LOCUS       NM_080764               5309 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 280B (ZNF280B), transcript variant
            1, mRNA.
ACCESSION   NM_080764 XM_006725400
VERSION     NM_080764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5309)
  AUTHORS   Gao,S., Hsieh,C.L., Zhou,J. and Shemshedini,L.
  TITLE     Zinc Finger 280B regulates sGCalpha1 and p53 in prostate cancer
            cells
  JOURNAL   PLoS One 8 (11), e78766 (2013)
   PUBMED   24236047
  REMARK    GeneRIF: ZNF280B upregulates GUCY1A3 expression and downregulates
            TP53 in prostate cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5309)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   3  (bases 1 to 5309)
  AUTHORS   Kawasaki,K., Minoshima,S., Nakato,E., Shibuya,K., Shintani,A.,
            Schmeits,J.L., Wang,J. and Shimizu,N.
  TITLE     One-megabase sequence analysis of the human immunoglobulin lambda
            gene locus
  JOURNAL   Genome Res 7 (3), 250-261 (1997)
   PUBMED   9074928
REFERENCE   4  (bases 1 to 5309)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK097608.1, AC245291.4 and
            AW021601.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080764.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that upregulates expression of MDM2, which negatively regulates p53
            expression. This gene is highly expressed in prostate cancer cells,
            which leads to a reduction in p53 levels and an increase in growth
            of the cancer cells. Several transcript variants have been found
            for this gene, but only one of them is protein-coding. [provided by
            RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) is the protein-coding variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB034475.1, SRR1803612.165839.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000626650.3/ ENSP00000485750.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1060              AK097608.1         446-1505
            1061-4988           AC245291.4         2025-5952
            4989-5309           AW021601.1         35-355
FEATURES             Location/Qualifiers
     source          1..5309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..5309
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /note="zinc finger protein 280B"
                     /db_xref="GeneID:140883"
                     /db_xref="HGNC:HGNC:23022"
     exon            1..84
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /inference="alignment:Splign:2.1.0"
     exon            85..145
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /inference="alignment:Splign:2.1.0"
     exon            146..263
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /inference="alignment:Splign:2.1.0"
     exon            264..5309
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1963
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /note="zinc finger protein 279; zinc finger protein 632;
                     suppressor of hairy wing homolog 2"
                     /codon_start=1
                     /product="zinc finger protein 280B"
                     /protein_id="NP_542942.2"
                     /db_xref="CCDS:CCDS13799.1"
                     /db_xref="GeneID:140883"
                     /db_xref="HGNC:HGNC:23022"
                     /translation="MEQSCEEEKEPEPQKNIQETKQVDDEDAELIFVGVEHVNEDAEL
                     IFVGVTSNSKPVVSNILNRVTPGSWSRRKKYDHLRKDTARKLQPKSHETVTSEAVTVL
                     PASQLESRSTDSPIIIEPLSKPDYRNSSPQVVPNNSSELPSPLITFTDSLHHPVSTAL
                     SVGGINESPRVSKQLSTFEVNSINPKRAKLRDGIIEGNSSASFPSDTFHTMNTQQSTP
                     SNNVHTSLSHVQNGAPFPAAFPKDNIHFKPINTNLDRANELAKTDILSLTSQNKTFDP
