LOCUS       NM_015021              12341 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens zinc finger protein 292 (ZNF292), transcript variant
            1, mRNA.
ACCESSION   NM_015021 XM_048070 XM_938563
VERSION     NM_015021.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12341)
  AUTHORS   Xie,H.S., Huang,J.F., Lin,Q.X., Chen,Y.W., Chen,G.P. and Lin,Q.C.
  TITLE     The role of exosomal circular RNA ZNF292 in intermittent
            hypoxia-induced AC16 cardiomyocytes injury
  JOURNAL   Sleep Breath 28 (1), 319-329 (2024)
   PUBMED   37726500
  REMARK    GeneRIF: The role of exosomal circular RNA ZNF292 in intermittent
            hypoxia-induced AC16 cardiomyocytes injury.
REFERENCE   2  (bases 1 to 12341)
  AUTHORS   Heumuller,A.W., Jones,A.N., Mourao,A., Klangwart,M., Shi,C.,
            Wittig,I., Fischer,A., Muhly-Reinholz,M., Buchmann,G.K.,
            Dieterich,C., Potente,M., Braun,T., Grote,P., Jae,N., Sattler,M.
            and Dimmeler,S.
  TITLE     Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow
            Responses
  JOURNAL   Circ Res 130 (1), 67-79 (2022)
   PUBMED   34789007
  REMARK    GeneRIF: Locus-Conserved Circular RNA cZNF292 Controls Endothelial
            Cell Flow Responses.
REFERENCE   3  (bases 1 to 12341)
  AUTHORS   Xu,X., Gao,R., Li,S., Li,N., Jiang,K., Sun,X. and Zhang,J.
  TITLE     Circular RNA circZNF292 regulates H2 O2 -induced injury in human
            lens epithelial HLE-B3 cells depending on the regulation of the
            miR-222-3p/E2F3 axis
  JOURNAL   Cell Biol Int 45 (8), 1757-1767 (2021)
   PUBMED   33851769
  REMARK    GeneRIF: Circular RNA circZNF292 regulates H2 O2 -induced injury in
            human lens epithelial HLE-B3 cells depending on the regulation of
            the miR-222-3p/E2F3 axis.
REFERENCE   4  (bases 1 to 12341)
  AUTHORS   Mirzaa,G.M., Chong,J.X., Piton,A., Popp,B., Foss,K., Guo,H.,
            Harripaul,R., Xia,K., Scheck,J., Aldinger,K.A., Sajan,S.A.,
            Tang,S., Bonneau,D., Beck,A., White,J., Mahida,S., Harris,J.,
            Smith-Hicks,C., Hoyer,J., Zweier,C., Reis,A., Thiel,C.T.,
            Jamra,R.A., Zeid,N., Yang,A., Farach,L.S., Walsh,L., Payne,K.,
            Rohena,L., Velinov,M., Ziegler,A., Schaefer,E., Gatinois,V.,
            Genevieve,D., Simon,M.E.H., Kohler,J., Rotenberg,J., Wheeler,P.,
            Larson,A., Ernst,M.E., Akman,C.I., Westman,R., Blanchet,P.,
            Schillaci,L.A., Vincent-Delorme,C., Gripp,K.W., Mattioli,F.,
            Guyader,G.L., Gerard,B., Mathieu-Dramard,M., Morin,G., Sasanfar,R.,
            Ayub,M., Vasli,N., Yang,S., Person,R., Monaghan,K.G.,
            Nickerson,D.A., van Binsbergen,E., Enns,G.M., Dries,A.M.,
            Rowe,L.J., Tsai,A.C.H., Svihovec,S., Friedman,J., Agha,Z.,
            Qamar,R., Rodan,L.H., Martinez-Agosto,J., Ockeloen,C.W.,
            Vincent,M., Sunderland,W.J., Bernstein,J.A., Eichler,E.E.,
            Vincent,J.B. and Bamshad,M.J.
  CONSRTM   Undiagnosed Diseases Network,; University of Washington Center for
            Mendelian Genomics (UW-CMG),
  TITLE     De novo and inherited variants in ZNF292 underlie a
            neurodevelopmental disorder with features of autism spectrum
            disorder
  JOURNAL   Genet Med 22 (3), 538-546 (2020)
   PUBMED   31723249
  REMARK    GeneRIF: De novo and inherited variants in ZNF292 underlie a
            neurodevelopmental disorder with features of autism spectrum
            disorder.
REFERENCE   5  (bases 1 to 12341)
  AUTHORS   Lee,J.H., Song,S.Y., Kim,M.S., Yoo,N.J. and Lee,S.H.
  TITLE     Frameshift mutations of a tumor suppressor gene ZNF292 in gastric
            and colorectal cancers with high microsatellite instability
  JOURNAL   APMIS 124 (7), 556-560 (2016)
   PUBMED   27150435
  REMARK    GeneRIF: Based on this, the ZNF292 frameshift mutations may
            possibly contribute to tumorigenesis by altering its tumor
            suppressor gene functions in gastric and colorectal cancers.
