LOCUS       NM_003575               3651 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 282 (ZNF282), transcript variant
            1, mRNA.
ACCESSION   NM_003575 XM_001131412 XM_001132213
VERSION     NM_003575.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Yeo,S.Y., Ha,S.Y., Yu,E.J., Lee,K.W., Kim,J.H. and Kim,S.H.
  TITLE     ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator,
            promotes esophageal squamous cell carcinoma
  JOURNAL   Oncotarget 5 (23), 12260-12272 (2014)
   PUBMED   25373738
  REMARK    GeneRIF: ZNF282 is E2F1 co-activator involved in esophageal
            squamous cell carcinoma
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Yu,E.J., Kim,S.H., Kim,M.J., Seo,W.Y., Song,K.A., Kang,M.S.,
            Yang,C.K., Stallcup,M.R. and Kim,J.H.
  TITLE     SUMOylation of ZFP282 potentiates its positive effect on estrogen
            signaling in breast tumorigenesis
  JOURNAL   Oncogene 32 (35), 4160-4168 (2013)
   PUBMED   22986521
  REMARK    GeneRIF: SUMOylation of ZFP282 potentiates its positive effect on
            estrogen signaling in breast tumorigenesis.
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   Okumura,K., Sakaguchi,G., Naito,K., Tamura,T. and Igarashi,H.
  TITLE     HUB1, a novel Kruppel type zinc finger protein, represses the human
            T cell leukemia virus type I long terminal repeat-mediated
            expression
  JOURNAL   Nucleic Acids Res 25 (24), 5025-5032 (1997)
   PUBMED   9396811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D30612.1, BC073805.1 and BC041704.1.
            
            On Nov 25, 2018 this sequence version replaced NM_003575.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30612.1, BC041704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610704.5/ ENSP00000477841.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                D30612.1           98-135
            39-2526             BC073805.1         16-2503
            2527-3651           BC041704.1         2338-3462
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3651
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="zinc finger protein 282"
                     /db_xref="GeneID:8427"
                     /db_xref="HGNC:HGNC:13076"
                     /db_xref="MIM:603397"
     exon            1..209
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2060
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HTLV-I U5 repressive element-binding protein 1; HUB-1;
                     HTLV-I U5RE-binding protein 1"
                     /codon_start=1
                     /product="zinc finger protein 282 isoform 1"
                     /protein_id="NP_003566.1"
                     /db_xref="CCDS:CCDS5895.1"
                     /db_xref="GeneID:8427"
                     /db_xref="HGNC:HGNC:13076"
                     /db_xref="MIM:603397"
                     /translation="MQFVSTRPQPQQLGIQGLGLDSGSWSWAQALPPEEVCHQEPALR
                     GEMAEGMPPMQAQEWDMDARRPMPFQFPPFPDRAPVFPDRMMREPQLPTAEISLWTVV
                     AAIQAVERKVDAQASQLLNLEGRTGTAEKKLADCEKTAVEFGNHMESKWAVLGTLLQE
