LOCUS       NM_006969               4558 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 28 (ZNF28), transcript variant 1,
            mRNA.
ACCESSION   NM_006969 XM_371189
VERSION     NM_006969.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4558)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 4558)
  AUTHORS   Rousseau-Merck,M.F., Hillion,J., Jonveaux,P., Couillin,P.,
            Seite,P., Thiesen,H.J. and Berger,R.
  TITLE     Chromosomal localization of 9 KOX zinc finger genes: physical
            linkages suggest clustering of KOX genes on chromosomes 12, 16, and
            19
  JOURNAL   Hum Genet 92 (6), 583-587 (1993)
   PUBMED   8262519
REFERENCE   3  (bases 1 to 4558)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008813.6.
            
            On Apr 17, 2019 this sequence version replaced NM_006969.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.261389.1,
                                           SRR1660809.157660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267756 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457749.7/ ENSP00000397693.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC008813.6         40344-40391
            49-136              AC008813.6         43946-44033
            137-263             AC008813.6         53844-53970
            264-4558            AC008813.6         60275-64569
FEATURES             Location/Qualifiers
     source          1..4558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4558
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /note="zinc finger protein 28"
                     /db_xref="GeneID:7576"
                     /db_xref="HGNC:HGNC:13073"
                     /db_xref="MIM:620466"
     exon            1..48
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /inference="alignment:Splign:2.1.0"
     exon            49..136
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2278
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein KOX24"
                     /codon_start=1
                     /product="zinc finger protein 28 isoform 1"
                     /protein_id="NP_008900.3"
                     /db_xref="CCDS:CCDS33093.2"
                     /db_xref="GeneID:7576"
                     /db_xref="HGNC:HGNC:13073"
                     /db_xref="MIM:620466"
                     /translation="MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDISSKCMMKTFFSTGQGNTEAFHTGTLQRQASHHIGDFCFQKIEKDIHGFQFQWK
                     EDETNDHAAPMTEIKELTGSTGQHDQRHAGNKHIKDQLGLSFHSHLPELHIFQPEGKI
                     GNQVEKSINNASSVSTSQRICCRPKTHISNKYGNNSLHSSLLTQKRNVHMREKSFQCI
                     ESGKSFNCSSLLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKCNEC
                     GKIFGHNTSLFLHKALHTADKPYECEECDKVFSRKSHLETHKIIYTGGKPYKCKVCDK
                     AFTCNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHRRLHTGEKPYECEECEKVF
                     SRKSHLERHKRIHTGEKPYKCKVCDKAFAYNSYLAKHSIIHTGEKPYKCNECGKVFNQ
                     QSTLARHHRLHTAEKPYKCEECDKVFRCKSHLERHRRIHTGEKPYKCKVCDKAFRSDS
                     CLTEHQRVHTGEKPYMCNECGKVFSTKANLACHHKLHTAEKPYKCEECEKVFSRKSHM
                     ERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHQRVHTGEKPYKCNECGKTFRQTSSLII
