LOCUS       NM_021148               3698 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 273 (ZNF273), transcript variant
            1, mRNA.
ACCESSION   NM_021148
VERSION     NM_021148.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3698)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 3698)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092161.3.
            
            On Jul 24, 2020 this sequence version replaced NM_021148.2.
            
            Summary: This gene is a member of the krueppel C2H2-type
            zinc-finger protein family and encodes a protein with 13 C2H2-type
            zinc fingers and a KRAB domain. This nuclear protein is involved in
            transcriptional regulation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2836827.1,
                                           SRR14038192.2402875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000476120.2/ ENSP00000418719.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC092161.3         13036-13182
            148-274             AC092161.3         27344-27470
            275-370             AC092161.3         27960-28055
            371-3698            AC092161.3         37417-40744
FEATURES             Location/Qualifiers
     source          1..3698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..3698
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="zinc finger protein 273"
                     /db_xref="GeneID:10793"
                     /db_xref="HGNC:HGNC:13067"
                     /db_xref="MIM:604756"
     exon            1..147
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1755
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 9; zinc finger protein HZF9"
                     /codon_start=1
                     /product="zinc finger protein 273 isoform 1"
                     /protein_id="NP_066971.2"
                     /db_xref="CCDS:CCDS5528.2"
                     /db_xref="GeneID:10793"
                     /db_xref="HGNC:HGNC:13067"
                     /db_xref="MIM:604756"
                     /translation="MSSAPRGPPSVAPLPAGIGRSTAKTPGLPGSLEMGPLTFRDVAI
                     EFSLEEWQCLDTSQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQGKEPCNMKRHA
                     MVAKPPVVCSHFAQDLWPKQGLKDSFQKVILRRYGKYGHENLQLRKGCKSADEHKVHK
                     RGYNGLNQCLTTTQSKIFQCDKYVKVLHKFSNSNIHKKRQTGKKPFKCKECGKSCCIL
                     SQLTQHKKTATRVNFYKCKTCGKAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQSLT
                     LTKHKKIHTEEKPYKCEDCGKVFSVFSVLTKHKIIHTGTKPYNCEECGKGFSIFSTLT
                     KHKIIHTGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSTLTRH
                     KIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYTKEKPYKCEECGKAFSVFSTLTKHKI
                     IHTGAKPYKCEECGSAFRAFSTLTEHKRVHTGEKPYKCNECGKAFNWSSTLTKHKRIH
                     TGEKPYKCEECGKAFNRSSNLTRHKKIHTGEKPYKPKRCDSAFDNTPNFSRHKRNHMG
                     EKS"
     exon            148..274
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /inference="alignment:Splign:2.1.0"
     exon            275..370
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /inference="alignment:Splign:2.1.0"
     exon            371..3698
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="hexamer: AATAAA"
     polyA_site      1974
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="major polyA site"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="hexamer: ATTACA"
     regulatory      3669..3674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="hexamer: AATAAA"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
                     /note="hexamer: AATACA"
     polyA_site      3681
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
     polyA_site      3690
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
     polyA_site      3698
                     /gene="ZNF273"
                     /gene_synonym="HZF9"
ORIGIN      
        1 gtctctcgct gcagtcgcag ctccaggtct cgtcttcact gctctatgtc ctctgctcct
       61 agaggtccac cttctgtggc cccgttacct gcaggtattg ggagatccac agctaagacg
      121 ccaggactcc ctggaagcct agaaatggga ccactgacat ttagggatgt ggccatagaa
      181 ttctctctgg aggagtggca atgcctggac acttcacagc agaatttgta taggaatgtg
      241 atgttagata actacagaaa cctggtcttc ctgggtattg ctgtctctaa gccagacctg
