke,Y., Pan,J., Zhou,M., Zeng,H., Song,G., Yu,Z., Fu,B.,
            Liu,Y., Huang,D. and Wu,H.
  TITLE     ZNF320 is a hypomethylated prognostic biomarker involved in immune
            infiltration of hepatocellular carcinoma and associated with cell
            cycle
  JOURNAL   Aging (Albany NY) 14 (20), 8411-8436 (2022)
   PUBMED   36287187
  REMARK    GeneRIF: ZNF320 is a hypomethylated prognostic biomarker involved
            in immune infiltration of hepatocellular carcinoma and associated
            with cell cycle.
REFERENCE   2  (bases 1 to 6331)
  AUTHORS   Hollingworth,P., Sweet,R., Sims,R., Harold,D., Russo,G.,
            Abraham,R., Stretton,A., Jones,N., Gerrish,A., Chapman,J.,
            Ivanov,D., Moskvina,V., Lovestone,S., Priotsi,P., Lupton,M.,
            Brayne,C., Gill,M., Lawlor,B., Lynch,A., Craig,D., McGuinness,B.,
            Johnston,J., Holmes,C., Livingston,G., Bass,N.J., Gurling,H.,
            McQuillin,A., Holmans,P., Jones,L., Devlin,B., Klei,L.,
            Barmada,M.M., Demirci,F.Y., DeKosky,S.T., Lopez,O.L., Passmore,P.,
            Owen,M.J., O'Donovan,M.C., Mayeux,R., Kamboh,M.I. and Williams,J.
  CONSRTM   GERAD Consortium; National Institute on Aging Late-Onset
            Alzheimer's Disease Family Study Group
  TITLE     Genome-wide association study of Alzheimer's disease with psychotic
            symptoms
  JOURNAL   Mol Psychiatry 17 (12), 1316-1327 (2012)
   PUBMED   22005930
REFERENCE   3  (bases 1 to 6331)
  AUTHORS   Chernova,O.B., Hunyadi,A., Malaj,E., Pan,H., Crooks,C., Roe,B. and
            Cowell,J.K.
  TITLE     A novel member of the WD-repeat gene family, WDR11, maps to the
            10q26 region and is disrupted by a chromosome translocation in
            human glioblastoma cells
  JOURNAL   Oncogene 20 (38), 5378-5392 (2001)
   PUBMED   11536051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA852671.1, BC105738.1, DA742339.1, BC131555.1, AK096348.1,
            AC010487.7 and AI344388.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001351774.1.
            
            Summary: ZNF320 encodes a Kruppel-like zinc finger protein. Members
            of this protein family are involved in activation or repression of
            transcription.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-5 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.15799.1,
                                           SRR14038196.2757693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156099, SAMN03267754
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682928.1/ ENSP00000506814.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DA852671.1         1-116
            117-194             BC105738.1         235-312
            195-598             DA742339.1         48-451
            599-2129            BC131555.1         260-1790
            2130-2960           AK096348.1         602-1432
            2961-5984           AC010487.7         27567-30590         c
            5985-6331           AI344388.1         14-360              c
FEATURES             Location/Qualifiers
     source          1..6331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..6331
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /note="zinc finger protein 320"
                     /db_xref="GeneID:162967"
                     /db_xref="HGNC:HGNC:13842"
                     /db_xref="MIM:606427"
     exon            1..116