REFERENCE   6  (bases 1 to 12341)
  AUTHORS   Takeda,H., Wei,Z., Koso,H., Rust,A.G., Yew,C.C., Mann,M.B.,
            Ward,J.M., Adams,D.J., Copeland,N.G. and Jenkins,N.A.
  TITLE     Transposon mutagenesis identifies genes and evolutionary forces
            driving gastrointestinal tract tumor progression
  JOURNAL   Nat Genet 47 (2), 142-150 (2015)
   PUBMED   25559195
  REMARK    GeneRIF: ZNF292 is a new tumor-suppressor gene with potential
            relevance to colorectal cancer.
REFERENCE   7  (bases 1 to 12341)
  AUTHORS   Furney,S.J., Simmons,A., Breen,G., Pedroso,I., Lunnon,K.,
            Proitsi,P., Hodges,A., Powell,J., Wahlund,L.O., Kloszewska,I.,
            Mecocci,P., Soininen,H., Tsolaki,M., Vellas,B., Spenger,C.,
            Lathrop,M., Shen,L., Kim,S., Saykin,A.J., Weiner,M.W. and
            Lovestone,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium
  TITLE     Genome-wide association with MRI atrophy measures as a quantitative
            trait locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 16 (11), 1130-1138 (2011)
   PUBMED   21116278
REFERENCE   8  (bases 1 to 12341)
  AUTHORS   Flynn,M.P. and Hurley,D.L.
  TITLE     Growth hormone transcription factor ZN-16 genomic coding regions
            are composed of a single exon and are evolutionarily conserved in
            mammals
  JOURNAL   Gene 368, 78-83 (2006)
   PUBMED   16303260
REFERENCE   9  (bases 1 to 12341)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   10 (bases 1 to 12341)
  AUTHORS   VanderHeyden,T.C., Wojtkiewicz,P.W., Voss,T.C., Mangin,T.M.,
            Harrelson,Z., Ahlers,K.M., Phelps,C.J. and Hurley,D.L.
  TITLE     Mouse growth hormone transcription factor Zn-16: unique bipartite
            structure containing tandemly repeated zinc finger domains not
            reported in rat Zn-15
  JOURNAL   Mol Cell Endocrinol 159 (1-2), 89-98 (2000)
   PUBMED   10687855
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA329523.1, BX537746.1,
            AK123473.1, AK127835.1, BC016386.1, BC063594.1, AB011102.1,
            AL139274.17 and BX112525.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_015021.2.
            
            Summary: This gene encodes a growth hormone-dependent, zinc finger
            transcription factor that functions as a tumor suppressor.
            Naturally occurring mutations in this gene are associated with
            gastric cancer, colorectal cancer, and chronic lymphocytic
            leukemia. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.132219.1,
                                           SRR1660803.20590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369577.8/ ENSP00000358590.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA329523.1         18-28
            12-299              BX537746.1         1-288
            300-565             AK123473.1         300-565
            566-1883            BX537746.1         555-1872
            1884-5284           AK127835.1         650-4050
            5285-5562           BX537746.1         5273-5550
            5563-5977           BC016386.1         1453-1867
            5978-6416           BX537746.1         5966-6404
            6417-8342           BC063594.1         118-2043
            8343-10084          AB011102.1         4837-6578
            10085-11896         AL139274.17        143929-145740
            11897-12341         BX112525.1         13-457              c
FEATURES             Location/Qualifiers
     source          1..12341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.3"
     gene            1..12341
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="zinc finger protein 292"
