LOCUS       NM_003415              13390 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 268 (ZNF268), transcript variant
            1, mRNA.
ACCESSION   NM_003415
VERSION     NM_003415.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13390)
  AUTHORS   Liu,Y., Yin,W., Wang,J., Lei,Y., Sun,G., Li,W., Huang,Z. and Guo,M.
  TITLE     KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
            Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
            Assembly
  JOURNAL   Cells 8 (12), 1604 (2019)
   PUBMED   31835635
  REMARK    GeneRIF: KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
            Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
            Assembly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13390)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
  REMARK    GeneRIF: The nuclear localization activity of KRAB domain is a
            conserved feature of ZNF268.
REFERENCE   3  (bases 1 to 13390)
  AUTHORS   Hu,L., Wang,W., Cai,J., Luo,J., Huang,Y., Xiong,S., Li,W. and
            Guo,M.
  TITLE     Aberrant expression of ZNF268 alters the growth and migration of
            ovarian cancer cells
  JOURNAL   Oncol Lett 6 (1), 49-54 (2013)
   PUBMED   23946776
REFERENCE   4  (bases 1 to 13390)
  AUTHORS   Wang,W., Guo,M., Hu,L., Cai,J., Zeng,Y., Luo,J., Shu,Z., Li,W. and
            Huang,Z.
  TITLE     The zinc finger protein ZNF268 is overexpressed in human cervical
            cancer and contributes to tumorigenesis via enhancing NF-kappaB
            signaling
  JOURNAL   J Biol Chem 287 (51), 42856-42866 (2012)
   PUBMED   23091055
  REMARK    GeneRIF: These results reveal a novel role of ZNF268b2 that
            contributes to cervical carcinogenesis in part through enhancing
            NF-kappaB signaling.
REFERENCE   5  (bases 1 to 13390)
  AUTHORS   Zeng,Y., Wang,W., Ma,J., Wang,X., Guo,M. and Li,W.
  TITLE     Knockdown of ZNF268, which is transcriptionally downregulated by
            GATA-1, promotes proliferation of K562 cells
  JOURNAL   PLoS One 7 (1), e29518 (2012)
   PUBMED   22235304
  REMARK    GeneRIF: ZNF268 is a crucial downstream target and effector of
            GATA-1
REFERENCE   6  (bases 1 to 13390)
  AUTHORS   Sun,C., Zhao,Z.Z., Gao,L., Sun,Y., Shao,H.J. and Li,W.X.
  TITLE     [Cloning and characterization of two novel alternatively spliced
            transcripts of ZNF268]
  JOURNAL   Yi Chuan 28 (5), 513-517 (2006)
   PUBMED   16735226
  REMARK    GeneRIF: 4 alternative transcripts of ZNF268 were detected in the
            human blood cells.
REFERENCE   7  (bases 1 to 13390)
  AUTHORS   Sun,Y., Shao,H., Li,Z., Liu,J., Gao,L., Peng,X., Meng,Y. and Li,W.
  TITLE     ZNF268, a novel kruppel-like zinc finger protein, is implicated in
            early human liver development
  JOURNAL   Int J Mol Med 14 (6), 971-975 (2004)
   PUBMED   15547661
  REMARK    GeneRIF: ZNF268 plays a role in early human liver development most
            likely by functioning through a cytoplasmic mechanism
REFERENCE   8  (bases 1 to 13390)
  AUTHORS   Sun,Y., Gou,D.M., Liu,H., Peng,X. and Li,W.X.
  TITLE     The KRAB domain of zinc finger gene ZNF268: a potential
            transcriptional repressor
  JOURNAL   IUBMB Life 55 (3), 127-131 (2003)
   PUBMED   12822888
  REMARK    GeneRIF: This protein has a conserved KRAB domain which localizes
            to the nucleus and has transcriptional repressor activity.
REFERENCE   9  (bases 1 to 13390)
  AUTHORS   Gou,D.M., Sun,Y., Gao,L., Chow,L.M., Huang,J., Feng,Y.D.,
            Jiang,D.H. and Li,W.X.
