LOCUS       NM_021994               2580 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 277 (ZNF277), mRNA.
ACCESSION   NM_021994
VERSION     NM_021994.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Dionne,K.L., Bergeron,D., Landry-Voyer,A.M. and Bachand,F.
  TITLE     The 40S ribosomal protein uS5 (RPS2) assembles into an
            extraribosomal complex with human ZNF277 that competes with the
            PRMT3-uS5 interaction
  JOURNAL   J Biol Chem 294 (6), 1944-1955 (2019)
   PUBMED   30530495
  REMARK    GeneRIF: ZNF277 and PRMT3 compete for uS5 binding, because
            overexpression of PRMT3 inhibited the formation of the ZNF277-uS5
            complex, whereas depletion of cellular ZNF277 resulted in increased
            levels of uS5-PRMT3.
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Ceroni,F., Simpson,N.H., Francks,C., Baird,G., Conti-Ramsden,G.,
            Clark,A., Bolton,P.F., Hennessy,E.R., Donnelly,P., Bentley,D.R.,
            Martin,H., Parr,J., Pagnamenta,A.T., Maestrini,E., Bacchelli,E.,
            Fisher,S.E. and Newbury,D.F.
  CONSRTM   IMGSAC; SLI Consortium; WGS500 Consortium
  TITLE     Homozygous microdeletion of exon 5 in ZNF277 in a girl with
            specific language impairment
  JOURNAL   Eur J Hum Genet 22 (10), 1165-1171 (2014)
   PUBMED   24518835
  REMARK    GeneRIF: ZNF277 microdeletions might contribute to the risk of
            language impairments
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Eriksson,N., Benton,G.M., Do,C.B., Kiefer,A.K., Mountain,J.L.,
            Hinds,D.A., Francke,U. and Tung,J.Y.
  TITLE     Genetic variants associated with breast size also influence breast
            cancer risk
  JOURNAL   BMC Med Genet 13, 53 (2012)
   PUBMED   22747683
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Hahn,Y. and Lee,B.
  TITLE     Human-specific nonsense mutations identified by genome sequence
            comparisons
  JOURNAL   Hum Genet 119 (1-2), 169-178 (2006)
   PUBMED   16395595
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Liang,H., Castro,P.D., Ma,J. and Nagarajan,L.
  TITLE     Finer delineation and transcript map of the 7q31 locus deleted in
            myeloid neoplasms
  JOURNAL   Cancer Genet Cytogenet 162 (2), 151-159 (2005)
   PUBMED   16213364
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Liang,H., Guo,W. and Nagarajan,L.
  TITLE     Chromosomal mapping and genomic organization of an evolutionarily
            conserved zinc finger gene ZNF277
  JOURNAL   Genomics 66 (2), 226-228 (2000)
   PUBMED   10860669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF209198.1, DA285525.1, BG924796.1 and DB543718.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_021994.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.420411.1,
                                           SRR1803611.428908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361822.8/ ENSP00000354501.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1675              AF209198.1         108-1782
            1676-2046           DA285525.1         130-500
            2047-2381           BG924796.1         221-555
            2382-2580           DB543718.1         248-446
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..2580
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="zinc finger protein 277"
                     /db_xref="GeneID:11179"
                     /db_xref="HGNC:HGNC:13070"
                     /db_xref="MIM:605465"
     exon            1..113
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1375
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="zinc finger protein 277 pseudogene; zinc finger
                     protein (C2H2 type) 277; nuclear receptor-interacting
                     factor 4"
                     /codon_start=1
                     /product="zinc finger protein 277"
                     /protein_id="NP_068834.2"
                     /db_xref="CCDS:CCDS5755.2"
                     /db_xref="GeneID:11179"
                     /db_xref="HGNC:HGNC:13070"
                     /db_xref="MIM:605465"
                     /translation="MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPE
                     SPGGTTTLEGSPSVPCIFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYILY
                     WRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREILE
                     QQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQ
                     KKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEV
                     QLEDDRELLDHQEDDWSDWEEHPASAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKS
                     ELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWD
                     QLEYYFPTYENDTLLCTLSDSESDLTAQEQNENVPIISEDTSKLYALKQSSILNQLLL
                     "
     exon            114..315
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            316..404
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            405..487
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            488..579
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            580..690
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            691..823
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            824..891
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            892..988
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1031
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1206
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2580
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1653..1658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="hexamer: ATTAAA"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="hexamer: ATTATA"
     polyA_site      1670
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="major polyA site"
     polyA_site      1695
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
                     /note="hexamer: TATAAA"
     polyA_site      1742
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
     polyA_site      2106
                     /gene="ZNF277"
                     /gene_synonym="NRIF4; ZNF277P"
ORIGIN      
        1 cccttttctt ttctgccggg taatggctgc ttccaagacc cagggggctg tcgcccgaat
       61 gcaggaagac cgtgatggga gctgcagcac agtcgggggt gtaggttatg gggacagtaa
      121 ggattgtatc ctggagccgc tttccctgcc agaaagtcca ggtggcacca ccactttaga
      181 aggttctcca tctgtgcctt gtattttctg tgaagaacat tttcctgtgg ctgaacaaga
      241 caaacttctg aagcacatga ttattgagca taagattgtc atagctgatg tcaagttggt
      301 tgctgatttc caaaggtaca ttttatattg gaggaaaagg ttcactgaac agcccatcac
      361 agatttttgt agtgtaataa gaattaattc cactgctcca tttgaagaac aagagaatta
      421 ttttttgtta tgtgacgttt taccagaaga tagaattctt agagaagagc ttcagaaaca
      481 gagactgaga gaaattctgg aacaacagca gcaagaacga aatgatacca attttcatgg
      541 cgtttgtatg ttttgcaatg aagaattcct tggaaacaga tctgttattt tgaaccacat
      601 ggccagagaa catgctttca acattggatt gccagacaac attgtaaact gcaatgaatt
      661 tttgtgtaca ttacagaaaa agcttgacaa tttgcagtgc ttgtactgtg agaagacctt
      721 cagggacaaa aatacactta aagatcacat gaggaaaaaa cagcatcgta agattaatcc
      781 taagaacaga gaatatgaca gattttatgt catcaattat ttggaacttg gaaaatcgtg
      841 ggaagaagtt cagttggaag atgatcggga gttgctggac catcaggaag atgactggtc
      901 tgattgggaa gaacaccctg cctctgcagt ctgcttattt tgtgaaaagc aagcagaaac
      961 aattgagaag ttgtatgtcc acatggagga tgcacacgaa tttgatcttc tcaaaataaa
     1021 gtcagaactt ggattaaatt tctatcagca agtgaaactg gtcaatttta ttcggaggca
     1081 agttcaccaa tgcagatgtt atggctgcca tgtgaagttc aaatccaaag cagacttaag
     1141 aactcacatg gaagaaacta aacacacttc gctgctcccc gatagaaaga cgtgggatca
     1201 actggagtat tattttccaa cctatgaaaa tgacactctc ctgtgtacac tatctgacag
     1261 tgaaagtgac ctgacagctc aggaacaaaa tgaaaatgtt cccatcatca gtgaagatac
     1321 atctaaactg tatgctttga aacaaagcag tattttgaac cagttgctac tataagagta
     1381 cttgaaaacc tagaagaaac taccacagaa gcaatttttc atgtttttct cctatgagac
     1441 agatatgaaa gaacaattta aatttgaaca tcaacaaaag attggtcctt ggtgaaataa
     1501 acttttcaaa aatgaatgtt cttttcaaaa aataaagtag aaaaatgcac ttactaagaa
     1561 catgaaaaaa aatgaagtag gaaaataaga tgaagacttt gtattttggc tgtaaagttt
     1621 tattgtgtga tcatcttaaa ttatctcact tcattaaact cataattata tatagaagta
     1681 tatgtcaatt acaaagaaat gaaatgttca aattatttat aaacctgatt tttcaatcag
     1741 tagtttcagt ctcctcccca aggaccttct tcatccaaca agttgcaaaa tttgaatatc
     1801 ccttctgtac tatattgggt gagctgtaaa tgtaatgact aaaagaaaag ccacagaaga
     1861 aagaagaaat ggtcaaagac gtggataata tgcaaattgg ccattatatt agaacaatca
     1921 agagctgact gtgttattac cactttctgc ctagggtggc caaattccct agaaatagac
     1981 atcaagccag ttaacttcac ttttccctgc aatttgtatg tcactaacat ttaaatgcca
     2041 ttttttaaaa acataaccac aataccatta tgacacctaa aaaacattaa cattaactta
     2101 atatcatctg ttttcagttt ttcccacttg tctcaaaatg tatgtttaca atattatcag
     2161 tttcattact gatgaatatt atatgcctcc tgataagatg tactgaggag gacagaatat
     2221 cacttttgta gatttatacc aaaaatgcat aatttggata taatgaagaa acagtcaaat
     2281 ccaagtttga ggctgggcac agtagctcat atctgtaatc ccagcacttt gggaggccaa
     2341 ggcagaggat cacatgaggt caggagttca agatcagcct ggccaacgtg gcaaaacccc
     2401 atctctacga aaaatacaca gattagccag gcatggtgga atgcacctat agtcccagct
     2461 acttgggagg ctgaagcaca agaatcgctt gaatccagga ggcaaaagtt gcagtgagcc
     2521 gagatcacac cactgcagtt cagcctgggc aacagaccaa gactctgtct caaaaaaagg
//