                     /db_xref="GeneID:23036"
                     /db_xref="HGNC:HGNC:18410"
                     /db_xref="MIM:616213"
     exon            1..195
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..8199
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="isoform 1 is encoded by transcript variant 1; 16
                     zinc-finger domain protein; putative protein product of
                     Nbla00365"
                     /codon_start=1
                     /product="zinc finger protein 292 isoform 1"
                     /protein_id="NP_055836.1"
                     /db_xref="CCDS:CCDS47457.1"
                     /db_xref="GeneID:23036"
                     /db_xref="HGNC:HGNC:18410"
                     /db_xref="MIM:616213"
                     /translation="MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAV
                     EAATDYCQQLCQTLLEYAEKWKTSEDPLPLLEVYTVAIQSYVKARPYLTSECENVALV
                     LERLALSCVELLLCLPVELSDKQWEQFQTLVQVAHEKLMENGSCELHFLATLAQETGV
                     WKNPVLCTILSQEPLDKDKVNEFLAFEGPILLDMRIKHLIKTNQLSQATALAKLCSDH
                     PEIGIKGSFKQTYLVCLCTSSPNGKLIEEISEVDCKDALEMICNLESEGDEKSALVLC
                     TAFLSRQLQQGDMYCAWELTLFWSKLQQRVEPSIQVYLERCRQLSLLTKTVYHIFFLI
                     KVINSETEGAGLATCIELCVKALRLESTENTEVKISICKTISCLLPDDLEVKRACQLS
                     EFLIEPTVDAYYAVEMLYNQPDQKYDEENLPIPNSLRCELLLVLKTQWPFDPEFWDWK
                     TLKRQCLALMGEEASIVSSIDELNDSEVYEKVVDYQEESKETSMNGLSGGVGANSGLL
                     KDIGDEKQKKREIKQLRERGFISARFRNWQAYMQYCVLCDKEFLGHRIVRHAQKHYKD
                     GIYSCPICAKNFNSKETFVPHVTLHVKQSSKERLAAMKPLRRLGRPPKITTTNENQKT
                     NTVAKQEQRPIKKNSLYSTDFIVFNDNDGSDDENDDKDKSYEPEVIPVQKPVPVNEFN
                     CPVTFCKKGFKYFKNLIAHVKGHKDNEDAKRFLEMQSKKVICQYCRRHFVSVTHLNDH
                     LQMHCGSKPYICIQMKCKAGFNSYAELLTHRKEHQVFRAKCMFPKCGRIFSEAYLLYD
                     HEAQHYNTYTCKFTGCGKVYRSQGELEKHLDDHSTPPEKVLPPEAQLNSSGDSIQPSE
                     VNQNTAENIEKERSMLPSENNIENSLLADRSDAWDKSKAESAVTKQDQISASELRQAN
                     GPLSNGLENPATTPLLQSSEVAVSIKVSLNQGIEDNFGKQENSTVEGSGEALVTDLHT
                     PVEDTCNDLCHPGFQERKEQDCFNDAHVTQNSLVNSETLKIGDLTPQNLERQVNNLMT
                     FSVQNQAAFQNNLPTSKFECGDNVKTSSNLYNLPLKTLESIAFVPPQSDLSNSLGTPS
                     VPPKAPVQKFSCQVEGCTRTYNSSQSIGKHMKTAHPDQYAAFKMQRKSKKGQKANNLN
                     TPNNGKFVYFLPSPVNSSNPFFTSQTKANGNPACSAQLQHVSPPIFPAHLASVSTPLL
                     SSMESVINPNITSQDKNEQGGMLCSQMENLPSTALPAQMEDLTKTVLPLNIDSGSDPF
                     LPLPAESSSMSLFPSPADSGTNSVFSQLENNTNHYSSQIEGNTNSSFLKGGNGENAVF
                     PSQVNVANNFSSTNAQQSAPEKVKKDRGRGPNGKERKPKHNKRAKWPAIIRDGKFICS
                     RCYRAFTNPRSLGGHLSKRSYCKPLDGAEIAQELLQSNGQPSLLASMILSTNAVNLQQ
                     PQQSTFNPEACFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQAL
                     ETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPTVPPLLHTVCHPNTLLTNQNR
                     TSNSKTSSIEECSSLPVFPTNDLLLKTVENGLCSSSFPNSGGPSQNFTSNSSRVSVIS
                     GPQNTRSSHLNKKGNSASKRRKKVAPPLIAPNASQNLVTSDLTTMGLIAKSVEIPTTN
                     LHSNVIPTCEPQSLVENLTQKLNNVNNQLFMTDVKENFKTSLESHTVLAPLTLKTENG
                     DSQMMALNSCTTSINSDLQISEDNVIQNFEKTLEIIKTAMNSQILEVKSGSQGAGETS
                     QNAQINYNIQLPSVNTVQNNKLPDSSPFSSFISVMPTKSNIPQSEVSHKEDQIQEILE
                     GLQKLKLENDLSTPASQCVLINTSVTLTPTPVKSTADITVIQPVSEMINIQFNDKVNK
                     PFVCQNQGCNYSAMTKDALFKHYGKIHQYTPEMILEIKKNQLKFAPFKCVVPTCTKTF
                     TRNSNLRAHCQLVHHFTTEEMVKLKIKRPYGRKSQSENVPASRSTQVKKQLAMTEENK
                     KESQPALELRAETQNTHSNVAVIPEKQLVEKKSPDKTESSLQVITVTSEQCNTNALTN