  TITLE     Cloning and characterization of a novel Kruppel-like zinc finger
            gene, ZNF268, expressed in early human embryo
  JOURNAL   Biochim Biophys Acta 1518 (3), 306-310 (2001)
   PUBMED   11311945
REFERENCE   10 (bases 1 to 13390)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF317549.1, AC226150.5 and KF455750.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003415.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.187240.1,
                                           SRR1660805.15153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536435.7/ ENSP00000444412.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3205              AF317549.1         87-3291
            3206-7040           AC226150.5         28292-32126         c
            7041-7394           KF455750.1         1-354
            7395-13390          AC226150.5         21942-27937         c
FEATURES             Location/Qualifiers
     source          1..13390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..13390
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="zinc finger protein 268"
                     /db_xref="GeneID:10795"
                     /db_xref="HGNC:HGNC:13061"
                     /db_xref="MIM:604753"
     exon            1..192
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..277
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3088
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 3; zinc finger protein HZF3"
                     /codon_start=1
                     /product="zinc finger protein 268 isoform a"
                     /protein_id="NP_003406.1"
                     /db_xref="CCDS:CCDS45012.1"
                     /db_xref="GeneID:10795"
                     /db_xref="HGNC:HGNC:13061"
                     /db_xref="MIM:604753"
                     /translation="MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQP
                     LPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQ
                     KCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDD
                     LMDWHQENKDKLGSTAKSFECTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSD
                     YARNNPNGFQVHGKSFFHSKHEQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPF
                     GCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHEC
                     SECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQLVSHQKTHSGQKPYVCNE
                     CGKAFGLKSQLIIHERIHTGEKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCG
                     KAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKA
                     FRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFS
                     RKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKAFNTK
                     SNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQ
                     LIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLI
                     VHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIH
                     MRTHSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQCEKSFSGKLRLLVHQR
                     MHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKTFSQKSILSAHQRTH
                     TGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH"
