LOCUS       NM_133502               2808 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 274 (ZNF274), transcript variant
            ZNF274c, mRNA.
ACCESSION   NM_133502
VERSION     NM_133502.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Langouet,M., Gorka,D., Orniacki,C., Dupont-Thibert,C.M.,
            Chung,M.S., Glatt-Deeley,H.R., Germain,N., Crandall,L.J.,
            Cotney,J.L., Stoddard,C.E., Lalande,M. and Chamberlain,S.J.
  TITLE     Specific ZNF274 binding interference at SNORD116 activates the
            maternal transcripts in Prader-Willi syndrome neurons
  JOURNAL   Hum Mol Genet 29 (19), 3285-3295 (2020)
   PUBMED   32977341
  REMARK    GeneRIF: Specific ZNF274 binding interference at SNORD116 activates
            the maternal transcripts in Prader-Willi syndrome neurons.
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   Valle-Garcia,D., Qadeer,Z.A., McHugh,D.S., Ghiraldini,F.G.,
            Chowdhury,A.H., Hasson,D., Dyer,M.A., Recillas-Targa,F. and
            Bernstein,E.
  TITLE     ATRX binds to atypical chromatin domains at the 3' exons of zinc
            finger genes to preserve H3K9me3 enrichment
  JOURNAL   Epigenetics 11 (6), 398-414 (2016)
   PUBMED   27029610
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Prokop,J.W., Rauscher,F.J. 3rd, Peng,H., Liu,Y., Araujo,F.C.,
            Watanabe,I., Reis,F.M. and Milsted,A.
  TITLE     MAS promoter regulation: a role for Sry and tyrosine nitration of
            the KRAB domain of ZNF274 as a feedback mechanism
  JOURNAL   Clin Sci (Lond) 126 (10), 727-738 (2014)
   PUBMED   24128372
  REMARK    GeneRIF: A proximal promoter construct for the MAS gene was
            repressed by the SOX [SRY (sex-determining region on the Y
            chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY
            is known to interact with the KRAB domain.
REFERENCE   5  (bases 1 to 2808)
  AUTHORS   Frietze,S., O'Geen,H., Blahnik,K.R., Jin,V.X. and Farnham,P.J.
  TITLE     ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends
            of ZNF genes
  JOURNAL   PLoS One 5 (12), e15082 (2010)
   PUBMED   21170338
  REMARK    GeneRIF: analysis of a KRAB domain-containing ZNF (ZNF274) that is
            involved in recruitment of the KAP1 and SETDB1 to specific regions
            of the human genome
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2808)
  AUTHORS   Sripathy,S.P., Stevens,J. and Schultz,D.C.
  TITLE     The KAP1 corepressor functions to coordinate the assembly of de
            novo HP1-demarcated microenvironments of heterochromatin required
            for KRAB zinc finger protein-mediated transcriptional repression
  JOURNAL   Mol Cell Biol 26 (22), 8623-8638 (2006)
   PUBMED   16954381
  REMARK    GeneRIF: KAP1 functions to coordinate activities that dynamically
            regulate changes in histone modifications and deposition of HP1 to
            establish a de novo microenvironment of heterochromatin, which is
            required for repression of gene transcription by KRAB-zfps.
REFERENCE   7  (bases 1 to 2808)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   8  (bases 1 to 2808)
  AUTHORS   Yano,K., Ueki,N., Oda,T., Seki,N., Masuho,Y. and Muramatsu,M.
  TITLE     Identification and characterization of human ZNF274 cDNA, which
            encodes a novel kruppel-type zinc-finger protein having nucleolar
            targeting ability
  JOURNAL   Genomics 65 (1), 75-80 (2000)
   PUBMED   10777669
REFERENCE   9  (bases 1 to 2808)
  AUTHORS   Casademunt,E., Carter,B.D., Benzel,I., Frade,J.M., Dechant,G. and
            Barde,Y.A.
