LOCUS       NM_001113525            4628 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 276 (ZNF276), transcript variant
            a, mRNA.
ACCESSION   NM_001113525
VERSION     NM_001113525.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Wong,J.C.Y., Gokgoz,N., Alon,N., Andrulis,I.L. and Buchwald,M.
  TITLE     Cloning and mutation analysis of ZFP276 as a candidate tumor
            suppressor in breast cancer
  JOURNAL   J Hum Genet 48 (12), 668-671 (2003)
   PUBMED   14605947
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Wong,J.C., Alon,N., Norga,K., Kruyt,F.A., Youssoufian,H. and
            Buchwald,M.
  TITLE     Cloning and analysis of the mouse Fanconi anemia group A cDNA and
            an overlapping penta zinc finger cDNA
  JOURNAL   Genomics 67 (3), 273-283 (2000)
   PUBMED   10936049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010538.9, DA891371.1, BC110348.1, BC107603.1, AK096762.1,
            AF354756.1, BC105959.1, BQ432535.1, AK096004.1, BQ549716.1 and
            AI283548.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001113525.1.
            
            Transcript Variant: This variant (a) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.208620.1, BC110348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443381.7/ ENSP00000415836.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC010538.9         20131-20137         c
            8-292               DA891371.1         2-286
            293-1444            BC110348.1         1-1152
            1445-2149           BC107603.1         1253-1957
            2150-2273           AK096762.1         2722-2845
            2274-3147           AF354756.1         2029-2902
            3148-3519           BC105959.1         2924-3295
            3520-3720           BQ432535.1         457-657
            3721-4339           AK096004.1         1476-2094
            4340-4353           BQ549716.1         1-14                c
            4354-4628           AI283548.1         3-277               c
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..4628
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="zinc finger protein 276"
                     /db_xref="GeneID:92822"
                     /db_xref="HGNC:HGNC:23330"
                     /db_xref="MIM:608460"
     exon            1..309
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1949
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="isoform a is encoded by transcript variant a; zinc
                     finger protein 477; zinc finger, AD-type; zinc finger
                     protein 276 homolog; centromere protein Z"
                     /codon_start=1
                     /product="zinc finger protein 276 isoform a"
                     /protein_id="NP_001106997.1"
                     /db_xref="CCDS:CCDS45554.1"
                     /db_xref="GeneID:92822"
                     /db_xref="HGNC:HGNC:23330"
                     /db_xref="MIM:608460"
                     /translation="MKRDRLGRFLSPGSSRQCGASDGGGGVSRTRGRPSLSGGPRVDG
                     ATARRAWGPVGSCGDAGEDGADEAGAGRALAMGHCRLCHGKFSSRSLRSISERAPGAS
                     MERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNAS
                     PAGRRKPCAKVGAQPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQR
                     TLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDSALAVKWPWDKETAPRLPQHRG
                     WNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRA
                     PGQLGEKQLPSSTSDDRVKDEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKVS
                     GKKSESKEAKKSEEPRIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADG
