LOCUS       NM_020653               7639 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 287 (ZNF287), transcript variant
            2, mRNA.
ACCESSION   NM_020653
VERSION     NM_020653.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7639)
  AUTHORS   Yang,R., Chen,L., Newman,S., Gandhi,K., Doho,G., Moreno,C.S.,
            Vertino,P.M., Bernal-Mizarchi,L., Lonial,S., Boise,L.H., Rossi,M.,
            Kowalski,J. and Qin,Z.S.
  TITLE     Integrated analysis of whole-genome paired-end and mate-pair
            sequencing data for identifying genomic structural variations in
            multiple myeloma
  JOURNAL   Cancer Inform 13 (Suppl 2), 49-53 (2014)
   PUBMED   25288879
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7639)
  AUTHORS   Dang,D.T., Pevsner,J. and Yang,V.W.
  TITLE     The biology of the mammalian Kruppel-like family of transcription
            factors
  JOURNAL   Int J Biochem Cell Biol 32 (11-12), 1103-1121 (2000)
   PUBMED   11137451
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA103127.1, BC057791.1 and
            AC127540.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020653.3.
            
            Summary: This gene encodes a member of the krueppel family of zinc
            finger proteins, suggesting a role as a transcription factor. Its
            specific function has not been determined. This gene is located
            near the Smith-Magenis syndrome region on chromosome 17. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.199132.1,
                                           SRR1660803.43302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267768 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395825.4/ ENSP00000379169.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               DA103127.1         9-562
            555-1483            BC057791.1         557-1485
            1484-7639           AC127540.10        41326-47481
FEATURES             Location/Qualifiers
     source          1..7639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..7639
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /note="zinc finger protein 287"
                     /db_xref="GeneID:57336"
                     /db_xref="HGNC:HGNC:13502"
     exon            1..253
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     exon            254..854
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..2737
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein with KRAB and SCAN domains 13"
                     /codon_start=1
                     /product="zinc finger protein 287 isoform a"
                     /protein_id="NP_065704.2"
                     /db_xref="CCDS:CCDS11179.2"
                     /db_xref="GeneID:57336"
                     /db_xref="HGNC:HGNC:13502"
                     /translation="MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRD
                     TETCRQNFRNFPYPDLAGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILP
                     GEVRTWVKSQYPESSEEAVTLVEDLTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGW
                     LNDLVTKESMTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTV
                     IPILEEPWMVIKEILEGPSPEWETKAQACTPVEDMSKLTKEETHTIKLEDSYDYDDRL
                     ERRGKGGFWKIHTDERGFSLKSVLSQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQ
                     LDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAK
                     EKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEK
                     PYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPY
