LOCUS       NM_001281293            4864 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 281 (ZNF281), transcript variant
            2, mRNA.
ACCESSION   NM_001281293
VERSION     NM_001281293.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4864)
  AUTHORS   Zeng,H., Hou,Y., Zhou,X., Lang,L., Luo,H., Sun,Y., Wan,X., Yuan,T.,
            Wang,R., Liu,Y., Tang,R., Cheng,S., Xu,M. and Liu,M.
  TITLE     Cancer-associated fibroblasts facilitate premetastatic niche
            formation through lncRNA SNHG5-mediated angiogenesis and vascular
            permeability in breast cancer
  JOURNAL   Theranostics 12 (17), 7351-7370 (2022)
   PUBMED   36438499
  REMARK    GeneRIF: Cancer-associated fibroblasts facilitate premetastatic
            niche formation through lncRNA SNHG5-mediated angiogenesis and
            vascular permeability in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4864)
  AUTHORS   Laudadio,I., Bastianelli,A., Fulci,V., Carissimi,C., Colantoni,E.,
            Palone,F., Vitali,R., Lorefice,E., Cucchiara,S., Negroni,A. and
            Stronati,L.
  TITLE     ZNF281 Promotes Colon Fibroblast Activation in TGFbeta1-Induced Gut
            Fibrosis
  JOURNAL   Int J Mol Sci 23 (18), 10261 (2022)
   PUBMED   36142169
  REMARK    GeneRIF: ZNF281 Promotes Colon Fibroblast Activation in
            TGFbeta1-Induced Gut Fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4864)
  AUTHORS   Hou,Y.M., Wang,X.P., Shen,C.C., Chen,L.T. and Zheng,X.X.
  TITLE     Cervical carcinoma progression is aggravated by lncRNA ZNF281 by
            binding KLF15
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (18), 5610-5618 (2021)
   PUBMED   34604953
  REMARK    GeneRIF: Cervical carcinoma progression is aggravated by lncRNA
            ZNF281 by binding KLF15.
REFERENCE   4  (bases 1 to 4864)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4864)
  AUTHORS   Zhang,Z., Yang,L., Yao,X., Yang,M. and Li,G.
  TITLE     LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular
            Carcinoma Cell Invasion and Migration
  JOURNAL   Cancer Biother Radiopharm 35 (2), 137-142 (2020)
   PUBMED   32073896
  REMARK    GeneRIF: LncRNA-ZNF281 Interacts with miR-539 to Promote
            Hepatocellular Carcinoma Cell Invasion and Migration.
REFERENCE   6  (bases 1 to 4864)
  AUTHORS   Scharer,C.D., McCabe,C.D., Ali-Seyed,M., Berger,M.F., Bulyk,M.L.
            and Moreno,C.S.
  TITLE     Genome-wide promoter analysis of the SOX4 transcriptional network
            in prostate cancer cells
  JOURNAL   Cancer Res 69 (2), 709-717 (2009)
   PUBMED   19147588
REFERENCE   7  (bases 1 to 4864)
  AUTHORS   Koch,H.B., Zhang,R., Verdoodt,B., Bailey,A., Zhang,C.D., Yates,J.R.
            3rd, Menssen,A. and Hermeking,H.
  TITLE     Large-scale identification of c-MYC-associated proteins using a
            combined TAP/MudPIT approach
  JOURNAL   Cell Cycle 6 (2), 205-217 (2007)
   PUBMED   17314511
REFERENCE   8  (bases 1 to 4864)
  AUTHORS   Zhang,X., Diab,I.H. and Zehner,Z.E.
  TITLE     ZBP-89 represses vimentin gene transcription by interacting with
            the transcriptional activator, Sp1
  JOURNAL   Nucleic Acids Res 31 (11), 2900-2914 (2003)
   PUBMED   12771217
REFERENCE   9  (bases 1 to 4864)
  AUTHORS   Law,D.J., Du,M., Law,G.L. and Merchant,J.L.
