LOCUS       NM_017666               4638 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 280C (ZNF280C), mRNA.
ACCESSION   NM_017666
VERSION     NM_017666.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Ying,Y., Wang,M., Chen,Y., Li,M., Ma,C., Zhang,J., Huang,X.,
            Jia,M., Zeng,J., Wang,Y., Li,L., Wang,X., Tao,Q. and Shu,X.S.
  TITLE     Zinc finger protein 280C contributes to colorectal tumorigenesis by
            maintaining epigenetic repression at H3K27me3-marked loci
  JOURNAL   Proc Natl Acad Sci U S A 119 (22), e2120633119 (2022)
   PUBMED   35605119
  REMARK    GeneRIF: Zinc finger protein 280C contributes to colorectal
            tumorigenesis by maintaining epigenetic repression at
            H3K27me3-marked loci.
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4638)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4638)
  AUTHORS   Moquin,D.M., Genois,M.M., Zhang,J.M., Ouyang,J., Yadav,T.,
            Buisson,R., Yazinski,S.A., Tan,J., Boukhali,M., Gagne,J.P.,
            Poirier,G.G., Lan,L., Haas,W. and Zou,L.
  TITLE     Localized protein biotinylation at DNA damage sites identifies
            ZPET, a repressor of homologous recombination
  JOURNAL   Genes Dev 33 (1-2), 75-89 (2019)
   PUBMED   30567999
  REMARK    GeneRIF: ZPET binds ssDNA and localizes to DNA double-strand breaks
            (DSBs) and stalled replication forks.
            Erratum:[Genes Dev. 2019 Feb 1;33(3-4):253. doi:
            10.1101/gad.324053.119.. PMID: 30709902]
REFERENCE   6  (bases 1 to 4638)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   7  (bases 1 to 4638)
  AUTHORS   Kroncke,K.D. and Klotz,L.O.
  TITLE     Zinc fingers as biologic redox switches?
  JOURNAL   Antioxid Redox Signal 11 (5), 1015-1027 (2009)
   PUBMED   19132878
  REMARK    Review article
REFERENCE   8  (bases 1 to 4638)
  AUTHORS   Brayer,K.J. and Segal,D.J.
  TITLE     Keep your fingers off my DNA: protein-protein interactions mediated
            by C2H2 zinc finger domains
  JOURNAL   Cell Biochem Biophys 50 (3), 111-131 (2008)
   PUBMED   18253864
  REMARK    Review article
REFERENCE   9  (bases 1 to 4638)
  AUTHORS   Gamsjaeger,R., Liew,C.K., Loughlin,F.E., Crossley,M. and
            Mackay,J.P.
  TITLE     Sticky fingers: zinc-fingers as protein-recognition motifs
  JOURNAL   Trends Biochem Sci 32 (2), 63-70 (2007)
   PUBMED   17210253
  REMARK    Review article
REFERENCE   10 (bases 1 to 4638)
  AUTHORS   Iuchi,S.
  TITLE     Three classes of C2H2 zinc finger proteins
  JOURNAL   Cell Mol Life Sci 58 (4), 625-635 (2001)
   PUBMED   11361095
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051728.1, DA441065.1 and AL139234.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017666.4.
            
            Summary: This gene encodes a member of the zinc finger
            domain-containing protein family. This family member contains
            multiple Cys2-His2(C2H2)-type zinc finger domains, the most common
            type of zinc finger domain that self-folds to form a
            beta-beta-alpha structure that binds a zinc ion. [provided by
            RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051728.1, SRR1660807.109014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370978.9/ ENSP00000360017.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2004              BC051728.1         1-2004
            2005-2486           DA441065.1         78-559
            2487-4638           AL139234.19        80884-83035         c
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..4638
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /note="zinc finger protein 280C"
                     /db_xref="GeneID:55609"
                     /db_xref="HGNC:HGNC:25955"
     exon            1..138
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            139..185
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2368
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /note="zinc finger protein 633; suppressor of hairy wing
                     homolog 3; zinc finger protein proximal to RAD eighteen"
                     /codon_start=1
                     /product="zinc finger protein 280C"
                     /protein_id="NP_060136.1"
                     /db_xref="CCDS:CCDS14622.1"
