LOCUS       NM_014345               8210 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 318 (ZNF318), mRNA.
ACCESSION   NM_014345
VERSION     NM_014345.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8210)
  AUTHORS   Tao,R.H., Kawate,H., Ohnaka,K., Ishizuka,M., Hagiwara,H. and
            Takayanagi,R.
  TITLE     Opposite effects of alternative TZF spliced variants on androgen
            receptor
  JOURNAL   Biochem Biophys Res Commun 341 (2), 515-521 (2006)
   PUBMED   16446156
  REMARK    GeneRIF: in the unique regulation system of AR-mediated
            transactivation, two spliced isoforms of TZF act as coactivator and
            corepressor, respectively
REFERENCE   2  (bases 1 to 8210)
  AUTHORS   Ishizuka,M., Kawate,H., Takayanagi,R., Ohshima,H., Tao,R.H. and
            Hagiwara,H.
  TITLE     A zinc finger protein TZF is a novel corepressor of androgen
            receptor
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1025-1031 (2005)
   PUBMED   15882980
REFERENCE   3  (bases 1 to 8210)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   4  (bases 1 to 8210)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 8210)
  AUTHORS   Inoue,A., Ishiji,A., Kasagi,S., Ishizuka,M., Hirose,S., Baba,T. and
            Hagiwara,H.
  TITLE     The transcript for a novel protein with a zinc finger motif is
            expressed at specific stages of mouse spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 273 (2), 398-403 (2000)
   PUBMED   10873617
REFERENCE   6  (bases 1 to 8210)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590383.6, BC098434.1, AL583834.6 and AK027061.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014345.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF090114.1, BC098434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361428.3/ ENSP00000354964.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL590383.6         7225-7428           c
            205-615             AL590383.6         6814-7224           c
            616-3917            BC098434.1         387-3688
            3918-8029           AL583834.6         41567-45678         c
            8030-8210           AK027061.1         2399-2579
FEATURES             Location/Qualifiers
     source          1..8210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..8210
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /note="zinc finger protein 318"
                     /db_xref="GeneID:24149"
                     /db_xref="HGNC:HGNC:13578"
                     /db_xref="MIM:617512"
     exon            1..681
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..7122
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /note="testicular zinc finger; endocrine regulator;
                     endocrine regulatory protein"
                     /codon_start=1
                     /product="zinc finger protein 318"
                     /protein_id="NP_055160.2"
                     /db_xref="CCDS:CCDS4895.2"