                     TQTKGRKIRRHKKEKEEKKRKKPVSQSLEFPTRYSPYRPYRCVHQGCFAAFTIQQNLI
                     LHYQAVHKSDLPAFSAEVEEESEAGKESEETETKQTLKEFRCQVSDCSRIFQAITGLI
                     QHYMKLHEMTPEEIESMTASVDVGKFPCDQLECKSSFTTYLNYVVHLEADHGIGLRAS
                     KTEEDGVYKCDCEGCDRIYATRSNLLRHIFNKHNDKHKAHLIRPRRLTPGQENMSSKA
                     NQEKSKSKHRGTKHSRCGKEGIKMPKTKRKKKNNLENKNAKIVQIEENKPYSLKRGKH
                     VYSIKARNDALSECTSRFVTQYPCMIKGCTSVVTSESNIIRHYKCHKLSKAFTSQHRN
                     LLIVFKRCCNSQVKETSEQEGAKNDVKDSDTCVSESNDNSRTTATVSQKEVEKNEKDE
                     MDELTELFITKLINEDSTSVETQANTSSNVSNDFQEDNLCQSERQKASNLKRVNKEKN
                     VSQNKKRKVEKAEPASAAELSSVRKEEETAVAIQTIEEHPASFDWSSFKPMGFEVSFL
                     KFLEESAVKQKKNTDKDHPNTGNKKGSHSNSRKNIDKTAVTSGNHVCPCKESETFVQF
                     ANPSQLQCSDNVKIVLDKNLKDCTELVLKQLQEMKPTVSLKKLEVHSNDPDMSVMKDI
                     SIGKATGRGQY"
     exon            196..350
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            351..429
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            430..565
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            566..768
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            769..905
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1047
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..12341
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9859..9864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: AATAAA"
     regulatory      9863..9868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: AATAAG"
     polyA_site      9880
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
     polyA_site      9885
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="major polyA site"
     regulatory      10060..10065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: AATAAA"
     polyA_site      10086
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
     regulatory      10560..10565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: ATTAAA"
     regulatory      10575..10580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: AATATA"
     polyA_site      10578
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
     polyA_site      10594
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
     regulatory      12304..12309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: ATTAAA"
     regulatory      12315..12320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
                     /note="hexamer: ATTAAA"
     polyA_site      12325
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
     polyA_site      12341
                     /gene="ZNF292"
                     /gene_synonym="bA393I2.3; MRD63; MRD64; Nbla00365; ZFP292;
                     Zn-15; ZN-16"
ORIGIN      
        1 gcgtacgcga cggagcgggg tgtgaagatg gcggacgaag aggccgagca ggagaggttg
       61 agttgcggcg aaggcggctg cgtcgcggag ctgcagcgcc tgggcgagcg gctccaggag
      121 ctggagctac agctgcggga gagccgggta ccggccgtgg aagcggccac cgactactgt
      181 cagcagctgt gccagacact cctagaatat gcagagaaat ggaaaacttc agaagatcct
      241 ttacctttat tggaggtata cacagtggct atccaaagtt atgttaaagc ccgaccttat
      301 cttacctctg aatgtgaaaa tgtagccttg gttctggaac gcttggcatt aagctgtgtt
      361 gaacttttac tgtgtctgcc tgttgagtta tcagataaac agtgggaaca atttcagaca
      421 ctggtgcagg tagctcatga aaagctgatg gagaatggca gctgtgaatt gcatttttta
      481 gctactctag ctcaagagac tggggtgtgg aaaaacccgg tactgtgcac tattctttcc
      541 caggaaccat tggataagga taaagtgaat gaatttttag cttttgaggg tcccatcttg
      601 ttggatatga gaattaaaca tctaatcaaa acaaatcagt taagtcaagc aactgctcta
      661 gcaaagctgt gttctgacca tccagagatt ggcataaaag gtagttttaa gcaaacttac
