LOCUS       NM_001130842            5284 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant
            2, mRNA.
ACCESSION   NM_001130842
VERSION     NM_001130842.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5284)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5284)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5284)
  AUTHORS   Murakami,T., Sun,Z.S., Lee,C.C. and Lupski,J.R.
  TITLE     Isolation of novel genes from the CMT1A duplication/HNPP deletion
            critical region in 17p11.2-p12
  JOURNAL   Genomics 39 (1), 99-103 (1997)
   PUBMED   9027492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315062.1, AF217226.1, AC005324.1 and BU687070.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001130842.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA193229.1, SRR1660803.69054.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583566.6/ ENSP00000464063.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AK315062.1         20-150
            132-2421            AF217226.1         226-2515
            2422-5003           AC005324.1         44519-47100         c
            5004-5284           BU687070.1         14-294              c
FEATURES             Location/Qualifiers
     source          1..5284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..5284
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /note="zinc finger protein 286A"
                     /db_xref="GeneID:57335"
                     /db_xref="HGNC:HGNC:13501"
     exon            1..26
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     exon            27..258
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1787
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein ZNF286"
                     /codon_start=1
                     /product="zinc finger protein 286A isoform 2"
                     /protein_id="NP_001124314.1"
                     /db_xref="CCDS:CCDS11172.1"
                     /db_xref="GeneID:57335"
                     /db_xref="HGNC:HGNC:13501"
                     /translation="METDLAEMPEKGALSSQDSPHFQEKSTEEGEVAALRLTARSQET
                     VTFKDVAMDFTPEEWGKLDPAQRDVMLENYRNLVSLWLPVSKPESYNLENGKEPLKLE
                     RKAPKSSYSDMETRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNLEAALECEN
                     WLENQQGNQERHLREMFTHMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFH
                     TLEKSLKQKSNLMKKQRTYKEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNEC
                     GKSFSHRANLTKHQRTHTRILFECSECKKTFTESSSLATHQRIHVGERPYECNECGKG
                     FNRSTHLVQHQLIHTGVKPYECNECDKAFIHSSALIKHQRTHTGEKPYKCQECGKAFS
                     HCSSLTKHQRVHTGEKPYECSECGKTFSQSTHLVQHQRIHTGEKPYECNECGKTFSRS
                     SNFAKHQRIHIGKKPYKCSECGKAFIHSSALIQHQRTHTGEKPFRCNECGKSFKCSSS
                     LIRHQRVHTEEQP"
     exon            259..347
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     exon            348..462
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     exon            463..555
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     exon            556..5284
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5253..5258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /note="hexamer: AATAAA"
     polyA_site      5284
                     /gene="ZNF286A"
                     /gene_synonym="ZNF286"