                     /db_xref="GeneID:24149"
                     /db_xref="HGNC:HGNC:13578"
                     /db_xref="MIM:617512"
                     /translation="MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPP
                     PSGSSSRTPARRPRSPSGHRGRRASPSPPRGRRVSPSPPRARRGSPSPPRGRRLFPPG
                     PAGFRGSSRGESRADYARDGRGDHPGDSGSRRRSPGLCSDSLEKSLRITVGNDHFCVS
                     TPERRRLSDRLGSPVDNLEDMDRDDLTDDSVFTRSSQCSRGLERYISQEEGPLSPFLG
                     QLDEDYRTKETFLHRSDYSPHISCHDELLRGTERNREKLKGYSIRSEERSREAKRPRY
                     DDTVKINSMGGDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRS
                     LSQELVGVDGGGTGCSIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDIME
                     PSMQLESFSSSTSSSQDHPLYSGHPSLPLSGAIAAFASEIENKGTMVETALKEPQGNL
                     YQWGPLPGIPKDNSPLREKFGSFLCHKDNLDLKAEGPERHTDFLLPHERASQDGSGFS
                     RILSMLADSTSTQEKRRRSFPDIEDEEKFLYGDEEEDLKAESVPKPLGSSESEVMRQK
                     ASSLPSSAPAVKLESLEETNPEYAKIHDLLKTIGLDIGVAEISQLAARTQERLHGKKP
                     SLRSSADRRSSVDRYFSADHCSSVDHRFSADRCSSVDHCFSADRRSSDPHRLESREAH
                     HSNTHSPEVSHPHPPSPVDPYLLTKNSPPFLKSDHPVGHISGPEVVGSGFQSSVAVRC
                     MLPSAPSAPIRLPHTAALSQFHMPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYA
                     ASRWPMYPTSQPSNHPVPEPHRIMPITKQATRSRPNLRVIPTVTPDKPKQKESLRGSI
                     PAAQVPVQVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKNDREARQKKMYYLRT
                     ELERLHKQQGEMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIAELRQEAEEAEKKQSE
                     LDKVAQILGINIFDKSQKSLSDSREPTEKPGKAEKSKSPEKVSSFSNSSSNKESKVNN
                     EKFRTKSPKPAESPQSATKQLDQPTAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNK
                     KHTQTLDPYNRPWASKTQSEAKQDAIKRTDKITVPAKGSEFLVPISGFYCQLCEEFLG
                     DPISGEQHVKGHQHNEKYKKYVDENPLYEERRNLDRQAGLAVVLETERRRQSELKRKL
                     SEKPKEEKKEKKAKAVKEVKEDDKVSEKLEDQLSEGRNSPEKAENKRNTGIKLQLKEE
                     VKKESPTSSSFGKFSWKKPEKEEEKSSLVTPSISKEEILESSKDKEDGKTEAGKAKPI
                     KIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSCSATMSKPAPLNTFLS
                     IKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKVVLAEKSEPSHL
                     PEQILPPPPPPPPPPPPPPPVIPHPAAPSAAQANAILAPVKSNPVVSQTLSPGFVGPN
                     ILNPVLPVAIMASAQPAAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKK
                     LEKRNSCLATANAKDLYDIFYSSGGKGAPETKGAPETKLSGGPLANGENSNLSRTKSS
                     DTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAKTLVALGKWSVVEHVGPKSTG
                     STYGFLQPLTRLCQSRPYETITPKTDTLAIWTSSSFQSDTSRDISPEKSELDLGEPGP
                     PGVEPPPQLLDIQCKESQKLVEIHLRESVNQDKESQELRKSEDCRESEIETNTELKER
                     VKELSEGIVDEGVSTSIGPHSIDDSNLNHGNRYMWEGEVKQPNLLMIDKEAEQSNKLM
                     TGSETPSKVVIKLSPQACSFTKAKLDSFLSEARSLLNPQDTPVKISAPELLLHSPARS