      721 cttgtctgtc tttgtacatc atcaccaaat ggaaagttaa tcgaagagat ttcagaagtt
      781 gattgcaaag atgcactgga aatgatctgt aacttagaat ctgagggtga tgaaaaaagc
      841 gctcttgttt tatgtactgc gtttttgtca cgtcagctcc aacaaggaga tatgtactgc
      901 gcttgggaac ttactctctt ttggagtaaa ttacaacaaa gagtagaacc atctatacaa
      961 gtgtaccttg agaggtgtcg tcaactttct ttgttaacga aaacagtata tcacattttc
     1021 ttcctgatta aagttattaa ttcagagact gaaggggctg gacttgctac ctgtatagaa
     1081 ctgtgtgtaa aggctcttcg cttggagtct acagaaaata ctgaagtgaa aatatctatt
     1141 tgcaagacca tttcatgttt gttgcctgat gatctggaag ttaaacgtgc ttgtcaactg
     1201 agtgaatttc ttattgagcc tacagtagat gcgtattatg ctgtggaaat gttgtataat
     1261 cagccagacc agaaatatga tgaagagaat cttccaatac caaattcttt acgctgtgag
     1321 ctgttacttg tattgaaaac tcaatggccc tttgatccag aattctggga ttggaaaacc
     1381 ttgaaacgac aatgtcttgc attaatggga gaagaagcat ccattgtgtc ttcaatagat
     1441 gaactaaatg acagtgaagt atatgaaaaa gtggtagact accaagaaga gagtaaagaa
     1501 acttctatga atgggctttc tggtggagtt ggtgctaatt ctggccttct taaagacatt
     1561 ggtgatgaaa agcagaagaa gagagagata aaacagttaa gagagagggg atttatatct
     1621 gctcggttta ggaattggca agcctacatg cagtattgtg tgttgtgtga caaagaattc
     1681 cttggtcaca gaatagtacg acatgctcag aaacattaca aagatggaat ttatagttgc
     1741 cccatatgtg caaagaactt taattctaaa gaaacttttg tccctcatgt cacactgcat
     1801 gttaaacaat ctagtaaaga gagactagca gctatgaaac cattaagaag attgggaagg
     1861 cctccaaaga tcacaactac caatgaaaat cagaagacta atactgtggc taaacaggag
     1921 cagcgaccta taaaaaagaa tagtctctat tcaacagatt ttatagtgtt taatgacaat
     1981 gatggttcag atgatgagaa tgatgacaaa gataaatcct atgagccaga agtgattcca
     2041 gtccagaaac cagtacctgt taatgaattt aattgccctg taactttttg taaaaagggc
     2101 tttaagtact ttaaaaattt aattgctcat gtgaaggggc ataaagataa tgaagacgcc
     2161 aagcgctttc ttgaaatgca gagcaaaaaa gttatttgcc agtactgtag gcggcatttt
     2221 gtgagtgtta ctcatctcaa tgatcactta cagatgcact gtggcagtaa accatatatc
     2281 tgtatacaga tgaaatgtaa agctggtttt aatagttacg ccgagctttt aacccaccga
     2341 aaggagcatc aagtctttag agcaaaatgt atgtttccta aatgtggaag aattttttcg
     2401 gaagcttatt tactatatga tcatgaagca caacattata atacgtacac ttgtaagttc
     2461 acaggttgtg gtaaagttta tcgttctcag ggtgagctgg aaaagcatct ggatgatcac
     2521 agtactcctc ctgaaaaagt gctgcctcct gaagcccaac ttaattcatc tggagattcc
     2581 attcagcctt ctgaagtgaa tcagaacaca gcagagaata ttgagaaaga aagatctatg
     2641 cttccttcag aaaataacat tgaaaacagc ttactagcag atagaagtga tgcttgggat
     2701 aaaagcaaag cagaatcagc tgtgaccaaa caagaccaga tttctgcctc tgagctcagg
     2761 caagctaatg gaccattgtc aaatggtttg gaaaaccctg ctactactcc tctacttcaa
     2821 tccagtgaag tagctgtgtc cattaaggtg tctctcaatc aggggattga ggataacttt
     2881 ggaaagcaag aaaactcaac tgtggaaggc agtggtgaag cactggtcac agacttacat
     2941 acgccagttg aagatacttg taatgatttg tgtcatccag gtttccagga gagaaaagaa
     3001 caagattgct ttaatgatgc ccatgttact cagaattctt tagtaaattc agaaactctc
     3061 aaaataggtg accttacccc acaaaactta gaaagacaag tgaacaactt gatgaccttt
     3121 tctgtgcaaa atcaggcagc atttcaaaac aatttaccaa cttccaaatt tgaatgtgga
     3181 gataatgtta aaacatcatc caatctttat aatttacctc ttaagacatt agaaagtatt
     3241 gcatttgttc caccgcagtc cgacctaagt aattcattag gaactccatc agtgcctcca
     3301 aaagctccag ttcagaaatt cagctgccag gtcgagggat gtactcgaac ctataattct
     3361 tcacagagta ttgggaaaca catgaagaca gcacaccctg accaatatgc tgcatttaaa
     3421 atgcagcgca aaagtaaaaa aggtcagaaa gctaacaact taaatacacc aaataatgga
     3481 aagtttgttt attttttgcc atcaccggtg aacagctcaa atccattttt tacatcacag
     3541 accaaagcca atgggaatcc tgcttgttcg gcccagttgc agcatgtctc gccacccatt
