LOCUS       NM_017661               4399 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 280D (ZNF280D), transcript variant
            1, mRNA.
ACCESSION   NM_017661
VERSION     NM_017661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4399)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4399)
  AUTHORS   Buonincontri,R., Bache,I., Silahtaroglu,A., Elbro,C., Nielsen,A.M.,
            Ullmann,R., Arkesteijn,G. and Tommerup,N.
  TITLE     A cohort of balanced reciprocal translocations associated with
            dyslexia: identification of two putative candidate genes at DYX1
  JOURNAL   Behav Genet 41 (1), 125-133 (2011)
   PUBMED   20798984
  REMARK    GeneRIF: As a first exploitation of this unique cohort, we identify
            three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21,
            and PDE7B at 6q23.3, by molecular mapping of the familial
            translocation with the 15q21 breakpoint.
REFERENCE   3  (bases 1 to 4399)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC130451.1, AC090518.2 and BC040532.1.
            
            On Aug 11, 2020 this sequence version replaced NM_017661.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 4
            encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130451.1, BX640707.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267807.12/ ENSP00000267807.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3058              BC130451.1         41-3098
            3059-3274           AC090518.2         106354-106569       c
            3275-4399           BC040532.1         3784-4908
FEATURES             Location/Qualifiers
     source          1..4399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..4399
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="zinc finger protein 280D"
                     /db_xref="GeneID:54816"
                     /db_xref="HGNC:HGNC:25953"
     exon            1..52
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            53..96
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            97..165
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3077
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 634; suppressor of hairy wing homolog 4"
                     /codon_start=1
                     /product="zinc finger protein 280D isoform 1"
                     /protein_id="NP_060131.2"
                     /db_xref="CCDS:CCDS32245.1"
                     /db_xref="GeneID:54816"
                     /db_xref="HGNC:HGNC:25953"
                     /translation="MGDNPFQPKSNSKMAELFMECEEEELEPWQKKVKEVEDDDDDEP
                     IFVGEISSSKPAISNILNRVNPSSYSRGLKNGALSRGITAAFKPTSQHYTNPTSNPVP
                     ASPINFHPESRSSDSSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGG
                     PTLSMAGMSESSFLSKRPSTSEVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQ
                     AMLAKGTNTSSNQSKNGTPFPRACPKCNIHFNLLDPLKNHMKYCCPDMINNFLGLAKT
                     EFSSTVNKNTTIDSEKGKLIMLVNDFYYGKHEGDVQEEQKTHTTFKCFSCLKILKNNI
                     RFMNHMKHHLELEKQSSESWENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKI
                     CELSFETEHVLLQHMKDNHKPGEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCP
                     FCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLE
                     GLPPGTKVTIRASVGPLQSGASPTPSISASASTLQLSPPRTKNITAKNPAKSNTSKPN
                     TVKSNASKPNTSKPNGSKSKYKPKISNMQKKQSTLASSNKKSKVNTALRNLRYRRGIH
                     KCIECCSEIKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRFCIFKKHS
                     ENLRGITLVCLNCDFLSDVSGLDNMATHLSQHKTHTCQVVMQKVSVCIPTSEHLSELK
                     KEAPAKEQEPVSKEIARPNMAERETETSNSESKQDKAASSKEKNGCNANSFEGSSTTK