                     MKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQR
                     KHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKA
                     HNLNVHMSMVHPLTQTQDKALPLEAEPPPGPPSPSVTTEGQAVKPEPT"
     exon            310..613
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            614..660
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1110
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1189
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1273
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1384
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1460
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1578
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1678
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..4628
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2255..2260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="major polyA site"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="hexamer: AGTAAA"
     polyA_site      3547
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="major polyA site"
     regulatory      4575..4580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="hexamer: AATAAA"
     regulatory      4600..4605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="hexamer: ATTAAA"
     polyA_site      4606
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="major polyA site"
     polyA_site      4628
                     /gene="ZNF276"
                     /gene_synonym="CENP-Z; CENPZ; ZADT; ZFP276; ZNF477"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcctc gcttccagcg cgccgagcgg agcctaacgc cgggtcctct aggaacctcg
       61 ggccgggcag cacccgcggg attctgctgg cgtcctccgc tgccatgaag cgggaccggc
      121 tgggccgctt cctgtctcct gggtcgtccc gacagtgcgg ggcctcggac ggcggcggcg
      181 gcgtcagccg gactcggggc cgcccttccc ttagcggtgg gccgagggtg gacggggcga
      241 cggcgcggcg cgcctggggc ccggtggggt cctgcgggga cgcgggcgag gacggcgcgg
      301 acgaggcagg agcaggccgg gctctcgcca tgggtcactg tcgcctctgc cacgggaagt
      361 tttcctcgag aagcctgcgc agcatctccg agagggcgcc tggagcgagc atggagaggc
      421 catccgcaga ggagcgcgtg ctcgtacggg acttccagcg cctgcttggt gtggctgtcc
      481 gccaggaccc caccttgtct ccgtttgtct gcaagagctg ccacgcccag ttctaccagt
      541 gccacagcct tctcaagtcc ttcctgcaga gggtcaacgc ctccccggct ggtcgccgga
      601 agccttgtgc aaaggtcggt gcccagcccc caacaggggc agaggaggga gcgtgtctgg
      661 tggatctgat cacatccagc ccccagtgcc tgcacggctt ggtggggtgg gtgcatggac
      721 atgcggccag ctgcggggcc ctgccccacc ttcagaggac actgtcctcc gagtactgcg
      781 gcgtcatcca ggtcgtgtgg ggctgcgacc agggccacga ctacaccatg gataccagct
      841 ccagctgcaa ggccttcttg ctggacagtg cgctggcagt caagtggcca tgggacaaag
      901 agacggcgcc acggctgccc cagcaccgag ggtggaaccc tggggatgcc cctcagacct
      961 cccagggtag agggacaggg accccagttg gggctgagac caagaccctg cccagcacgg
     1021 atgtggccca gcctccttcg gacagcgacg cggtggggcc caggtcgggc ttcccacctc
     1081 agccaagcct gcccctttgc agggccccag ggcagttggg tgagaagcag cttccatctt
     1141 caacctcgga tgatcgggta aaagacgagt tcagtgacct ttctgaggga gacgtcttga
     1201 gtgaagatga aaatgacaag aagcaaaatg cccagtcttc ggacgagtcc tttgagcctt
     1261 acccagaaag gaaagtctct ggtaagaaga gtgaaagcaa agaagccaag aagtctgaag
     1321 aaccaagaat tcggaagaag ccgggaccca agcccggatg gaagaagaag cttcgttgtg
     1381 agagggagga gcttcccacc atctacaagt gtccttacca gggctgcacg gccgtgtacc
     1441 gaggcgctga cggcatgaag aagcacatca aggagcacca cgaggaggtc cgggagcggc
     1501 cctgccccca ccctggctgc aacaaggttt tcatgatcga ccgctacctg cagcgccacg
     1561 tgaagctcat ccacacagag gtgcggaact atatctgtga cgaatgtgga caaaccttca
     1621 agcagcggaa gcaccttctc gtccaccaaa tgcgacattc gggagccaag cctttgcagt
     1681 gtgaggtctg tgggttccag tgcaggcagc gggcatccct caagtaccac atgaccaaac
