LOCUS       NM_152354               6031 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 285 (ZNF285), transcript variant
            2, mRNA.
ACCESSION   NM_152354
VERSION     NM_152354.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6031)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 6031)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6031)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA949487.1, BC117302.1, BM987858.1 and AC245748.2.
            
            On Jun 2, 2019 this sequence version replaced NM_152354.5.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (b) is shorter than isoform 1. Variants 2 and 3 encode the
            same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833447.1, SRR1803617.272747.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614994.5/ ENSP00000483662.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA949487.1         4-36
            34-2400             BC117302.1         1-2367
            2401-2683           BM987858.1         18-300              c
            2684-6031           AC245748.2         52516-55863         c
FEATURES             Location/Qualifiers
     source          1..6031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..6031
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /note="zinc finger protein 285"
                     /db_xref="GeneID:26974"
                     /db_xref="HGNC:HGNC:13079"
     exon            1..41
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /inference="alignment:Splign:2.1.0"
     exon            42..99
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1857
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /note="isoform b is encoded by transcript variant 2; zinc
                     finger protein 285A"
                     /codon_start=1
                     /product="zinc finger protein 285 isoform b"
                     /protein_id="NP_689567.4"
                     /db_xref="CCDS:CCDS12638.1"
                     /db_xref="GeneID:26974"
                     /db_xref="HGNC:HGNC:13079"
                     /translation="MIKFQERVTFKDVAVVFTKEELALLDKAQINLYQDVMLENFRNL
                     MLVRDGIKNNILNLQAKGLSYLSQEVLHCWQIWKQRIRDLTVSQDYIVNLQEECSPHL
                     EDVSLSEEWAGISLQISENENYVVNAIIKNQDITAWQSLTQVLTPESWRKANIMTEPQ
                     NSQGRYKGIYMEEKLYRRAQHDDSLSWTSCDHHESQECKGEDPGRHPSCGKNLGMKST
                     VEKRNAAHVLPQPFPCNNCGVAFADDTDPHVHHSTHLGEKSYKCDQYGKNFSQSQDLI
                     VHCKTHSGKTPYEFHEWPMGCKQSSDLPRYQKVSSGDKPYKCKECGKGFRRSSSLHNH
                     HRVHTGEMPYKCDECGKGFGFRSLLCIHQGVHTGKKPYKCEECGKGFDQSSNLLVHQR
                     VHTGEKPYKCSECGKCFSSSSVLQVHWRFHTGEKPYRCGECGKGFSQCTHLHIHQRVH
                     TGEKPYKCNVCGKDFAYSSVLHTHQRVHTGEKPYKCEVCGKCFSYSSYFHLHQRDHIR
                     EKPYKCDECGKGFSRNSDLNVHLRVHTGERPYKCKACGKGFSRNSYLLAHQRVHIDET
                     QYTHCERGKDLLTHQRLHEQRETL"
     exon            100..226
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /inference="alignment:Splign:2.1.0"
     exon            227..6031
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /note="hexamer: AATAAA"
     polyA_site      2683
                     /gene="ZNF285"
                     /gene_synonym="ZNF285A"
                     /note="major polyA site"
ORIGIN      
        1 actggacgca cgctgcgggc gacattgttt gggacgctgg gttctgcttt tccagaatcc
       61 tgccctttcc aaaaggaaga cggtatgatt aagttccagg aaagggtgac attcaaggat
      121 gtggctgttg tcttcaccaa ggaagagctg gcactattgg ataaagccca gataaacctg
      181 taccaagatg tgatgctgga aaacttcagg aacctcatgt tagtgagaga cgggattaaa
