LOCUS       NM_052860               3258 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 300 (ZNF300), transcript variant
            2, mRNA.
ACCESSION   NM_052860
VERSION     NM_052860.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Xiang,W., Ni,J., Dong,L. and Zhu,G.
  TITLE     ZNF300 promotes proliferation and migration of hepatocellular
            carcinoma by upregulating c-MYC gene expression
  JOURNAL   Clin Res Hepatol Gastroenterol 48 (7), 102415 (2024)
   PUBMED   39018766
  REMARK    GeneRIF: ZNF300 promotes proliferation and migration of
            hepatocellular carcinoma by upregulating c-MYC gene expression.
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Ding,L., Li,L. and Tang,Z.
  TITLE     Cisplatin resistance and malignant behaviors of lung cancer cells
            are promoted by circ_0002360 via targeting miR-6751-3p to regulate
            the expression of ZNF300
  JOURNAL   Thorac Cancer 13 (7), 986-996 (2022)
   PUBMED   35166026
  REMARK    GeneRIF: Cisplatin resistance and malignant behaviors of lung
            cancer cells are promoted by circ_0002360 via targeting miR-6751-3p
            to regulate the expression of ZNF300.
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Yu,S., Ao,Z., Wu,Y., Song,L., Zhang,P., Li,X., Liu,M., Qian,P.,
            Zhang,R., Li,X., Chen,Y., Wang,X., Wang,X., Ruan,X., Qian,G. and
            Ji,F.
  TITLE     ZNF300 promotes chemoresistance and aggressive behaviour in
            non-small-cell lung cancer
  JOURNAL   Cell Prolif 53 (11), e12924 (2020)
   PUBMED   33078469
  REMARK    GeneRIF: ZNF300 promotes chemoresistance and aggressive behaviour
            in non-small-cell lung cancer.
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Yan,F.J., Wang,Y.J., Yan,S.R., Lu,J. and Zheng,Y.L.
  TITLE     ZNF300 stimulates fatty acid oxidation and alleviates
            hepatosteatosis through regulating PPARalpha
  JOURNAL   Biochem J 476 (2), 385-404 (2019)
   PUBMED   30568000
  REMARK    GeneRIF: These results suggested that ZNF300 plays an important
            role in hepatic lipid metabolism via PPARalpha promoting fatty acid
            oxidation and this effect might be blocked by DNMT3a-mediated
            methylation of ZNF300.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Qiu,H., Xue,L., Gao,L., Shao,H., Wang,D., Guo,M. and Li,W.
  TITLE     Identification of the DNA binding element of the human ZNF300
            protein
  JOURNAL   Cell Mol Biol Lett 13 (3), 391-403 (2008)
   PUBMED   18350257
  REMARK    GeneRIF: Results show that the ZNF300 gene encodes a 68-kDa nuclear
            protein that binds DNA in a sequence-specific manner.
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Cao,Y., Li,J.X., Ji,C.N., Xu,X.W. and Wu,M.
  TITLE     Molecular cloning and characterization of a novel splice variant of
            human ZNF300 gene, which expressed highly in testis
  JOURNAL   DNA Seq 18 (4), 312-315 (2007)
   PUBMED   17541838
  REMARK    GeneRIF: ZNF-300 and novel splice variant ZNF300-B are both
            expressed highly in human testis.
REFERENCE   8  (bases 1 to 3258)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Gou,D., Wang,J., Gao,L., Sun,Y., Peng,X., Huang,J. and Li,W.
  TITLE     Identification and functional analysis of a novel human KRAB/C2H2
            zinc finger gene ZNF300
  JOURNAL   Biochim Biophys Acta 1676 (2), 203-209 (2004)
   PUBMED   14746915
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010441.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 27, 2020 this sequence version replaced NM_052860.3.
            
            Summary: The protein encoded by this gene is a C2H2-type zinc
            finger DNA binding protein and likely transcriptional regulator.