                     AMCLTGSPQEQGVSVVSEEGLENSAPESASRTSRYRSLKLKRERSKDFQVKKIYELAV
                     WDENKKRPETWESPEKPKTEALELQDVHPELTVTIESKALEDFEATDLKVEELTALGN
                     LGDMPVDFCTTRVSPAHRSPTVLCQKVCEENSVSPIGCNSSDPADFEPIPSFSGFPLD
                     SPKTLVLDFETEGERNSPNPRSVRIPSPNILKTGLTENVDRGLGGLEGTHQALDLLAG
                     GMMPEEVKESSQLDKQESLGLELKTINSAGLGPSPCLPDLVDFVTRTSGVQKDKLCSP
                     LSEPGDPSKCSSLELGPLQLEISNASTTEVAILQVDDDSGDPLNLVKAPVSRSPPREQ
                     VIEDNMVPQGMPEQETTVGAIQDHTESSVHN"
     exon            682..830
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1470
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..2952
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3052
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3354
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3558
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3658
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3777
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..8210
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7406..7411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /note="hexamer: ATTAAA"
     polyA_site      7435
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
     regulatory      8192..8197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /note="hexamer: AATAAA"
     polyA_site      8210
                     /gene="ZNF318"
                     /gene_synonym="HRIHFB2436; TZF; ZFP318"
                     /note="major polyA site"
ORIGIN      
        1 cttggttcct gcggccgctc cctgagtgga ggagcgggga accccggagg cggggggggg
       61 tgtgtcggac gcgtgctcgc gccctccaac cgccagccgc gggggcgcgc tcggccgggc
      121 ccccggggcg acgcggggcc gaggggaggg ggctgctccc gcggctgagg cggcgcgcag
      181 cggccgaggt ggcggcggct gcagctgcgg cggcgcgctc cgagcctgcg tctagggcgc
      241 ccccgggtca gagctgtcgc cgtggccgcc gctgcaagaa ccatgtaccg cagcagcgct
      301 cgctcctccg tctcttccca ccggcctaaa gacgacggcg ggggcggccc gcgcagcggc
      361 cgcagctctg gctcctcctc aggcccggct cgccgcagct caccgccgcc tccgccctcc
      421 ggctcctcgt cgcggacccc ggctcgccga ccccgctcgc cctcagggca ccgcggccgc
      481 cgggcctcgc cgtccccgcc acggggtcgt cgcgtctccc cgtccccgcc tcgggcccgt
      541 cgcggctccc cgtcgccacc gcggggccga cgactcttcc cgccgggccc ggccggcttc
      601 agaggcagca gccgggggga gtcccgcgcc gactatgccc gggacggccg cggagaccat
      661 ccaggcgaca gcggcagccg gagacgctct cctggtctgt gttctgactc tttggaaaag
      721 agcttaagga tcactgttgg caatgaccac ttctgtgtta gcacaccaga acggcgacgg
      781 cttagtgatc ggctggggtc accagtggat aatctggaag acatggacag ggatgacctg
      841 actgatgatt ctgtcttcac tcgaagctcc cagtgctctc ggggtcttga gcgatatatt
      901 tcccaggagg aagggcctct cagtcccttc ttgggacaac ttgatgagga ctaccgaaca
      961 aaagaaactt tcctgcatcg atctgattat agtccccata tcagttgtca tgatgagctg
     1021 ttgcggggaa cagaacggaa tcgagaaaaa ctcaaaggct actccatacg atctgaagaa
     1081 aggagccggg aggccaaaag accccgttat gatgacacag tgaagataaa cagcatggga