      241 aacaacattt tgaatcttca ggcaaagggg ttaagttacc tttcgcaaga agtgcttcat
      301 tgctggcaga tttggaaaca aaggatccgg gatttaactg tgagtcagga ttatatcgtg
      361 aaccttcaag aagagtgttc cccacattta gaagatgttt ccctcagtga agagtgggca
      421 ggcatttctc ttcagatttc tgaaaatgaa aactatgtag taaatgccat tatcaaaaat
      481 caagatatca cagcatggca aagcctgaca caggttctta ccccagaatc gtggaggaaa
      541 gccaacataa tgaccgagcc ccagaactct cagggaagat ataagggaat ttacatggaa
      601 gagaaattgt acagacgtgc tcagcatgat gacagcctca gttggacctc atgtgatcat
      661 catgagtccc aagaatgtaa aggagaggac cctggtagac atcccagctg tgggaaaaac
      721 ttgggtatga aatcaacggt tgaaaaacgt aatgcggccc atgtattacc acagcctttc
      781 ccatgtaata actgtggggt ggcctttgca gatgatacag atcctcatgt ccatcacagc
      841 actcacctag gagaaaaatc ttataaatgt gaccagtatg gaaagaactt tagtcagagc
      901 caagatctta tcgttcattg taaaactcac tctggcaaga ctccctatga attccacgaa
      961 tggcctatgg gctgcaaaca gagctcagac cttcccagat atcagaaagt ctcctcagga
     1021 gacaaaccct acaaatgtaa agaatgtggc aagggcttca ggcgcagctc ttcccttcac
     1081 aaccatcatc gagtccacac aggggagatg ccctacaaat gcgatgaatg tgggaaaggg
     1141 tttggattta ggtcacttct ttgtattcat cagggagtac acacagggaa aaagccctat
     1201 aaatgtgaag agtgtgggaa gggctttgat cagagctcca accttcttgt ccatcagaga
     1261 gtccacactg gagagaagcc ctacaaatgc agtgagtgtg gcaagtgctt tagttcaagc
     1321 tccgttcttc aagtccactg gaggtttcac acaggggaga aaccatatag gtgtggtgag
     1381 tgtggaaagg gcttcagcca atgtacacac cttcacattc accagagagt ccacacaggg
     1441 gagaaaccat acaaatgcaa tgtgtgtgga aaggattttg cgtatagctc tgttcttcac
     1501 actcatcaga gagttcacac tggagaaaaa ccatataaat gtgaagtgtg tggaaagtgc
     1561 ttcagttaca gttcatattt tcacttacat caaagagatc acatcagaga gaaaccatat
     1621 aaatgtgatg agtgtggtaa aggcttcagc cggaattcag atcttaatgt tcacctcaga
     1681 gtccacacag gagagaggcc ctataagtgt aaggcatgtg gtaagggctt cagtcgtaat
     1741 tcatacctcc ttgcccatca gagagtgcat atagatgaga cacagtacac acactgtgag
     1801 cgtggaaagg accttctgac tcatcaaaga ctacatgagc agagagaaac attataaatg
     1861 tagtaagtca gggttcaatt agtaaaacag aagccacact gtattccaga tgatagaggc
     1921 ttactcagcc tgtgggaggg ctaggggagc aaaagacagg gacactgcca tcgataatgt
     1981 cagcctgcag cactgaagtg tgccaggcaa ggactgtgga tttcaagaac ttctgtgaag
     2041 ctcccatcaa ctgctgtatg ctacaatggc aaagaggtta cttttgacaa atgggtggtt
     2101 tgtggtagtg gttgtagtta gtggtcaaat ttccattaaa gggtgtgtcc aggaaggaaa
     2161 ttctaattgg gatgatcatg gtaaggtctt cagttcagcc aacgtcttta gatttttttt
     2221 tagtccccag tagaaaaata ctctctgtat gaagaacatt caaaagtgtg ctcaaaaatg
     2281 aaacccatgc tcttactatg aaagaacgtt agtacccagg ttttccatga gattctctac
     2341 acaggcaaga agctccatag aagtggcatt tgaagggtgt ggcagaggca gtgctgtgtt
     2401 tatcacactg gttccatttc cttgcaaata agaagtctat ttcccagtaa cccttgcagt
     2461 taagagtgtg cccatgtgat tgagttctag ccaatggagt gtgagcaaaa gtgatataag
     2521 ccactttcag gtctagcctt tacaaacatc ctcaggcttc tctatccctg ccaaggtgac
     2581 cttggaggct gcttattcca gactgggttg atagaaggtc actacttcat ctgtgttgga
     2641 tttcttttta gagtaagaaa taaaagttca ttgtgtctca ccactgagat ttttggtggt
     2701 ttatttatta ctgcagcatt gcctaggcta tcctgactag catggaggga ttttatagca
     2761 atatgtttca ttgtcattgg agtccacata cagaagtaac ataattcaga gttcaaaact
     2821 tttaaatctt taaggcttga tgtggcagtg caaccatcta aaatggtatg gatgggactt
     2881 cttcagtgat aaccttcatt cattggtgag tacaccaaag agaaatgttc cagatgatat
     2941 agctgtggta aaactttact gaaaagtata acccaccgac gtaagaaatc tcatataata
     3001 gagaaactct ataatgtggg atgctgaata ggtttgtcag ctcacacctt aaatgcgatt
     3061 aaaaattaac tagaataggt gttctgtggt tagtcttaat aaaattaatt gaataaaatc
     3121 aacatttact aaagtgacca acaacatgta aaaaaccaac agtgttcatt gcagactgat
