LOCUS       NM_181845               5684 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 283 (ZNF283), transcript variant
            1, mRNA.
ACCESSION   NM_181845
VERSION     NM_181845.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5684)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   2  (bases 1 to 5684)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   3  (bases 1 to 5684)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   4  (bases 1 to 5684)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC324604.1, DC384756.1 and AC011508.5.
            
            On Nov 23, 2018 this sequence version replaced NM_181845.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.197370.1,
                                           SRR1660803.103133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618787.5/ ENSP00000484852.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               DC324604.1         1-590
            591-642             DC384756.1         519-570
            643-2565            AC011508.5         53766-55688
            2566-5684           AC011508.5         55689-58807
FEATURES             Location/Qualifiers
     source          1..5684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..5684
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /note="zinc finger protein 283"
                     /db_xref="GeneID:284349"
                     /db_xref="HGNC:HGNC:13077"
     exon            1..124
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     exon            125..204
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     exon            205..268
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2308
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 41; zinc finger protein HZF19"
                     /codon_start=1
                     /product="zinc finger protein 283 isoform 1"
                     /protein_id="NP_862828.1"
                     /db_xref="CCDS:CCDS46097.1"
                     /db_xref="GeneID:284349"
                     /db_xref="HGNC:HGNC:13077"
                     /translation="MESRSVAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGF
                     SGFCASPIEESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVM
                     LENYSNLVSLDLESKTYETKKIFSENDIFEINFSQWEMKDKSKTLGLEASIFRNNWKC
                     KSIFEGLKGHQEGYFSQMIISYEKIPSYRKSKSLTPHQRIHNTEKSYVCKECGKACSH
                     GSKLVQHERTHTAEKHFECKECGKNYLSAYQLNVHQRFHTGEKPYECKECGKTFSWGS
                     SLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGVKSYKCKECGKAFFWGSSL
                     AKHEIIHTGEKPYKCKECGKAFSRGYQLTQHQKIHTGKKPYECKICGKAFCWGYQLTR
                     HQIFHTGEKPYECKECGKAFNCGSSLIQHERIHTGEKPYECKECGKAFSRGYHLSQHQ
                     KIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKTFCSGYQLTRHQVF
                     HTGEKPYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHT
                     GEKPFKCKECGKAFSWGSSLVKHERVHTNEKSYECKDCGKAFGSGYQLSVHQRFHTGE
                     KLYQRKEFGKTFTCGSKLVHERTHSNDKPYKYNECGEAFLWTTYSNEKIDTDETL"
     exon            269..390
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     exon            391..478
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     exon            479..605
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     exon            606..5684
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2565
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
     regulatory      5664..5669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /note="hexamer: ATTAAA"
     polyA_site      5684
                     /gene="ZNF283"
