LOCUS       NM_020807               5027 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 319 (ZNF319), transcript variant
            1, mRNA.
ACCESSION   NM_020807 XM_168030
VERSION     NM_020807.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Wang,L., Zhou,L., Li,M., Zhao,J., Liu,Y., Chen,Y., Qin,X., Wang,S.,
            Chen,H., Piao,Y., Xiang,R., Li,J. and Shi,Y.
  TITLE     Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319 as a
            novel tumor suppressor critical for breast cancer metastasis
  JOURNAL   Biochem Biophys Res Commun 589, 107-115 (2022)
   PUBMED   34902746
  REMARK    GeneRIF: Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319
            as a novel tumor suppressor critical for breast cancer metastasis.
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Laub,F., Aldabe,R., Ou,J. and Ramirez,F.
  TITLE     Overexpression of a novel zinc-finger protein induces apoptosis in
            NIH3T3 fibroblasts
  JOURNAL   Genomics 70 (3), 375-380 (2000)
   PUBMED   11161788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010543.9.
            
            On Jun 17, 2020 this sequence version replaced NM_020807.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037809.1, SRR14038194.2920976.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299237.3/ ENSP00000299237.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1180              AC010543.9         162361-163540       c
            1181-5027           AC010543.9         157544-161390       c
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..5027
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /note="zinc finger protein 319"
                     /db_xref="GeneID:57567"
                     /db_xref="HGNC:HGNC:13644"
     exon            1..1180
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..5027
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /inference="alignment:Splign:2.1.0"
     CDS             1438..3186
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /codon_start=1
                     /product="zinc finger protein 319"
                     /protein_id="NP_065858.1"
                     /db_xref="CCDS:CCDS32462.1"
                     /db_xref="GeneID:57567"
                     /db_xref="HGNC:HGNC:13644"
                     /translation="MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENP
                     LGCAVYGILLQPDPGLQPPQHAPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDR
                     SFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSSHSGLVKC
                     SICEKTYKPAEAAEPATTAAPSLPAAPAPSTVTPAEQADKPYSCPICQKPFKHLSELS
                     RHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRH
                     MYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHE
                     RTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHV
                     HTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCNKAYKRASALQKHQLAH
                     CAAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVH
                     TGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSA
                     AAAAAEGAYQVAACLP"
     regulatory      5004..5009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /note="hexamer: AGTAAA"