     exon            278..478
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..605
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..701
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..13390
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3656..3661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      3684
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="major polyA site"
     regulatory      4620..4625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATACA"
     polyA_site      4645
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="major polyA site"
     regulatory      5456..5461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      5474
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
     regulatory      9719..9724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      9738
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
     regulatory      13367..13372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      13390
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
ORIGIN      
        1 atacgtagcg gccgccattg ttccgcgccg atggcgagat ccttgttcct cagatagcgt
       61 tcatcgcccg tcgtggtcaa cgggccagcc gagtctggag tggttgcgaa cccttctggc
      121 tgcagatctg gaggtggagg cagtaccctg gactctattc tgctgcccct tcagggtttg
      181 gaggagccgg agcatccctc gcgtcctgtc acttccagcg aggcacacaa aactgaccgt
      241 agggatggcc accagggtcc ggacagcttc tatttgggtc ccacctctcc aagaacgaaa
      301 cagttcatgg gataggatca gaaagctcca aggtcaggaa tccatcttgg gccaagggac
      361 tcctggtctg caacctctcc ctggaacacc caggcagaag cagaagagtc gcagaataga
      421 gaaagtccta gagtggctgt ttatttccca agagcagcca aaaatcacca agtcctgggg
      481 acctttgtca ttcatggatg tgtttgtgga ttttacctgg gaggagtggc agctgctaga
      541 cccagcacag aagtgcctgt acaggagtgt gatgttggag aactatagca acctggtgtc
      601 cctagggtac caacacacca aacctgatat catcttcaag ttggaacaag gagaagagct
      661 gtgtatggtg caggcccaag ttccaaatca gacctgtcca aacacagtct ggaaaattga
      721 tgatcttatg gattggcatc aggaaaataa agacaagctg ggaagtacgg caaaaagctt
      781 tgaatgcact acatttggaa aactatgtct tcttagtaca aagtatcttt caagacaaaa
      841 acctcataaa tgtggcacgc atggaaagag tttgaaatat atagatttca ctagtgatta
      901 tgctagaaat aatcctaatg ggtttcaggt acatggaaaa tcattcttcc attctaaaca
      961 tgagcaaact gttattggaa taaaatactg tgaaagtatt gaatctggaa aaaccgtcaa
     1021 taagaaatcg caacttatgt gccaacaaat gtatatgggc gaaaaaccct ttggatgcag
     1081 ctgttgtgag aaagccttca gcagcaagtc ataccttcta gtgcatcagc aaactcatgc
     1141 cgaagagaaa ccctatggtt gtaatgaatg tgggaaagac ttcagtagta aatcatacct
     1201 cattgtacat cagagaattc atacaggaga gaaactacat gaatgcagtg aatgcaggaa
     1261 aacattcagt ttccattcac agcttgttat acatcagaga attcacacag gtgagaatcc
     1321 ctatgagtgc tgtgaatgtg ggaaagtctt cagtaggaaa gaccagcttg tttcacacca
     1381 gaaaactcat tcaggacaga aaccatatgt gtgtaatgaa tgtgggaaag cttttggttt
     1441 aaaatcacag ctcattatac atgaaagaat tcatacagga gagaaaccat atgaatgcaa
     1501 tgaatgtcag aaagccttta atacaaagtc aaaccttatg gtacatcaga gaacccatac
     1561 aggggagaaa ccttatgttt gtagtgattg tggaaaagcc tttacattca agtcacagct
     1621 cattgtacat caggggattc acacaggagt aaagccctat gggtgtattc agtgtggtaa