  TITLE     The zinc finger protein NRIF interacts with the neurotrophin
            receptor p75(NTR) and participates in programmed cell death
  JOURNAL   EMBO J 18 (21), 6050-6061 (1999)
   PUBMED   10545116
REFERENCE   10 (bases 1 to 2808)
  AUTHORS   Petroni,D., Bartolini,E., Chiaramonte,R., Ottolenghi,S. and Comi,P.
  TITLE     Computer sequence analysis of human highly conserved zinc finger
            modules
  JOURNAL   DNA Seq 9 (3), 163-169 (1998)
   PUBMED   10520746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC366107.1, BC009763.2,
            AB029150.1 and CA942346.1.
            
            On Nov 22, 2018 this sequence version replaced NM_133502.2.
            
            Summary: This gene encodes a zinc finger protein containing five
            C2H2-type zinc finger domains, one or two Kruppel-associated box A
            (KRAB A) domains, and a leucine-rich domain. The encoded protein
            has been suggested to be a transcriptional repressor. It localizes
            predominantly to the nucleolus. Alternatively spliced transcript
            variants encoding different isoforms exist. These variants utilize
            alternative polyadenylation signals. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (ZNF274c) encodes the longest
            isoform (c). Isoform c contains two KRAB A domains.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.600798.1,
                                           SRR1803611.226983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617501.5/ ENSP00000484810.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               DC366107.1         73-540
            469-865             BC009763.2         68-464
            866-2800            AB029150.1         744-2678
            2801-2808           CA942346.1         507-514
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2808
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /note="zinc finger protein 274"
                     /db_xref="GeneID:10782"
                     /db_xref="HGNC:HGNC:13068"
                     /db_xref="MIM:605467"
     exon            1..382
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            383..460
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2389
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /note="isoform c is encoded by transcript variant ZNF274c;
                     KRAB zinc finger protein HFB101; zinc finger protein zfp2;
                     neurotrophin receptor-interacting factor homolog; zinc
                     finger protein with KRAB and SCAN domains 19"
                     /codon_start=1
                     /product="neurotrophin receptor-interacting factor homolog
                     isoform c"
                     /protein_id="NP_598009.1"
                     /db_xref="CCDS:CCDS74473.1"
                     /db_xref="GeneID:10782"
                     /db_xref="HGNC:HGNC:13068"
                     /db_xref="MIM:605467"
                     /translation="MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVML
                     ENYRNLVSVEHQLSKPDVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAE
                     SPLMNIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAA
                     RQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLR
                     TWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAI
                     CPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLEN
                     KELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEK
                     DLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRL
                     RKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCR
                     CSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQ
                     ECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKC
                     GKAFTQSSHLIGHQRTHNRTKRKKKQPTS"
     exon            461..587
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            588..683