     polyA_site      5027
                     /gene="ZNF319"
                     /gene_synonym="ZFP319"
                     /note="major polyA site"
ORIGIN      
        1 gcccgtctcc gcaaggccat cggtccgtcc gcccgccctc ccggcgctcc tcgccccggc
       61 cccgctactc cggcagcgcg cgtcgcttcc tccgttccgg ccgccgctag cccgtccccc
      121 gcccccggtc cggccgcagc cgctacgcga ggccggggat tggcagcgcg cgtaggccgc
      181 gccgccgcgg atggagccgg aataaagggg cggccgagag agcagctggt cgccgctcgc
      241 cccgcgcctg ccctgcaggc ggcctggagc aggtgagcgg cggggcgccc ggggccgcat
      301 ctgggggcca cccccgcgcc cgccgcaccc cttcctctgc cggcccggcc gcccccccgc
      361 gcccctccgc cgcgacctag cggcctcttg agcttctggg cggcccaggc cgggcctcga
      421 ggcgcagccg cttcctgggc ccggcctgta gccctggggc ctttctccag cccggccgcc
      481 ctcggggctc gccctcgggt cgcagcggcc gggccatccc ggacgagggc tgacaggacg
      541 cagcccagct gggcctgcag gcagggccgg cgggaggtga tcggctttca ttcggtttct
      601 cagggaggaa gaagagacgg ggtggggcgc aggtgggggg cctcccctgc ctctccttgc
      661 ctcctctctc ccctttgcgg agtgatcaca gaggcttcct ggctgcacct tgctgcagga
      721 gggccagggt gggcaggggg tgctgcagac caagccaggg gacactgtct gacagccatt
      781 catgccagaa aaagcaaaca aaacagtggg ttggcacagc ggacctacag gcgctcagag
      841 aagcccacct tccccctctc tgtcccgaga aggcttagag tggtacctgc ttgctcaagc
      901 aacctgctgc ctccacccag agcagccgct cctctcctcc ctcccttccg gaagatgctg
      961 aggatgacag cttttagcct gactcttaca tttctttggc agagcagtta gaggccagac
     1021 tgtcctgtga aggcttctcc ttccttcttc ctctgctcag gagaaaactt acaaactttt
     1081 aaatgtaaga ggcagatgag ctgggaacct ggaagtgggt tgcatctgac tctgaaagtt
     1141 cctccctctc gctggcatta cctcatgctg ccacaaagtg aacggatcac tggggaaggc
     1201 agagtctccc cggcactgct gggaccctcc cttgaagagc ccccatgtcc tgtaggcaga
     1261 gccttgtagt ctgtccgctt ggttactgac tcgggctgtc tgaccagccc ctcttctgtg
     1321 ccttgtctga ggtccttgtc catctctgtg attgggcagc ttctctctct ggattgggtc
     1381 acgtgaagcg ggaaactgaa gccattactc tccaaaccct gtttcatctt cccaagcatg
     1441 tcggaaagct ggcaacagcc gccacagacg cagccgcagc agccacagcc accgcagcct
     1501 cagcaccatg cagagccacc gccagccctg gcagagcaca cgctgcctcc gggcacggcg
     1561 gagaaccccc tgggctgtgc cgtctatggc atcctcctgc agccagaccc cggcctgcag
     1621 cccccacaac acgcacccct gcaggcagca ggagagccag gccccaaatg tggcgtgtgt
     1681 ggtcacgacc tggcgcacct gtccagtccg catgagcacc agtgtctggc gggccatgac
     1741 cgctcattcc agtgcacaca gtgtctcaag atcttccacc aggccactga cctgctggag
     1801 caccagtgcg tgcaggctga gcagaagccc ttcgtctgtg gggtctgcaa gatgggcttc
     1861 tcactactca cctcactggc acagcaccac agctcccaca gtggcctggt gaagtgttcc
     1921 atctgtgaaa agacctacaa gccagctgag gcagcggagc cagccaccac agccgccccg
     1981 tcgcttcccg cagcacccgc gccttccact gtcacccctg ctgaacaggc cgacaagccc
     2041 tacagctgcc ccatctgcca aaagcccttc aagcacctgt cggagctctc tcggcatgag
     2101 cggatccaca ccggtgagaa gccctacaag tgcacgctgt gtgacaaaag cttcagccag
     2161 tcgtcgcacc tggtgcacca caagcgcacg cacagctccg agcggcccta caagtgcgca
     2221 gtctgcgaga agaccttcaa gcaccgctct cacctggtgc gccacatgta cgcgcactcg
     2281 ggcgagcacc acctgttccg ctgcaacgtg tgcgagttgc atttcaagga gtcgtcggag
     2341 ctgctgcagc acccgtgcac gccaagtggg gagcggccct tccgctgcgg cgagtgccag
     2401 aaggccttca agcggccctc ggacctgcgg cagcatgagc gcacacacag cgccgagcgg