     3181 gcagtcttct tctcagcaga cctgtataat aatgggtttt taaaggatgc tctttctgtc
     3241 agtttccccc caaatttgtc atttaattgg ggataataga tgaattcgag aggagatctc
     3301 tttgcttttt tttttttttt ttttttttgg aaacagggtc ttgctgtgtc acccaggtgg
     3361 ctggagtgca gtggcctgat cattgctcgc tgaagccttg aactcctggc ttcagtgatc
     3421 ctcctgcctc agcctcctga gtagctggga ctacagacat acaccaccgt gttcagctga
     3481 tgttttcttt aaaaattgta cttgtagaga tggggtctta ctttgttgcc caggttagtc
     3541 tcaaacttct ggtttcaagc gatcctccta cctcagcttc ccaaagtgca gggattacag
     3601 gtttgggcca ctgcactcat cccacaaggt gttttttttt tccttcaaaa acagtgtcct
     3661 tttttgtttt aattgactta taggtttctt catttggatc atggtttatt cctagttttt
     3721 cttgcattac agtttcctgc tagttatagt ttgtaaacag aacagccatt caagtgcaaa
     3781 taaaaccatc cctgaagtgt cattttctta ctgatcaggt ggataatagt gaaatatttt
     3841 aaaaattcta tgtcagtaga aatgaggaaa tgagtgttct tacataagtt ggtgggggaa
     3901 agaaaaacag gtacaaagtt gctggagagg atcttgtcta tatgtatcat atgtacaatg
     3961 tgcattgtct ttgagccaat gatcctgctt ctcagaatgt atttttagga tgtaattaca
     4021 tgagtgggga aaatatggtt tcagaaagaa atatgttcta agaattttgc aatgagaaga
     4081 ctgtaaacaa cctgaaggtt catgtataag agattgagta aattagggca tcccatataa
     4141 tggaataaca tggctccatc aacaatgatc tagacctata aaaatgtcca catgttattg
     4201 tccatgtcca ccacatactc cagtactcct acttgcaaac attaagttag agaaaaaatc
     4261 cgggatacac attatcctag gaagcttttg gggtttagaa tgggtgcaac attccttcat
     4321 gacagaatca gccctcagtg ttggtggagg tgtcccaggc aatcctctag tttggccggg
     4381 agcagcgctt gcatatcaca ttaagctttt taaatatatg atgctaacag gaatgtctcc
     4441 ctacttcaca aaattgtttg cttttcctct tgtagcaaag tagcatggaa aaagcagaaa
     4501 ttagtctagc tcccaatcag tgggagccaa tctcatttac aaatgaagat gcagagatcc
     4561 taaataaata tgagcatgtc aaatccaatg atttgataaa agcgtaacag actcgctcat
     4621 gtataattta tcctaaatat gcttatcagc ttctgcctca taacacacac aagaactgag
     4681 tagctctaaa tacatattta tttagctcat gatgtgtgag ctggcaagtt caactgggct
     4741 tagctgggca gttctggtgt gggacatgct agattatctt aactgggctt tgtacatgca
     4801 tctgcagtca gctgatggtt catctgggcc tggctgtttt atgatggtca tagatgagac
     4861 aacgaagttc tctctgtcat catggtctct caccctccag aagaccaatc gagggttggt
     4921 cccatagtgc cagggtttca agggcaaaag ctgtgatctc ttaaggcctc atcagggaac
     4981 aggctcaatg atactttcac cacattttaa tgattaaagc aagtcacaac actggcccag
     5041 attcatgggg tgagattaag acaaaataaa aaatgttgag acataatcat tggaaggaaa
     5101 aggaagatac tatttttatg ctagagaata atgttattta cttataaaat tcaaatccac
     5161 ctgtaaaatt tgaccaattg aaggctgttt taaaattatc gggtcaacaa attggtttca
     5221 cacgaaattg gcatgtgaaa attcatagca ttactatgta agagtctttt ataaaatgta
     5281 gccaaaatgt ttcattcaca ataacaattg tgtgcaatga ccagaattgt ccaaaggtaa
     5341 ttctgggagt tccctttggg atgcctaggt gaggagctat ctggggcctc agactcccac
     5401 attcttcagt gggaagggct ttacatgaac tcaacttccc agcggctttc tcttcctgat
     5461 gggaggtgtt agaacctggc tttctcatgc aacttctgtg aagctctgac aactaaagcc
     5521 agattgtctg ctttagttaa gtagtccaga ttacctgcat agtcaatttg ttccctcacc
     5581 aacatggatg ccttcacaat tgctctttaa gaaggataaa aacatagcgg tgaggtgtgg
     5641 tctatttcct gcttcaccca ggccctggtg cttcttcaag tggtatgaga aattgtggtc
     5701 ctgtgccttc tcttccagac ccttagctta catgttttcc ctataaaact tagtcctaat
     5761 cccagcactt tgggaggcca aggtggctga atcacaagat caggagtttg agaccagcct
     5821 ggccaacata gtgaaacccc gtctctacta aaaatacaca aaattagctg ggcatagtgg
     5881 caggcacctg taatcccagc tactcaggag gctgaggcag gagaatcgct tgagcacagg
     5941 aggtggaggt tgcaatgagc caagatcgca ccactgcact ccagcccagg cgacagggca
     6001 agactctgtc tcaaaaaaaa aaaaaaaaaa a
//