                     /db_xref="GeneID:55609"
                     /db_xref="HGNC:HGNC:25955"
                     /translation="MDDDKPFQPKNISKMAELFMECEEEELEPWQKKVEETQDEDDDE
                     LIFVGEISSSKPAISNILNRGHSSSSSKGIKSEPHSPGIPEIFRTASQRCRDPPSNPV
                     AASPRFHLVSKSSQSSVTVENASKPDFTKNSQVGSDNSSILLFDSTQESLPPSQDIPA
                     IFREGMKNTSYVLKHPSTSKVNSVTPKKPKTSEDVPQINPSTSLPLIGSPPVTSSQVM
                     LSKGTNTSSPYDAGADYLRACPKCNVQFNLLDPLKYHMKHCCPDMITKFLGVIVKSER
                     PCDEDKTDSETGKLIMLVNEFYYGRHEGVTEKEPKTYTTFKCFSCSKVLKNNIRFMNH
                     MKHHLELEKQNNESWENHTTCQHCYRQYPTPFQLQCHIESTHTPHEFSTICKICELSF
                     ETEHILLQHMKDTHKPGEMPYVCQVCQFRSSTFSDVEAHFRAAHENTKNLLCPFCLKV
                     SKMATPYMNHYMKHQKKGVHRCPKCRLQFLTSKEKAEHKAQHRTFIKPKELEGLPPGA
                     KVTIRASLGPLQSKLPTAPFGCAPGTSFLQVTPPTSQNTTARNPRKSNASRSKTSKLH
                     ATTSTASKVNTSKPRGRIAKSKAKPSYKQKRQRNRKNKMSLALKNIRCRRGIHKCIEC
                     HSKIKDFASHFSIYIHCSFCKYNTNCNKAFVNHMMSSHSNHPGKRFCIFKKHSGTLRG
                     ITLVCLKCDFLADSSGLDRMAKHLSQRKTHTCQVIIENVSKSTSTSEPTTGCSLK"
     exon            186..332
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            333..398
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            399..535
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            536..647
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            648..818
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            819..925
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1143
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1301
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1402
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1549
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1681
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1992
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2133
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2196
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2315
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2352
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..4638
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4576..4581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /note="hexamer: AATAAA"
     polyA_site      4596
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /note="major polyA site"
     regulatory      4614..4619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
                     /note="hexamer: AATAAA"
     polyA_site      4638
                     /gene="ZNF280C"
                     /gene_synonym="SUHW3; ZNF633; ZPET"
ORIGIN      
        1 ggttccgcgc tggaagtctc cgggggagtc gctgttgctg aggctgtcgc ctgaggtttt
       61 tcgcgctcct ccctttcctc ctcctctttc tcctcctcct tatccgaacc ccagtcagac
      121 cgatctgctc tgctctcggt gaccttgcaa cttcatggat gacgacaaac cttttcaacc
      181 aaaaaacatt tcaaaaatgg cagaactctt tatggaatgt gaagaagaag agctagagcc
      241 atggcagaag aaagtagaag aaactcagga tgaggatgac gatgaactga tctttgttgg
      301 agagatatca agttcaaaac cagccatttc aaatattttg aacagaggcc actccagctc
      361 atcttcaaaa ggaataaaga gtgagccaca cagtccaggt attcctgaaa tattcaggac
      421 tgcaagtcaa cgctgcagag acccaccatc aaatccagtg gctgcctcgc ctagatttca
      481 tcttgtatct aaatcttcac aaagctctgt tactgttgag aatgcgtcta aacctgattt
      541 tacaaagaat tcacaagttg gatcggataa ttcttcaatt ttactgtttg actcgaccca
      601 ggaatcacta ccaccatccc aagacatacc agcaattttt agagaaggta tgaaaaatac
      661 ttcatatgtg ttgaaacatc cttctacttc taaagtaaac agtgttactc caaaaaaacc
      721 aaagaccagt gaagatgttc ctcagataaa tccctccact tcattgcctt taattggctc
      781 tcctccagtg acatcctccc aagttatgct gtcaaaaggt acaaatacct catctccata
      841 tgatgctgga gcagattacc taagagcttg tccaaagtgc aatgttcagt tcaatctttt
      901 ggatcctttg aaataccaca tgaagcattg ttgtccagac atgataacta aatttttggg
      961 agtaattgtt aaatcagaac gtccatgtga tgaagacaag actgattcag agacaggaaa
     1021 gttgatcatg ttagtcaatg agttttatta tggaaggcat gaaggagtca ctgagaaaga
     1081 gccaaagact tacacaacct ttaaatgctt cagttgctcg aaagttctta aaaataatat
     1141 taggtttatg aaccacatga aacatcactt ggaacttgag aagcagaaca atgaaagctg
     1201 ggaaaaccac accacctgcc agcactgtta ccggcaatat cccacaccct tccaactgca