     1141 ggggatcacc caagttttac atcaggaact cgcaactatc gacagcgtag aagaagccca
     1201 agtcctaggt ttctcgaccc tgagtttcga gaactggatc ttgccagacg aaagcgagag
     1261 gaagaggagg agcgaagtag gagcttgagt caggagctgg ttggagttga tggtggtggt
     1321 actggctgtt ccatccctgg attgtcaggt gtcctaacag catcggagcc aggatattct
     1381 ttgcatcggc ctgaggaagt atctgtgatg cccaagaaat ccattttgaa gaagcggatt
     1441 gaggtggaca taatggagcc ctccatgcag cttgagagtt tttccagcag taccagctcc
     1501 agccaggatc accctctcta ctctgggcac ccatcccttc cactaagtgg tgctattgct
     1561 gcttttgcct cagagattga aaacaagggg actatggtag agactgcctt gaaggaacct
     1621 cagggcaacc tctaccaatg gggtcccctt cctgggattc ccaaagacaa cagtcctctc
     1681 agagaaaaat ttggaagttt tctatgccac aaggataatt tggatttgaa ggctgaggga
     1741 cctgagcgac acacagactt cctgctgccc catgagagag ctagccagga tggcagtggt
     1801 ttttcccgca ttctgagcat gttggctgat tctaccagta cacaggaaaa aaggcgacgt
     1861 agctttcccg acattgaaga tgaggagaaa tttctctatg gggatgaaga agaggattta
     1921 aaggcagaat ccgtaccaaa gccccttggg agctctgaga gtgaagttat gaggcagaag
     1981 gcaagctccc tgccgtcttc agctccagct gtaaagctag aatcactaga agagaccaat
     2041 ccagaatatg cgaagatcca tgacttgctc aagacaatag ggctggatat tggagtagca
     2101 gagattagtc aattggctgc acgcacccag gaacgacttc atggcaagaa gccatcatta
     2161 cgctcctcag ctgaccgccg ttcctcagtt gaccgatact tttcagctga ccactgttcc
     2221 tcagttgacc accgcttctc agctgaccgc tgttcctcag ttgaccactg cttctcagct
     2281 gatcgacgtt cctcagatcc ccacagacta gagagcaggg aggcacatca tagcaatacc
     2341 cactctccag aggtgtccca tccacaccca ccttctcctg tggatcctta cctgctcaca
     2401 aaaaacagcc ctccattcct aaagtctgac catccagtgg gtcatatttc aggaccagag
     2461 gtggttggta gtgggtttca gtcatctgtt gcagtcaggt gcatgttgcc atcagcccca
     2521 tctgccccaa ttagacttcc acacactgct gctttatctc agtttcacat gccaagggcc
     2581 tctcagtttg ctgcagctcg gatacctccg aactaccagg gacctgccat tccccctgcc
     2641 tcttttgatg cctataggca ctacatggca tatgcagcct ccagatggcc catgtatccc
     2701 acctctcaac cgtcaaacca ccctgtacct gaaccacaca ggataatgcc aataaccaaa
     2761 caagctactc gtagccgtcc caatcttcgt gtgatcccca ctgtgactcc tgataagcct
     2821 aagcagaaag agtctctgcg aggctcaatt cctgcggccc aagtgcctgt ccaggtgtcc
     2881 attccatcac tcataagata taatccagag aagatctctg atgagaagaa ccgtgcttcc
     2941 cagaagcaaa aggttattga agagagggaa aaactaaaga atgaccggga agcccgccag
     3001 aagaagatgt actatcttag gaccgagtta gagcggcttc ataaacaaca aggagaaatg
     3061 ctgcgcaaga aacgaaggga gaaggatggc cacaaagatc ctctcttggt ggaggtgagt
     3121 cggcttcagg ataacattat gaaggacatt gcagagctac ggcaagaggc agaagaggca
     3181 gaaaagaagc aatctgaact ggacaaagtg gctcagatct tgggaattaa catcttcgat
     3241 aaatcccaga agtctttaag tgacagtaga gagcctacag agaagcctgg gaaagcagaa
     3301 aaatctaaga gcccagaaaa agtgtcatcg ttctcaaact cctcctccaa caaggaatca
     3361 aaagtaaaca atgagaagtt tcgtactaag agccccaagc ctgccgaaag cccccagtca
     3421 gccactaagc agttggatca gcccactgct gcttatgagt attatgatgc tggcaatcac