     1681 aggattcagt ttgaaatcac agctcattgt acatcagaga agtcacacag gaatgaaacc
     1741 ttatgtatgc aatgaatgtg gcaaagcctt caggagcaag tcatacctta ttatacatac
     1801 aaggactcat acaggagaaa aactccatga atgcaacaat tgtgggaaag ccttcagttt
     1861 taaatcacag ctcattatac atcagaggat tcatacagga gagaacccct atgaatgcca
     1921 tgaatgtggg aaagccttca gtcggaaata ccagcttatt tcacaccaga gaactcatgc
     1981 aggagagaag ccttatgaat gcaccgactg tggaaaggct tttggtttaa agtcacagct
     2041 tattatacac cagagaactc atacagggga gaaaccattt gaatgtagtg agtgtcagaa
     2101 agcctttaat acaaagtcaa acctgattgt acatcagaga actcatacag gagagaaacc
     2161 ctatagttgt aatgaatgtg gaaaagcctt tacgttcaaa tcacagctca ttgtacataa
     2221 aggagtgcac actggagtaa aaccctatgg atgcagtcaa tgtgcaaaaa cctttagttt
     2281 gaagtcccag ctcattgtac atcagagaag tcacacagga gtaaaaccat atggatgcag
     2341 tgagtgtggg aaagccttca ggagcaagtc ataccttatt atacatatga gaactcatac
     2401 aggagagaaa ccacatgagt gcagggaatg cgggaaatcc tttagtttca attcacaact
     2461 cattgtgcat cagagaattc acacaggaga aaatccctat gaatgcagtg aatgtgggaa
     2521 agcctttaat aggaaagacc agctcatttc acatcagcga actcatgcag gggaaaagcc
     2581 ttatgggtgc agtgaatgtg ggaaagcttt tagcagcaag tcatacctaa ttatacacat
     2641 gagaactcat tcaggtgaaa aaccatatga atgtaatgaa tgtgggaaag ccttcatttg
     2701 gaaatcacta ctcattgtac atgagcgaac tcatgcaggg gtcaaccctt ataaatgcag
     2761 tcaatgtgag aaatccttca gtgggaaatt acgccttctt gtacaccaga gaatgcacac
     2821 aagagagaaa ccatatgaat gcagtgagtg tggaaaagcc ttcattagga attctcaact
     2881 cattgtacat caaagaactc attcaggaga gaaaccctat gggtgcaatg aatgtgggaa
     2941 aaccttctct caaaaatcaa ttctcagtgc acatcagaga acacatacag gagagaagcc
     3001 ttgtaagtgc actgaatgtg ggaaagcctt ttgttggaag tcacagctca ttatgcatca
     3061 gagaactcat gtagatgaca aacattgata attttacgaa actctgaaaa gtggattcac
     3121 aagagataga aacaatcata tataaagaga aactctgtaa gtggaatcat cttgtcatct
     3181 tccagaaaac tcatactgaa tagaaacttt atgaatgcac agcatatgga aaggcatcca
     3241 cagaaagctg ttctttacat gcaaaaagat agtagacaat acacaggaaa actgaattta
     3301 gtaaccactc tgaaaatttt tagcagcaag tcataccttt ttttaaaaag ttcatacagg
     3361 tgaggaacca tgttaaacgt tgtaaagtca ttttactaaa ataagattca caaagaggaa
     3421 acttcatgaa ccagatgaat atagaataga cttctttgaa attcatagtt tacagaattt
     3481 taatgagaga aattattgag ctaatgaatg gcagaattaa caaaattaca aacattttat
     3541 gtatcggaag catatacctt ggagggacca tgctataagg gaaagtgtaa atctagaaat
     3601 gagaaacccc tagggaaaaa atatatatag gagtgaacat cttatgaatg taccaaataa
     3661 accacagctg gactgttaac ctcaccttag aagcttcatt ctaaaaaaaa aaaaaaaaaa
     3721 aaaaaaaaaa accaacctgt tattatatct taatattaat tttgaagaat tatttctttt
     3781 aggaatcatt ttaagaaatt ttattccagg tgttccaaaa tttcaggaaa aggtttgaga
     3841 aaattctcaa ttataaataa taagatacag attatttcat tgtacaagtg aatctagtaa
     3901 ggaggttaag aataagaaat aacatcccag agcctacagg gatatttaga tatcttccta
     3961 tgtgtactac ataatatgaa ttttgcagtt tggcatttta cttgcgaatg ccatatgtga
     4021 gacaaaaatc atcttccaga gatttcagta tctctgatac tgacaatatc tctgatatga
     4081 caatatcatc ttccagagat ttctactctg cataccaaca ttgtttcttt gtgtcttacc
     4141 aaatgcaact tgttactaga atatgactta ctaaaaatgc atttccacac tgcaaacatt
     4201 ttttagggct atcttctgcc ctttggaagc agtcttggca gcaacctctt tagtaatcaa