     1261 gtgccacatt gagagtacac acactcccca tgagttttct actatttgca aaatctgtga
     1321 attatcattt gaaacagagc atattctttt acaacatatg aaggacaccc ataaacctgg
     1381 tgaaatgcca tatgtttgcc aggtttgcca gtttagatca tcaacatttt ctgatgtaga
     1441 agctcatttt agagcagccc atgaaaacac taagaacttg ctatgtccat tttgcctcaa
     1501 agttagtaaa atggcaaccc cctacatgaa tcattacatg aagcatcaga aaaaaggagt
     1561 tcatcgttgc ccaaaatgca gactacaatt tttgaccagc aaggagaaag ctgaacataa
     1621 ggcgcagcat cgtacattta taaagcctaa agaactagaa ggattgcctc ctggagcaaa
     1681 agttactatt cgagcttcac ttggacctct ccagtcaaaa ttaccaactg cacctttcgg
     1741 ttgcgctcca ggcacttctt ttcttcaggt cacacctccg acatctcaaa atacaactgc
     1801 tagaaatcct agaaaatcta atgccagtag atctaagaca agtaagcttc atgcaactac
     1861 atccactgca agtaaagtta atacaagtaa gccaagggga cgtatagcta agtccaaagc
     1921 aaaaccctct tacaagcaaa agcgacagcg caacagaaaa aataaaatga gccttgcttt
     1981 gaagaacata aggtgtcgtc ggggaattca caagtgcatt gaatgtcatt ccaaaataaa
     2041 agattttgca agccactttt ctatatacat ccactgcagt ttttgcaagt acaatactaa
     2101 ctgtaacaaa gcctttgtaa atcatatgat gagctctcat agcaaccatc caggtaaacg
     2161 gttttgtatt ttcaagaagc attcaggaac tctcaggggc attactctag tgtgccttaa
     2221 atgtgatttc ctagctgatt cttccggctt agatcgtatg gctaaacact taagtcaacg
     2281 taaaactcat acttgccaag ttataataga gaatgtttcc aaaagtacct caacttctga
     2341 acccactact ggctgctcat tgaaatagat tcctgctcca tggagttcat gcaacctggt
     2401 gcaagacaag ttggaagttc ctaagttcaa agttctgaag tattttctca cacaaagggc
     2461 agttaaacag ccaagtttat gacactagct ctcattattc agctcttttc agctttcaga
     2521 tgccactaca ttgttattcc accttatctt tgcgtcaggt taacatatct taacatattt
     2581 ttttctccag ttggctctct ccaaaaatgc cttttgtttt tctctgctat acttgacttg
     2641 ccttcagaat attacattcc agataatatg actgttcatc tttttctgtc tgttttgtct
     2701 gctttcttaa tttcttataa gtcttacatg tttaggtcag ataaccattt tttcttcatt
     2761 ccttgttcat tactgttcta tttttcatat ttttcaaatg aagaagcaac acataagttt
     2821 caaaaaatat ccagggtact cctggacagt gtcccctttt gatggacaca actgatacct
     2881 gttctttctt tccaagaaat gtgaattatt tgactgtgag acgtcctcta gtttgtggcc
     2941 ttcagaaatc agatcttggg gagagtccct tcctacctga ctgacctccc ataaggctga
     3001 tgctgatttg gccagagatg acctcaaggc ccaccaaata gagcacaact tcccattggg
     3061 agctttggct tttgatctta agcttatggg tcgattctaa ccaagaaaag tccatgagat
     3121 cagtgcttca acatccaggt tgacgtttaa ccattttggc tgctgctctt taattttcct
     3181 ctagcaggca tgcagtccaa ggaatatcaa aattctgatt gtatgggaac caaggttact
     3241 ttcttgttct tggataaaga aaatttctac aattacagtt cccaaagaca cagttgttca
     3301 tgttatttaa agttttatcc agtattctag gaattttcag caatactaat attctcattt
     3361 ttaaacattt tttacatttt attttgtttt attttggtag cttggtttta tattgttttt
     3421 agatcagtgc ttcaacatcc aggctgacgt ttagccattt tggctgctgt tctttaatct
     3481 tcctctagca ggcatgcagt ccaaggaata tcaaaattct ggttgtattg ggaaccaagg
     3541 ttactttctt gtttttggaa aaacaaaatt tctacaatta cagttcccaa agtcagttat
     3601 tcatgttttc atttaaagtt ttatccaata ttctaggaat tttcagcaat actgatattc
     3661 actttatttt ttttcttttt ttaagacaga gtcttgctct gtcacccagg ctggagtgca
     3721 gtggcgcgat cttggctcac tgcaagctcc gcctcctggg ttcacgccat tctcctgcct
     3781 cagtctccca agtacctggg atgacaggcg cctgccacca cgcccggcta atttttaatt
     3841 ttttgtattt ttagtagaga cagggtttca ccatgttagc caggatggtc tcgatctcct
     3901 gacgtcgtga tcagtccgcc tcgtcctccc aaagtgctgg gattacaggt gtgagccact
     3961 gcacccgacc gatactcaca tttttaaact ttttttttaa ttttattttg gtagctaggt
     4021 tttatattgt tcttaaattt attttactct attttatttt tccatcactt ctttgtccca
     4081 gattcatgaa atttgctgat gtccatttta tgtctacttt tgaactcttc tctttgtgtt
     4141 tgttttgttc ttattacaaa ctccaagaca tttcttagaa ttgtctacag atttcgtgta
     4201 gctacttatt ggtagcttct taatttcata cttgtccaga ccattagaca ttattacatg
     4261 ctctgtcttg ggcctatcat taacattagc ttagggattc tgatttcaaa gacataaaga
     4321 attggcaaaa ctcttcttac agaacttaaa acaagtttta aagttacatt tctatacatc
     4381 taatacataa taccttctta gccattaatg taattcctct ggataaagat aatatattca
     4441 aaaaatattg ggaccaaaaa atgcacttgt ttcttgctca tatatatata gatgtatatt
     4501 ttttttaatt tcttgtttgt ttattttggt tacattgaat acagatttgc tgaacagttt
     4561 tgatgttatt tttttaataa aatttgtatt gttaaagtgc cttggaaatt tctaataaat
     4621 aacttcatat aaaagcta
//