     3481 tggtgcaaag actgcaacac catctgtggg accatgtttg atttcttcac tcatatgcac
     3541 aataagaagc acacacagac actggatccc tacaacagac cttgggcttc aaagacccag
     3601 agtgaggcca agcaagatgc cataaagcgc actgacaaga taactgttcc tgcaaaaggc
     3661 tctgagtttc tggttcccat cagtggattt tattgccagc tctgtgagga atttttgggg
     3721 gatccaattt ctggggagca acatgtgaag ggtcaccaac acaatgagaa atacaagaaa
     3781 tatgtggatg aaaacccatt atatgaggag cggcggaatc tggaccgcca agctggcttg
     3841 gctgtggtcc tagagacaga acggcgacgg cagagtgagc taaagcgcaa acttagtgag
     3901 aaaccaaagg aggagaagaa agaaaaaaag gcaaaggctg tgaaagaagt aaaggaggat
     3961 gacaaggtct ctgagaaatt agaagaccaa ctctctgagg gtaggaactc ccctgaaaaa
     4021 gctgaaaata aaaggaacac tggcatcaaa ctccagttaa aagaagaggt aaagaaggaa
     4081 tcaccaacat catcttcttt tgggaaattc agctggaaga agccagaaaa agaagaggag
     4141 aaaagttcat tggtgacccc aagtatctct aaagaagaga ttctagaaag tagtaaggac
     4201 aaagaggatg gcaaaactga agctgggaag gcaaagccta tcaaaatcaa gctctctggg
     4261 aaaactgttg ttgcacatac cagcccttgg atgcctgttg tgacaacttc cacacagact
     4321 aagatccgac ccaacctgcc tattccatcc acagtactcc gcaagtcatg ttcagccaca
     4381 atgagcaagc cagctcctct taacaccttt ctgtctatta agtcctctgg aaccactgct
     4441 aaacctctgc cagtggttaa agagtcttca gctgatctcc tcttacctcc agacatcatc
     4501 tccaaagcat ttggagggga agaggtgatt ctaaaagggt ctccagagga aaaagtggtg
     4561 ttggctgaaa agagtgagcc atctcattta cctgaacaaa tactaccacc tcctccacca
     4621 cccccacctc caccacctcc accacccccc gttatacctc atccagctgc cccgtctgct
     4681 gctcaagcaa atgctatctt ggctccagta aaatcaaacc cagttgtatc tcagactctc
     4741 agccctggct tcgtgggtcc taacattttg aacccagtgt tgcctgtagc catcatggcc
     4801 tcagcacagc cagctgccat tccttctgat gagacagctc ctggggtgag tgagagtgac
     4861 cgagaccaga ccctgttctc tgtgttagta cgtcctccac cacccctctc aagtgtgttc
     4921 agtgaacaag ccaaaaaatt agagaagcga aattcatgct tagccacagc caatgctaag
     4981 gacctgtatg acatattcta tagtagtggt ggaaaggggg cccctgagac taagggggcc
     5041 cctgagacta agctaagtgg tggtccattg gccaatgggg aaaatagcaa cctctctaga
     5101 accaaaagtt cagacacctc ttctacttct cctttgaaca gcagtgcatc ccaagaggag
     5161 ttgcatcaag atgagggttt ggtcgctgct cctatagtta gcaactctga aaagcccatt
     5221 gcaaaaactc tggtggccct agggaaatgg tcagttgtag aacatgtagg cccaaaaagc
     5281 acaggcagca cctatggctt cctacagcct ctgacaaggt tgtgccaaag caggccttat
     5341 gaaacaatta ccccaaagac agacactttg gccatatgga cctctagttc cttccagagt
     5401 gacactagta gggatatatc tccagagaag agtgagcttg acctgggaga gccaggacca
     5461 cctggtgtag aaccacctcc tcaactgtta gatatacagt gcaaagaatc tcagaagttg
     5521 gtagaaatcc acctcagaga atctgttaac caggataagg aaagccaaga gctccgtaaa
     5581 tctgaggatt gtagagaaag tgagatagag acaaacactg aactaaaaga aagggtaaag
     5641 gagctgtctg aggggatagt tgatgaggga gtaagtacca gcattggacc ccacagcata
     5701 gatgattcta atttgaacca tggaaacaga tacatgtggg agggagaagt aaaacagccc
     5761 aacttgctaa tgattgacaa agaggctgaa cagtccaata aattgatgac aggaagtgaa
     5821 actccaagta aagtagtgat caaattgagt ccacaggctt gctctttcac aaaggcaaaa