      301 atcacttgtc tggagcaagg aaaagagccc tgcaatatga agagacatgc gatggtagcc
      361 aaacccccag ttgtgtgttc tcattttgcc caagaccttt ggccaaagca gggcttaaaa
      421 gattcttttc aaaaagtgat actgagaaga tatggaaaat atggacatga gaatttacaa
      481 ttaagaaaag gctgtaaaag tgcggatgag cataaggtgc acaaaagagg ttataatgga
      541 cttaaccaat gtttgacaac tacccagagc aaaatatttc aatgtgataa atatgttaaa
      601 gtccttcata aattctcaaa ttcaaatata cataagaaaa gacaaactgg aaagaaacct
      661 ttcaaatgta aagaatgtgg caaatcatgt tgcatacttt cacaactaac tcagcataag
      721 aaaactgcta ctagagtgaa tttctacaaa tgtaagacat gtggaaaagc ctttaaccag
      781 ttctcaaatc ttactaaaca taagataatt catcctgaag tgaatcccta caaatgtgaa
      841 gaatgtggca aagcctttaa ccagtcctta actcttacta aacataaaaa aattcatact
      901 gaagagaaac cttacaaatg tgaagattgt ggcaaagtct ttagtgtatt ttcagtcctt
      961 actaaacata agataattca tacaggaaca aaaccctaca attgtgaaga atgtggcaaa
     1021 ggctttagta tattctcaac ccttactaaa cataagataa ttcatactgg agagaaaccc
     1081 tacaaatgca atgaatgtgg taaagccttt aactggtcct caactcttac taaacataag
     1141 agaattcata ctggagagaa accctacaaa tgtgaagaat gtggcaaagc ttttaaccag
     1201 tcctcaaccc ttactagaca taagatagtt catactggag agaaacccta caaatgtgaa
     1261 gaatgtggta aagcctttaa acggtccaca actcttacta aacataagag aatttatact
     1321 aaagagaaac catacaaatg tgaagaatgt ggaaaagcct ttagtgtatt ctcaaccctt
     1381 actaaacata agataattca tactggagca aaaccttaca aatgtgaaga atgtggcagt
     1441 gcctttaggg cattctcaac ccttactgaa cataagagag ttcatactgg agagaaacct
     1501 tacaaatgca atgaatgtgg taaagccttt aactggtcct caactcttac taaacataag
     1561 agaattcata ctggagagaa gccctacaaa tgtgaagaat gtggcaaagc ttttaaccgg
     1621 tcctcaaacc ttactcgaca taagaaaatt catactggag agaaaccata caaacctaaa
     1681 agatgtgaca gtgcttttga caacacccca aacttttcta gacataaaag aaatcatatg
     1741 ggtgagaaat cctagaaatg tgaagaatgt gacaaagcct ttaagcggtt gtcacacttg
     1801 attgtatata agataattca tactggagaa aactcccaga agtggagttt tccttattgc
     1861 acaggaaagc atttatactt gagaaaaatt gtataaagaa tggaaaagtc attaatatct
     1921 gctcatatct taacatcagc gagttggtat ttaataaaag cattatcaat gaaattactg
     1981 tcaaaagatc tttcagacaa tataagcctg caaagtgcag cagagtattt attttgaaga
     2041 gaaacattaa aagtacaaag aggtttgtag tacctttgtt tgtatcatag atcttattgt
     2101 acacattttg taccagagaa aaaccctgaa gcagttgttc aaactttgtt caataccagg
     2161 aaatttatat tggagaaaaa ccctatgagt gtaatgaatt tggaaaaata tttttttcaa
     2221 caacagctta gaaaacatgg gaggaattac actaaaatat atttttgcaa atgcagcagt
     2281 aaatatgaaa gaaatgatcc aaagttaggt ttatataaat atcagagaat tcacaataca
     2341 gatatctaag atactgacac ttcagacatt acacaaaatc agagtgctga gtacagaaag
     2401 ttatccaaaa caaaagttgg tagataacta atagtgaaca agtttttggc agaggtatat
     2461 ttacattcag agtacacttt tctttggaaa aaattacagg ttttttgaaa agtgaataat
     2521 gtaattcaac tctcaaattc atggtttttt tttttttggt tttggttttg ggttttttgt
     2581 ttgtttgttt gtttgttttt gagacggagt ttcactcttg ttgcccaggc tggagtgcaa
     2641 tggcgtgatc tcagctcacc gcaacctctg cctcccagat tcaagcaatt ctcctgcctc
     2701 agcctcccta gtagctggga ttacaggcat gtgccacacc tggctaattt ttgtggtttt
     2761 agtagagaca gggtttctcc atgttggtca gtctggtctc aaactcccaa cctcaggtga
     2821 tatgcccgcc tcggcctccc aaaatgttgg gattacaggc atgagccact gcacccggcg
     2881 catgtttttt cttcattcct attgtattca catgtgaaag catgtgatca acttgctgca
     2941 tcaaagatat gagatttttt tttttattag gtgggcatta tttatgacct tttctgtgga
     3001 agagtaagaa cattaaaatg aaagatgcat gatgaaaatc taagtagaga ggctcttgtg
     3061 gttaactgat aatattgagt gatgcatgag gtaggtgttc agagtaatat tctgcattat
     3121 agtgaaaaat ttttaatatt aaaattcaat tatatcattt tatgaattgt gcttttcata
     3181 atgcagtaca tttcaaaatt tttagattat gtatgaactt agatttttaa acatgtttta
     3241 acatgttaag acttgtgcat tcagtgaagc gttattatgc cacaaactaa cctacctcac
     3301 cttactcaat ggtgtaggta aaagatgata gcaatatatt atttggttac atagtggact
     3361 aacattttta gtaatctctt ttgccagtgg ctttaaactg cagataagtt aaatattccc
     3421 ataggtttta catttatatt ttttcttatt taaatttatt gttcttattt ttcatgggta
     3481 catagtatgt ttttatgctg tatatggcat gttttgatac aggtatataa tatgtaataa
     3541 tcacatcagg gtaaatgagg tatcccttac tagcatttat cctttgtatt ttattttaaa
     3601 atgtacaact aaattgttat ggactacagg gttattttta tggtcataat aaaaattaca
     3661 aaagtatgaa taaaatacat acatttctga gtcctgaa
//