     3601 tttccagctc atttagcaag tgtgtcaact ccattgttgt cctcaatgga aagtgtcata
     3661 aatccaaata taacttctca ggataaaaat gaacaaggtg gtatgttatg ttcccaaatg
     3721 gaaaatttac ctagtactgc cttgccagca caaatggaag atctaaccaa aacagttctg
     3781 cctttgaata ttgacagtgg ctcagatcct ttccttcctt tacctgcaga aagtagttca
     3841 atgtctctct tcccttcacc agcagatagt gggactaatt ctgttttttc ccaactggaa
     3901 aataatacaa atcattattc ctcacagatt gaaggaaaca ctaattcctc ctttctaaag
     3961 gggggtaatg gtgaaaatgc agtttttcct tcacaagtga atgttgcaaa taacttcagt
     4021 agcaccaatg cccaacagtc tgcacctgaa aaagttaaaa aagaccgtgg gcggggccca
     4081 aatgggaagg aaagaaaacc taagcacaac aaaagggcta aatggcctgc aattatcaga
     4141 gatgggaaat ttatctgtag caggtgttac agggctttta ctaatcccag atcactgggt
     4201 gggcacttat ccaagcgatc ttactgtaaa ccactggatg gagccgaaat tgctcaagaa
     4261 cttctacaga gtaatggaca gccttctctt cttgccagca tgattctctc cacaaatgca
     4321 gtaaatttgc agcagccaca acaatctacc ttcaatccag aagcatgttt taaagatcca
     4381 tcatttctac agcttcttgc tgaaaatcgc tcgccagcat ttttaccaaa tacatttcct
     4441 cgatctggtg tgactaactt taataccagt gtcagtcaag aaggtagtga aattattaaa
     4501 caggctttgg aaactgctgg cattcccagt acatttgagg gtgccgaaat gctttctcat
     4561 gtttcaacag gttgtgtctc tgatgcatca caagtaaatg caacggtgat gccaaatcca
     4621 actgtaccac ccctgttgca cactgtatgc catccaaaca ccttgctgac caaccagaat
     4681 aggacgtcaa actccaaaac ttcctccatt gaggaatgta gcagcttgcc tgtttttcca
     4741 acgaatgact tactactgaa gactgttgaa aatggtttgt gctctagttc atttcctaat
     4801 tctggtgggc catcacaaaa ttttaccagt aacagttctc gtgtttctgt tataagtggt
     4861 cctcagaaca caagatccag tcatttaaat aaaaagggaa acagtgcttc taagagaaga
     4921 aagaaagttg ctcctccact aattgcacct aacgcttccc aaaacttggt aacaagtgac
     4981 ttaacaacaa tgggactcat agcaaagagt gttgaaatcc caactactaa ccttcattca
     5041 aatgtaattc caacttgtga acctcagagt ttggtggaaa atctaacaca gaaattaaat
     5101 aatgttaaca atcagttatt tatgactgat gtaaaagaga atttcaaaac cagtcttgag
     5161 tcccatacag tgttagcccc tttaacatta aaaactgaaa atggtgattc ccaaatgatg
     5221 gctttgaatt catgcacaac ttcaataaat tctgatttgc agatttctga agacaatgtt
     5281 atacaaaact ttgaaaagac tcttgaaatt attaaaactg ctatgaattc tcaaatactt
     5341 gaggtaaaaa gtggatctca gggtgctggt gaaacttcac aaaatgctca aataaattat
     5401 aacattcagc ttccttcagt aaacactgtg caaaataaca aattacccga ttcttctccg
     5461 ttttcctcct ttataagtgt catgccaaca aaaagtaaca ttcctcagtc tgaagtatca
     5521 cataaggagg atcaaataca ggaaatttta gaaggcttac agaaattaaa attagaaaat
     5581 gacctatcca ctccagcatc ccaatgtgta ctgataaata catcagtgac actgactccc
     5641 acgcctgtta aatcaactgc agatatcaca gttattcagc cagtttctga aatgataaac
     5701 attcaattta atgacaaagt taataaaccc tttgtgtgtc aaaaccaagg ctgtaactac
     5761 agtgctatga caaaggatgc actatttaag cactatggta aaattcatca atacactcca
     5821 gaaatgattc ttgaaattaa gaagaatcaa ttgaaatttg ctccctttaa atgtgtagta
     5881 cctacatgta caaaaacatt tacaagaaat tctaacctcc gggcacactg tcagttggtg
     5941 catcatttta caactgaaga aatggtaaag ttaaaaatta aaaggcctta tggaagaaaa
     6001 tctcagagtg aaaatgtgcc ggcctcacga agtacacaag tgaaaaaaca gctagctatg
     6061 acagaggaaa ataaaaagga atctcagcct gctttagaat tgagagcaga gacccaaaat
     6121 acccacagta atgtagcagt gatcccagaa aaacaacttg tagaaaaaaa aagtcctgac
     6181 aaaacagaaa gttctttaca agtgattaca gttacttcag aacaatgtaa tacaaatgca
     6241 ctcacaaaca cacaaaccaa aggacggaag attaggaggc ataaaaaaga aaaggaggag
     6301 aaaaaacgaa agaagccagt ttcccaatcc cttgagtttc caacaagata cagtccttac
     6361 agaccttatc gatgtgttca ccagggatgc tttgctgcct ttacgataca gcaaaacttg
     6421 attctccatt accaggctgt acacaaatca gatctacctg cattttcagc agaggtcgaa
     6481 gaggaaagtg aagctggtaa agaaagtgaa gaaactgaaa ctaaacaaac tttgaaagaa