                     HRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKPYKCNECGKVFNQQAHLAQHQ
                     RVHTGEKPYKCNECGKTFSQMSNLVYHHRLHSGEKP"
     exon            137..263
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /inference="alignment:Splign:2.1.0"
     exon            264..4558
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4532..4537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /note="hexamer: AATAAA"
     polyA_site      4558
                     /gene="ZNF28"
                     /gene_synonym="KOX24"
                     /note="major polyA site"
ORIGIN      
        1 agaccaggaa gcggatcccg tggaatgacg gtgacgccgc ggcgggcgga ttgacttcta
       61 aagaatcttg gtacgtgagg aagaaaccca gaagaggaag aggaaagcaa aggagtcagg
      121 gatggctctt cctcagggtc tattgacatt cagggacgtg gccatagaat tctctcagga
      181 ggagtggaaa tgcctggacc ctgctcagag gactctttac agggatgtga tgctggagaa
      241 ttataggaac ctggtctccc tggatatctc ttccaaatgc atgatgaaga cattcttctc
      301 aacagggcaa ggcaatacag aagcgttcca cacagggaca ttgcaaagac aagcaagtca
      361 tcacattgga gatttttgct tccagaaaat tgagaaagac attcatggct tccagtttca
      421 gtggaaagaa gatgaaacaa atgaccatgc agcacccatg acagaaatca aagagttgac
      481 tggtagtaca ggccaacatg atcaaaggca tgctggaaac aagcatatta aagatcagct
      541 tggattaagc tttcattcgc atctgcctga actgcacata tttcagcctg aagggaaaat
      601 tggtaatcaa gttgagaagt ctatcaacaa tgcttcctca gtttcaacat cccaaagaat
      661 ttgttgtagg cccaaaaccc atatttctaa taagtatgga aataattccc tccattcttc
      721 attactcaca caaaaacgga atgtacacat gagagaaaaa tctttccaat gtattgagag
      781 tggcaaatcc tttaattgta gctcactttt aaaaaaacat cagataaccc acttagaaga
      841 gaaacaatgt aaatgtgatg tatatggcaa ggtatttaat cagaagcgat accttgcatg
      901 ccatcgtaga tctcacattg atgagaaacc ttacaagtgt aatgagtgtg gcaagatctt
      961 tggtcacaat acatccctct tccttcacaa ggcgcttcat actgcagaca aaccttatga
     1021 atgtgaagaa tgtgacaaag ttttcagtcg caaatcacac cttgaaacac ataagataat
     1081 ttatactgga gggaaaccat acaaatgtaa ggtttgtgac aaagctttca catgtaattc
     1141 atacctagca aaacatacta taattcacac tggagagaaa ccttacaagt gtaatgaatg
     1201 tggcaaggtt tttaatcgac tgtcaaccct tgcacgccat cgtaggcttc atactggaga
     1261 gaaaccttat gaatgtgaag aatgtgaaaa agttttcagt cgcaaatcac atcttgaaag
     1321 acataagagg attcatactg gagagaaacc atacaaatgt aaggtttgtg acaaggcttt
     1381 tgcatataat tcatacctgg caaaacatag tataattcac actggagaga agccttacaa
     1441 gtgtaatgaa tgtggcaagg tttttaatca acaatcaact cttgcacgcc atcatagact
     1501 tcatactgca gagaaaccat acaaatgtga agaatgtgac aaagttttca ggtgcaaatc
     1561 acaccttgaa agacatagga ggattcatac tggagagaaa ccatacaaat gtaaggtttg
     1621 tgacaaggct ttccggagtg attcatgcct tacagaacat cagagagttc atactggaga
     1681 gaaaccatac atgtgtaatg aatgtggcaa ggtttttagt acaaaagcaa accttgcatg
     1741 tcatcataaa cttcatactg cagagaaacc gtacaaatgt gaagaatgtg agaaagtttt
     1801 cagtcgcaaa tcacacatgg aaagacatag gaggattcat actggagaga aaccgtacaa
     1861 atgtaaggtt tgtgacaagg ctttccggag ggattcacac ctggcacaac atcagagagt
     1921 tcatactgga gagaaacctt acaagtgtaa tgagtgtggc aagaccttcc gtcagacatc
     1981 atcgcttata atccatcgta ggcttcatac tggagagaaa ccttacaagt gtaatgagtg