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     exon            117..194
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     exon            195..312
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     exon            313..400
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1915
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /note="isoform 1 is encoded by transcript variant 3; zinc
                     finger gene 320; zinc finger protein like"
                     /codon_start=1
                     /product="zinc finger protein 320 isoform 1"
                     /protein_id="NP_001338703.1"
                     /db_xref="CCDS:CCDS33095.1"
                     /db_xref="GeneID:162967"
                     /db_xref="HGNC:HGNC:13842"
                     /db_xref="MIM:606427"
                     /translation="MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDISSKCMMNTLSSTGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQ
                     EDETNDHEAPMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKP
                     YKCEECEKVFSCKSHLEIHRIIHTGEKPYKCKVCDKAFKHDSHLAKHTRIHRGDKHYT
                     CNECGKVFDQKATLACHHRSHTGEKPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCN
                     ECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGEKPYRCEEC
                     DKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGK
                     VFSTKAYLACHQKLHTGEKLYECEECDKVYIRKSHLERHRRIHTGEKPHKCGDCGKAF
                     NSPSHLIRHQRIHTGQKSYKCHQCGKVFSLRSLLAEHQKIPFGDNCFKCNEYSKPSSI
                     N"
     exon            401..527
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     exon            528..6331
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4764..4769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /note="hexamer: AATAAA"
     polyA_site      4784
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
     regulatory      6312..6317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /note="hexamer: ATTAAA"
     polyA_site      6331
                     /gene="ZNF320"
                     /gene_synonym="ZFPL"
                     /note="major polyA site"
ORIGIN      
        1 ctgttttatg tgtgcttccc agtcctgtgg tgctgctata ccggggacgt tgagtcccca
       61 cagacctgga aattgcggcc cctctttctc aacccagagc aaattgagac gtccgggctg
      121 gagggcagtt gtgcgatctt gattcacttc aacctctgct ctccgggctc aagcaattct
      181 cccacctcag cctgagtctc actctgtcct tcaggctgtg agtgcagtct cctgatcttg
      241 gctcactgca acctctgtct cctgggttca agtgattctt gtgcctcagc ctaccaagta
      301 gctgagatac aggattgact tctaaagact cttggtacct gaggaagaaa cccagaagag
      361 gaagaggaaa gcaaaggagt cggggatggc tctttctcag ggtctactga cattcaggga
      421 tgtggccata gaattctctc aggaggagtg gaaatgcctg gaccctgctc agaggactct
      481 atacagagac gtgatgctgg agaattatag gaacctggtc tccctggata tctcttccaa
      541 atgcatgatg aatacattgt catcaacagg gcaaggcaat acagaagtga tccacacagg
      601 gacattgcag agacaagcaa gttatcacat tggagcattt tgctcccagg aaattgagaa
      661 agacattcat gactttgtgt ttcagtggca agaagatgaa acaaatgacc atgaagcacc
      721 catgacagaa ataaaaaagt tgactagtag tacagaccga tatgatcaaa ggcatgctgg
      781 aaacaagcct attaaaggtc agcttgaatc aagatttcat ttgcatttgc gaagacatag
      841 gagaattcat actggagaga aaccttacaa atgtgaagaa tgtgagaaag ttttcagttg
      901 caaatcacat cttgaaatac ataggataat tcatactgga gagaaaccat acaaatgtaa