            The function of this protein is not yet known. Three transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096465.1, AF395541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274599.10/ ENSP00000274599.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC010441.6         6487-6763
            278-391             AC010441.6         7490-7603
            392-433             AC010441.6         8285-8326
            434-560             AC010441.6         12913-13039
            561-683             AC010441.6         13283-13405
            684-3258            AC010441.6         14494-17068
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..3258
                     /gene="ZNF300"
                     /note="zinc finger protein 300"
                     /db_xref="GeneID:91975"
                     /db_xref="HGNC:HGNC:13091"
                     /db_xref="MIM:612429"
     exon            1..277
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     exon            278..391
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     exon            392..433
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..2233
                     /gene="ZNF300"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kruppel-like zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 300 isoform 2"
                     /protein_id="NP_443092.1"
                     /db_xref="CCDS:CCDS4311.2"
                     /db_xref="GeneID:91975"
                     /db_xref="HGNC:HGNC:13091"
                     /db_xref="MIM:612429"
                     /translation="MMKSQGLVSFKDVAVDFTQEEWQQLDPSQRTLYRDVMLENYSHL
                     VSMGYPVSKPDVISKLEQGEEPWIIKGDISNWIYPDEYQADGRQDRKSNLHNSQSCIL
                     GTVSFHHKILKGVTRDGSLCSILKVCQGDGQLQRFLENQDKLFRQVTFVNSKTVTEAS
                     GHKYNPLGKIFQECIETDISIQRFHKYDAFKKNLKPNIDLPSCYKSNSRKKPDQSFGG
                     GKSSSQSEPNSNLEKIHNGVIPFDDNQCGNVFRNTQSLIQYQNVETKEKSCVCVTCGK
                     AFAKKSQLIVHQRIHTGKKPYDCGACGKAFSEKFHLVVHQRTHTGEKPYDCSECGKAF
                     SQKSSLIIHQRVHTGEKPYECSECGKAFSQKSPLIIHQRIHTGEKPYECRECGKAFSQ
                     KSQLIIHHRAHTGEKPYECTECGKAFCEKSHLIIHKRIHTGEKPYKCAQCEEAFSRKT
                     ELITHQLVHTGEKPYECTECGKTFSRKSQLIIHQRTHTGEKPYKCSECGKAFCQKSHL
                     IGHQRIHTGEKPYICTECGKAFSQKSHLPGHQRIHTGEKPYICAECGKAFSQKSDLVL
                     HQRIHTGERPYQCAICGKAFIQKSQLTVHQRIHTVVKS"
     exon            434..560
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     exon            561..683
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     exon            684..3258
                     /gene="ZNF300"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF300"
                     /note="hexamer: CATAAA"
     polyA_site      3258
                     /gene="ZNF300"
                     /note="major polyA site"
ORIGIN      
        1 acgaagacga ccgggctctc aagatggcgg ccccatgcgg aaacagctcc agggagcagc
       61 catgttgctt cctgaacaaa gcctctgaag atgcggaacg ggcaaaaccg cccagtacgg
      121 aacggcgcag cctcgggagc ccggtgtggt gctcgcggac aggaagcagg agagtttgcc
      181 aatagggatg tgacagcggt tcccattaag cggtgatggt ggttttggga cctgataatc
      241 gagctgggag tcagaggcgg gatgtgtgcg gtgaaggatg ttttgatacc cccatataaa
      301 ataatctgtc tgtcatggga gcccccacgt cctctgaaat agttcagctc tgtctgcatg
      361 acttgtcctg ggactgagga aaatttacca gtcatctggc cttttggaag agcaaaaaat
      421 gatgaagtcc caggggttag tatcattcaa ggatgtggct gtggatttca cccaggagga