                     ICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKC
                     NECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSV
                     CGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECG
                     KAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRICGKT
                     FTQSTNLIQHQRVHTGAKHRN"
     exon            855..952
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1079
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1166
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..7639
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7444..7449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /note="hexamer: ACTAAA"
     polyA_site      7469
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /note="major polyA site"
     regulatory      7612..7617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
                     /note="hexamer: ATTAAA"
     polyA_site      7639
                     /gene="ZNF287"
                     /gene_synonym="ZKSCAN13; ZSCAN45"
ORIGIN      
        1 agtgacgccg aggcgaggtc gcggctaagc agaggcgccg gggtttctgg gccgggcttc
       61 tcaggaccgg gctggaacgt gcagctcctg gccgggacac tctgtgcttt gcggggaagg
      121 gaagtggcgg agcccgagga tccgctgccg ctcgggactg agcccgccac gcaggcgcct
      181 gtgccagcgt cgccattgtt gcctgtggcc ttagggccgc tccggctgcc cgtcggccgg
      241 gtcccagcga cagggtctct tatccatccc tgcaagttct gggctcagaa tttgtcacta
      301 aggctgctaa ctctaccttg attctgttct gccctcggct gcagcagcct ttgatatagt
      361 gtccttgtga ctctagcatg agacttcaag cagttggctc actactggag aaataaagga
      421 tattgccaga ttgactctcc tgtctgtagc aatgttagcc tcaagcaaga ggatgaacag
      481 ttcttcacgt tctcaaatcc ttctaaggtg gaagtcagac aaggctcaga gtggacccta
      541 caatgttgag aaggaaatcc ttacttcaag attcttgcgt gacactgaga cctgtcgaca
      601 gaattttagg aattttccat acccagacct ggctggtcct cgaaaggcat tgagtcaact
      661 ccgagagctc tgccttaagt ggctgagacc tgagattcac tcaaaggaac aaattttgga
      721 gctgctggtg ctggagcaat tcctgaccat cctgcctggt gaggttagga cttgggtaaa
      781 gtcccagtat ccagagagca gcgaggaagc agtgactctg gtggaggatt tgactcagat
      841 tctagaagag gaagctcctc aaaactctac cctttcccaa gataccccag aggaagaccc
      901 cagaggaaaa catgctttcc agacaggatg gctaaatgac ttggtgacca aagaatcgat
      961 gacattcaaa gatgtggctg tagacatcac ccaggaggac tgggagttaa tgcgtcctgt
     1021 gcagaaggaa ttatacaaga ctgtgacgtt acagaactat tggaacatgg tttctctggg
     1081 acttacagtg tacagaccaa ctgtgattcc catattggaa gaaccatgga tggtgataaa
     1141 agaaatttta gaaggcccta gtccagaatg ggaaactaaa gcccaagcat gtactccagt
     1201 ggaggatatg tctaaactca caaaggaaga aacccatacc atcaaattag aagactcata
     1261 tgactacgat gatagactag agaggcgagg aaaaggtggc ttctggaaaa ttcacactga
     1321 tgaaagaggt ttcagtttga agtcagtcct ttcacaagaa tatgatccta cagaagaatg
     1381 tcttagtaaa tatgatatat atagaaataa ttttgaaaag cattcaaacc taattgtaca
     1441 gtttgatacc caattagata ataaaacttc tgtgtataat gaaggcaggg caaccttcaa
     1501 tcatgtctca tatggtattg tacataggaa aatacttcct ggagagaagc cttacaagtg
     1561 taatgtgtgt gggaaaaaat ttaggaaata cccatccctc ctgaaacacc aaagtaccca
     1621 tgccaaagag aaatcgtatg aatgtgaaga atgtgggaaa gagtttaggc atatctcatc
     1681 ccttattgca catcagagaa tgcacactgg agaaaaacca tatgaatgcc accagtgtgg
     1741 taaagccttc agccagcgtg cacaccttac tatacatcag agaattcata ctggagagaa
     1801 accctataag tgtgatgact gtgggaaaga cttcagtcag cgtgcacacc ttaccatcca
     1861 tcaaaggaca catactggag agaaaccata taaatgcttg gaatgtggta aaaccttcag
     1921 tcatagttca tcactgatta atcatcagag agttcatact ggagaaaaac cttatatatg