                     /gene_synonym="HZF19; HZF41"
                     /note="major polyA site"
ORIGIN      
        1 agaagctcct ctcccagcct gcgagcattt ccaggctctt gtttcccatc agcctctggg
       61 tccaaactaa ccacaggtct ctgggtcctt ttccggtgtc cttaaggttc ttggactctg
      121 catgtgctgc caggttgcca gatttctaag aaggagtttg aagaggagaa aaggattttt
      181 gcatgtttag aaatcaaggt tcaggagaat cttgacagtg aatgtgtctc attacattga
      241 ataacagcta caggatgttc gagagctgat ggagtctcgc tctgtcgccc aggctggagt
      301 gcagtggtgc gatcttggct cactgcaagc tccgcctcct gggttcacgc tattctcctg
      361 cctcagcctc ctgagtagct gggactacag ttctggcttt tctggattct gtgcttcacc
      421 aatagaggaa tcccatggag cattaattag ttcttgcaat tccagaacca tgactgatgg
      481 gttggtgaca ttcagggatg tggccatcga cttctctcag gaggagtggg aatgcctgga
      541 ccctgctcag agggacttgt acgtggatgt aatgttggag aactatagta acttggtgtc
      601 actggatttg gagtcaaaaa cgtatgagac caaaaaaata ttttcagaaa atgatatttt
      661 tgaaataaat ttttcccagt gggagatgaa ggacaaaagt aaaacccttg gccttgaggc
      721 atccatcttc agaaataatt ggaagtgcaa aagcatattc gagggactaa aaggacatca
      781 agagggatac ttcagtcaaa tgataatcag ctatgaaaaa ataccttctt acagaaaaag
      841 taaatctctt actccacatc aaagaattca taatacagag aaatcctatg tttgtaagga
      901 atgtgggaag gcttgcagtc atggctcaaa acttgttcaa catgagagaa ctcatacagc
      961 tgaaaaacac tttgaatgta aagaatgtgg gaagaattat ttaagtgcct atcaactcaa
     1021 tgtgcatcag agatttcata ctggtgagaa accctatgag tgtaaggaat gtgggaagac
     1081 ctttagctgg ggatcaagcc ttgttaaaca tgagagaatt cacactggtg agaaacccta
     1141 tgaatgtaaa gaatgtggga aggcctttag tcgtggctat caccttaccc aacatcagaa
     1201 aattcatact ggtgtgaaat cttataaatg taaggaatgt gggaaggcct ttttttgggg
     1261 ctcaagcctt gctaaacatg agataattca tacaggtgag aaaccttata aatgtaaaga
     1321 atgtgggaag gccttcagtc gtggctatca gcttactcag catcagaaaa tccatactgg
     1381 taagaaacct tatgaatgta aaatatgtgg aaaggctttt tgttggggct atcaacttac
     1441 tcgacatcag atatttcata ctggtgagaa accctatgaa tgcaaggaat gtgggaaggc
     1501 ttttaattgc ggatcaagtc ttattcaaca tgaaagaatt catactggtg agaaacctta
     1561 tgaatgtaaa gaatgtggaa aggcctttag tcgtggctat cacctttctc aacatcagaa
     1621 aatccatact ggtgagaaac cttttgaatg taaggaatgt gggaaggcct ttagttgggg
     1681 ttcaagcctt gttaaacatg agagagttca tactggtgag aaatcccatg aatgtaaaga
     1741 atgcggaaag accttttgta gtgggtatca acttactcga catcaggtat ttcacactgg
     1801 tgagaaaccc tatgaatgta aggaatgtgg gaaggctttt aattgtggat caagccttgt
     1861 tcaacatgaa agaatccata caggggagaa accctatgaa tgtaaagaat gtgggaaggc
     1921 ttttagtcgt ggctatcacc ttactcaaca tcagaaaatt cataccggtg agaaaccttt
     1981 caaatgtaag gaatgtggga aggccttcag ttggggttca agcctagtta agcatgagag
     2041 agtccatact aatgagaagt cttatgaatg taaagactgt gggaaggcct ttggtagtgg
     2101 ctatcaactt agtgttcatc agagatttca tactggtgag aagctttatc aacgtaagga
     2161 attcgggaag acctttactt gtggctcaaa acttgttcat gagagaactc atagtaatga
     2221 taaaccctac aaatataacg aatgtgggga agcctttctg tggacaactt actcaaatga
     2281 gaaaattgat actgatgaaa ccttatgatt gaaagttgta aaagaatatt ttgtgtgtgt
     2341 gtatagacaa cttatcataa taagaactct tactcttgag aaaccttgtg aatgtaaggg
     2401 ttgtgcaaaa gccattcatt tctgtttatg ggcaattatc ttgctatcca gcaattcata
     2461 ctagtgagaa atattttgaa tataattaat atgaaaaggc ctttagactt ctgtacagtc
     2521 ttattggata tcaatttata ctgatgtaaa atcatttaaa tgtaaggaat gtgtgaagat
     2581 cttcattcat gacataaggt ctgattaaca tcaaataatt ggtatttgtt aaaaagagtt
     2641 taaataggag gaatgtggga aggacctaaa cttaattcag ttcttgctgc acatcagaga
     2701 attcatactg ctgtgtaatc ctatgcacat aaggaatttg ggaaggctta tagacacagt
     2761 aaatatctta gagtacatca gagaattcat ccaaatgaga aatcatttga attagaatta