     4261 tataaggcac acttcatgtg tttgtgtagc ctggaatcta ttctaccttc acaggttaga
     4321 acatcttgat ttcctcttaa cgaaacattc cctaacggtg tatgtagtca tgagggaacc
     4381 accattcaag atgccctgct caggacttgg catgagcact atggtcagct gaggctcaga
     4441 actgtacatt gttaatgggt ttttcaagtt cagaaaagca acatgagctt ttgttctgtg
     4501 gtagcatgtt gatgtaataa gtagctattt caatagaggt tcccagaaca gcttttgtta
     4561 ctgtcatttt cttaactttg ttcacttgtc ttttattttg agctattggg tgtgctttta
     4621 atacattcct tgtttgattg cattagccat tgtgtatctt ttgcatacag cttactaaat
     4681 cagatggctt cagaaatggg tggtagagga gtaggcagaa acttgcaagg atatgtggat
     4741 atttggaaat ggttgtttcc caagacagga tggaagtctt ttaagcaaga aacttggccc
     4801 atgctatgaa gtcatgaaat gaattgttgg catcatgtgc tcactgaggc tttggggaaa
     4861 tggataagtt gtcattgaaa aattttaaac agaattctgg agtggtcaag aggggaatgc
     4921 ttttgatacc catgtataac atggagaata atgatcttaa aacttcaatt taagattatg
     4981 tgtcagtgat actacttagt tacatgtagc tatagagtca cagtggtgaa aaactctgcc
     5041 agttgcttac tcacaaagtt agttttcttc actacctcat caggtttgtt atgtgagtgg
     5101 gcattaatct gggaagagtg ggaccctgcc agttagatta gggctatctt ggaggaatat
     5161 gcggattcaa tactgcaaat atttctgaaa caccttctgc tttgtactct attagatacc
     5221 caaagaaatt ttcatccttg aagcggagga atttaatgat acctgaatgc ctaactgttg
     5281 tattctgctt atacagaatc caatctcaag atacttgggg tgaagaatga tgattcacag
     5341 aagggaaggg acatcttaca taaacaaata atcgcagata cttgctaaag tgtatccccc
     5401 aatctgggaa atactgtaaa ggtgtatatt attattgatg taccaaagaa gacagaataa
     5461 attcataaga gaaagtttat attcagttta ctactaccta gggttagatt ttagtttgtt
     5521 gttttttcag atgcaaatct acatgcagcc ttgcctggta gaagccagaa gtgttgacag
     5581 tattgaggac agcactcaca tactgtggga aagaataata cttgattagg acttattatt
     5641 taatgaaatg aaaattttac aaaacagaaa ttgagttact ggtttgtaaa tctatctagt
     5701 ccttctaccc cagccccaga aaagaaagac attccagaga cttttcagga atagttatta
     5761 taaggaaaat ccaaggaaaa ataaccccaa tattttacaa cttccccatc aaatagaaat
     5821 ttaggagaaa aaatgacttg caaaccatat ttgtgaacat aggtttaaaa atccatattt
     5881 gtgaacatag gtttaaaaat ccatatttgt gaacataggt ttaaaaattc taaatggaat
     5941 tatagcaaac caatgtatag ctaacaagaa agtcatgata ttaggtttaa cagactatta
     6001 gtggatccag catcctttgt tcattaccag cagaatcact attatttata atggcagtat
     6061 gcccacttaa aaagagatat atggggccag gcacggtggc tcacacctat aatcccagca
     6121 cttcaggagg ctgagatggt ggatcacctg aggtcaggag tttgagacca gcctggccaa
     6181 catggtgaaa cccctctcta ctaaaaatac aaaaaaatag cagggcatgg taactgacac
     6241 ctataatccc agctacttgg gaggctggga cgggagaatc acttgaatct aggaggcgga
     6301 agttgcagtg agctgagatc gtaccactgt actccaccct gggtgacaga actagaccct
     6361 gtctcaaaaa acagaagagt atgtttggaa gatttaatat tagaaaatat tttaattaac
     6421 taccagataa aactcataag gattatctca gtatatgctg ataaatcact tgatggaatt
     6481 taacacccat agatgacact aaaatactat taagttggga attaaaatta actcctgtaa
     6541 cttggtaggg aatatatgtt ctgaaaacac aaatgtcata cttaatgata aaatagtaga
     6601 aagattcctt taaagtaaaa ttagccaggt gcagtggctc atccatgtaa taccagcact
     6661 tgggaaggct gaggctggag gattgctgga acccaggagt tcgagacaag cctgaccaat
     6721 atagggagac cctgtctgta caaaaacttt ttaaaaagat tagccaggtg tggtcaggcg
     6781 ccgtggctca tgcctgtaat cccagcactt tgggaggccg aggtgggcag atcacttgag