                     SEESITVSDKENETCLADQETGSKNIVSCDSNIGADKVEKKKQIQHVCQEMELKMCQS
                     SENIILSDQIKDHNSSEARFSSKNIKDLRLASDNVSIDQFLRKRHEPESVSSDVSEQG
                     SIHLEPLTPSEVLEYEATEILQKGSGDPSAKTDEVVSDQTDDIPGGNNPSTTEATVDL
                     EDEKERS"
     exon            166..312
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            313..378
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            379..518
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            519..636
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            637..807
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            808..917
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1141
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1299
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1400
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1547
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1682
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1990
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2131
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2194
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2313
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2350
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2396
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2452
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..4399
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="hexamer: ATTAAA"
     polyA_site      4349
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="major polyA site"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="hexamer: AATAAA"
     polyA_site      4399
                     /gene="ZNF280D"
                     /gene_synonym="SUHW4; ZNF634"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctcc tcctcctcag ggctccagtc aggccgatcc gctccgctca cggaaggaaa
       61 acagaaataa cttgctggct tgtctggagt cacatgtact taggtgacaa tttacagaaa
      121 gtcatctctg cagcttgatg ggcgacaacc cttttcaacc aaaaagtaat tcaaaaatgg
      181 cagaactgtt tatggaatgt gaagaagagg agctggaacc atggcagaag aaagtaaaag
      241 aagttgagga tgacgatgat gatgagccaa tctttgttgg cgagatatca agttcaaaac
      301 cagcaatttc aaatattttg aacagagtta accccagctc atattcaagg ggactaaaga
      361 atggtgcact cagtcgaggt attactgctg cattcaagcc tacaagtcaa cactacacga
      421 atccaacatc aaatccagtg cctgcctcac caataaattt tcatcctgag tctagatctt
      481 cagatagttc tgttattgtt cagccttttt ctaaacctgg ttatataaca aactcatcac
      541 gagttgtgtc taataagtca tcagagttac tgtttgactt gacccaggat acaggattat
      601 cacattacca agggggacca acactttcta tggcaggtat gagtgaaagt tcatttttat
      661 caaaacgtcc ttctacttct gaagtaaata atgttaatcc aaagaagcct aaacccagcg
      721 aaagtgtttc tggagcaaat tcctcagctg tattaccttc agttaaatct ccttcagtga
      781 cttcttccca ggctatgcta gcaaaaggta caaatacctc atcaaatcag tctaaaaatg
      841 gaacaccttt tccaagagct tgtccaaagt gcaacattca tttcaatctt ttggatcctt
      901 tgaaaaatca catgaagtat tgttgtccag acatgataaa taactttttg ggactggcta
      961 aaacagaatt ttcaagtaca gtaaataaaa acacaactat tgattcagag aaaggaaaat
     1021 tgatcatgtt agttaatgac ttttattatg gaaaacatga aggagatgtc caggaggaac
     1081 agaagactca cacaaccttt aaatgcttca gttgcttgaa aattctaaaa aataacatta
     1141 ggtttatgaa ccacatgaaa caccatttgg aacttgagaa gcagagcagt gagagctggg
     1201 aaaaccatac cacctgccag cactgctacc gtcagtttcc cacaccattt cagttgcagt
     1261 gtcacatcga aagtacacat acgccccatg aattttctac tatttgtaaa atctgtgaat
     1321 tgtcatttga aacagaacat gttcttttac aacatatgaa ggacaatcat aaacctggtg
     1381 aaatgccata tgtctgccag gtttgtaatt atagatcatc atcattttct gatgtagaaa
     1441 ctcattttag aacatcccat gaaaacacta agaacttgct atgcccgttt tgcctcaaag