                     KKENPIVLLSDFYYGQHKGEGQPEQKTHTTFKCLSCVKVLKNVKFMNHVKHHLEFEKQ
                     RNDSWENHTTCQHCHRQFPTPFQLQCHIENVHTAQEPSTVCKICELSFETDQVLLQHM
                     KDHHKPGEMPYVCQVCHYRSSVFADVETHFRTCHENTKNLLCPFCLKIFKTATPYMCH
                     YRGHWGKSAHQCSKCRLQFLTFKEKMEHKTQCHQMFKKPKQLEGLPPETKVTIQVSLE
                     PLQPGSVDVASITVSTSDSEPSLPRSKSKISKKSH"
     regulatory      5287..5292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /note="hexamer: AATAAA"
     polyA_site      5309
                     /gene="ZNF280B"
                     /gene_synonym="5'OY11.1; D87009.C22.3; SUHW2; ZNF279;
                     ZNF632"
                     /note="major polyA site"
ORIGIN      
        1 gtagtcgccg ccggctgtgc cccgggagcg cctccggggc tggtgcgtgg ccggcagctc
       61 gcgaacagca gctgatccgg actggatgtg accttctgcc tggaatagct caagttctta
      121 aaagttgcgt tgtaataaac ctgaggctgg gaagttcaag atcaagatgc tggacgattt
      181 ggttccttag tgaaggctct cttcctggct ggtggatgac agccttcttg ctgtgttctc
      241 acatgacaga aagaggaagc aaggtggcag tttatataaa ggaagcattg ggacttgtgg
      301 ccccaccatt caggaataaa aaaattagaa aatggaacaa tcatgtgagg aagagaaaga
      361 gcctgaacca cagaagaaca tacaagaaac caaacaagta gatgacgaag atgctgagct
      421 catctttgtt ggtgtggaac atgtaaatga agatgctgag ctaatctttg ttggggtgac
      481 ttcaaattca aaaccagtcg tttcaaacat tttgaacaga gtcaccccgg gttcatggtc
      541 aaggagaaaa aagtatgatc accttagaaa agatactgct cgcaaattgc agcctaaaag
      601 tcatgagacc gttacatcag aagcagtgac cgtcctgcca gcttcccaac ttgaatcgag
      661 atcaacagat agtcctatta ttattgagcc tttgtctaaa cctgattata gaaatagttc
      721 accacaagtt gtgcctaata actcttcaga attaccttct cctttgatta cattcacaga
      781 ttcattgcat catccagtaa gtacagcact ttcagtagga ggtataaatg aaagtcctcg
      841 tgtatcaaag caactttcca ctttcgaagt aaacagcata aatcccaaaa gggctaaact
      901 cagggatgga attatagaag gaaattcttc agcttcattc ccttcagata cctttcatac
      961 aatgaatact cagcaaagta caccctcaaa taatgttcat acctcattaa gccatgttca
     1021 gaatggagca ccttttccag cagcttttcc aaaggacaat atccatttca agcctataaa
     1081 tacaaatctt gatagggcaa atgaattggc aaaaacagac attttgagtc taacaagtca
     1141 aaacaagacc tttgatccca agaaagaaaa tcccattgtg ttacttagtg acttttacta
     1201 tggacagcat aaaggagaag ggcagccgga acagaagact cacaccacct ttaaatgcct
     1261 cagctgcgtg aaagttctaa aaaatgttaa gtttatgaat cacgtgaagc atcatttgga
     1321 atttgagaag cagaggaacg acagctggga aaaccacacc acctgccagc actgccaccg
     1381 gcagtttccc actcccttcc agctacagtg tcacatcgaa aatgtccaca ctgcccagga
     1441 gccctctact gtctgtaaaa tctgtgaatt gtcatttgaa acagatcagg tcctcttaca
     1501 acacatgaag gaccatcata agcctggcga aatgccctat gtgtgccagg tttgccatta
     1561 tagatcgtcg gtctttgctg atgtagaaac acattttaga acgtgccatg aaaacacaaa
     1621 gaatttgctt tgtccctttt gtctcaaaat tttcaaaaca gcaacaccat acatgtgtca
     1681 ttataggggc cactggggaa agagtgcaca ccagtgttcc aagtgccggc tacagttttt
     1741 aactttcaag gagaaaatgg agcacaagac ccagtgtcat caaatgttta agaagcctaa
     1801 gcaactagaa ggattacctc ctgaaacaaa agttactatt caagtgtcgc tggaacctct
     1861 tcagccagga tcagtggatg tagcatccat aactgtgagc acatctgact ctgaaccatc
     1921 actccccagg tctaaaagca aaatttcaaa aaagtcccat taattctagt ttcagtaaat
     1981 ctaaagcaag tatttcaaac caaattaaaa aacctcataa aacaaaaaat acaaaccata
     2041 cattattcag tagcaccaaa aatagtgaaa ctagtggatt atatatgact ttttaaacaa
     2101 gattcaggat atatattatt tgatctgaat tttgaggtat tattttaaaa catctggttt
     2161 tcatgttaac tgtatctggc ttaacacata aaaggtgttt gtgtgtgtgt gtgagagaga
     2221 gaaaaaggta ttaatttatt tttttaattt taattttttt tttttttttt tttttttttt
     2281 ttactttaga gacagggtct cactgttacc caggctggag tgcagtggcg tgatcctagc
     2341 tcactgcaac cttgaacttc caggctcaag cattcctccg cctcagcctt tggagagtag