  TITLE     ZBP-99 defines a conserved family of transcription factors and
            regulates ornithine decarboxylase gene expression
  JOURNAL   Biochem Biophys Res Commun 262 (1), 113-120 (1999)
   PUBMED   10448078
REFERENCE   10 (bases 1 to 4864)
  AUTHORS   Lisowsky,T., Polosa,P.L., Sagliano,A., Roberti,M., Gadaleta,M.N.
            and Cantatore,P.
  TITLE     Identification of human GC-box-binding zinc finger protein, a new
            Kruppel-like zinc finger protein, by the yeast one-hybrid screening
            with a GC-rich target sequence
  JOURNAL   FEBS Lett 453 (3), 369-374 (1999)
   PUBMED   10405178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP216938.1, AJ132592.1 and AC104461.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001281293.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Variants 1 and 2 encode the
            same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2068957.1,
                                           SRR18074967.2892198.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367353.2/ ENSP00000356322.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               BP216938.1         23-588
            567-2845            AJ132592.1         565-2843
            2846-4864           AC104461.2         91766-93784         c
FEATURES             Location/Qualifiers
     source          1..4864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4864
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /note="zinc finger protein 281"
                     /db_xref="GeneID:23528"
                     /db_xref="HGNC:HGNC:13075"
                     /db_xref="MIM:618703"
     exon            1..91
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /inference="alignment:Splign:2.1.0"
     exon            92..4864
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2797
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /note="isoform 1 is encoded by transcript variant 2;
                     ZNP-99 transcription factor; transcription factor ZBP-99;
                     zinc finger DNA-binding protein 99; GC-box-binding zinc
                     finger protein 1"
                     /codon_start=1
                     /product="zinc finger protein 281 isoform 1"
                     /protein_id="NP_001268222.1"
                     /db_xref="CCDS:CCDS1402.1"
                     /db_xref="GeneID:23528"
                     /db_xref="HGNC:HGNC:13075"
                     /db_xref="MIM:618703"
                     /translation="MKIGSGFLSGGGGTGSSGGSGSGGGGSGGGGGGGSSGRRAEMEP
                     TFPQGMVMFNHRLPPVTSFTRPAGSAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKK
                     EPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLFAGAEERS
                     PGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLSSSSRTDDHHGTEEPKQDTNV
                     KKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHL
                     RRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMER
                     HKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNLA
                     VLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISNNINMQSYSVEMPTVSSSGGI
                     IGTGIDELQKRVPKLIFKKGSRKNTDKNYLNFVSPLPDIVGQKSLSGKPSGSLGIVSN
                     NSVETIGLLQSTSGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSV
                     IQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKED
                     PFNIAEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNA
                     SFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGML
                     FGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQKNLE
                     SSTGFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGE
                     VDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR"
     regulatory      4842..4847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /note="hexamer: AATAAA"
     polyA_site      4864
                     /gene="ZNF281"
                     /gene_synonym="GZP1; ZBP-99; ZBP99; ZNP-99"
                     /note="major polyA site"
ORIGIN      
        1 agtacacggg aggcttttaa ttccattgtg gagaggacgg cgttattttt attaactgga
       61 ggcgacggcg gctgcggcgg cggcgggacc cccaggcctc ctccggggta tgaaaatcgg
      121 cagtgggttc ctgagtggcg gcggaggtac cggcagtagc ggtggtagcg gctccggcgg
      181 cggtggtagt ggcggcggcg gcggcggcgg cagcagcggc aggagggcag agatggaacc
      241 cacctttccc cagggtatgg ttatgttcaa ccaccgtctt cccccggtca ccagcttcac
      301 ccggccggcg gggtcggccg cccctccccc gcaatgcgtg ttatcctcct ctacctccgc
      361 agccccggcc gctgagcccc cccctccgcc agccccggac atgactttca agaaggagcc
      421 ggcggcgtca gccgcggcct tcccctcgca gaggacctcc tgggggttct tgcagtcttt
      481 ggttagcatc aaacaggaga aacccgcgga tcctgaggag cagcagtccc accaccacca
      541 tcaccaccac cactatgggg ggctgttcgc tggagctgaa gagaggtctc caggcctagg
      601 aggcggtgaa ggggggagtc acggcgtcat ccaggacctc agtattctcc accagcatgt
      661 ccagcagcaa ccagcccagc accaccgtga cgtattactc agcagcagta gcaggactga
      721 tgaccaccat ggcactgagg agccaaagca ggacactaat gtcaaaaagg caaaaaggcc
      781 aaagccagaa tctcagggaa tcaaagccaa gaggaagcca agtgcatctt ccaaaccttc
      841 tttggttgga gatggagaag gtgccatcct ctccccaagt cagaaacctc atatctgtga
      901 tcactgtagt gctgctttcc gaagctccta tcacctgcgg agacatgtcc tcattcatac
      961 aggagaaaga cctttccagt gcagccagtg tagtatgggt ttcattcaga aatacctact
     1021 acagagacat gagaaaattc atagtagaga gaagccattt ggatgtgatc agtgcagcat
     1081 gaagtttatt cagaagtacc atatggagag acacaagagg acacatagtg gagaaaagcc
     1141 atataagtgt gacacttgcc aacagtattt ttcaaggact gatagattgt tgaagcacag
     1201 gcgcacatgt ggtgaagtca tagttaaagg agccactagt gcagaacctg ggtcatcaaa
     1261 ccataccaat atgggtaatc tggctgtgtt gtctcaggga aatacaagtt cttcaaggag
     1321 aaaaacaaag tcaaaaagca tagctattga aaataaggaa cagaagaccg gtaaaacaaa
     1381 tgaatcgcaa atttcaaata atataaacat gcagagttac tcagtagaaa tgcctaccgt
     1441 gtcttccagt ggaggcataa ttggcactgg aatagatgaa ctgcagaaga gggtgccaaa
     1501 attgatcttt aagaaaggaa gcagaaagaa tacagataaa aactacctta actttgtgtc
     1561 accattacca gacatagtag gacagaaatc cttgtctgga aaaccaagtg gctcacttgg
     1621 catagtatca aataatagtg tggagaccat tggtcttctc caaagtacaa gtggcaaaca
     1681 aggtcagata agtagtaatt atgatgatgc catgcagttt tcaaagaaaa gaagatattt
     1741 accaactgcc agcagcaaca gtgccttttc tataaacgta ggacacatgg tctcccaaca
     1801 gtctgtcatt cagtctgcag gtgtcagtgt tttggacaat gaggcaccat tgtcacttat
     1861 tgactcctca gctctaaatg ctgaaattaa atcttgtcat gacaagtctg gaattcctga
     1921 tgaggtttta caaagtattt tggatcaata ctccaacaaa tcagaaagcc agaaagagga
     1981 tcctttcaat attgcagaac cacgagtgga tttacacacc tcaggagaac actcagaatt
     2041 ggttcaagaa gaaaatttga gcccaggcac ccaaacacct tcaaatgata aagcaagtat
     2101 gttgcaagaa tactccaaat acctccaaca ggcttttgaa aaatccacta atgcaagttt