                     /note="major polyA site"
ORIGIN      
        1 cccctttgtg aggcccggga tgggaggctc cagcgccgta ggactgaggc agactccacg
       61 gtgagaaaga gacccgatct aacccaggcc tttcatcaga gcccaggagg gaaggcagga
      121 agtgggacca cgaggcccgg ggggcttcta actcgtctgg ccagggagat ctgaattggg
      181 gtgaagagca gaatctccag aacaaggagg aggtggtgat catggagaca gatttggctg
      241 aaatgcctga gaaaggagct ctgtcttccc aggattctcc ccatttccaa gagaagagca
      301 cagaagaggg agaagtggct gctctgcgcc tcacggccag atcccaggaa acagtgacat
      361 tcaaggatgt ggccatggac tttacaccag aggagtgggg gaagctggat cctgcacaaa
      421 gggatgtgat gctggagaac tataggaacc tagtctcact ttggcttcca gtttccaaac
      481 ctgagagcta caacttggag aatggaaaag aaccattgaa gcttgagaga aaagccccca
      541 aaagcagcta ttcagacatg gagactagac cacagagcaa ggattcaact tcagtgcaag
      601 atttttccaa agcagaatca tgcaaagttg caataataga cagactgaca cggaatagtg
      661 tctatgactc taacttggaa gcagcccttg aatgtgaaaa ttggttagag aatcagcaag
      721 gaaatcagga gagacatttg agagaaatgt tcactcacat gaattcactc tctgaggaaa
      781 cagaccataa gcatgatgta tactggaaaa gcttcaatca gaaatctgtc cttatcactg
      841 aagacagagt tcccaaagga tcttatgcct tccatacact tgaaaaaagc ttgaaacaaa
      901 aatcaaactt aatgaaaaag cagagaactt ataaagagaa aaaacctcat aaatgtaatg
      961 attgtggtga actcttcacc taccattcag tgcttattcg acaccagaga gtccatactg
     1021 gagagaaacc ctatacctgc aatgaatgtg ggaaatcttt tagccacaga gctaatttaa
     1081 ctaaacacca gagaactcat actagaattc tctttgaatg cagtgaatgc aagaaaacct
     1141 tcacagaaag ctcatccctt gcaacacatc agagaattca cgttggagag agaccttatg
     1201 aatgcaatga atgtgggaaa ggttttaatc gaagtacaca tcttgtgcag catcagttga
     1261 ttcatactgg agtgaagcct tatgaatgta atgaatgtga taaagctttt attcattcat
     1321 cagcactcat taaacatcaa agaactcata ctggagagaa accttataaa tgtcaagaat
     1381 gtgggaaagc ctttagccat tgctcatccc taactaagca tcagagagtt catactggag
     1441 aaaagccata tgaatgcagt gaatgtggaa aaacttttag tcagagcaca catcttgttc
     1501 aacatcagag aattcacact ggagagaaac cctatgagtg taatgaatgt gggaaaacct
     1561 tcagccggag ctccaatttt gctaaacatc aaagaattca tattggaaag aaaccgtaca
     1621 aatgtagcga gtgtggaaaa gccttcattc attcatcagc tctcattcaa catcagagaa
     1681 ctcataccgg agagaaaccc tttagatgta atgagtgtgg gaaaagcttt aagtgcagtt
     1741 catctctcat cagacatcaa agagttcaca ctgaagagca accctgaaaa attactgaat
     1801 gtgaagaaat gtaagttggt tttatcactg tattaaatac ttgagtgttt aggtggaagg
     1861 cgcatccata atatgcatgt gaggaccaat tctgtatgca tctaatttca tttgcgtaat
     1921 acatagtttt gagccataag caggttcttt atgtccgtta atttgataat tatgaaatct
     1981 agccagcgat ttcaaaattt taatctccaa cgtcccaaat agctatctgt ggaaattcaa
     2041 gaagtccctg agagtaggta gcagtacgaa cattgtgaaa tccagttttc ccctctcttg
     2101 tttatgtcag agctttgttg taagcctctc actttgtaag gaaattctta ttgggtaggt
     2161 taggctgagg gcttacatcc ttatcatcag gaagacacaa tgttgttatt tattactcct
     2221 tgagatctag atacacatat ggtataattc atctagagtg taatttcttt tatattagcc
     2281 ttaaaaacca aaaatgctgg gttcaaagtc cttagaattc ccttcctccc tcaacaagct
     2341 gctgtctatg ttgatgacca taactgggat gtataatatt tacagacaac tctaagttac
     2401 gttcacatgg attatgtaca tcattgattt tttttttttt ttttttttga gacagagtct
     2461 tgctctgttg cccgggctgg agtgcagtgg cgcgatctcg gctcactgca acctccacct
     2521 cccaggttca tgccattctc ttgtctcagc ctcccaagta gctgggacta caggcacctg
     2581 ccagtacgcc tggctaattt tttttgtatt tttagtagag atggggtttc accatgttag