     1981 caatgaatgt gggaagactt tcagtcagag tacacacctt cttcagcatc aaaaaataca
     2041 tactgggaag aaaccatata aatgcaatga atgttggaaa gtgtttagtc agagtactta
     2101 ccttattcga catcagagaa ttcattctgg agagaagtgt tataaatgta atgaatgtgg
     2161 aaaagccttt gctcattcct caacccttat tcaacatcaa accactcaca ctggagagaa
     2221 atcctatata tgtaatatat gtgggaaagc cttcagccag agtgcaaatc ttactcaaca
     2281 tcatagaaca catactggag agaaaccata taaatgcagt gtgtgtggga aagcattcag
     2341 ccagagtgtg caccttactc aacatcagag gattcataat ggagaaaaac cctttaaatg
     2401 caatatatgt gggaaagcat atagacaagg cgcaaatctt actcagcatc aaaggattca
     2461 tactggagaa aaaccctata aatgtaatga atgtgggaaa gctttcattt attcctcatc
     2521 acttaatcaa catcagagaa ctcatactgg agagagaccc tataaatgta atgaatgtga
     2581 taaggatttt agccagagaa catgccttat tcaacaccag agaattcaca caggagagaa
     2641 accctatgca tgtcgtatat gtggtaaaac cttcacccag agtacaaacc ttattcagca
     2701 tcaacgtgtt catacaggtg ccaaacatcg taattaatgg ataagggaaa cttcaattcg
     2761 gttttacaac tttgtttcaa ttttgttttg tgcattctat gtgtcagaac attcagaaga
     2821 agtctgaaga agtgcaatat gttagatact cagcagaagt atcagaagta gtggtatgga
     2881 tataacctat ttagatttaa tgtgaaattt aagaaggaaa cttgacttct taaccttaat
     2941 ttgatatgat tttaattcat tacagaaaga aaccctgtga agggtattca aaaacataac
     3001 tcatcaactc tctatttcaa gtacacttat cctttggtat actcggggga ttggttccag
     3061 gaccacccat gtatacgaaa atctacccat actcaagttg cacggtcagc ctggtggaac
     3121 ctgtgtatat gaaaagccct acatctatgc aggtttccca tccctgaata atgtgctttc
     3181 aaactctgtt cagttgaaaa aaaaaattcc agtataaatg gatctgtaca gttcaaatgt
     3241 gttgttcaag ggtcaactgt acatcctaat gaggccttat gagtgtaact taggaaggtg
     3301 tccatcaaat agagatttca cactagagag tgatcttaaa attacagaaa agagtaagct
     3361 gctttcaggc cttttattcc cagctttgaa gccttaaaat atgtaaagga ctcccttccc
     3421 tgttttactt ccccttctcc tgttatgcca taactgccat atggagccag taggtttgaa
     3481 aaaaaaacag ttggaagtat cttaaagatt tctatgtgac cactggttac accttccctc
     3541 agatatggaa atattaaaga gaagcttaat gaaagatatg ttatgataga aactaatgtg
     3601 tatataacat tagatgtgta gagatttagt taaacaggca aaaattaaat gcctcaagct
     3661 taaatgaatt ttcaatacac attagccttg atttcactag gttttgacat tcaaggtcat
     3721 cctgaaggaa aaaagtaggt ataaagtata cagttcccat ttttttcacc tgactcctaa
     3781 atttatactt taggtttctc tgtgactgtt ttactatgga aagttcattt cttccactga
     3841 aacacgtttc ttgagtgtct actatgctca ggtcccaaac ttcctaattg gatcctctca
     3901 agcttgttac agtgctgaaa atcacaggtg gtttacacaa cagaaagatt tctagagtga
     3961 tgagaaagtg aggatgtgat attttgtcat gggttgagca taagcaacct gctaaaatgg
     4021 gttgccaaat gctacctata tcccaagaga aggaagtgga agtgatagtg tagctatata
     4081 aataatgtga gaaaaaaatg gaaaatagat ctgaattcac tgcagaatgt gggtcgggga
     4141 aaaggtgaaa ttttagtgga gtgaggaaaa catacataga taattgctat aacatgaaat
     4201 gtaattggac ttgctttgcc tatgaaatga gagtggctaa ataaaaaaga attcagcctg
     4261 gttattagaa gaaactaaaa acaaaatgac cgatttttaa agaataattg gaagcctgac
     4321 actccttcat acatacaagt aaaacagaga ttactcttaa catgtcagga aaaaatttaa
     4381 ttggaaaaag cattgatgca gtaatcatta aacaatgata actgggtttg tgggtctcaa
     4441 aaggaaaact ggcagaaatg caaatagaaa tagataaaaa tactattgta tttcatattt
     4501 acagcattcc actaccagaa tataaggcca tattctgaga actgagattt cattgtgctc
     4561 ttacttgttt ctccagtccc ttgcataata gtgcatggtc aatacatggt tgaattaatg
     4621 aataaattat ataaattaga tttcagtaat aaagtagaat tgactggcat ggagtgaaaa
     4681 ttggtataac gaaaaatatt tttgtgcata tatcaaagaa atgttcaaca aataacattt
     4741 acttgggaac tgcttaaaaa tcgtgaatca ggtttcctgg gacatctttg tacaggaagt