     6841 gtcaggattt caagaccagt gtggctaaca tggtgaaacc ccgtctctac taaaaataca
     6901 aaagtcagcc aggtgtggtg gcacgtgcct gtaatcccat ctactcggga ggctgaggca
     6961 gaagaattgc ttgaacctag gaggtggcag ttgcagtgag ccaagattgc accactgcac
     7021 tccaggctgg gcgacagaac aagcctccat ctcaaaaaaa agatcagcca ggtgtagtgg
     7081 caagtgccgg tagtcccacc tactgaggag gctgaggcag gaggttagct tgagtccagt
     7141 agttcaaggc tacagtgagc tatgatcatg cccctgcact ccatcctggg caacaaagtg
     7201 agaccctgtc tgtaaaaaac aaagcaaaat tacaagaatg cgcatcactt ttatgaaatg
     7261 agtaacatct agccaaggtg tgaaaacaag gaatgtgagg aattagggat gggtgcagaa
     7321 acaactgcca tgaattggag atgtgatcgt gtaattagga aacccaaaat aaaccacaaa
     7381 caaatgtttg gaactgccag tagagtagca agtatgcagt tgtcagtatt catggaggac
     7441 ccccccgcaa ccacagatac tccctgtgga tgctcaagct ccttatatgg catagtattt
     7501 gcattttttt tttttttttt gagatggagt ctcgctgtat tgccaggctg gagtgcagtg
     7561 gtgtgttctt ggctcactgc aacctctgcc tcctgggttc aagcaattct cctgcctcag
     7621 cctccctagt agctggaatt acaggcacac gccaccacgc ccagctaatt tttgtgtttt
     7681 tagtagagat ggggtttcac catgttggcc aggctggtct tgaactcctg acctcgtgat
     7741 ccaccctcag cctcccaaag tgctgggatt acaggtgtga gccactggtc tgtattgatt
     7801 tttcttaatt ctttgctaaa gggccaggta gagttattta tttcttgtag agatggggtt
     7861 ttaccatgtt ttccagtctg gtttcaaact cctgggctca agcagtccac ctgccttggc
     7921 ctcccaaagt gctaggatta caggtgtgag ccaagcaccc agccataaat cttaaataaa
     7981 ttctgatttt ggtataaatg atatatttaa atttaaatga agttgcaagt tttaacatgt
     8041 ctactcttta attttcaaca ttgtttcaac tacttgttag aaacacaggc cattaaaaca
     8101 ttaataaaaa ggctgggcat ggtggctcat gcctgtaatc tcagcatttt gtgaggctga
     8161 ggcaggtgga tgacttgagg tcaggagttc gagaccagcc tggtgaaacc ccgtctctac
     8221 taaaaataca aaaattggcc agctgtggtg gcatgcatct ataatccaag ctactcagga
     8281 gaattgcttg aactggagag gcggaggttg cagtgagctg agattgtgcc attgcactcc
     8341 agcccgggca gcagagtgag actccttcaa aaaaaattaa taaaagcaag cacatagggt
     8401 gcacatttgc ccttccctct tgggatccag ggtgatccca caggtgctgt tcatccccaa
     8461 ctttgacctg gactgttgca gtgttttgtc gcagtgtttc tccctttttt tgtactggga
     8521 tttctcccca gaaacaaacc catatgtata aaaagtagtt gggcttgcta taaagatgac
     8581 tagtggaaac ctcaatagag gtacgatttc ctaaaataaa tcttgttcag atattacagg
     8641 gcaaagtgaa acagcaaagc tccctcctca gcactcaggg tgcaggcctc acttttcctc
     8701 atcttttcct cctgtggcct ccatgtatcc caaaggtgag atgacatcgc cccagattgg
     8761 tccggaaagt gcactggtcg tcactgtggg tgtaccctac aggagtcttc agatatggaa
     8821 gctctggatc tcactgtgat gtatccccct agggggtccc caggttgtga ggaaaaggaa
     8881 gctttagtcc tcactgtggt tgcatccccc accacgggtc agtcctgagg aggatactct
     8941 ggtcatcact gtgatctacc tcccaggggt ccccaggttg gtcctgagga gaaggaagct
     9001 cagaacctca ctgtggattt gccccactag ggtccctagg tcagtcctga agagaaacaa
     9061 gctccagtct tcactgtggt tgtgccccac agtggtcctc aggttggcca gtggagaagg
     9121 aagctctggt tctcagtgtg atgcatcccc caggttggtc ctgagatgag gtaaattctg
     9181 gtcatcactg tgaagtgccc tcgggggtct ccgggtcctg agtagaagca aggtctgttt
     9241 gtcactgtgg attcccccct gccaagggtc cccaggtcag tcctgaggag aaggcagctc
     9301 agtctttact gtgatgcagc ctctagtgat ccccaggtcc tgagtagaag gaaggcctgg
     9361 tcctctgtgg attcaaccca gaggtctgtg agcagaatgc aggtactgca agcaggctag
