LOCUS       NM_080740               2148 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 280A (ZNF280A), mRNA.
ACCESSION   NM_080740
VERSION     NM_080740.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   He,L., Wang,X., Chen,P., Du,C. and Li,J.
  TITLE     Knockdown of ZNF280A inhibits cell proliferation and promotes cell
            apoptosis of bladder cancer
  JOURNAL   Histol Histopathol 39 (3), 367-379 (2024)
   PUBMED   37345848
  REMARK    GeneRIF: Knockdown of ZNF280A inhibits cell proliferation and
            promotes cell apoptosis of bladder cancer.
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Liu,H., Qin,Y., Zhou,N., Ma,D. and Wang,Y.
  TITLE     ZNF280A promotes lung adenocarcinoma development by regulating the
            expression of EIF3C
  JOURNAL   Cell Death Dis 12 (1), 39 (2021)
   PUBMED   33414445
  REMARK    GeneRIF: ZNF280A promotes lung adenocarcinoma development by
            regulating the expression of EIF3C.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Kawasaki,K., Minoshima,S., Nakato,E., Shibuya,K., Shintani,A.,
            Schmeits,J.L., Wang,J. and Shimizu,N.
  TITLE     One-megabase sequence analysis of the human immunoglobulin lambda
            gene locus
  JOURNAL   Genome Res 7 (3), 250-261 (1997)
   PUBMED   9074928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP283207.1, AC246793.1 and
            BC053901.1.
            
            On Nov 24, 2018 this sequence version replaced NM_080740.4.
            
            Summary: This gene encodes a zinc finger protein. The encoded
            protein contains 4 C2H2-type zinc fingers, which are commonly found
            in transcription factors. A variety of functions may be performed
            by this type of zinc finger protein, including the binding of DNA
            or RNA. [provided by RefSeq, Apr 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053901.1, AK093108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302097.3/ ENSP00000302855.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BP283207.1         12-15
            5-5                 AC246793.1         103992-103992
            6-117               BP283207.1         16-127
            118-1997            BC053901.1         103-1982
            1998-2148           BC053901.1         1984-2134
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..2148
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /note="zinc finger protein 280A"
                     /db_xref="GeneID:129025"
                     /db_xref="HGNC:HGNC:18597"
     exon            1..182
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /inference="alignment:Splign:2.1.0"
     exon            183..2148
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1882
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /note="zinc finger protein 280; zinc finger protein 636;
                     suppressor of hairy wing homolog 1"
                     /codon_start=1
                     /product="zinc finger protein 280A"
                     /protein_id="NP_542778.2"
                     /db_xref="CCDS:CCDS13800.1"
                     /db_xref="GeneID:129025"
                     /db_xref="HGNC:HGNC:18597"
                     /translation="MGDIFLCKKVESPKKNLRESKQREEDDEDPDLIYVGVEHVHRDA
                     EVLFVGMISNSKPVVSNILNRVTPGSNSRRKKGHFRQYPAHVSQPANHVTSMAKAIMP
                     VSLSEGRSTDSPVTMKSSSEPGYKMSSPQVVSPSSSDSLPPGTQCLVGAMVSGGGRNE