     5881 ttagactcat ttttatcaga agctaggtct ttactcaacc cacaagatac acctgtgaaa
     5941 atttctgccc cagagttgct gcttcattcc ccagccagat cagctatgtg tttaacaggt
     6001 agtccacaag agcaaggagt ttcagttgtt agtgaggagg ggctagagaa ttcagctcca
     6061 gaatcagctt ctagaacttc taggtacaga agtctcaaac tcaagagaga aagatcaaaa
     6121 gactttcaag ttaaaaagat ctatgagttg gctgtttggg atgaaaacaa gaagaggcca
     6181 gagacctggg agagcccaga gaaaccaaaa acagaagcac tggagctaca agatgtccat
     6241 ccagagttaa cagtgacaat agaaagcaag gccctagaag actttgaagc tacagactta
     6301 aaggtagagg agcttactgc cctggggaat ctgggggata tgcctgttga tttctgcact
     6361 actcgggtaa gcccagcaca tagatcccca actgtcttgt gtcagaaagt gtgtgaagaa
     6421 aattctgtat cacctatagg gtgtaattcc tccgatcccg ctgacttcga accaatccca
     6481 tctttttctg ggtttccgtt agattctccc aaaaccttgg tgcttgactt tgagacagag
     6541 ggtgaacgaa actcacctaa tcccaggagt gttaggatcc cttctcctaa cattttgaaa
     6601 actggactta cagaaaatgt tgaccgtggc ttggggggcc tagagggaac acaccaggcc
     6661 cttgacctgt tagcaggagg aatgatgcct gaggaagtaa aagaatcttc ccaattagac
     6721 aaacaagagt cactcggatt ggaattaaaa acaattaatt ctgcaggcct tgggccatct
     6781 ccttgccttc cagaccttgt tgactttgtc acacggacct ctggagttca aaaagataaa
     6841 ctgtgttctc cactctctga gccaggtgac ccttctaaat gtagttccct ggagttgggg
     6901 ccattacagc tagaaatatc gaatgcatcc accacagagg tggcaattct gcaagtagat
     6961 gatgacagtg gcgaccctct gaatttggtt aaagctccag tgtcaaggtc ccctccaagg
     7021 gagcaggtaa ttgaagacaa tatggtccct cagggaatgc ctgaacagga aactacagtt
     7081 ggtgccatcc aggaccacac agaatccagt gttcacaact aagaataaat acctagagct
     7141 acttgtgagt gaatcattgg cttctagaaa tcagatgccc agatgatcca agactagttt
     7201 gttatctcat ctggaaccta caccaagaga tgcagtcagc atcttaaagt aaatgttcat
     7261 ggaagctaaa aaatttacct cctttccttt tccctttccc cttaaaacac cagacaaatc
     7321 gataacaact tatatatata tatatatatc tgtaaaaatg tattttgtta atttttttgg
     7381 ccaatttatt ttctcccact ttgtcattaa aatcacatgt ctaactggct caccacatag
     7441 tgtgctttga ttgtattttg gctttgactc tgccatttct gaaatgtggg ggaggatgga
     7501 ggcagctgac ctctccagtt gctgtgttgt attcctaccc aatttcctgg gcagttgatg
     7561 catctctggg aaaaacacca gaaagcttgc tgaaatggaa aacttggaag aattgttcat
     7621 ctcttaggct tccatttgga tgggcctgcc ttaacattgt ttgaaatgca gcgtgagtag
     7681 ctcttttgtt tactgtttac accccttatt ggcatgtcaa ctcctgtact tcccttactc
     7741 tgttgccttt cttgagatgc attgtcctgc taacccacaa acctgtttgg aaataaacat
     7801 ggaagaatat ctggcaggct tacttttaga agacgacaaa tcggtaaggc ttattcatgg
     7861 ttcattgcca ggagcagata tgcttttgag atcactttta tttttgaaat ggcctttgtt
     7921 cattgtattg tgatccaata acactttgta ttaaattgtt tagcagccat ttgtgttgtg
     7981 aaggggtaga agatctctga aacttgtctt gagattgaac tcattccctg ttccacaaac
     8041 ccatatgtat cctttcctct acctcctcct ttcccaatta atttcaacca tagtacgatg
     8101 tttggggttg tatattttgt taaaaagatt aaagaattta tgagttggct tggacaagtt
     8161 taactttatt tttaatgtgt taattacttg gaataaatgc attaatctca
//