      961 ggtttgcgac aaggctttta agcatgattc acacctggca aaacatacta gaattcacag
     1021 gggagacaaa cattacacat gtaatgaatg tggcaaggtt tttgatcaaa aagcaaccct
     1081 tgcatgtcat catagaagtc atactggaga gaaaccttat aagtgtaatg agtgtggcaa
     1141 gacctttagt cagacatcac accttgtgta ccatcataga ctgcatactg gagagaaacc
     1201 ttacaaatgt aatgagtgtg gcaagacctt cgctcgaaat tcagtcctcg taattcataa
     1261 ggcagttcat actgcagaga aaccctataa gtgtaatgaa tgtggcaagg tttttaagca
     1321 acgagcaact cttgcaggac atcgtagagt tcacactgga gagaaacctt acagatgtga
     1381 agaatgcgac aaagttttca gtcgcaaatc acatcttgaa agacatagga ggattcatac
     1441 tggagagaaa ccatacaaat gtaaggtttg tgacaaggct ttccggagtg attcacgtct
     1501 tgcagaacat cagagagttc atactggaga gagaccttac acatgtaatg aatgtggcaa
     1561 ggtttttagt acaaaagcgt acctcgcatg tcatcaaaaa cttcatactg gagagaaact
     1621 ttacgaatgt gaagaatgtg acaaagttta cattcgcaaa tcacaccttg aaagacatag
     1681 gaggattcat acaggagaga aacctcacaa gtgtggtgat tgtggtaaag cctttaattc
     1741 accttcacac cttattaggc atcagagaat ccatactgga cagaaatctt acaaatgtca
     1801 tcagtgtggc aaggtcttta gtctgaggtc actccttgca gaacatcaga aaattccttt
     1861 tggagacaat tgtttcaagt gcaatgagta tagcaaacca tcaagcatta attgacatca
     1921 gagtcaaatc agcattgacc tgagtttgag ttgacttaac attgatttca agcattaatc
     1981 gacattaaac tgtttatgtt aagaggattg ggccaggcgt ggtgtctcac acctgtaatc
     2041 ccagcacttt gagaggccaa gacaggtagg tcacttgagg tcatgaattt gagaccagcc
     2101 tggccaacag acgggagcca cttttcccag cctgtatgtt cttttattta tttatttatt
     2161 tttaagatgg aatcttgctc tgtcgcccac gttggagtgc agtgatgtga tctcggttca
     2221 ctgcaacatt cacctcccag gttcatgcaa ttctcctgcc tcagtctcct gagtagctgg
     2281 gactacaggt gcgtgccacc atgcccgggt aattttttgt atttttagta gagactgggt
     2341 ttcaccgtgt tagctaggat ggtctcgatc ttctgtcctt aaaatccacc tgcctccacc
     2401 tgccaaagtg ctgagattac aggcgtgagc caccacacct ggcctgtttt ttgtttcttt
     2461 aacaaaaagt tatagaaatt tctctgggta ttgtgttgaa tctacatcac attcagttat
     2521 aatcatttag caatattatt ccattcaata tggcttgtat ctcttatttg cacatgtttt
     2581 tatcactttg atcaatgttt gtagatttga aggtagaaac ttctcaactt ttttcattta
     2641 ttcctaagta tttcttactt taagttcttt agcaaatgaa agtgtttttt taattttctt
     2701 tttaaattgt ttattgttaa tgtatggaaa ttcaactaat ttttggtgct gttattctat
     2761 tcttcaaatc cactgcatat gttttttagt tccagttgca ttttggttga ctctttgtga
     2821 ttttctacac agaagatcat gtcatctaca aagaaatagt tttacttctt tctttctgat
     2881 ttggatgagt ttgatttctt ttgctatttc attgctctag ctaggacagc cagtattgat
     2941 tgaatagaag gggtgagagc attcttgcat catgtgagat cctacaggaa aagcattcca
     3001 ttttccctga ctggttattt ctgctgtggt catttcatgg atggtctttg tattgttgag
     3061 gtaaatttcc ttctctttct attttgttta ggatttccat gatgactgga tgttgaattt
     3121 tgtgaaatgc tttttctcca tgtattgaga tgatgtggtt ttcatctttc attatgttca
     3181 agtggtatat cacattgatt tgcttgacta tgttgaacca ttttgcatcc cagaaataag
     3241 tggcacttgc atatcaacaa tcctttttat aacctcttga atacagttcg ctagtacaag
     3301 gggtcttcag gaagttcatg gaaaaataca tattatgaga aaattgtgca tgatatcaca
     3361 ttttttgcac caagataaac tgatacaaat ccgttataac atgtctgaac agggtttggt
     3421 ttgaggcact cagatgggta agacatgagt ttgaaaagag actcaatcaa ggcaatgtaa
     3481 attctgctaa aactgaaaca agaagaaaca tcaaatttgc gatgagacca gatgctgtgg
     3541 ctcaggcctg taatcccata attttcagag gctgagacag ttgggtcacg tgggccccgg
     3601 tactcaagac cagcctgggc agaatggtga aaccaccttc tctacaaaaa atacataaat
