LOCUS       NM_001290319            4504 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 304 (ZNF304), transcript variant
            3, mRNA.
ACCESSION   NM_001290319 XM_005259090
VERSION     NM_001290319.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4504)
  AUTHORS   Krasnopolsky,S., Kuzmina,A. and Taube,R.
  TITLE     Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer
            of HIV transcription that promotes viral latency
  JOURNAL   PLoS Pathog 16 (9), e1008834 (2020)
   PUBMED   32956422
  REMARK    GeneRIF: Genome-wide CRISPR knockout screen identifies ZNF304 as a
            silencer of HIV transcription that promotes viral latency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4504)
  AUTHORS   Aslan,B., Monroig,P., Hsu,M.C., Pena,G.A., Rodriguez-Aguayo,C.,
            Gonzalez-Villasana,V., Rupaimoole,R., Nagaraja,A.S., Mangala,S.,
            Han,H.D., Yuca,E., Wu,S.Y., Ivan,C., Moss,T.J., Ram,P.T., Wang,H.,
            Gol-Chambers,A., Ozkayar,O., Kanlikilicer,P., Fuentes-Mattei,E.,
            Kahraman,N., Pradeep,S., Ozpolat,B., Tucker,S., Hung,M.C.,
            Baggerly,K., Bartholomeusz,G., Calin,G., Sood,A.K. and
            Lopez-Berestein,G.
  TITLE     The ZNF304-integrin axis protects against anoikis in cancer
  JOURNAL   Nat Commun 6, 7351 (2015)
   PUBMED   26081979
  REMARK    GeneRIF: transcriptional regulator of beta1 integrin, promotes
            cancer cell survival and protects against anoikis in ovarian cancer
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4504)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4504)
  AUTHORS   Sabater,L., Ashhab,Y., Caro,P., Kolkowski,E.C., Pujol-Borrell,R.
            and Dominguez,O.
  TITLE     Identification of a KRAB-containing zinc finger protein, ZNF304, by
            AU-motif-directed display method and initial characterization in
            lymphocyte activation
  JOURNAL   Biochem Biophys Res Commun 293 (3), 1066-1072 (2002)
   PUBMED   12051768
  REMARK    GeneRIF: Identification of ZNF304, by AU-motif-directed display
            method and characterization of its role in lymphocyte activation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005261.2, BP315423.1 and
            BC111531.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001290319.1.
            
            Summary: This gene encodes a member of the Krueppel C2H2-type
            zinc-finger family of proteins. The encoded protein functions as a
            transcriptional repressor that recruits a corepressor complex to
            stimulate promoter hypermethylation and transcriptional silencing
            of target genes. Expression of this gene is upregulated in
            colorectal, ovarian and breast cancer, and this gene may promote
            cancer cell survival, growth and invasion. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, initiates translation at a downstream start codon
            and lacks an alternate in-frame exon in the 5' coding region,
            compared to variant 1. It encodes isoform 3, which is shorter than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4009990.1, BC111531.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC005261.2         179047-179049
            4-414               BP315423.1         1-411
            415-1573            BC111531.1         360-1518
            1574-4504           AC005261.2         184744-187674
FEATURES             Location/Qualifiers
     source          1..4504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4504
                     /gene="ZNF304"
                     /note="zinc finger protein 304"
                     /db_xref="GeneID:57343"
                     /db_xref="HGNC:HGNC:13505"
                     /db_xref="MIM:613840"
     exon            1..427
                     /gene="ZNF304"