     1741 acaaggctga gactgagctg gactttgcct gtgaccagtg tggccggcgg tttgagaagg
     1801 cccacaacct caatgtacac atgtccatgg tgcacccgct gacacagacc caggacaagg
     1861 ccctgcccct ggaggcggaa ccaccacctg ggccaccgag cccctctgtg accacagagg
     1921 gccaggcggt gaagcccgaa cccacctgag gacggcagtg aggatgagca cctctagcag
     1981 cctggactcc gcagtggctg tgtcagcctc acccttcgtg tgcacccgca tgggagggtc
     2041 ggagggtgct gcccgccctt ggtgctggag gcgggcttgg tgtccggctc aagtagcctt
     2101 cctctgctct gggaccagtg gtttattttc ccgcaaacgc tgagtgactc ggggccggac
     2161 agttcataaa taattgattc ctttccccac taaagcagtc gaggagattt gtaatccact
     2221 ttttagtgca acaagagctc catgttatgc ttgtaataaa ttatttacac gggagctggg
     2281 ctggtgtgca gtggcaggtc ccgtcagaag agatgaggct cctgggacag gtcagcgtca
     2341 ggggcagcct gctgtctgct ctggagggcg gcgctcacct ctgggtcgca gtccccacga
     2401 tcagccagca gctgtgagag aggagcaggt cctcagccca tgccgcccac taggcctcag
     2461 accacagggg aggggctctg gcagaaatag tcgagttgta ttgccagcca ggcaggcaca
     2521 tggcccaggc agctgtcaat tctcatgtcc cccacatggc ccaaggtggg catcttgacg
     2581 ttacctctgc cacgtgtgag aagctctttt tcgggcaccg aggtattaac tgcagcagaa
     2641 aaagacgagc ttttgttatc agttccacgg ggttgcccta gagagaaaac aggcaaactc
     2701 acaggttaga agacatacag aaacagggct ggtgtgtccc ccatagtctg catgctgtgc
     2761 cggaacattc tttggcagaa ggagcctccg gctgggggga gctcccctgg aggtgggact
     2821 ggcccttgca cctgcctgac ccttgagctc caggctcctg ccagctggag gtgaaactgt
     2881 gcttgtatcc ccagccacga agagctggac cagcttcaag tacatgtcca cagcaacatg
     2941 caggaaggcc tcttccctga tggccgcgtc ttcatggaag taggagagaa gactagaggt
     3001 aaagacatag tgacaaatgg ctacagactg ctggaaaggt agcaggtgat gccaagggat
     3061 actgctcatc tgtggagcag aggcacagac aacccttccc atctggcggg acccagaggt
     3121 gctgagatgg gggtctggga aacactgccc agccctgacc agccctgtgg gtggaggtac
     3181 ctgtaaaaag cgaaaggcag cagcctggtg tgctgatccg gggccacacg gaggaggagc
     3241 cgccccagcc tgaggtctgc aacaccaaga agtggctcag gcaactctgg acatctctgc
     3301 ctattatcag tgctggggac acccctgggg gtcgggacgt gtaccctggg aggcctggct
     3361 gtggggatag tgtggggcga acagcctgag ctgaggatac ccaggtacct gtcagcagct
     3421 gggagaggat gggggggtcg acctcttgca ggagggtggg tgtggtgcag agagaggcag
     3481 tccccatgat aggcccattg gtcctggggt tgaccagtga gccagtaaat tatcttattg
     3541 ctttaaacaa gtttgtgctt aatctgtccc aactaaaatg gagcttataa acttacttag
     3601 caaggaacct caaggagggc tcgttcttaa ccatttgcaa gatgcctctg aaaagagcgg
     3661 ccctccgcat ttgtgcctca gcagcgtgtt tcttaccact ctctgtcaac tgaaagagtg
     3721 ccagccagga tatcttcctc ttctctaaac actcgaggat tgctgcacaa acgtggaaag
     3781 cctttggcag gtctgtggtg ctctgtaaac cgcaggagac caaccctgag aatggccgac
     3841 ctggtgctcc catgggtagg agggtacagc cctcagcaca gaagagggca tttcctcttt
     3901 gcttattgta agtcttaaaa ctggtgacag ttttacctat agaaggtaat actgggcctc
     3961 tggacagaag aggctcaggt aggaggccag ggacttcgag cacccacacc aaggctgctg
     4021 caccacgtcc tcaaataaga cattaaaaga aaggcccaca ggccggatgc agtggctcat
     4081 gcctgtaatc ccaacacttt gggaggccga ggtcggcgga tcactgaggc cagttcaaga
     4141 ccagcctggc aatatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgggtgt
     4201 gacagactca cgcctgtaat cccagctact cgggaggctg atgcaggaga attgcttgaa
     4261 cccaggaggc tgaggttgca gtgagctgag atcacaccac tgcactccag cctgggtgac
     4321 agagtgagac ccccatctca aaaaaaaaaa aaaaaaaccc acggcctggg agttctcact
     4381 cacacttccg caaacacaag gagctcctga gctagtctgg aaaccctgac ttggaagctg
     4441 gctgcctggt gcccctgcct ggcccacagt gggagaggac accttggctg gtaaggtctg
     4501 acttacattt gaggtcagat gtgacgacag caggcccatc aaggagaaga agaaaaggaa
     4561 aaccaatagc tgtaaataaa aacgtgcact tattattaca ttaaaattac ctgtgctgtc
     4621 attctaaa
//