     2461 cccttcaagt gcgacctgtg ccccatgggc ttcaagcagc agtacgcact gatgcgccac
     2521 cggcgcacac acaagaccga ggagcccttc aaatgcggcc tatgtgagaa gggctttggg
     2581 cagcccagcc acctgctcta ccaccagcac gtgcacaccc tcgagactct cttcaagtgc
     2641 cccgtgtgcc agaaaggctt tgaccaatct gccgagctgc tgcggcacaa gtgcctgccc
     2701 ggcgcggccg agcggccctt caagtgccct gtgtgcaaca aggcctacaa gcgcgcgtcg
     2761 gccctgcaga agcaccagct ggcccactgt gcggcggcag agaagcccct gcgctgcacg
     2821 ctttgcgaac gccgcttctt ctcctcttcc gagttcgtgc agcaccgctg cgatccggcc
     2881 cgcgagaagc cactcaagtg cccagactgc gagaaacgct tcaagtacgc gtcagacctg
     2941 cagcggcacc ggcgggtaca cacaggcgag aagccctaca agtgccccaa ctgcgacaag
     3001 gccttcaagc agcgggagca tctcaacaag caccagggcg tgcacgcccg cgagcagcag
     3061 ttcaagtgtg tatggtgcgg ggagcgcttc ctagacgtgg ccttgttgca ggagcacagc
     3121 gcgcagcaca gtgccgccgc cgcggcagcg gagggcgcct accaggtagc cgcctgcctg
     3181 ccctgactct gcggctgtgg cccctaccag cctgacctga gtcggcgccg tgggcccagc
     3241 aggcctcgcg cagcctagct cctcacagct gccttgcacc aagggcccca cccagctcgg
     3301 tgttctgaga cctcgggagt gaggacgcag gggtatgagg cagggagagg gtgtgccgct
     3361 cgtactcctg gcaccagcgg gcagtgcggg cggccagatt gctgtggccc atcctgattc
     3421 cacaaacctc tttcccatga caagattcac tttcttgaga gccatcagca ccccccttat
     3481 ttccggggca ctggagccag gctggaagtc aagtggcttc tccctgccct aaggagggtg
     3541 tgatgccagc ccaaccttcc catatctttc aagctagcag ccacataggt taggaaagcg
     3601 gaggctcatg gtggggctgg ggccccagag gtgggctagg tgtaaggcat cagttgccgt
     3661 gtgggggaga aggccagctt taagacgtag gcctggggac tgggagggca gagggtgagt
     3721 cacagccctc tccgtctgct ctagccaggg gcgacgtgtc cccaggtttc tggcagggga
     3781 gatgtgcagg gtgggtcttg gggctgggtc tgcctggaga ccagtgggcc cagggggaag
     3841 ggggaagctg agaagttcgt gtgacaccct cagccaaggg acagtgccat ccttggggac
     3901 aggaggaaaa gcagcctgtc tctgctaagg gcaaatcctc cggttttgga agcgcccctc
     3961 ccacctttgt agtgcagttc ctaggtgtgg tggggaatgt gccgtgctct cagcagacag
     4021 aactgctggt gtgaaaggca gggattgtca gcccacctga ggctgggagg aagcaggacc
     4081 aggcctagga tctccccagc agatgcaaac aagtgtcctc ccctgaattg tgtgaaccaa
     4141 agcgtcaggg gcttggggca cagccccagt cagctcaacc cagtcctgct tcagagccaa
     4201 gactaggcca gggtggggac ccccccagta ccctccctac atcaatgtgg ctgctggcct
     4261 ggaccccagg ggtctggtac agccaagatg ttctggacaa catccagcta cttcaaaggc
     4321 cagagtgtcc tttgggtcct cctagagtcc ccctaggtct ctggctgccc atgaggctca
     4381 tgaagcagag ggtatcccag tcatagggag cagaaagagc aagtgggtta aggaagcctg
     4441 tgggggacct ggtggatgga gttgaccaac atcgctgggt ggctacggcc ctccttagga
     4501 agcccagaag gacctttatt attaaaataa tcattttgaa ccctgctcta tcccctgccc
     4561 tcttccagcc ccacccctcc ctggtcttga aagaagacta atcagtgggc acaccaaggg
     4621 ccctgagggg cagggagatg ccaccatgct tctctgtcac cgtaagaagg ctgaccagcc
     4681 acgcccacct cctctgtctg actgagttcc ttcctgtggc cacagggagg ggctggtcct
     4741 tcccctcggt gctggctctc tgtcacaatg cctcaaaaga catggaaccc aggcctacaa
     4801 ccgtcccaac tgctaattct tttcctttca ttttgctttc tgaaagcagt ttgttatact
     4861 attcataaca ttgtagagtt taatttcatg tcattttgga tcttatataa aaatgtgagg
     4921 atttggattt ttaaaaagaa tgactccatt ttaggtagcc acttttgatg ttaatatata
     4981 gtgagtccaa tgtatgcttt agaagtaaag acattgaccg tcacaga
//