     6541 tttcgatgtc aggtaagtga ctgttctcga attttccaag caattactgg cctaatacaa
     6601 cactacatga aacttcatga aatgactcct gaagaaattg aaagtatgac tgcttcagtg
     6661 gatgttggga agtttccatg tgaccagtta gagtgtaaat cttcatttac tacatatttg
     6721 aactatgttg ttcatctaga ggcagaccac gggattggac taagggcaag taaaacagaa
     6781 gaagatggtg tatacaaatg tgattgtgaa ggctgtgacc gtatatatgc aacccggtcg
     6841 aatctcctcc gacacatttt taataagcat aatgacaaac ataaggctca tttgattcgt
     6901 ccaagaagat taacaccagg ccaggaaaat atgtcaagca aggcaaacca agaaaaatca
     6961 aagtctaaac atcgggggac caagcacagc agatgtggaa aggaaggaat aaaaatgccc
     7021 aagaccaaac gaaagaaaaa aaataattta gaaaacaaga atgcaaagat tgtgcagatt
     7081 gaagaaaata agccttattc tctgaaacgt gggaagcatg tatattctat aaaggctaga
     7141 aatgatgccc tgtctgagtg tacaagcaga tttgtaaccc agtatccatg tatgataaag
     7201 ggatgtactt cagttgttac aagtgaaagc aatataatta gacattataa gtgccataaa
     7261 ttatctaagg catttacatc acaacaccga aatcttctta ttgtattcaa acggtgttgc
     7321 aactcacaag taaaggaaac gtctgagcaa gaaggtgcta agaatgatgt gaaagattct
     7381 gacacgtgtg tatcagagag caatgataat tcaagaacaa cagctacagt ttcacaaaag
     7441 gaagttgaaa aaaatgaaaa agatgaaatg gatgaactaa cagaattgtt tattacaaaa
     7501 ttaataaatg aagatagcac aagtgtagag acccaagcta atacttcttc aaatgtaagt
     7561 aatgattttc aggaagataa cctctgccag tcagaaagac aaaaagcaag taatttgaag
     7621 agagttaata aggaaaaaaa tgtctcacaa aataaaaaaa ggaaagttga aaaagctgaa
     7681 ccagcatcag cagctgagtt aagtagcgtg cgtaaagaag aagaaactgc tgttgccatt
     7741 caaaccattg aggagcatcc tgcatctttt gactggagct cttttaagcc aatgggattt
     7801 gaagtatcat ttctgaagtt tcttgaggag tctgcagtga agcagaagaa aaatactgac
     7861 aaagaccatc cgaatactgg aaacaaaaaa ggatcccatt caaattcaag aaaaaatatt
     7921 gataagactg ctgtgactag tggaaatcat gtatgtcctt gtaaagaaag cgaaacgttt
     7981 gtacagtttg ccaatccatc acagcttcag tgcagtgata atgtaaaaat tgttttagac
     8041 aagaatctta aagattgcac tgagcttgtc ttaaagcaac ttcaggaaat gaaacctacc
     8101 gtcagtctga aaaaacttga agtacattca aatgatccag atatgtctgt tatgaaagat
     8161 atcagtatag gtaaagccac aggcagaggt cagtactgat aattaatgta gtataaatac
     8221 atcatttacc attttatttt aaataggaag ccatcaagca tgctagaatt gtgaaacttt
     8281 cattatattt ttttgttgtt gacatgaatt aacctggcca aaaacaaaaa agaaaaaaaa
     8341 aacatgacat ttgtcatgta aaactttttt ttatccctat gggacttgag gaacagaatc
     8401 agtacttcag ttattgtaaa tagtgagcta aacctcaaat ttctatcacc cagttgccct
     8461 tttcatgaac taaacaatta tctgtgtgat tggtatgttt caccaggtca ctgctcatgt
     8521 ataacagtac tctttatttg tagatacctt ttttgtatat atttattatt gtaaatcatg
     8581 tgctgccacc agcagtctgt aagtctaaac tattaaatga cacatttata tttggaattt
     8641 taatttttaa ctaagcgatc aagtttttta aattgttctt ttattgtttt aaattaagaa
     8701 ctttttgaac taaaaccaga aactctgcca tagttcattg atttttacat gaaacattta
     8761 tttacaagat gatatcaaga ttacttttca caaaataggc acattatatc aacactttgc
     8821 tctgctttgt aaatttgcca tccaggattt tggggtggta ttcatgtgaa attaaagcag
     8881 attctctagc agtttcctat agctacagtt tttttttttc attgcttcta attggatata
     8941 gttactatga gtccatgaaa tacaatggaa atgtgaataa agaatttact acattgaaga
     9001 ttttaaacat ttggtattaa aaaaaaatcc tttgtgaatg tgatagaaaa ctagtagtgt
     9061 ggagcagtgt aaatatttga ggtggtgatt tgtgaagtag cccagtattg ccttaaataa
     9121 aatcacattt catttcttgt tttatacatg tgatcttata aagatttttt gttttgtttt
     9181 gttttccatt ttctgagatt tatagattgg tgtatagctt taaactgtat aaagttttgt
     9241 ggaaagattt ttttaaacat ttttataaat cttaaaattg atatcatcaa agtgagccca
     9301 tcttgtgttt ataaaataca agagtcctta acatttataa ttacatagat aaaacacttt
     9361 ctataaggaa gttggatgtt ttgattttac tgtttataga tgttagattg tacagatttg