                     YGLLQRRLENLENLLRNRNFWVLRLPPGSKGEAPKVPVTFVDIAVYFSEDEWKNLDEW
                     QKELYNNLVKENYKTLMSLDAEGSVPKPDAPVQAEPREEPCVWEQRHPEEREIPMDPE
                     AGAEPLVPAQDASSQVKREDTLCVRGQRGLEERAIPTESITDSPISAQDLLSRIKQEE
                     HQCVWDQQDLADRDIPTDPNSESLISAHDILSWIKQEEQPYPWGPRDSMDGELGLDSG
                     PSDSLLMVKNPPPAPPQPQPQPQPPQPQLQSQPQPQSLPPIAVAENPGGPPSRGLLDD
                     GFQVLPGERGSGEAPPGGDRSTGGGGGDGGGGGGGAEAGTGAGGGCGSCCPGGLRRSL
                     LLHGARSKPYSCPECGKSFGVRKSLIIHHRSHTKERPYECAECEKSFNCHSGLIRHQM
                     THRGERPYKCSECEKTYSRKEHLQNHQRLHTGERPFQCALCGKSFIRKQNLLKHQRIH
                     TGERPYTCGECGKSFRYKESLKDHLRVHSGGPGPGAPRQLPPPPERD"
     exon            210..629
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..756
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..876
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..996
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1110
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1224
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..3651
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="hexamer: AATAAA"
     polyA_site      3586
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="major polyA site"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="hexamer: AGTAAA"
     polyA_site      3651
                     /gene="ZNF282"
                     /gene_synonym="HUB1"
                     /note="major polyA site"
ORIGIN      
        1 cttcttctcc ctggccgacc cgagcgggga acagcactcc caggatgcag tttgtgtcaa
       61 cacggccgca gcctcagcag ctgggcatcc agggcctggg gctggacagc gggagctgga
      121 gctgggccca ggctctgccc ccggaggagg tctgccacca ggagccggcg ctgcgcgggg
      181 aaatggccga gggaatgccg cccatgcagg ctcaagaatg ggacatggac gcccggcggc
      241 caatgccttt tcagttccca ccctttccag atagggcacc tgtcttcccc gaccgcatga
      301 tgcgagagcc ccagttgccc acagcagaga tctcactctg gactgtggtg gctgccattc
      361 aggctgtgga gaggaaggtg gatgcccagg ccagccagct gctgaacctg gaggggcgca
      421 cggggacagc cgagaagaag ctggccgact gtgaaaagac ggccgtggaa tttgggaacc
      481 acatggagag caagtgggcc gtgctgggga ccctgctgca ggagtacggg ctgctgcaga
      541 ggcggctgga gaacttggag aacttgctgc gcaacaggaa cttctgggtc ctgcggctgc
      601 ccccgggcag caagggggag gcccccaagg ttccagtgac ttttgtcgac attgctgtgt
      661 acttctccga agacgagtgg aagaacttgg acgaatggca gaaggagctt tataacaacc
      721 ttgttaagga gaactacaaa accctcatgt ccctggacgc ggagggctca gtccccaagc
      781 cagatgctcc agtccaggct gagcccaggg aagaaccttg tgtgtgggag cagcgccacc
      841 ccgaagagag agaaatccca atggatcccg aagcaggagc agagcccctg gtgcctgcgc
      901 aggatgcgtc ctcccaggtg aagcgtgagg acaccctgtg tgtccggggt cagcggggcc
      961 tggaggaaag agccatccct acggaatcca ttaccgactc cccaatttct gcccaggacc
     1021 tcttgtcccg gattaaacag gaggagcatc agtgcgtgtg ggatcagcag gatttggcag
     1081 acagagatat tcccacggat cccaattcag agtctctcat ctcagcacat gacattttgt
     1141 catggatcaa gcaggaggag cagccatacc catggggacc acgcgactca atggacggag
