LOCUS       NM_032924               2797 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 3 (ZNF3), transcript variant 2,
            mRNA.
ACCESSION   NM_032924
VERSION     NM_032924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2797)
  AUTHORS   Du,L., Liu,N., Jin,J., Cao,M., Sun,Y., Gao,X., Ruan,B., Yang,S.,
            Ge,D., Ye,Y., Zhou,Y., Chen,E. and Yang,J.
  TITLE     ZNF3 regulates proliferation, migration and invasion through MMP1
            and TWIST in colorectal cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (12), 1889-1896 (2022)
   PUBMED   36789689
  REMARK    GeneRIF: ZNF3 regulates proliferation, migration and invasion
            through MMP1 and TWIST in colorectal cancer.
REFERENCE   2  (bases 1 to 2797)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2797)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 2797)
  AUTHORS   Gao,J., Li,W.X., Feng,S.Q., Yuan,Y.S., Wan,D.F., Han,W. and Yu,Y.
  TITLE     A protein-protein interaction network of transcription factors
            acting during liver cell proliferation
  JOURNAL   Genomics 91 (4), 347-355 (2008)
   PUBMED   18255255
REFERENCE   5  (bases 1 to 2797)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 2797)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 2797)
  AUTHORS   Rosati,M., Marino,M., Franze,A., Tramontano,A. and Grimaldi,G.
  TITLE     Members of the zinc finger protein gene family sharing a conserved
            N-terminal module
  JOURNAL   Nucleic Acids Res 19 (20), 5661-5667 (1991)
   PUBMED   1945843
REFERENCE   8  (bases 1 to 2797)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
REFERENCE   9  (bases 1 to 2797)
  AUTHORS   Pannuti,A., Lanfrancone,L., Pascucci,A., Pelicci,P.G., La Mantia,G.
            and Lania,L.
  TITLE     Isolation of cDNAs encoding finger proteins and measurement of the
            corresponding mRNA levels during myeloid terminal differentiation
  JOURNAL   Nucleic Acids Res 16 (10), 4227-4237 (1988)
   PUBMED   3380682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC384519.1, BC013603.1 and CA439866.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032924.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same
            isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.111324.1,
                                           SRR1803612.262411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299667.9/ ENSP00000299667.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC384519.1         42-57
            17-2611             BC013603.1         1-2595
            2612-2797           CA439866.1         20-205              c
FEATURES             Location/Qualifiers
     source          1..2797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2797
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /note="zinc finger protein 3"
                     /db_xref="GeneID:7551"
                     /db_xref="HGNC:HGNC:13089"
                     /db_xref="MIM:194510"
     exon            1..89
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     exon            90..210
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     exon            211..341
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1627
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /note="isoform 2 is encoded by transcript variant 2; C2-H2
                     type zinc finger protein; zinc finger protein HF.12; zinc
                     finger protein KOX25; zinc finger protein HZF3.1"
                     /codon_start=1
                     /product="zinc finger protein 3 isoform 2"
                     /protein_id="NP_116313.3"
                     /db_xref="CCDS:CCDS43619.1"
                     /db_xref="GeneID:7551"
                     /db_xref="HGNC:HGNC:13089"
                     /db_xref="MIM:194510"
                     /translation="METQADLVSQEPQALLDSALPSKVPAFSDKDSLGDEMLAAALLK
                     AKSQELVTFEDVAVYFIRKEWKRLEPAQRDLYRDVMLENYGNVFSLDRETRTENDQEI
                     SEDTRSHGVLLGRFQKDISQGLKFKEAYEREVSLKRPLGNSPGERLNRKMPDFGQVTV
                     EEKLTPRGERSEKYNDFGNSFTVNSNLISHQRLPVGDRPHKCDECSKSFNRTSDLIQH
                     QRIHTGEKPYECNECGKAFSQSSHLIQHQRIHTGEKPYECSDCGKTFSCSSALILHRR