     3661 tagctgggca ttgtggcaca tgtctgctgg ttcagcttct gtggagtctg cagtgggagg
     3721 atggcttgag cctaggagtt cgaggctgca gggagccatg atcatgccat tgtactccag
     3781 catgggtgac agagacagat agtgtatcga aaaatgaatc tggtaaagtt tgggtagagg
     3841 gacaatgaaa tcattgatgc tttatgaaaa ggttatgggg acgattccca aaataaatca
     3901 ccagtttgta aatggaaaac ttattttaag ttgggacaag atgatgttga aagtgatgca
     3961 caggacaggt gtggtggctc acacctgtaa tcccagcact ttgggaggcc gaggcaagag
     4021 catcacgagg tcaggagatc gagaaaatcc tggctaacac ggtgaaaccc catctctact
     4081 aaaaatacaa aaaattagcc aggcgtggtt gtgggcgcct gtagtcccag ctactcagga
     4141 ggctgaggca ggagaatggc atgaaccgag gaggtggagc ttgccatgag cagagatcat
     4201 gctactgcac tccagcctgg gtgacagagc gagactccat ctcaaaaaaa aaaaaaaaaa
     4261 aaaaaaaaag aaagtgatgc acagagtggc aggcagacca tccacataag ttttataggt
     4321 acaactgtca aagacgacac tggagaagag ccaagctgga tctataagga attgcatatg
     4381 agatggcaca catattcatg ctgtctgaag attcagtcac gttaccatat caagctgaaa
     4441 atgtcaccac tatctggaga gttggacatg ttttattgag aatgtatttt ttttctctgg
     4501 atctgttatg aacacctttg ttggcttggt tcagtaataa atatgtgaga cttttcattt
     4561 aaaaaaagtc aaatgactta attctgtatt ttaaattctg ttttgtttgt tttgtttttt
     4621 tgagatggag tcttctgaaa attttctcat cttctctaac ccggttcatg acagaccctt
     4681 ggactttact gttgtggaaa aatctatata aaacagtatc agtgtgtcaa agcattatgg
     4741 ctgtcacaag cttgtgaaag gaaaataaaa attactaagc caaagagaaa agtcaatctg
     4801 ggaactgcgt cagacaaacc tgccttccat tttattccta aacaagatag ttacaaagat
     4861 tttttaaaaa gctacatatg cccctcccaa accgggaacc tcaagatctc caccctaaaa
     4921 tagttctgtt gaatttcacc ctggcgatgt aaactgagag cttatcttca cagatgtggg
     4981 aaagagccca tccctctgca cacctgagtc aaatgtctat ctgattgctt cccttgccct
     5041 atttatgtaa aaatacaggg tccctgagcc agcctaaggc ataagtgact tatccctcct
     5101 ccctgctcac atataaattg tgtatttagt gaaaggctga tcaaagattc aaagaatgtt
     5161 atttgttatc tacctgtgac ccagaaggtc cccaattcca gttattccac ctttccagac
     5221 cggaccaatg tatatatgta ctgattgctg tctcgtgtgt ctgtaaaatg tgtgaaacca
     5281 aactgcagcc tcaacaccat ggacacacgt catcaggacc tcctgaggtt cgtgttaatt
     5341 ggccttagac tctccctgtc cccagaccca ggacgcatgt gtttcctttt tcttcatttc
     5401 tattaaagat gggtctcatt ctgttggcca ggcatgagag cggtgacagg atcagccctc
     5461 actgaagctt caatctcctg ggttcaaggg atcctcccac ctcagcctcc aaagttgcta
     5521 ggaccatagc caggtgccac cgcaccgggc aaatttttgt gttcctagta gagatgggct
     5581 ttcaccatgt tgcccgagct ggtcttgaat tccagggctc aagcgatcca gccgtattgg
     5641 cctcccaagg tgctgggatt acagccatga gccaccatga ccaacgtgtt tcttaattta
     5701 aaaaaaaaaa aatagaccag gtgctctggc tcatgcctgt aatcccagca ctttgggagg
     5761 ccaaggtggg cagatcacct gagatcaagt atttgagaac agcctggcta acatggcgaa
     5821 tcctcgtttt gaccaaaata tagaaattag cctggtgtgg tggcgagtgc ctgtaatccc
     5881 agctattcag gagggtgagg cagaagaatg gcttgaattc gggaggcgga ggttgcagtg
     5941 agctgagatc ctgcaactgc actctggctg ggcaagagcg agactccatc tctaaaataa
     6001 aattaaagta atataaaaaa ctgcttctca tgaaagcttt ggtataatct tacgaggtaa
     6061 catcattgtt ttgcaactac ggtatgtgtt caaaatgttc ttctttgacc ccacatttca
     6121 ttagatatat ttttaagcca ttttaaaatt gtttttctct gaaatttatt gtgtttagtt
     6181 tacattgagg actgcatgct ttctagtctg tatcatacat tggaaacatt ttctagtacc
     6241 tgataaatga ttttaggttg tttcgatgtg tacttgataa agatatcaag gaactttttc
     6301 tttatgctaa cattaaaatt tagttgaagt a
//
