LOCUS       NM_001289187            2853 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 302 (ZNF302), transcript variant
            9, mRNA.
ACCESSION   NM_001289187
VERSION     NM_001289187.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2853)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2853)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2853)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   5  (bases 1 to 2853)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB066674.1, DA793666.1, AC020910.7, DN997090.1 and AL834318.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001289187.1.
            
            Summary: This gene encodes a member of the zinc-finger protein
            family. The encoded protein contains seven C2H2-type zinc fingers
            and a KRAB domain, but its function has yet to be determined.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (9) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 3. The
            resulting isoform (c) has the same N- and C-termini but is shorter
            compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the
            same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.49572.1,
                                           SRR1660803.15369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505242.6/ ENSP00000421028.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               DB066674.1         40-218
            180-212             DA793666.1         211-243
            213-213             AC020910.7         79745-79745
            214-372             DA793666.1         245-403
            373-955             DN997090.1         159-741
            956-2853            AL834318.1         702-2599
FEATURES             Location/Qualifiers
     source          1..2853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..2853
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /note="zinc finger protein 302"
                     /db_xref="GeneID:55900"
                     /db_xref="HGNC:HGNC:13848"
     exon            1..426
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /inference="alignment:Splign:2.1.0"
     exon            427..503
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..1694
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /note="isoform c is encoded by transcript variant 9; zinc
                     finger protein 327"
                     /codon_start=1
                     /product="zinc finger protein 302 isoform c"
                     /protein_id="NP_001276116.1"
                     /db_xref="CCDS:CCDS46042.1"
                     /db_xref="GeneID:55900"
                     /db_xref="HGNC:HGNC:13848"
                     /translation="MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVG
                     LSVTKPYVIMLLEDGKEPWMMEKKLSKDWESRWENKELSTKKDIYDEDSPQPVTMEKV
                     VKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKS
                     VIKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSR
                     HWRIHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSSLTNHQ
                     STHTGEKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKS
                     HTGEKPYECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFSSFSFLVQHQSIHT
                     EEKPFEV"
     exon            504..624
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /inference="alignment:Splign:2.1.0"
     exon            625..708
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /inference="alignment:Splign:2.1.0"
     exon            709..2853
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2828..2833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /note="hexamer: AATAAA"
     polyA_site      2853