     2821 taggaaggcc tttagacaaa tgctacccaa attattatcc agagactggt gcagtcataa
     2881 aattgtcatc tgtcaattgt gagataaacg tggaaagtga gtaaatattt ggaactttta
     2941 tagcaatttg acatttccat aacattctgt tttacaaaat tatcagtcca taaatgattg
     3001 agaattgaaa acaaagtttg ttctttccca gaaataattt gagacaagac tcacactttt
     3061 caagacatga gacaagtgac aatttaaata agaaattctt cacttgcacc tctctgatta
     3121 gaatagcaga atattcatac tatagcaaga tttggcaaat gagggaatca aaattttcta
     3181 atgcctgtaa cagcataaga taatttatac cagatatgtt aaatgtgcag aagccttcca
     3241 acactattca gtctttgtta aacttcagta agttcatcct agagagtaac tctgttaatg
     3301 taacaaatgt aggaaaaccc ttatccatgg caaataccat actgtcatca ccatttcacc
     3361 tccatactac ctgtaggatg gtgagcaaaa tgcttatctc ttctggacat gatgtttcaa
     3421 atgctgatgg taactaataa tgctgttaca gagattagat ggatttagta tgcatcatat
     3481 ccttggaaga gtatctggta tgtagcctat gcttaataca tattagctat tgttcatatt
     3541 gtctttatta ttagtattac tactggtgaa ttcttaggag aggcacaacc gttttgagga
     3601 atgaattcag aaaagcttcc cataaccact catccatttg aatttcagat agttcattct
     3661 ggataagatc tagtacagta taaagaattt gaggggattt taattcagag tttatccctt
     3721 aagctgagct aaaaaaatga gacttgaaaa aatccagact tttgaagagt ttaggaaagc
     3781 tgttttatag aatgtcacac attagtttca ttcctcatgg tgaaatttga tatgggcctc
     3841 tccttcacat ttctcgtaac atgaagttgg aaatagaggc ttaaacattt tttaccagaa
     3901 cacttcatag atggtgatgt gtacttcatc ttgcaatacc tcagaagcag atagtatcca
     3961 tttcccccag tatcaccagt gccaagtttg atcacttatg gtaactactg gagttgtctg
     4021 ttataaagat ccattatata cctaatagga ttggtcagcc ttgatcaatg atctttggaa
     4081 atgtgtgatc atatggtatg tattttactt tttttttttt ttgggacagg atctctcttt
     4141 ctgtcaccaa ggctggagtg cagtggtgtg atttcggctc actgcaacct gcacctctcg
     4201 ggttcaagtg attctcgtgc ctcagcctcc caagtagctg gatacacagg tgtgcaccac
     4261 catactggct aattcttgta tttttagtag agatggggtt ttgccatgtt ggtccaggct
     4321 gatcttgaac tcctgcacct gcctcagcct cccaaagtgt tgggattaca ggtgtgagac
     4381 actgcgcctg gctatatttt actatttgga aatcacaatg catcttaaaa ttgatggctt
     4441 cttgcaacca ctttcaacca ggtgcctgtc atgatttagt gctagcatca aggcaggtta
     4501 gttatgaaga aatagagtgt gtgtttatat actcacacag ttagaaatcg acccttttaa
     4561 aaattatttc tttttgaaaa taatgtcagt tccatcagaa ctaatgcatt gataactaaa
     4621 tgtctgtggt tccttgtcat aggtctacac ctgacctctc tattttgtgc acatagggga
     4681 ttcgtaatat cactgttcag tcagtcattc accatctagt gatcatcatt ctacatgatt
     4741 gcactttttc aaaggcataa aaagccaaca gttgcactct taataatcaa ctgtaacaca
     4801 aagcagagta ctttgggagt tttaacagga tatattattg gtaactggct attatgccac
     4861 tccctctggg tgccacattt gcctgttaac caagaaatgt agacatggtg ccttatccca
     4921 acatttctga aattatatct caaggaatca ccagtgctta ctagtacttg acaatgaagg
     4981 aggattttac agttaaagaa gcttataaag tagcatctac taaatcccct cctaaggaac
     5041 aagcaaaagc acctcaccag cttatcaaaa gactaaagag aagtgaaaaa aaaaaaaaga
     5101 cggccgggcg cggtggctca tgcctgtaat cccagaactt tgggaagccg aggcgggcgg
     5161 atcacgaggt caggagatca agaccatcct ggctaacacg gtgaaacccc gtctctacta
     5221 aaaatagaaa aaattagccg ggcgtggtgg cgggcgcctg tggtcccagc tactcgggga
     5281 ggctgaggca ggagaatggc gtgaacccgg gaggcagagc ttgcagtgag ccgagattgc
     5341 gccactgcac tccagcctgg gcgacagagc gagactccgt ctcaaaaaaa taaaaataaa
     5401 aaaagactaa ggagtattct agtgaagaaa atggttgaac tttgtttaaa ctggtgtatg
     5461 gcaaacttca ctgttgaaat acttattccc atgacctatt atctttgtag gtgggtgaaa
     5521 ttgcattggg aactgctgct ataaccaaaa gagaatttca gtcaccatgt ctggttgtta
     5581 gctatgatgg aatggcagca tcatggtctc agttatgagt gaaaatcttt gttgtagcta
     5641 agtagtggtg cctcctgagt tttattaaat gccgtttcac tatc
//