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1166
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1279
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1406
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..2808
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2782..2787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="ZNF274"
                     /gene_synonym="HFB101; ZF2; ZKSCAN19; ZSCAN51"
                     /note="major polyA site"
ORIGIN      
        1 attccagcac ttccggcctg acccctgtcc agcgcctttc ctttctccag cttctgctct
       61 gccccaagag tggtcgcctt cgtggcaggg cacgactctc tcccagctcg ggtcgccgcc
      121 cacattagtg tggggccctg cggcctagcg tccctcacca gaggcctccc cttgcctagc
      181 tggaccgccg agggacatcg acgagtatcc tcctcctgct gtccccggct tcgcctgccg
      241 cccctaaccg gccagtcaag atggccgccg ctgggtgagg caagctggcg cgccgcgggg
      301 gcgtctggga gttgtagttc gggacggcgg gctgacgcac ttcgccgccg gccgacgggc
      361 gccattgtgc ggcgcgcgcc gggactctgc ccacttccac cagagacaca ttgagaagga
      421 ggaaactatg gcctccaggc ttccgacggc ctggtcctgt gaaccagtga cctttgaaga
      481 tgtaacactg ggttttaccc cggaagagtg gggactgctg gacctcaaac agaagtccct
      541 gtacagggaa gtgatgctgg agaactacag gaacctggtc tcagtggaac atcagctttc
      601 caaaccagat gtggtatctc agttagagga ggcagaagat ttctggccag tggagagagg
      661 aattcctcaa gacaccattc cagagtatcc tgagctccag ctggacccta aattggatcc
      721 tcttcctgct gagagtcccc taatgaacat tgaggttgtt gaggtcctca cactgaacca
      781 ggaggtggct ggtccccgga atgcccagat ccaggcccta tatgctgaag atggaagcct
      841 gagtgcagat gcccccagtg agcaggtcca acagcagggc aagcatccag gtgaccctga
      901 ggccgcgcgc cagaggttcc ggcagttccg ttataaggac atgacaggtc cccgggaggc
      961 cctggaccag ctccgagagc tgtgtcacca gtggctacag cctaaggcac gctccaagga
     1021 gcagatcctg gagctgctgg tgctggagca gttcctaggt gcactgcctg tgaagctccg
     1081 gacatgggtg gaatcgcagc acccagagaa ctgccaagag gtggtggccc tggtagaggg
     1141 tgtgacctgg atgtctgagg aggaagtact tcctgcagga caacctgccg agggcaccac
     1201 ctgctgcctc gaggtcactg cccagcagga ggagaagcag gaggatgcag ccatctgccc
     1261 agtgacagtg ctccctgagg agccagtgac cttccaggat gtggctgtgg acttcagccg
     1321 ggaggagtgg gggctgctgg gcccgacaca gaggaccgag taccgcgatg tgatgctgga
     1381 gacctttggg cacctggtct ctgtggggtg ggagactaca ctggaaaata aagagttagc
     1441 tccaaattct gacattcctg aggaagaacc agcccccagc ctgaaagtac aagaatcctc
     1501 aagggattgt gccttgtcct ctacattaga agataccttg cagggtgggg tccaggaagt
     1561 ccaagacaca gtgttgaagc agatggagtc tgctcaggaa aaagaccttc ctcagaagaa
     1621 gcactttgac aaccgtgagt cccaggcaaa cagtggtgct cttgacacaa accaagtttc
     1681 gctccagaaa attgacaacc ctgagtccca ggcaaacagt ggcgctcttg acacaaacca
     1741 agttttgctc cacaaaattc ctcctagaaa acgattgcgc aaacgtgact cacaagttaa
     1801 aagtatgaaa cataattcac gtgtaaaaat tcatcagaag agctgtgaaa ggcaaaaggc
     1861 caaggaaggc aatggttgta ggaaaacctt cagtcggagt actaaacaga ttacgtttat
     1921 aagaattcac aaggggagcc aagtttgccg atgcagtgaa tgtggtaaaa tattccggaa
     1981 cccaagatac ttttctgtgc ataagaaaat ccataccgga gagaggccct atgtgtgtca
     2041 agactgtggg aaaggatttg ttcagagctc ttccctcaca cagcatcaga gagttcattc
     2101 tggagagaga ccatttgaat gtcaggagtg tgggaggacc ttcaatgatc gctcagccat
     2161 ctcccagcac ctgaggactc acactggcgc taagccctac aagtgtcagg actgtggaaa
     2221 agccttccgc cagagctccc acctcatcag acatcagagg actcacaccg gggagcgccc
     2281 atatgcatgc aacaaatgtg gaaaggcctt cacccagagc tcacacctta ttgggcacca
     2341 gagaacccac aataggacaa agcgaaagaa gaaacagcct acctcatagc tctcaagcca
     2401 gttgaagaaa ccttgccttt tcagcttgac cctgcaatat aacatgcaca ggcctgcttg
     2461 tgaatcagga ctgaatgtga aagggaagta ttgagtgagg acattcccaa aaccaaagga
     2521 caactgagga gactgcccag cacataatga ataaataaga aaatgagtga ggagttatta
     2581 acatcatttg gaaaaaagat ttcccattca cttgatattg tttgttcact catttagtca
     2641 ttaaaagtga gattaataaa atctgaaaat gttatataat aactttaaaa agccaggtaa
     2701 ttaataatct gcactgatat tacatccaca gtaccacagt atttatgtgt atgaattaag
     2761 gattaaaaga taatgtggat aaataaacta ttgatctatg tctgtgta
//