                     /inference="alignment:Splign:2.1.0"
     exon            428..508
                     /gene="ZNF304"
                     /inference="alignment:Splign:2.1.0"
     exon            509..635
                     /gene="ZNF304"
                     /inference="alignment:Splign:2.1.0"
     CDS             602..2455
                     /gene="ZNF304"
                     /note="isoform 3 is encoded by transcript variant 3;
                     KRAB-containing zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 304 isoform 3"
                     /protein_id="NP_001277248.1"
                     /db_xref="CCDS:CCDS74462.1"
                     /db_xref="GeneID:57343"
                     /db_xref="HGNC:HGNC:13505"
                     /db_xref="MIM:613840"
                     /translation="MLENFALVATLGFWCEAEHEAPSEQSVSVEGVSQVRTAESGLFQ
                     KAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRGLCRRRFSFSANFYQHQKQHNGENC
                     FRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSSGLFQHQTTYNRVSPCRRTECME
                     SFPHSSSLRQHQGDYDGQMLFSCGDEGKAFLDTFTLLDSQMTHAEVRPFRCLPCGNVF
                     KEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCSECGKAFSR
                     KDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNKCGKAFSRKD
                     TLVQHQRFHTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSL
                     IKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSECGKAFSRKDTLVQ
                     HQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQ
                     RVHTGARPYVCSECGKAYISSSHLVQHKKVHTGARPYECSECGKFFSRNSGLILHQRV
                     HTGEKPYVCSECGKAYSRSSHLVRHQKAHTGERAHECNSFGGPLAASLKLV"
     exon            636..4504
                     /gene="ZNF304"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF304"
                     /note="hexamer: AATAAA"
     polyA_site      4504
                     /gene="ZNF304"
                     /note="major polyA site"
ORIGIN      
        1 gtatttttcc tatgcccggt ccgtgcattc tggttgtgaa ggctgagttc tagagatcgg
       61 gtcggctttc tacgcggctc tcgtggaacc tagcaaagaa agacagtgaa gactgcagga
      121 ccttccttcg cgcttttgtt acaatccatg acccctgtcg tgggacgggc ggcctctcgc
      181 ggaggtgtct gccggggctg ggctcttacc gaggcctcca cacacgtcct cttgtccttg
      241 tctcccccag aagcagccgc cttagtcttg tgagcgtttt tacaccgggt agattgagac
      301 ttggagtgct acactcagcc cgagggcgtc cagcgcggtg gaggcgtggg gtttcggctg
      361 agcccacagg gcacagactg ttcatccgct tctcatggca gcggcggtgc tgatggaccg
      421 ggttcaggtt gagaacagac tgtgagcatg agggagcagc tactgcagta gtgttgatgg
      481 tgtctggtct agaggtgtgg ctgtggagag ttgtgtgacc ttcgaggatg tgttcgtgta
      541 cttctctcgg gaggagtggg aactccttga ggaggcacag agattcctgt accgtgatgt
      601 gatgctggag aactttgcac ttgtggctac actaggtttt tggtgtgaag cagaacatga
      661 ggcaccttct gagcagagcg tttctgtaga aggagtgtca caggtcagga ctgctgagtc
      721 aggtcttttc cagaaagcac acccatgtga gatgtgtgac ccactcttga aagacatttt
      781 gcacctggct gaacaccagg gatcacacct tacacagaaa ctgtgcacac gtgggctgtg
      841 taggagaaga ttctcgttca gtgcaaactt ttaccagcac cagaagcaac ataatggaga
      901 gaattgcttc agaggggatg atggaggggc ctcatttgtg aagagctgta cagtccacat
      961 gttagggaga tcctttacgt gcagggagga agggatggac ttaccagata gctctggcct
     1021 tttccagcac cagaccactt acaatagggt gagtccatgc agaaggactg aatgcatgga
     1081 gtctttccca cacagctcca gtctcaggca acaccaagga gactatgatg gacagatgct
     1141 tttcagttgc ggtgatgaag ggaaagcctt cctggacacc tttactcttc ttgacagcca
     1201 gatgactcat gctgaggtga gacccttcag atgcctacca tgtggaaatg tgttcaagga
     1261 gaaatcagct cttattaatc acagaaaaat ccacagtgga gaaatatctc atgtgtgtaa
     1321 ggagtgtgga aaagccttca ttcacttgca ccacctaaaa atgcaccaga aatttcacac
     1381 tggaaaaaga cactatacat gcagtgaatg tgggaaggcc ttcagccgca aggacacact