     9421 tctgtatttc tcaccatatc taatgatact tttttcatta gattggtctt caagaacagt
     9481 attagttata attattttgg ttattcagta tatagttagc tcttacagtt tagctttatt
     9541 caccatattt atactgtgga ttcacagcga gaggtagagg ttattccagg agagttgatg
     9601 accttcattt aaagtccaac taaaatcagt agtagaaaca taagaaaaca tctttgcaat
     9661 atttactttt gtttctgttt gccgtaaata gtaacattgt ttttttttat tttgtgtttg
     9721 ttataaaaca gttgcattca caatattatt ggcctgagat attgatgata ttgtgatggt
     9781 atgaaaatgt gtacattccc tgtgcaacat cagatttgca ggaaaaatga agcacttact
     9841 gaaatcgctg gtactctgaa taaataagca tggtcaagga gtgaactatt ttcttttgga
     9901 aatttctttt taatttttat tattaaagta ttttattttt agggcctttt gggttttatt
     9961 gaatagttca tttcacctgt ttaagactta ctaccaataa gcataaaacc tgacacgtta
    10021 aaatccctgc cctttggtga gcccactgtt atttattaaa ataaaagtta ttttatgggt
    10081 gattaataca tgggttttct ttttcctaaa ttaacaataa tttaaataac tgagtaattt
    10141 taatattaaa tttttgttaa caactgaatg tttccataca gttttcttag aaattgacct
    10201 agctcttaaa ggtgggcact tggcaaaact gccctatata gcacagtagc aagtaggttt
    10261 atttctgatc attgtaacta tgagccactg ttaagtgaaa atgccaatgt attggggctt
    10321 ttcttttgct cattagctta agaaaattta taactagaca tttctaattg ttttacatgt
    10381 catggggaag agtttgccaa catttaatga aatttttata ttccaggtaa tgtatactaa
    10441 aggtaattat gagagtgggc tttttagcat gaaacaaaaa aaatcaaact atggtaaaaa
    10501 gacatgaatt tatagaatag catgttggta aattttgata cggaatgtaa tgtctaagta
    10561 ttaaaaaatc ataaaatata tttttttcat ggtatacttt tccccagcct attgtcttga
    10621 gatatcttct acagcctaaa tttgctaaag tttcatcact aaaaagtagg agtttttcct
    10681 cttctgaacc cgcaaagttt gcatattaca ggtcagaatt gtattattca aaatacatca
    10741 ccttaagtga aatgtaacag tttttgaaat tttcaacggt gttaaattta acataggtac
    10801 attattattt taaagggcta gacatatttt taaggcaaat ttttatcaag tgagcagtca
    10861 cagttgctgt agataatatg aaagtacaat aatactatac ctagggacat cagaaagaat
    10921 gccctatttt tctggaaaag gaggtaggta gttgggaaag tctttgtaga aaatatgagt
    10981 tttgaaagat gaatgaatgc tcattggttc agggggacaa gggaattcca gacttggggg
    11041 tagagcgtaa ttgcggtatt gccagtgggc cacttggaaa gataggaagt tgaagaaggt
    11101 gaagctgaag aagcagatgg gtggtgggat caggagtgtt cttgtatgct gtattaagtc
    11161 tttattttgg tttttgaaaa ttgttattgg atgcatgtat attgaacaat ttaatcagta
    11221 tcagttttag aaagataatt gtcatggtat agtggataaa ttgagtaagt tggagattaa
    11281 ttagggggac ctaaaatagt ccaggcaaaa aatgatggga gccagaagaa aggctaacga
    11341 agttggggaa gagactaatg gataagagag ataataaaaa gtaatgtcta aggcagcctg
    11401 tttcagcatg tttattgtag tgagatacta ggcaggtgga aggttattgc tgtgatgaaa
    11461 taagttttct aaattgtgtg ctgtagttct ctctctctct ctctcttttt ttttctttgt
    11521 tttttttgga gacagagtct cgctctgttg cccaggctgg agtgcagtgt tgcacgatct
    11581 cggcttactg caacttctgc ctcccaagtt caagtgattc tcctgcctca gcctccccag
    11641 tagctgggac tacagatgca tgctatcaca cccagctaat tttgtagttt tggcacaatc
    11701 tcagctcagt gcaacttcca tctcccaggt tcaagtgatt ctcctacctc agccacccaa
    11761 gtaggtgcac accaccacac ctggctgatt ttatattttt agtagagacg gtttcaccat
    11821 gttggccagg ctggtcttga actcctgacc tcaggtgatc acccacctcc acctcccaaa
    11881 gtgcaggtat tacaagcatg agccaccaca cccagcctct cttaaataat ttaatgcatg
    11941 tttgcatatt aaagacaaaa gttctactgt aaatatgtaa aaagttgaaa gggaattttc
    12001 cagacttaat tgaccctgag aacatttttc ttcttttaat gttaatactt agttatatcc
    12061 cactgaacta gcattctaaa gaacacactt tgggaaatgc tgatctcaaa tggcatttat
    12121 tcaaccagga ctgataatca acgtgtacac caattcaatt gtatcagctg tttgcaaatg
    12181 gtgattattc tgattgatca atttatatat cccaatgggt tgattccttt gctgtattgg
    12241 ttgttaatgt tttgaatatt acccggtatt caagtaatgc tcattgaatt tcaagtaatt
    12301 gtgattaaac gttgattaaa atccagtcat acttgccaga a
//