     2161 tactcttgga cacggtttcc aatttgtcag tttgtcttca cctctccaca accacacttt
     2221 gtttccagaa aaacaaatat acactacgtc tcctttggag tgtggtttcg gccaatctgt
     2281 tacctcagtg ttgccatctt cattgccaaa gcctcctttt gggatgttgt ttggatctca
     2341 gccaggtctt tatttgtctg ctttggatgc tacacatcag cagttgacac cttcccagga
     2401 gctggatgat ctgatagatt ctcagaagaa cttagagact tcatcagcct tccagtcctc
     2461 atctcagaaa ttgactagcc agaaggaaca gaaaaactta gagtcttcaa caggctttca
     2521 gattccatct caggagttag ctagccagat agatcctcag aaagacatag agcctagaac
     2581 aacgtatcag attgagaact ttgcacaagc gtttggttct cagtttaagt cgggcagcag
     2641 ggtgccaatg acctttatca ctaactctaa tggagaagtg gaccatagag taaggacttc
     2701 agtgtcagat ttctcagggt atacaaatat gatgtctgat gtaagtgagc catgtagtac
     2761 aagagtaaag acacccacca gccagagtta caggtaaggt cccaaaagtg gccaggctgg
     2821 aggtcttcta atgtaatttt gttttatttt gagaacactg ccattggaat gtttctacac
     2881 gatcctatta agaataatgt gatgcccttt caatgcaact tttcatattt agtttatttt
     2941 gttagcgtga ttttagctct gtttgtatta tgatttttaa tcaaaatcaa tagattaaaa
     3001 atagtttgac attcaaagtg acaatgttta gcaatcaaat ttacatgtat agatcgtcag
     3061 ggaatagccc aaatgtttta aacgcaaaaa aaaagacaaa aaaaaaccaa aaaaaaaaaa
     3121 cctacaaaaa aaactttgtt gctaggatta aggttattct aattgcttta ctctcaggaa
     3181 agtgtaataa cgcatgggaa ttctgtacgt tatcactgta atggaatatc caatttacag
     3241 atagtatgat atacatttca tcatttaagt aagggatcga aaacatttca aattgctcta
     3301 tctgggctga tagacatttc gtcatttaag taagggatcg aagacatttc aaattgctat
     3361 ctccatctgg gctgatccaa aattctgaga ttgttggcta cctatatttt gttgcagctt
     3421 ttaaatgtac tctgaacttc caaaccacat tcattccagc ctggtagaac aaatattctt
     3481 ggatctttga tcaaagcctg gaatgatagc tttaataaaa gaaggaaaaa aaaaaagcac
     3541 cctctcttga tctcaactgt aacaaggctg taattccatc aagcgattct actgacatct
     3601 agtacagtgt tgaagcccaa gtggttggct ggttccagta ttagaactca agttgaaatt
     3661 atatgattaa ctgaaatttg gggcatgcat tatttattat acatggccta caacggttct
     3721 gtctgcgctg ttacgtatta cctacacttc tgggtttttt tgttcttgtt ctcagcctct
     3781 ctttaagagt tcttgggcct tccttttccc tctttctatt ttaacagttt taattttaga
     3841 accatttaca ttccagtagg taattcacta tgcgctttat atgccttagg gcatccaaat
     3901 aaaaaacaat agggtaaaca tccccaaaac ccacctttaa aaaaaaaaaa acccatacag
     3961 atttccatat gtaataaaac cccgtgttct tggatagata ttaataaggt tgtaattcca
     4021 actggtgaca taactcctgt gagggataag aatgtgtctg cttatagtaa taacatcaga
     4081 acctctttgt gaaattgcgg cctttaatgt acattttaat gaaagggtgc attagtattg
     4141 tacaggggtc ttgtaaagtc atcaaaactt gctatgaact ctaattgcca tttgaagcta
     4201 ctgattggca gtggctctac tctaaaactg ctttttagca attgtatttt tttcctgatt
     4261 atatttttta atgtactttg atgtttatgc tgatgagttt tttatgtact tttggtgatg
     4321 tttcagtctt atgtactctt ctgacgtcag aaaagtacca ctggttgttt gcagtcttat
     4381 tgtgtaatca gcctaccgca ggcttccatg tataataaag taattaatat tgtgcaagtg
     4441 taaaacactt ctgttataaa agcagtgttt ggaaaataag aaatattaaa aatggttaca
     4501 aagtattagt taatttcctt ttcccacttt cctcccttta gctttagcag ctaaagggtc
     4561 accaacttgt cattgcaaga ttcttagaaa atgtacttaa tcttaaatac gctgagtact
     4621 aaaaagtgtt tatttcttat ttcagtaagt gcggtaagtt ctattgagta cagagtacaa
     4681 gctgtaatca aaggatggag aggaccttta ccactgtatc tcttaagctg tatgattttt
     4741 ctccagtttg ttttatacag gttttgaatt tctttaactt ttattgtgtg tactgaatac
     4801 tgcatatgta ttattctgat tgtttgctct agtttactac caataaaagt cctgttaatc
     4861 acaa
//