     1441 tgttcagcat cagagagttc acactggaga aagatcttat gactgcagtg aatgtggaaa
     1501 agcctacagc agaagctccc accttgttca gcaccagaga attcacacag gagaaaggcc
     1561 ttataagtgc aacaaatgtg ggaaagcctt tagccgtaaa gacacacttg ttcagcacca
     1621 gagatttcat actggagaaa ggccttatga gtgcagtgaa tgtggaaaat tctttagcca
     1681 aagctcccac cttattgagc actggagaat tcataccggg gcaaggccct atgaatgcat
     1741 agaatgtgga aaattcttta gccataactc tagcctcatt aaacatcgga gagtccacac
     1801 aggagcaaga tcctacgtgt gcagcaaatg tgggaaggcc tttggctgca aagacacact
     1861 tgttcagcac cagataattc acactggagc aaggccttat gagtgcagtg aatgtgggaa
     1921 ggccttcagc cgtaaagaca cacttgtgca acaccaaaaa atccacactg gagaaaggcc
     1981 ttatgagtgt ggtgaatgtg gtaaattctt cagccatagc tccaacctta ttgtacacca
     2041 gagaattcac actggagcaa agccttatga gtgcaatgaa tgtgggaaat gctttagcca
     2101 caactccagc ctcattttgc accagagagt tcacacagga gcaaggcctt atgtgtgcag
     2161 tgaatgtggg aaggcttaca ttagtagctc ccaccttgtt caacacaaga aagttcacac
     2221 tggagcaaga ccttatgagt gcagtgaatg tgggaaattc tttagccgca actctggcct
     2281 cattctgcac cagagggttc acactggaga aaagccttac gtatgcagcg aatgtgggaa
     2341 agcctatagc agaagctccc atcttgttcg tcaccagaaa gctcacactg gagaaagagc
     2401 tcacgagtgc aacagttttg gtggcccttt agctgcatct cttaaacttg tttaacacca
     2461 gaaaattcac acaagagaaa ggccttatga atgcagaaaa tatgtcatct tgttcatcct
     2521 cataggactc acaccagagc aatgctctgt gagtaccctt tgtgagggaa ccatcagcta
     2581 gcagatgagc accgtatatt cattccaccc tggggagatt cctgataagc accacatatg
     2641 tgggaggctt tcatgaggtg tgttgcactt tgtaactgtc tagagctctt gatggaatta
     2701 tatcactgcc agtgcctgtg gcggaagcca tcttattgct accagctgtg tgtgtcaatc
     2761 actccatttt gctcagggaa ggcagacttc tgtgctttct ttcctgttcc ctacaggtaa
     2821 tcatgaatat tttcaaggac ttcccccccc ccccacttca ccccctacca ttgagggtcc
     2881 tcatcttttc cctcatgatt aggttctgag caaacatgat ctagctctca ccaaaaggac
     2941 ctgagctagg gtctgctggg atttcctgac acgattttcc atcttcatgg acaatgttaa
     3001 ctgtaaacgt gatagctgtg acttacttgt cttactgcca aatcgcccaa atttggaact
     3061 gcttgtccca tgctgctctg atttatacag tgataagggc ctattgtggc agtctttact
     3121 cttggggatt ttgttactgt gtagagtgga ttgagaaaag aattgggttc tgtcatgaag
     3181 ggagtagcac cttttgtggg caccaccttt atgtgcctca gaggggacca aaggatggca
     3241 gaaaactgtt ctcagtctag tttgacctaa tttacactat tgccctaggc ttgctaggaa
     3301 agactgaaaa aatttttgtg cctaactttg tggcctggct gccaggattt cctgtgagcc
     3361 cagtgaggag ggcatagttg gtgcgaaaat ctcctgtgct tgtggaagca acataagttg
     3421 ggtcccttaa ctgtcacgta ctccccagca ctgttgaggg attgctgtct tctgtacctg
     3481 tacaggatca agtccctgat atccagaacc ccataggcaa gtaacattga ctgtaagacc
     3541 tctgtagggc aatgtgaaaa tcatgattgc tacagaagca ctgagataat ggagtgggga
     3601 tgactgtggc aaacaaaagg agattcgaac attctagagg ggcatccaca agtctcggtg
     3661 cagttatgat ggtgtgggat gggagtgcat agaaattctc aggaccttca gacatctgta
     3721 tctcctgtgg ccaaggccac tgtcagagga aataatctaa atgtttgtgg attcctgtgt
     3781 ctccctgggc agttgacctg cacagacagg aacctcagca gtgacagaag agagatccag
     3841 ggatgggtct tctctgaccc agccagcatt ccgagtgact gaggtggatg tggacatcat
     3901 tgcttaccaa tttttaccaa cattgaggca gggctcactc tcctaaattg tagggagagg
     3961 aatatggtaa agccaaaata gttgacagat ctaactttcc tagtggaaca gtatatatag
     4021 attttaatga ggaacattta tttaatagct ttatggaggt atgattaaca tgcaataaac
     4081 tgcaaatatg taaagtgtaa aatgtgctgt ttcagcatgt gtgtacacct atgaaaccac
     4141 cacagtcaag atatccaaca caacaaaaga ttgtcccttt ataatcctca atttttcctt
     4201 atcttgtttt ccacaattca caagcaacag caagcatttt ctataatttt ataaatgaaa
     4261 ccatatggtg tgtacttttt agggggtggg gctctggctt tttcagtaaa cataactatt
     4321 ttaaggttaa tccattatct tgttgcatga atcaattgtt tgctcatttg tattgctgcg
     4381 tagtatttca gtatttcatt gtataccaca atttttcttc tttgtcaact taattgttat
     4441 ggatgtttgg gtaactttca gtttttggct attacaaata aacctctgaa gatttgtgtg
     4501 caaa
//