     1501 ttattaaaat tgcaacacca tatatgcatc attatatgaa gcatcagaaa aaaggaatac
     1561 atcgttgtac aaaatgcagg ctgcagtttt tgacatgcaa ggagaaaatg gatcataaga
     1621 ctcaacacca tcgaacattt ataaaaccta aacaactaga aggattgcct cctggaacaa
     1681 aagttactat tcgagcttca gttggacctc tgcaatcagg agcttcacct acaccttcca
     1741 ttagtgcaag tgcttctacc cttcagctct cacctccaag gactaaaaat ataactgcta
     1801 aaaatcctgc aaaatctaat acaagtaaac ctaatacagt caaatccaac gcaagtaaac
     1861 ctaatacaag taagcctaat ggaagtaaat ctaaatacaa accaaaaatc tctaatatgc
     1921 aaaagaaaca aagcacattg gctagtagca ataaaaaaag taaagtcaat acagcattga
     1981 ggaatttaag gtatcgtcgg ggcattcaca aatgcattga gtgttgttcc gaaataaaag
     2041 attttgcaaa ccactttcct acgtacgtcc actgtagttt ttgcagatac aacactagct
     2101 gtagcaaagc ctatgtaaat catatgatga gctttcatag taaccgtcca agcaaaaggt
     2161 tttgtatttt taagaagcat tcagaaaatc tccggggcat tactctagtg tgccttaatt
     2221 gtgatttcct aagtgatgtt tctggcttag ataatatggc tacacactta agtcaacata
     2281 aaactcatac ttgccaagtt gtaatgcaga aagtttctgt ttgtatccca acttctgagc
     2341 acctttctga attaaaaaaa gaagctcccg caaaggaaca agaacctgtg tctaaggaaa
     2401 ttgcaagacc taacatggct gaaagagaaa cagaaacatc aaattctgaa agtaaacaag
     2461 ataaagctgc ttcttcaaaa gaaaaaaatg gatgtaatgc aaattcattt gaaggctcat
     2521 caacaacaaa aagtgaagaa agcataacag tttcagataa ggaaaatgaa acctgtcttg
     2581 cagaccagga aactggctca aaaaacatcg tcagttgtga ttcaaatatt ggtgcagata
     2641 aagtggaaaa gaaaaaacaa atacaacacg tttgtcagga aatggagttg aagatgtgcc
     2701 aaagttcaga aaacataatc ttatctgatc agattaaaga tcacaactcc agtgaagcca
     2761 gattttcttc aaagaatatt aaggatttgc gattagcatc agataatgta agcattgatc
     2821 agtttttgag aaaaagacat gaacctgaat ctgttagttc tgatgttagc gagcaaggca
     2881 gtattcattt ggaacctctg actccatccg aggtacttga gtatgaagcc acagagattc
     2941 ttcagaaagg tagtggtgat ccttcagcca agactgatga agtagtgtct gatcaaacag
     3001 atgacattcc tggaggaaat aaccctagca caacagaggc aacagtagac ctggaagacg
     3061 aaaaagaaag aagttgaaat tagtcatttt aagtttcagt gtaccaacga taagggcatt
     3121 tggaacagtg ctatcaggtg agctcagtgg tgctgttgta ggttcagaaa tggaaatatg
     3181 taagggaggt cacacataca ctttacctgt atgttcaacc tatgttatca aacaaatcaa
     3241 ttcaccaata atagcatgat tagtagggat tcccaaaaag tttttaaaaa cacgaacagg
     3301 attttaatga taattaaatt tgcagtggaa aggtctcatt taatggtttt caaggaaatg
     3361 ggatttggtt gctgacatga attgatgata ttagtaatat ttataaagcc tttcaaactt
     3421 ccatcaatcc taagctaaaa atctttatta cctgtatatc cttttcagtt aactgagagg
     3481 aagggatttg gaaaccatgt acttttgggg agtaattgat taaaaacaat ggctgattgg
     3541 cattgttaat gaaggcttta tttgtgagga tgatgctggt aaatggagca tgcttagagt
     3601 actaaattga tctaatgaga atttggatga acataaactt aattttggat ttaatataac
     3661 attccagtca gacgcatgta aacagaatat ttgaatcttt gtacctccat acaagtgtta
     3721 gcctgccagg ctgtaagctt accttaatta aactttcagt gaaagtggaa ttattaagat
     3781 ataaatttat atttgtgctt tttgtcagtg tgtaagctgt gtagaaattc tttgatgtat
     3841 tagttgtatt aatgtaaagt agaaacccat tgttgaaact cctgtagcta ttatgctttt
     3901 aatattgttt taatgatctt ccttagaaat aggcccataa aaatggtctg gaagccaaac
     3961 caaagtatgg tataatgtag atattgtaaa gcagtaaact gaaaacatgt cctggcatgt
     4021 attcagccat gtttaagtga cttttctgta attgtaaaat aaaaacttca aatgggacct
     4081 aaaacagtga tgtaaaagaa ctggttttgg aaatttagcc taatttatct ataagatggc
     4141 tgctaaattg atttttcagt tctttttatc atctagaata taatagatat agaaatgaat
     4201 aatatgaaga acagtagttt gctttgaaat actaataaac ttttatttaa aatgcttcat
     4261 ttttacttct taaaatgtgc tttggattct taaattttgt ttcactgaat gttcaatgtt
     4321 ttaaatggcg attaaaatac tctgctgtat atagtagttt ttgagtaaat atttgcaata
     4381 aaaatctgcc cccgaataa
//