     2641 ccaggatggt cttgatctcc tgacctcgtg atctgcctgc ctcggcctcc caaagtgctg
     2701 ggattacagg catgagccac catgcctggc atcatcattg atttatgtca ttgttatccc
     2761 tctaccgcgg agaccttctt tcattttcca tttccctggg agttcacgtg aagtagtgaa
     2821 tgggtcaaaa tcttaacagt ggttgttgat caagtccttc ctttcttatc cttggcactg
     2881 aataaatctt tggttttcca taatcaaagg gtgagggaga cttcttttgt ctacattatt
     2941 cagctttctg aaagctatgc tgtgtccatt tgagaaaaag ccccagggat attgaaggtc
     3001 tgagaagttg agtggttcag tgtgttatta tatttagggt cccagtaaag aagaactgaa
     3061 gcaactgtga gacaccaggg catacttccc tgtatgagtg gaaaacaagg cacggaaaat
     3121 agctcacagg atagtcctca actgacttgc ttgaggataa gcagcttccc ttcgtgaaga
     3181 agttgccatt tctctggcct tcatatttat ctactttttg ttattgttgt ctgtatcggt
     3241 tcaatctcac actgctataa agaaatgcct gagactgggt aacttataaa gaaaaaaggt
     3301 ttaattggct catggttcca tgggctgtac aggaagtatg actggggagg tctcagggag
     3361 cttttactca tggcaaaagg caaagccaga gcaggtatct tcacagggct agagcaagag
     3421 gaaaagagag aggggaggtg ctacacactt tttatgcaac caaatctcat gagaactcta
     3481 tcacgagaca gcagtagggg gacagtgcta aatcattcat gagaaactac ctgcgtggtc
     3541 cagtcacctt gcaccaggcc ccacctccca cattggggat tacaattaaa catgagattt
     3601 gggtggggat acagatctaa actgtatcat tactcaaaaa aaaaaaaaaa aagaaagaaa
     3661 agaaaacaca ggaaaaggaa ctcacctctt ttatcatctt agtatttagt actaatggtt
     3721 tagagcagga attgacaaac tgtggcctgg actcatggac caactctggc ccaccacctg
     3781 tttctcagaa gaaaatttta ttggaactca gccacactta ctcatttaca tgttgtcctt
     3841 gactgccttt gtgtccagtg tcagaactga gtagctgcag cggaggttgt gcctctgggc
     3901 tttaatatca caaacagagc agcttataag caacagaaac ttacttctca cagttttgga
     3961 ggctgggaag tccaagatca aggtgtcaac atatttaggg tctagggaag gtctgcttct
     4021 tggttaatag aaagcacctt tcactgtgtc ttcacatggt agaaggggag agctctggta
     4081 tcttcagccc cttataaggg cactaatccc attcatgaga gctccaccct cacgacctaa
     4141 tcacctccaa aaggccccat ttcgtaatac cgtcagttaa gtttcattat atgactttga
     4201 tggggatata gcccatagta ggttgtatgt ccctgaaagc ctaaaatatt tactgtttgg
     4261 ctctttacag aaaatatttt cttggcccct gttccagagc attcatcaag tcagataaag
     4321 ggtttaaacc agtcagagaa actaggtgga atggaaaagt actgagagat aattggggac
     4381 agaaaaataa aagagatggg aaatgctgca tcaaaatact cctacctcta ggatgttact
     4441 atatattgtt aggagaattc aagttattga aacttgccaa attcttgagt gaagaggaat
     4501 tcatttgaga gccaaaattt gactaaggaa agaagaccaa catgggcttt ccaaagttga
     4561 gtttgaattc tgccatcccc actaagcagt catgtgacct tggaaaaact ccctactctg
     4621 agtctcagtt tctttatctg tattaggttt caacaaaggg aataaatcat tggcttctca
     4681 tgaggttgtc ataaggatta aataagacaa tgcatataaa agaactggca gacaataaat
     4741 atagagtccc ccactcctgc ttggtgctct ctttctctct ccttctctac atagagaagt
     4801 gccagagcat ccgtcagtag aagttactta aggttggctg tgtcttccac atcttttgtt
     4861 tacccatgaa gaactgtgac catcttgttc tgtgtcttgt cataaagatg ggacgtgact
     4921 tctttctgct cttgcttcca tctggtgctg ttttctgcac agcctccttg agaccttcca
     4981 gaaccttctt ttttcctact tcatatcact taaccagtag ctatctggga tggttccaga
     5041 ggctgaagtt tgcagttgaa taacatttta aatagtgtta agcgacttgg gatctctggc
     5101 cctttgcgtt tcagtatttg tcctttttat gcctgatgtt taacctgcca catgtttgta
     5161 ctgcaacatg aatcttggaa attttaatgt tatgcatttc aaatgttttt ggttatctgt
     5221 aaactaaatg tgcccttatt ggctcacttg tcaataaaga tgtttgtata tgtattgtca
     5281 gaaa
//