                     SSPDSKRLSTSDINSRDSKRVKLRDGIPGVPSLAVVPSDMSSTISTNTPSQGICNSSN
                     HVQNGVTFPWPDANGKAHFNLTDPERASESALAMTDISSLASQNKTFDPKKENPIVLL
                     SDFYYGQHKGDGQPEQKTHTTFKCLSCVKVLKNIKFMNHMKHHLEFEKQRNDSWEDHT
                     TCQHCHRQFPTPFQLQCHIDSVHIAMGPSAVCKICELSFETDQVLLQHMKDHHKPGEM
                     PYVCQVCHYRSSVFADVETHFRTCHENTKNLLCLFCLKLFKTAIPYMNHCWRHSRRRV
                     LQCSKCRLQFLTLKEEIEHKTKDHQTFKKPEQLQGLPSETKVIIQTSVQPGSSGMASV
                     IVSNTDPQSSPVKTKKKTAMNTRDSRLPCSKDSS"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="ZNF280A"
                     /gene_synonym="3'OY11.1; SUHW1; ZNF280; ZNF636"
                     /note="major polyA site"
ORIGIN      
        1 agaaaggact ttgaagagca agcggcgttg ttcgcctgcg gaagcagtgc tgccggtctc
       61 tggacaaatt tctccgggag gtggagacaa ggaagctcca gcttcgcttt cccttgcggc
      121 ccagagtgga acatactgag ctgcactgaa tcatctggat gcactcgcaa ctttaggaac
      181 tggtggcaat ttgtaaaaag acagctctgg aagttgaaga gaccagtggc ttcaagcaaa
      241 aagtaaattg aaaatgggag atatcttttt gtgtaagaaa gtggaatcac caaagaagaa
      301 tttgagagaa tccaaacaaa gggaggagga tgatgaagat ccagatctga tctatgttgg
      361 ggtggagcat gtacatagag atgctgaagt tctctttgtc gggatgattt caaattcaaa
      421 accagtcgtt tcaaacattt tgaacagagt caccccaggc tcaaattcaa gaagaaagaa
      481 aggccacttc cgtcaatatc ctgctcacgt gtcgcagcct gcaaatcatg tgacctctat
      541 ggcaaaagcc atcatgccgg tttctctgtc tgaggggcga tcgacagata gtcctgtcac
      601 tatgaagtct tcatctgaac ctggttataa aatgagctca ccacaagttg tttctcccag
      661 ttcctcagac tcgctccccc cagggactca gtgtctagtt ggagctatgg tctctggagg
      721 aggcagaaat gagagttctc ctgattcaaa gcgactttcc acttcagata taaacagcag
      781 agattccaaa agggttaaac tcagggatgg aatcccaggg gtaccttctt tagctgtggt
      841 cccttcagat atgtcttcta caataagcac aaatacaccc tcacagggga tctgcaactc
      901 atcaaaccat gttcagaatg gagtaacatt tccttggcct gatgctaatg gaaaggcaca
      961 tttcaatctt acagatccag agagagcaag tgagtctgcc ctggcaatga cagacatttc
     1021 aagtctagca agtcaaaaca agacctttga tcccaagaaa gaaaatccca tcgtgttact
     1081 tagcgacttt tactatggac agcataaagg agatgggcag ccggaacaga agactcacac
     1141 cacctttaaa tgcctcagct gcgtgaaagt tctaaaaaat attaagttta tgaatcacat
     1201 gaagcatcat ttggaatttg agaagcagag gaacgacagc tgggaagacc acaccacctg
     1261 ccagcactgc caccggcagt ttcccactcc cttccagcta cagtgtcaca ttgatagtgt
     1321 acacatcgcc atggggccct ctgctgtctg taaaatctgt gaattgtcat ttgaaacaga
     1381 tcaggtcctc ttacaacaca tgaaggacca tcataagcct ggcgaaatgc cttatgtgtg
     1441 ccaggtttgc cattacagat cgtcggtctt tgctgatgtg gaaacacatt ttagaacgtg
     1501 ccatgaaaac acaaagaatt tgctttgtct gttttgtctc aaacttttca aaactgcaat
     1561 accatacatg aatcattgtt ggaggcacag cagaaggagg gtccttcagt gttccaagtg
     1621 ccggctacag tttttgacgt tgaaggagga aatagagcac aaaaccaagg accatcaaac
     1681 atttaaaaag ccggagcaac tgcaagggtt gcctagtgaa acaaaagtta ttattcaaac
     1741 ttcagttcag ccaggatcaa gtggtatggc ttccgttatt gttagcaaca ctgaccctca
     1801 gtcttctcct gtaaaaacta aaaagaagac ggctatgaac actagagatt ccagactccc
     1861 ttgcagcaag gattctagct gaaaatatgt tcgactgact tccaggagtt ccgaaaggca
     1921 gaagtgaggc taggccatat gtgcattgtg gctgtagatg ctagcaagca atgtcatcaa
     1981 ctgtcaggtt gttttttaca gtgacatctc atcagctccc tattgtcaag aagtagctcc
     2041 aaagtctttg agccctttcc cagtcaaatg ctcccaacag ggcatccctt attctgacct
     2101 cagaggtttt tcttgttcat gaactttaaa taaatggaat cacacaaa
//
