LOCUS       NM_006973               1159 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 32 (ZNF32), transcript variant 1,
            mRNA.
ACCESSION   NM_006973
VERSION     NM_006973.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Li,Q., Yuan,H., Zhao,G., Zhang,J., Li,S., Gong,D., Feng,T., Kou,Q.,
            Wang,Q., Wang,G., Li,S., Li,K. and Lin,P.
  TITLE     ZNF32 prevents the activation of cancer-associated fibroblasts
            through negative regulation of TGFB1 transcription in breast cancer
  JOURNAL   FASEB J 37 (4), e22837 (2023)
   PUBMED   36934389
  REMARK    GeneRIF: ZNF32 prevents the activation of cancer-associated
            fibroblasts through negative regulation of TGFB1 transcription in
            breast cancer.
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Li,J., Li,X., Lan,L., Sun,L., Li,X., Li,Y., Tian,Y., Zhang,T.,
            Zhou,Y., Mo,C. and Fu,X.
  TITLE     ZNF32 promotes the self-renewal of colorectal cancer cells by
            regulating the LEPR-STAT3 signaling pathway
  JOURNAL   Cell Death Dis 13 (2), 108 (2022)
   PUBMED   35115495
  REMARK    GeneRIF: ZNF32 promotes the self-renewal of colorectal cancer cells
            by regulating the LEPR-STAT3 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Li,Y., Gong,D., Zhang,L., Li,H., Zhang,S., Zhang,J., Li,K.,
            Zheng,Q., Zhao,G., Zhang,Y., Chen,Y., Guo,Y., Xiang,R., Lin,P. and
            Wei,Y.
  TITLE     Zinc finger protein 32 promotes breast cancer stem cell-like
            properties through directly promoting GPER transcription
  JOURNAL   Cell Death Dis 9 (12), 1162 (2018)
   PUBMED   30478301
  REMARK    GeneRIF: We conclude that ZNF32 can engage GPER/ERK signalling and
            confer breast cancer stem cell-like properties, which may indicate
            poor prognosis of breast cancer patients. ZNF32 and GPER targeted
            therapies might provide new solutions for breast cancer treatment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Drew,P.D., Gado,A.M., Canning,R.D., Nagle,J.W., Dehejia,A.M.,
            Polymeropoulos,M.H., Biddison,W.E., Jacobson,S. and Becker,K.G.
  TITLE     C2H2-546: a zinc finger protein differentially expressed in HTLV-1
            infected T cells
  JOURNAL   J Neurovirol 3 (6), 455-459 (1997)
   PUBMED   9475118
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Cannizzaro,L.A., Aronson,M.M. and Thiesen,H.J.
  TITLE     Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene
            cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region
            10q23-q24
  JOURNAL   Hum Genet 91 (4), 383-385 (1993)
   PUBMED   8500793
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645634.6, BG477527.1 and BC022842.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006973.2.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring variant. Variants 1 and 2 both encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69645.1, SRR5189652.23271.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374433.7/ ENSP00000363556.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL645634.6         50658-50660         c
            4-68                BG477527.1         2-66
            69-1159             BC022842.1         1-1091
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..1159
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /note="zinc finger protein 32"
                     /db_xref="GeneID:7580"
                     /db_xref="HGNC:HGNC:13095"
                     /db_xref="MIM:194539"
     exon            1..80
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /inference="alignment:Splign:2.1.0"
     exon            81..219
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..971
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 32 (KOX 30); C2H2-546; zinc finger protein
                     KOX30"
                     /codon_start=1
                     /product="zinc finger protein 32 isoform a"
                     /protein_id="NP_008904.1"
                     /db_xref="CCDS:CCDS7206.1"
                     /db_xref="GeneID:7580"
                     /db_xref="HGNC:HGNC:13095"
                     /db_xref="MIM:194539"
                     /translation="MFGFPTATLLDCHGRYAQNVAFFNVMTEAHHKYDHSEATGSSSW
                     DIQNSFRREKLEQKSPDSKTLQEDSPGVRQRVYECQECGKSFRQKGSLTLHERIHTGQ
                     KPFECTHCGKSFRAKGNLVTHQRIHTGEKPYQCKECGKSFSQRGSLAVHERLHTGQKP
                     YECAICQRSFRNQSNLAVHRRVHSGEKPYRCDQCGKAFSQKGSLIVHIRVHTGLKPYA
                     CTQCRKSFHTRGNCILHGKIHTGETPYLCGQCGKSFTQRGSLAVHQRSCSQRLTL"
     exon            220..1159
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1134..1139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /note="hexamer: AATAAA"
     polyA_site      1159
                     /gene="ZNF32"
                     /gene_synonym="KOX30; Zfp637; ZNF637"
                     /note="major polyA site"
ORIGIN      
        1 gtagtccatt ccgccggcgc cggcgctggc gctgctgcgg gctcggcgcc ggcctttgtc
       61 tgcgggcacg cgccgctgcg gtgctcagga acagcccatg gaagaatcat atgaagaggt
      121 ggtgactgag gtcgtaagca ggagtggaca tgtttggatt tccaacagct accctgctgg
      181 actgtcatgg aagatatgcc cagaatgtag cgttcttcaa tgtgatgact gaagcccacc
      241 acaaatatga ccactctgag gctacaggat cctcaagctg ggatatccaa aattctttca
      301 gaagagagaa gctggaacaa aaatccccag attcgaagac actacaggaa gattcacctg
      361 gagtgagaca aagggtctat gagtgccagg agtgtggaaa atccttccgg caaaaaggta
      421 gtctaacgtt acatgagaga atccacactg gtcaaaagcc ttttgagtgc acccactgtg
      481 gaaaaagctt cagggccaaa ggcaatcttg ttacacatca acggatacac acgggagaga
      541 agccttatca gtgcaaggag tgtgggaaaa gcttcagtca acgaggtagt ctcgctgtcc
      601 acgagagact ccacactgga cagaaaccct acgagtgtgc tatttgtcag agaagcttca
      661 ggaatcagag taaccttgct gttcacagga gagttcacag tggtgagaag ccctatagat
      721 gtgatcagtg tggaaaagcc ttcagtcaga aaggaagctt aattgttcac atcagagtcc
      781 acacaggcct gaagccctat gcctgtaccc agtgcaggaa gagtttccac accaggggga
      841 attgtattct gcatggcaaa atccacacag gagagacacc ctatctgtgc ggccagtgtg
      901 gaaaaagctt cacccagaga gggagtctgg ctgtgcacca gcgaagctgc tcacagaggc
      961 tcaccctttg accactttcc tgaagagaag ttctctttat gaattaagag tacaaaatcc
     1021 tctgagatga agcaacctat ccagttctat ggaatgaatg gagaatcttt cagaaagacc
     1081 atcattgggt agggcaaact gatttttttc ctttccccca aaagagtatg aaaaataaat
     1141 gtcttgttta ttatcatta
//