                     /gene="ZNF302"
                     /gene_synonym="HSD16; MST154; MSTP154; ZNF135L; ZNF140L;
                     ZNF327"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcccg cgatagcttc aggcctggcg gcggcttcca agctaaggaa cggtttgggg
       61 cagtgtcgtt cccggaggtc ggccgccgtt acccgctcac cagctacgcg gcgcgtcagg
      121 tccgcggagg cgcgggctcg gggcgcctgc gggacggtga ggccctgctg aggactccgg
      181 caagtgtggg tcgcggcgac ggcggggcta aggccctggg tccgcgcgcg gtttgaccac
      241 ggccggggcc ttgggcattt cctggccttc ctgttgagcc gtgtaaacgc ggggtgatga
      301 cggcgccgac ctcttggcac tgttgtgaga gcgaagtggg cgcgagagca gacgccagct
      361 acagtttttt ttgggttatg tcgtcatgaa gccggcgctt tcagttgtgc aaccttgaac
      421 aaatgggaca ctgcccatct ctaagataag aacctggaaa ggggactctg ttggccattg
      481 gaaattgcag aataatgtct caggtgacat ttagtgatgt ggctatagac ttctctcatg
      541 aagagtgggc atgcctagat tctgctcaga gggacttata caaggatgtg atggtccaga
      601 attatgagaa cctggtctct gtaggtcttt ccgtaactaa gccatatgtg atcatgttat
      661 tggaggatgg aaaagagccc tggatgatgg agaaaaaact gtcaaaagat tgggaatcaa
      721 gatgggaaaa caaggaatta tcaacaaaga aggatattta tgatgaagat tcaccccaac
      781 cagtaacaat ggaaaaagtt gtaaaacaaa gttatgaatt ttcaaattct aataagaatt
      841 tggaatatac agaatgcgac acatttagaa gcacctttca ttcaaagtct actctttctg
      901 aaccacaaaa caattctgct gaagggaatt cacacaaata tgatatatta aagaagaatt
      961 tatcaaaaaa gtcagttata aaaagtgaga gaataaatgg tggaaagaaa cttttaaatt
     1021 ctaataaaag tggggcagcc ttcaaccaga gcaaatctct tacccttccc cagacttgta
     1081 atagagagaa aatctataca tgcagtgaat gtgggaaagc ctttggcaaa cagtcaatcc
     1141 tcagtcgcca ctggagaatt catacaggag agaagcccta tgaatgtcgt gaatgtggga
     1201 agacttttag ccatggttca tcccttacac gacatcagat aagccatagt ggagagaaac
     1261 cttacaaatg cattgaatgt gggaaggcct ttagccatgg ctcatcactt actaaccatc
     1321 agagcactca cacgggagag aaaccgtatg aatgtatgaa ctgtggaaag tcttttagtc
     1381 gtgtgtccct tctcattcag catctaagaa ttcatacgca agaaaaacgc tatgagtgtc
     1441 gtatatgtgg aaaggccttc attcatagtt cgtctctcat tcaccatcag aaaagccata
     1501 ctggagagaa gccttatgaa tgtagagaat gtgggaaagc tttctgctgt agctcacacc
     1561 ttactcaaca tcaaagaatt cacagtatga agaaaaaata tgaatgcaac aaatgtctca
     1621 aggtctttag tagcttctca tttcttgttc aacatcagag tattcatact gaagaaaaac
     1681 cgtttgaagt ttagaaatgc aggaaatcct tcaaccagct tgaatcactg aatatgcatt
     1741 tgagaaatca cattagattg aaaccctacg aatgcagtat atgtgggaaa gcctttagtc
     1801 ataggtcgtc cctgcttcaa catcacagta ttcatactgg agagaaacct tacgaatgta
     1861 ttaaatgtgg gaagaccttc agctgtagtt caaaccttac tgtacatcag agaattcata
     1921 ctggagaaaa gccatataaa tgtagtgagt gtgggaaagc ttttagcaaa ggctcgaatc
     1981 ttactgccca tcaaagagta cataatggag agaaacccaa tagtgtggta agtgtggaaa
     2041 agcctttaga tcatatgaat ccctatacat gtgagaaatc ttacagaaga gaagcagtgt
     2101 ttatcacggt aaacttcatt catagatcct cccttattta acatcagaaa aatgtatact
     2161 ggggaaaagt tgtatgaagg tggtgaacat gggagacttt tagcaatgat gcagattttt
     2221 ttattagagt ttatactgta gagaaatcat atgaagtcaa taaatgtggg aaagcctttg
     2281 tcagtattaa tcccttaatt gacctaagta tactcacact aggaaaaatc tgtgtacatg
     2341 tagcaaatgt gggaaagact ataggcaata ggaatctcct gcaaactcct acaggagaaa
     2401 agttgtatga atgtggaaac tttagaaatt gaaggaattt ttcagttcca agtgcatccc
     2461 ttattctata ggaaataaac tggagacaaa tctcatttaa gagatgcagc aaagtgttca
     2521 ctaagagtgt ttatcttgcc agacataaga agatgaatgg tagagcaacc tgaaggattt
     2581 agaaattaca tataaatctt tgcagttatg ctatttgtaa acaggattat ataggagagc
     2641 aaataaacat aagtatgcat ttcttagagc agtagcttgc agtttcagtt gagttctact
     2701 tagaaattct ttttagctag tgggcatgtg aagatattta gtcacccaga ggagccagta
     2761 aatgttataa tgttaaaaat taaagctgca aaagaaataa aatggtgtta ataaaaattt
     2821 ggcatctaat aaaatcattt tgtatatcat gaa
//