      481 gtggcagcaa cttgaccctt ctcagaggac cctgtacagg gatgtgatgc tggagaacta
      541 cagccacctg gtctcaatgg ggtatccagt ttccaaacca gatgtcatct ccaagttgga
      601 acaaggagaa gagccatgga tcataaaggg agacatatca aattggatct atccagatga
      661 atatcaggca gatgggagac aagacaggaa gagtaacctt cacaactccc agtcatgtat
      721 tttggggaca gtttccttcc atcataagat actgaaagga gtcacaaggg atggttcatt
      781 gtgctccatt ttaaaagtct gtcaaggtga tggtcagctg cagagatttc tagagaatca
      841 agacaaactc ttcaggcagg tcacatttgt taacagcaaa acagtgactg aggcatcagg
      901 gcataaatat aatccactgg ggaaaatatt tcaagagtgc atagaaacag atatatcaat
      961 acagagattc cataaatatg atgcttttaa aaagaactta aaaccaaata ttgacctacc
     1021 gagttgttat aagagcaatt caagaaaaaa acctgatcag agttttggag gtggaaaatc
     1081 atctagccag agtgagccca attctaatct tgagaagatt cacaatggag taataccttt
     1141 tgatgataat cagtgtggaa acgtttttag aaatacacaa tcccttattc aatatcagaa
     1201 tgtggaaact aaagagaaaa gctgtgtatg tgttacatgt ggaaaagcct ttgctaagaa
     1261 gtcacaactc attgtacatc aaagaattca tactggaaag aaaccatatg attgtggtgc
     1321 atgcggaaaa gccttcagtg agaagtttca tcttgttgta catcagagaa ctcatactgg
     1381 ggagaaacct tatgattgtt ctgaatgtgg aaaagccttc tctcagaaat cgtcccttat
     1441 tatacatcag agagttcaca ctggggaaaa accctatgaa tgtagtgaat gcgggaaagc
     1501 cttctcccag aaatcacccc tcattataca tcagagaata catactgggg aaaaacccta
     1561 tgaatgtaga gagtgtggga aggccttttc ccagaagtca cagctgatta tacaccacag
     1621 agctcatact ggagagaagc cgtatgagtg taccgaatgt gggaaagcct tctgtgagaa
     1681 gtcccacctc attatacata aaagaattca cactggtgag aaaccctaca aatgtgctca
     1741 atgtgaggaa gccttcagca ggaagacaga actcattaca catcagttag ttcatactgg
     1801 ggaaaaacct tatgaatgta ctgaatgtgg aaagacattc tcccgcaagt cacagctcat
     1861 catacatcag agaacacata ctggagaaaa accctataaa tgtagtgaat gtggcaaagc
     1921 cttctgccag aagtcacatc tcattggaca tcagagaatt cacacaggag aaaaacctta
     1981 tatatgtact gaatgtggga aagccttctc tcagaagtcc caccttccgg gacaccagcg
     2041 aattcataca ggagagaaac cttacatatg tgctgaatgt ggaaaggcct tttctcagaa
     2101 gtcagacctt gttttacatc agaggattca tactggggaa agaccctatc aatgtgctat
     2161 atgtgggaag gccttcatcc agaagtcaca actaactgta caccagagaa ttcacacagt
     2221 ggtaaaatca taatgaactg gccacagaaa agccttagta ttagctcaag ccttaataat
     2281 tactagaaac ccaattaatt tgataagctt ggggacaaca tcccaataga taaaaatttt
     2341 taagggaatt tgtttctagt ttggtgatgc ctaacttttc cagcaaagat gatggaaaat
     2401 agttatataa atgaagaaca tttttaatat ggcatgtaaa gcttttaaag ttatgaactc
     2461 agtgatcagc acagcaagtt aagcatacag aatattgtca agttgcatat tccttatact
     2521 acaaaatgat aatcagccat tgtgaaactg ctaatattag cttgtcataa ttatggccat
     2581 aaactaattt ttctataaaa gacgtggaag aaagcttaag taaacaataa aataaaacct
     2641 atacactatt ttaagaaggg gcttgagcat gacccctaaa gctacatgta aagttcttgt
     2701 acaaaaaatg gaatgatagg ttgatcagat tcagtaaagt tgatctgtat gcattttccc
     2761 atctcaagca tataagttga cctgcatctc tggaaggacc ttgagattga tgcattttga
     2821 gcaggtctcc cttttactct tcccaactgg gaacttggag ctgaaaaaca ttggcactga
     2881 ggccagatgg ccttgggttt aatcctggct cagtgcctca cagattgtgt gactttaggc
     2941 aaacatactt ctcctagctg agtatttttt atcagtaagt acaaatacaa tgcagagctc
     3001 attttcagtt aatattagta ctttttaaat ctttactctc tatcttgaag cattagatgt
     3061 taagactaat gtgtaaaaac cacgtctgag cttgcttttc cctctggaca ctctgctttt
     3121 gattgcctat ccctataagt ggctcatttt actgtcttct gatcctggtg gccttatttt
     3181 tgctatgtta aggttgtgtt ttttaatact tggatttatt ttcatatact tacataaacc
     3241 gtggtgattg cacataaa
//