     4801 tttcctgagc taaatgaggg gaaattggta tcaattctgg tgctataaat atcaatttaa
     4861 gcatgtatta accatgcaac ttcctttgga cattactgtt tataaaacca tcctacaaac
     4921 aggtactgaa ggaaagaccc aggatgctag tatcctaaag gctatattat tgagtgtttt
     4981 ctttaaaaaa cttgatttcc atttccctta cattagttaa ccttgatttc atagtatcat
     5041 cctgcacaaa gtacaggttg cagaatactc aaactgtgct tatatagctg ttttttaaaa
     5101 taacagttgt ttgaaaatct tatttttttg atgctgcttc atccctcaca cagcacttat
     5161 ttcccttggt tgagcatgtg gcatgtgaca gtccatagcg ccttcctttg cattactctg
     5221 ttatttcctg cctttgtatg ttttatgtaa ataatgcatt tataaagtct tccactgata
     5281 aacagaggca attgatgccc ttataaaata acagactagt aatagtggag aaccctagat
     5341 ctttgtgtat ttttcccact tttacagttg tctgacccgc aaattattca acagttttta
     5401 gcaaatagcc ttattttcca gaacttttta ttatgagttt tcaaatatat agaaagtttt
     5461 aaaaatcata aaattaacta tatacccacc taaatttaaa aactaacatt ctgccgtatt
     5521 ttttttaacc aaacattgga aagtaactta cagacatgac atttcatctc taaatacttc
     5581 agcatgcatc ttacaaaaat aaggatggtc ttttacataa ccacaataca tttacatacc
     5641 tttaaaaaaa aaacaaatag taattcccta atatctgaag acttagtctg tgtttaaatt
     5701 tcctctgttg atccagtcag ttttcacaca tagtatttga ttatctgttt catctatcta
     5761 gaacagtccc cactttggtt tttccttttt tttgagacgg agtctcactc tgtcacccag
     5821 gccagagtgc agtggtgcaa tctcggctca ctgcaaggtc cgcctcccag gttcacgcca
     5881 ttctcctgcc tcagcctccc gagtagctgg gactacagac acccgccacc acgcccggct
     5941 aatttctttg tattttttta gtagagatgg ggtttcactg tgttagccag gcttgtctcg
     6001 atatcctgac ctcgtgatcc acccgcctca gcctcccaaa gtactggcat tacaggcgtg
     6061 aaccaccgcg cccggacagt ttttcctctt taagagagca ggtcagttgt cttgaaaaat
     6121 gtctcatgtt caggattcaa ctgattattt acatgtgggt tgttccggta ccccctgtag
     6181 tttccataaa ttagaagtta gggcaaaagg cttgattggg ttgtttaaac atttttaatg
     6241 ataacacctc acagatgtat ttcatagtgc atcatatcaa aagtctcatt aatatcaggt
     6301 tgactcatta tcaatggatc actcatttga ggtcaccaga tcttcccaat ataaaggtag
     6361 tttttcctat tgcaattaat ctgtggactg acactggcag cacatggata ttttgattgc
     6421 caacaacttt ttacctggta aaaagtaacc aacggtgatc gttgcctgaa tccattgtct
     6481 catcaatgtt tgcaaaatga caattttcta attctatcac tctacacttg ttgagtggca
     6541 ttcttgtata atgttccctc atcaactagg aatgcactag aggcacagtc agcaattatt
     6601 ttaccttaat taccagtgta ggagtttaat taccagtaaa gagtttgatg ctttcatctg
     6661 cagtgataac acatgattca atgtgttaag tcatttatga tcattgtttc tgatgttcag
     6721 attgtcccaa atttggccag gtggagccct tcaagtatct cttatgtcct tttgacattc
     6781 actctctagt ctttggacac ttgattgcct tctaacacaa gatatctcaa gttggccttg
     6841 cattttcaat gccccaggcc tggaatgaaa cctttttcca agaatccctg gctcctttta
     6901 ataggtagct atttagaaac caagatctgg gcactaggga ttctcactgc tcccggagtg
     6961 tcactggcaa ttctttccaa ccattcaagt tggttttcat aaagacaact cttcactcat
     7021 gccatcagtt acctaatatc tgtgtaatga gggatataat tacataactg ggataaactt
     7081 tcgggtgcaa acaactaaat cttgttaagc atgcacctaa attggagaga acacttccat
     7141 gttatgtatg ctagaaagca gcaaattagc tgcaaaaggc ctgtgacaat gccatcagga
     7201 aatttacaag ggaatagaac ttgtcagtta atctgccaag tgggttaagt agagggcaat
     7261 taagaaagca actagatgta tacctaatac gttgtgtttt aactattata tgtctataac
     7321 ttacggtgtt tataagctaa tagccctcct ttcccatcac atctcttaag gcagatttct
     7381 ggtaagatct aaatattaat cctaaggatc tgtttcatgc aaatctaagt actagttttt
     7441 cttactaaac ctttatttgg tctctaaaac tttaaggctg ttatgtttca ttctttgtct
     7501 tctggtgtca gttcacttgc atgtgcccga aaatgtattc ttactcctct gtttctgttc
     7561 tccccatggc tctatctttc ataattatta gccccttaga acactataac cattaaaaat
     7621 ggcaagcatg tgcactaca
//
