LOCUS       NM_145288               1634 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 296 (ZNF296), mRNA.
ACCESSION   NM_145288
VERSION     NM_145288.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Poland,K.S., Shardy,D.L., Azim,M., Naeem,R., Krance,R.A.,
            Dreyer,Z.E., Neeley,E.S., Zhang,N., Qiu,Y.H., Kornblau,S.M. and
            Plon,S.E.
  TITLE     Overexpression of ZNF342 by juxtaposition with MPO
            promoter/enhancer in the novel translocation t(17;19)(q23;q13.32)
            in pediatric acute myeloid leukemia and analysis of ZNF342
            expression in leukemia
  JOURNAL   Genes Chromosomes Cancer 48 (6), 480-489 (2009)
   PUBMED   19255975
  REMARK    GeneRIF: novel translocation t(17;19)(q22;q13.32)in acute myeloid
            leukemia mapping to 352 bp 5 of MPO on 17q & 2,085 bp 5 of ZNF342
            on 19q on derivative chromosome 17; higher level of ZNF342
            expression in acute lymphoblastic leukemia associated with poorer
            outcome
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Hong,C., Bollen,A.W. and Costello,J.F.
  TITLE     The contribution of genetic and epigenetic mechanisms to gene
            silencing in oligodendrogliomas
  JOURNAL   Cancer Res 63 (22), 7600-7605 (2003)
   PUBMED   14633674
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Dear,T.N.
  TITLE     Cloning, structure, expression analysis, and assignment to mouse
            chromosome 7 of the gene Zfp296 encoding a zinc finger protein
  JOURNAL   Mamm Genome 11 (11), 1037-1039 (2000)
   PUBMED   11063263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF434185.1 and BC019352.1.
            
            On Nov 24, 2018 this sequence version replaced NM_145288.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.504281.1,
                                           SRR3476690.949249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303809.7/ ENSP00000302770.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BF434185.1         375-422             c
            49-1634             BC019352.1         1-1586
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1634
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /note="zinc finger protein 296"
                     /db_xref="GeneID:162979"
                     /db_xref="HGNC:HGNC:15981"
                     /db_xref="MIM:613226"
     exon            1..403
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1533
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /note="zinc finger protein 342"
                     /codon_start=1
                     /product="zinc finger protein 296"
                     /protein_id="NP_660331.1"
                     /db_xref="CCDS:CCDS12653.1"
                     /db_xref="GeneID:162979"
                     /db_xref="HGNC:HGNC:15981"
                     /db_xref="MIM:613226"
                     /translation="MSRRKAGSAPRRVEPAPAANPDDEMEMQDLVIELKPEPDAQPQQ
                     APRLGPFSPKEVSSAGRFGGEPHHSPGPMPAGAALLALGPRNPWTLWTPLTPNYPDRQ
                     PWTDKHPDLLTCGRCLQTFPLEAITAFMDHKKLGCQLFRGPSRGQGSEREELKALSCL
                     RCGKQFTVAWKLLRHAQWDHGLSIYQTESEAPEAPLLGLAEVAAAVSAVVGPAAEAKS
                     PRASGSGLTRRSPTCPVCKKTLSSFSNLKVHMRSHTGERPYACDQCPYACAQSSKLNR
                     HKKTHRQVPPQSPLMADTSQEQASAAPPEPAVHAAAPTSTLPCSGGEGAGAAATAGVQ
                     EPGAPGSGAQAGPGGDTWGAITTEQRTDPANSQKASPKKMPKSGGKSRGPGGSCEFCG
                     KHFTNSSNLTVHRRSHTGERPYTCEFCNYACAQSSKLNRHRRMHGMTPGSTRFECPHC
                     HVPFGLRATLDKHLRQKHPEAAGEA"
     exon            404..553
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /inference="alignment:Splign:2.1.0"
     exon            554..1634
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /note="hexamer: AGTAAA"
     polyA_site      1634
                     /gene="ZNF296"
                     /gene_synonym="ZFP296; ZNF342"
                     /note="major polyA site"
ORIGIN      
        1 agtcactcac ctgagcgcgc acggtccgcg cgtcctccgc tcgtgcgtcc tccgcccgcc
       61 cgcctgcctg cctgcccgcc cgctcgctcg cccggcccgc gactcatgtc ccgccgcaag
      121 gccggcagcg cgccccgccg agtagagccc gcgcccgccg ccaacccaga cgacgagatg
      181 gaaatgcagg acctcgtcat cgaactcaag cccgagccag acgcgcagcc ccaacaggcc
      241 ccaaggctgg ggcccttctc cccgaaggag gtgtcctcgg cggggcggtt cggcggcgaa
      301 ccccaccact cccctggccc catgcccgcc ggggccgccc tcctcgccct cggcccgcgg
      361 aacccgtgga ccctgtggac gccgttgacc ccgaactatc ccgaccgcca gccctggacc
      421 gacaaacacc cagatctgtt gacctgcggc cgctgcctgc agaccttccc gttggaggcc
      481 atcactgcct tcatggacca caagaagctg ggctgtcagc tcttcagagg ccccagccgc
      541 ggccagggct cagaacgaga ggagctgaag gccttgagct gcctgcgctg tggcaaacag
      601 ttcacagtgg cctggaagct gctgcgtcac gcccagtggg accacggact gtccatctac
      661 cagacagaat cagaggcccc ggaggccccg ctcctgggcc tggccgaggt ggctgcagcc
      721 gtgtcggcag tggtggggcc agcagctgag gccaagagcc cccgtgcaag tggcagcggc
      781 ctcacccggc ggagccccac ctgtcctgtg tgcaagaaga ccctcagctc cttcagcaac
      841 ctcaaagtgc acatgcgctc acacacaggc gagcggccct atgcttgcga ccagtgtccc
      901 tacgcctgcg cccagagcag caagctcaac cgccacaaga agacccaccg gcaggtgccg
      961 ccccagagcc ccctcatggc cgacaccagc caggagcagg cctctgcagc ccctccggag
     1021 ccggctgtcc atgctgctgc ccccaccagc acccttccat gcagcggtgg tgagggggct
     1081 ggagccgccg ccacagcagg tgtccaggaa cccggggctc ctggcagtgg ggctcaagcc
     1141 ggccctggtg gagacacttg gggagccatc accacggaac aaagaactga ccctgcaaac
     1201 agccagaagg catcacccaa aaagatgccc aagtcagggg gcaagagccg cgggcccggg
     1261 ggcagctgtg agttctgcgg gaagcatttt accaacagca gcaacctgac ggtgcaccgg
     1321 cgctcacaca ccggggagcg cccctacacc tgtgagttct gcaactacgc ctgcgcccag
     1381 agcagtaagc tcaaccgcca ccgccgcatg cacggcatga cgcctggcag cacccgcttc
     1441 gagtgccccc actgccatgt gcccttcggc ctgcgagcca ccctggacaa acacctgcgg
     1501 cagaagcacc ctgaggcggc cggcgaggcc tgagcccagg aaagcccccc tcactgtccc
     1561 tggtaccgct gccaacaccc attgacctcc tcgtttttgc ccgccttctc caagtaaatt
     1621 ttccctttta ttta
//