     1201 agcttggatt agactctggc cctagtgaca gcctgctgat ggtgaagaac ccacccccgg
     1261 ccccgccaca gccccagccc cagccccagc caccgcagcc gcagctgcag tcgcagcccc
     1321 agccccagag cctgcccccc atcgcggtgg ccgagaaccc gggcggcccc ccgagccgag
     1381 ggctgctgga cgacggtttc caggtgctgc ccggggagcg tggctccggc gaggcgccgc
     1441 cgggtgggga ccgcagcacc gggggcggcg ggggcgatgg gggcggtggg ggcggcggcg
     1501 cggaggcggg gacgggggca ggcggcggct gtggcagctg ctgccctggc gggctgcggc
     1561 ggagcctcct cctgcacggc gcccgcagca agccctactc gtgccccgag tgcggcaaga
     1621 gcttcggcgt gcgcaagagc ctcatcatcc accaccgcag ccacaccaag gagcggccct
     1681 acgagtgcgc tgagtgcgag aagagcttca actgccactc gggcctcatc cgccaccaga
     1741 tgacgcaccg cggcgagcgg ccctacaagt gctcggagtg cgagaagacc tacagccgta
     1801 aggagcacct gcagaaccac cagcggctgc acacgggcga gcggcctttc caatgtgcac
     1861 tgtgcggcaa gagcttcatc cgcaagcaga acctgctcaa gcaccagcgc atccacacgg
     1921 gcgagcgccc ctacacgtgc ggcgagtgcg gcaagagctt ccgctacaag gagtcgctca
     1981 aggaccacct gcgcgtgcac agcggcggcc cgggccccgg cgccccacgg cagctcccgc
     2041 cgcctcctga gcgagactag ggctgggctg ggggagggca gggccggacg gagtggatcg
     2101 ggggcggcct gagcaccaac caccttgccg ggtgtcctca gccaccgtct ggaaatcggc
     2161 aacaggcatt gcactccggt tgggggtccc ccagggtggg gcagggatcc cccagatctg
     2221 tctggtctga atggacgccc agctcatcta gggtggaccc agctgctggg gaagagccag
     2281 ggggaccgcg aggagccgag cgtcctcggg caccgccctc acacctcctc gagtgccctg
     2341 ggaccactgg gccacagatg gtcatcaggg gaagccacca gggagtcccg aagcccttct
     2401 gagatcagga aatcaggtcc caaggttagg agacgccctg aaaaaaagcg aaggccgagg
     2461 gatgtgctaa gggtaacacc ttcatgatga caacactgcc tcgcgtttca atagcgcttt
     2521 atactttttt aagtgttttc tatccgttat ccatttcacc cttggcctat ccctctcaga
     2581 taggtggggt aggattttcc tggtgaccga gtaaagtgag aggcaggtga gacggttcac
     2641 ccaatcacac gggaaggggc gcgcgctgcc caaccgcgct ctccgcctac ctccgctgct
     2701 cgggaagctg ctggcctggc cctcctggtc tctcttcctt tcctggtctc tcttcctttc
     2761 cttgctctca cccacggata aaaccagaag cgacaggagg ccagctcctg gggttcctgg
     2821 gagccgggaa cagattggct acggaacgcc ccaggttgta cattcagagg gctctttctc
     2881 catgggagct cctggtgccg cctcggcccc agcctgtccc cagcccctca atctggtgca
     2941 gcagcatctt gtcactgcac aacagtggcc tggtccccca caggcagtta gggccccagg
     3001 tcagacctca ccatgatgat ttgttccagt tctcccaggg cagaggggcg agggagaggc
     3061 ttttgctgtg agagtagccg tcacgtgtct cttcccagca gcgccgggca agtgggtgct
     3121 agagtctgag cctcaggctc tcctgccctg ggcctcccaa ttggtgctat ctgttactgc
     3181 ccgtgctcac ggacatggat acagaccctg ctgtgctcca caccctgcag gcgcctcggg
     3241 aagcgcccaa aggattcccc ttcacgttgg tgcacctgct ccatagctcc gggcgctgcg
     3301 tcccgagggg ccacagtctc catttcagcg tcttgcatgg cctggcaccg ggtggggtgg
     3361 tatgccccag gacccttgtt tgtgtcaaaa atgactttcc ctgcccttgc cgtgggtccg
     3421 gcgttcctcc cagccgggat cacagtgggc agccggcacc cggcaccact ttggcgagcg
     3481 tcctgcttcc gccctcgccc tcatctacgc tgctccgctt tcctcagacc cctttttgcc
     3541 gtgcaaaggg aattcttgac attaaataaa aggtatccag attgcagact gcatgttcac
     3601 agagctgggg gttctccagc ttgcctacag taaagcctca atgaactgga a
//