     2401 ctaggactac aggcgcagcc accacaccca gctaattttt tattttaatt ttttgtagcg
     2461 atggaatctt gttatgtcgc ccagggtggt ctcgaactcc tgaccttagg ggagcctcct
     2521 gcctcagcct ccccaagtgc tgggttgtgt gagtcactgc ccctggcacc tatttattgt
     2581 tttggtattt catgttactc ctaagcttga aagctctttt ttctatatac agaattcata
     2641 gaatttttga aatacttagt tttctttaca gctttttcca tgcattcagc atttcatggt
     2701 taactctagt cagactggaa tggctttgtt atgccctggc ccacttgctg ccgaattccc
     2761 agaagtgcct ctgctgtgct ggcataaaat aacctgaaaa gattctgaaa agccaggatg
     2821 tggaattgaa agagaagctg ctgcgtgagc agagaccaag aaggcggagg ttagttgagg
     2881 gagagcagtg gttctttgtt ctagttgaag tataggcaca cattcattct agtcttgggg
     2941 ccaggtcaaa aggaacactg cttcagagtg tctttaccta cctgaaaaca tccaaggaag
     3001 ccaaaccatt caaagtaaaa tgcttttgtt tggtgaaggg cccctgcaga catcaaacag
     3061 ccgtcatgta tcattggttt gaggtgaaat agcaataaaa ttaatagaat ggtgcctggt
     3121 actagctgac ttcctgttct gtgatctaaa ggtgaatttg attcattccc tctcctctcc
     3181 cttctggcta gccgttagtg gagaatgaac tggccatatt ctcagccaca gctgtaaagc
     3241 aagtttccca aggggaagaa gccctaatat ctataatttg aactgtactg gacccatagt
     3301 tttaactgaa aagggccaaa caagtggtgt ctgtccagtt cctggactgg gctaaattta
     3361 gttttcccac tgttaagctg gaatgaggac tgtcccaaca acagtaggta cagtggacaa
     3421 aaatagccca gggtgactga ctgaatttaa acccataatg gctttatatt tttctgtgca
     3481 tatatatctt accctaattg aacatgtgaa gcttgcaact ttatgtcttg ctttggacat
     3541 gaatgtatta cagcttgcag ctattctgtt aaatgtatag tttcccagtt ttttgacact
     3601 aatgctgttt gggtcttacc tgacacacac cagtgtgcaa gaaatgtctc tctaattcaa
     3661 taagttttaa gacttagagt taatgtcctt catctgatct atcctatcta atctgtacta
     3721 tgggtgaatc tttttccctt gctctcccca ggggctgttt cacagtattc tggagtacct
     3781 tttgagtatt ggttcctgaa catcagcagt cttggctgcc tctgtggact cccggagttg
     3841 tctccctgct tgtgttctgg tgccatcctt tgttcctcca cccctgacca aggtgcccag
     3901 cagcctgtct tcaccagtca aggaatccgc catcttggct gtagacatac ataggtctgg
     3961 agaaatctct ccctttttcc ttgatttctt tttaaaggta ccttatctct ccccactcct
     4021 ttcttccctc ctcaatctag ttaaatttcc taagctttca caaaaatccg ggaagagata
     4081 attaagagct tagcatccct cttagagtag aaggcagtac agataacaaa gaagttgtga
     4141 gtatattatc tacattttag aaaattttct gactctagat ccatagattc tgttgtattt
     4201 atttgccgga cactcatttg attgatttgc accttgaaca ctatactagg tcttttcagt
     4261 tacgttgctt gggttaagac actttgctaa aattacagcc tgaatccttt ctttagttga
     4321 agaaagggta tgtgtgtgca agtgggtgtg tgtgtgccag tttttcttgt ctcaggtaga
     4381 tactcccact gtgtataaat agatctacag acttttcata cttacctccc gtattctgtt
     4441 tctgtggtaa aaatatgaag tgttttagtt gtatgttgag tgattggttg gtattatcaa
     4501 cactgttgtt tgcagtctca ttaaagcatg ctcttaagga gtacatatgg tcattaattg
     4561 ccaactgtag attccagtga tctggcccct gcctacctcc ttcctctctt tttcattctc
     4621 tgtcatgctt ctccactgtt ttccccaatg atgcactatt ttgacacact ggccttgcta
     4681 ttccttaagc aaatcacatt cttcccaatc caaagacttt gcacatgctg ttgtctttct
     4741 tagaatgccc ttcccctagg cctgcatggc ttgctacctc acttaattgt ttgacacttc
     4801 ctttggttca ttgagcttca aggctcttaa aatgccactg acaatgagat ctccctttaa
     4861 aaaaaaaaaa aaacttctac ttttcctctt aaaggcactt tactctctcc ccactctttt
     4921 cttcctcttc aaagtattta aatttcctag gttttcatga aaaagctgga aagcgatcat
     4981 catcaagggc tttgcttctg tcttagaatt gagctagctt gagtcaattt ctgtgcctgc
     5041 aaccaaatga aaattaatat agtgagttct ttcaggagct ttctctgttt ttctattgat
     5101 acctctatat atttttaagg caatgtcact ttgttttgtt tacaaatata ttgaatatgt
     5161 caagattact attttgttat tgccctttgt gaatttcctt gtctattttg ctcgcttgtt
     5221 ctttcaggtg aaatttatta ttttattaat gttgccaaaa attataagta aaatatcaat
     5281 tatagtaata aaatgttttg tgaaaaaaa
//