                     IHTGEKPYECNECGKTFSWSSTLTHHQRIHTGEKPYACNECGKAFSRSSTLIHHQRIH
                     TGEKPYECNECGKAFSQSSHLYQHQRIHTGEKPYECMECGGKFTYSSGLIQHQRIHTG
                     ENPYECSECGKAFRYSSALVRHQRIHTGEKPLNGIGMSKSSLRVTTELNIREST"
     exon            342..430
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     exon            431..557
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     exon            558..2797
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /note="hexamer: ATTAAA"
     polyA_site      2797
                     /gene="ZNF3"
                     /gene_synonym="A8-51; HF.12; KOX25; PP838; Zfp113"
                     /note="major polyA site"
ORIGIN      
        1 gttctgtccc cggtgtgtgg gtctgtgaca gggtccaaca gggcctggtc cgtgtccggt
       61 cccccaaatc tgtcgtccct gcccccaggc attggcatca acaaaagtca gaattcccgg
      121 gaacttgaac agaggctgct aaattcccag taattgctcc tttggccttc tagggactga
      181 cttcaaagaa ggaaggaaag aatcaggcag tgcttcctca ttctctttta aaacccgctt
      241 cccgctgagt ctgcacccag gagaccagag agcaccttgc ccttccatgg aaactcaggc
      301 tgatctcgta tctcaggaac ctcaggccct gcttgacagt gctcttcctt caaaagttcc
      361 tgccttttcc gacaaggaca gcctggggga tgagatgttg gcggctgcgc tcctaaaggc
      421 caagtcccag gagctggtaa cctttgagga tgtagctgtg tacttcatcc ggaaggagtg
      481 gaagcgtttg gaacctgctc agagggacct ctatagagat gtgatgctgg agaattacgg
      541 gaatgtgttc tcactggatc gtgagaccag gactgaaaat gatcaagaaa tttctgaaga
      601 cacaagatca catggggtcc tactgggaag atttcaaaag gatatttctc agggtctcaa
      661 gtttaaagaa gcctatgaac gagaagtcag tctgaaaagg ccgctgggga actcccctgg
      721 agaaagactg aacaggaaaa tgccagattt tggtcaagtg acagttgagg agaagctaac
      781 ccccagggga gagagaagcg agaaatataa tgattttggg aacagcttca ctgtgaattc
      841 caaccttatc tcacatcaga gactccccgt gggagacaga ccccataagt gtgatgaatg
      901 tagcaagagc tttaatcgaa cttcagacct tattcaacat cagagaatcc acactgggga
      961 aaagccctat gaatgtaatg agtgtgggaa ggccttcagc cagagctcac accttattca
     1021 gcatcagaga atccacactg gggaaaaacc ttatgaatgt agtgattgtg ggaaaacctt
     1081 cagctgtagc tctgccctca ttctgcatcg gaggatccac acgggggaga aaccctatga
     1141 atgtaatgag tgtgggaaga ccttcagctg gagctccacc ctcacccacc atcagagaat
     1201 ccacactggt gagaaaccct acgcctgcaa tgaatgtggg aaggccttca gcaggagctc
     1261 aacccttatt caccatcaga gaatccacac tggagaaaaa ccctatgaat gtaatgaatg
     1321 tgggaaagcc ttcagccaga gctcacacct ctatcagcac cagagaatcc acactggaga
     1381 gaagccctac gaatgtatgg aatgtggagg aaagtttacc tacagttcag gccttattca
     1441 gcatcaaaga atccacaccg gggagaaccc ctatgaatgt agtgagtgtg ggaaagcctt
     1501 caggtacagc tcggctcttg ttcgccatca gagaattcac actggagaga agcctttgaa
     1561 tgggatcggc atgagcaaaa gctccctcag agttacgacc gagttaaata tcagagagtc
     1621 cacgtgaaag agccacacac ccattttcct cactttccct gagtctcaag agctcttgcc
     1681 ttaccctata aatctcaaca gcttaggatg tgtccctttc aactcagact tttcatttta
     1741 gagaatgggg cagatggggc aaatcgttga attttcccag aaatcacacc agccttagaa
     1801 agcgtcaagg caagtggatg gcgtgctggg aatagaaagc agctctggga ccagttaccc
     1861 catttaggaa aggagtttgc actaaactgt ttttctcaca gcagaggaac ctttccaagg
     1921 tggggatgga agcacagtcg ggacagaatt cgatggattc ctttagttgg agtccgcgta
     1981 gtcagcacag acagcagtgg aaaggacgct ctgggtcctg ttatttgcta gggagggtaa
     2041 agggagacta tttcaaagct actgttccta gtccagcttt aagtttcggt aagaaacatg
     2101 ctgttttgtt tcatgatttc gttaattatg gaaatttggc attgagggat tattttattg
     2161 agggtagaag agattccaga atcatcatct gtgatgatgg tgtcctttag ggctcttgga
     2221 gcagccagac catgtttcca agagaaacct ggtgatattg ccagcagacc ccctgccatc
     2281 ccccccagtt gtcctggggc tgaatgggca aatctgtcca aacagctagt aaccggctgt
     2341 gagggagagg gtcagaagca cttagcgttg gcctctgatt gctgtcctct cttgtcctct
     2401 tcccactcca atgatgaaaa tgattttctc taaatgcctg ggtaaggatg ctttcaagga
     2461 gctcacttgg cctgcttgcc ctgccctctc acctctgaca cccagcccca ggagccagac
     2521 cactcctgcc tccacctctg actcttcagc agctgaagat taatgcagag aaagagcaaa
     2581 gcccaaaagg gagaaaaaaa aaacaaaaaa acaaaaaaac gaagcccaga gaaggcaggc
     2641 tgtgcctgag cctggtagca gagctcgttg ctgggtgagg atggcactcc ccgagttttc
     2701 ccaaccgacg ggatgacctt ccattgtgtt ttcccaaccc tgctcatcct gtagcataaa
     2761 tgaagtgcac tattaaacag aatagttttt cagaaga
//