     2041 tggcaagacc ttcagtcaga tgtcatccct cgtataccat cataggcttc atagtggaga
     2101 gaaaccttac aagtgtaatg aatgtggcaa ggtttttaat caacaagcac accttgcaca
     2161 gcatcagaga gttcatactg gagagaaacc ttacaagtgt aatgagtgtg gcaagacctt
     2221 cagtcagatg tcaaaccttg tataccatca tagacttcat agtggagaga aaccttgaaa
     2281 gtgtaatgag tgtggcaaga ccttcagtca gatgtcaaac cttgtatacc atcatagact
     2341 tcatagtgga gagaaacctt aaaagtgtaa tgagtgtggc aacaccttcc atcacaattc
     2401 aacccttgta agtcacaaag ccattcatac tggagagaaa ctttacaagt gtaatgaatg
     2461 tggcaaggtt tttaatcaaa aaacaaccct tgcacgtcat catagaattc atactgcaga
     2521 gaaactttac aaataggaag aatgtgacaa agttttcggt tgcaaatcaa accttgaaac
     2581 acataagaaa atgcatgctg aagagaaacc acacagatgt aaggtttatg acaagatttt
     2641 tgaatataat tcatacctgg caaaacatat tagaattcaa actggagaga aaccttacaa
     2701 atgtgatgag tgtggcaaca cctttggtca aaattcatac cttgtaattc aaaaggcaat
     2761 tcgtattgga gagaaaccct acaagtgtaa tgaatgtggc atagttttta atcaacagtc
     2821 acaccttgca agtcatcata gtcttcatac tgcagagaaa tcttacaaat gtgaagactg
     2881 tgacaaagtt gtcagtcaca aatcacagct tgaaagacag gagaattcat actggagaaa
     2941 aaacatacaa atgtaaggtt tgtaacaagg cttttgggag tgattcacac ctggcacacc
     3001 atactagaat tcacactgga gagaaacctt acaagtgcaa tgagtgtggc aaagccttta
     3061 gtgggcagtc accacttatt caccatcaag caatccatag tatagggaaa cttgactaat
     3121 ataatgattg tcacaaagtt ttcagtaatg ctacaaccat tgcaaatcat tggagaatcc
     3181 ataatgagag atcttacaag tgtaataaat gtgacagatt tttcagatat cgttcatata
     3241 ttgctattca tcatcgaact catgctggag agaaacctta taaatgtcat gattgtggca
     3301 aggtcttcag tcaagtttca tcctatgcaa aacataggag gattcataca ggagagaaac
     3361 tcacaagtgt gatgattgtg gcaaagcgtt tacttcacat tcacacctca atagacatca
     3421 gagaatccat gctggacaga aatcttacaa atgtcatcag tgtggtaagg tcttcagtcc
     3481 gagatcactc cttgcagacc atcagacaat tccttttgga gacagttgtt tcaaatgcca
     3541 ttagtatagc aagccatcaa gcattaattg acattacagt taaatgagca ctgacctgag
     3601 tttgagttga cttaacattg agtttaagca ttaattgaca ttaaactgtt tatgttaaga
     3661 ggactgggct gggcactgtg gctcacgcct gcaatgccag cactttgaga ggccaagact
     3721 ggtaggtcac tggaggttaa gagtttgaga acagcctggc caacagacgg gagccacttt
     3781 tcccagcctg tgttttcatt tctattcttt ctttcttttt tctttttttt gtttttgttt
     3841 ttgagatgga gtctcttgct ctgtcatcca ggttggagtg cagtggcatg atcttgactc
     3901 actacaacct ccgcctccca ggttcaagcg atcctcctgc ctcagtctcc tgactagctg
     3961 ggactacagg tgcatgccac cacacctgga taattttttg tatttttagt agagactggg
     4021 tttcgctgtg ttagcctgga tggtctcgat tttctgatct tatgattcac ccacctctac
     4081 ctcccgaagt gctgagatta tgggcgtgag ccaccgtgac tggcctgttt tttgtttctt
     4141 taacaaaaag ttatggggat ttctatgagt attgtgttga atctaaatca cattcggtta
     4201 tataatcatt gagcaatact aatttttcca atcagtatgg attgtatgtg tatttatatg
     4261 tttttaatca ttttgatcaa tgtttgtaga tttcaaggta caaacttctc acctttatat
     4321 gtttattcct aaatatttct tactttaagc tctttagcaa atggaagtgg tttttaattt
     4381 tattttaaaa ttatttaatg ttaatgtatg gaaattcaac taatttttgg tgctattatt
     4441 ctattctgca aatacactga atatgtttat tagttccagt tgtattttgg ttgactgtga
     4501 ttttcttcac agatcatgtc atctacaaac aaataaaatt tgacttcttt ctttctga
//