     9421 acaaggtgtg tgcttgcacc ccttccttac tacctaggca cagtgttgga tggtcagtgc
     9481 ttcctgtttt gtgatggcca tgtgccccct cttgcagtcc cagtgaaccc ctgaaattca
     9541 atcttacgat tttccatgcc ataattttgg aaaacgaaac tgaaatagag tccatcattc
     9601 catgccttaa ttggaatgga tagagataat aaaaggcaaa gtagatggcc atagacaaaa
     9661 gtcaagtgat ttcctatata tttgaaataa tgtatagcaa taattggaat ttgtaatgaa
     9721 taaaatcatt caaaaaaatc tgaaaaagtg tttgtatgca aaatataaaa aaaaaaccct
     9781 aaaattgaac aagaagacaa cccaattaaa aatggggaca gatccaaata catactttcc
     9841 aaagatatac agatggtggc caggcacggt ggctcacgcc tgtaatccca gcactttggg
     9901 aggccgaggc gggcagatca cctgaggtcc ggagttcgag accagcctga ccaacatgga
     9961 gaaaccctgt ctctactaaa aatacaaaat tagccaggcg tggtggcgct actctgccac
    10021 caagtggtag ctactccgga ggcggaggca ggagaatggc ttgaacccgg gaggcggagg
    10081 ttgctgtgag ccgagatcgc gccattgcac tccagcctgg gcaacaagag tgaaactccg
    10141 tctcaaaaaa aaaaaaaaga agatatacag atggcaaata agcataccaa ataatgctca
    10201 gtgacacttg tcatgaggga aaagcaaatt aaaacaacga gatagcaccg cacatctatt
    10261 aaagtgacta taatctaaaa ataagtaaat ttgcaattgc aacaggaact ctcattcatt
    10321 gctggtgcaa tgcataatag tatagccact ttggaagata gtttgacttt tccccaaagc
    10381 taaacaaagc ttcacaatat gagccaacaa tcacactcct aggtatttag ataactgctt
    10441 tgaaaacata ggagtttgat ctaaacaaaa cccagcatgt actcacgtac agcagctctt
    10501 ttcataacag acaaatactt taaggaatca ggataacctt caataggtga atgactaact
    10561 aggctggggt acatccatgc aatggagtcc tgttcagcaa gagcaagctc tgaggccatg
    10621 caggacatgg atgaatctga taggcatatt gctaagtgaa agagaccagt gtgaaaaggc
    10681 tgtatgatcc tatttctatg atgttatgga aaagcagaaa ctacaggggt agcaaacata
    10741 tctgtgattg atgacggttt gtagagggca gggagtgagt taaataggag gatataatga
    10801 tagaaacagg cacaaatggg cctttggaga gtgtactccc tctgcttggt gaaattatgc
    10861 tgggtgtgtg tggaagagcc tgggatgtat aatgccagca tgaacaaaaa ggccacttat
    10921 cactccagga gagcagggtg ttctttcatc acacatgaaa ttatttcagg atcagttcca
    10981 agggagactt tcatgtgtga ttttatatat atatatatat atatatatat atatatatat
    11041 atatatatat atatatgtat atatacacac acacatacac acatatatac acatatatat
    11101 acacatatac acatatatat acacatatat ataataagaa catttaccat tttaactatt
    11161 tttaagtgta cacttcagtg gcatgaagta cattatttcc attattgtgc aactatcatt
    11221 ttacattcca ccagcagtgc acaaggcttc caatttctcc acatacttgc caatattaat
    11281 tagtttgttt ctctctcatt tcataggcat gatcataact cactgcagcc ccaacctcct
    11341 gggctcaagg gatccttcca cctcagcctc ctgggtagct ggaactacag gtgccactac
    11401 acccaaatag ttttttggtt tttttgaaat ggagtttcac tctgtcaccc aggctggagt
    11461 gcagtggcac catttcagct cactgcaacc tccgcctcct aggtttaagt gattctcctt
    11521 cctcggcctc ctgagtagct gggattacag gcatgtgcca ccatgtatgg ctattttttg
    11581 tatttttagt agagacaggg tttcaccatg ttggccaggc caggctagtc tcaaactcct
    11641 gtcctcaagt gatccactta ccttggcctc ccaaagtgct gggattacag gcttgaacca
    11701 ctgcacttgg cctccatatt ttttataata gccactctaa catgtatgaa atggtatctc
    11761 attgtggttt tgattttcct ttacctaatg gctagtgatg ttgaaaatct tttcatgtac
    11821 ttcttggcac tggatttggc aatgatttat tggatatgac accagaagca tgggaaacaa
    11881 aagaaaaaat aggtaaattg gacttcacca aaattgaaaa ctttcggcat cagtggacac
    11941 tatcaagaaa gtgaaaagga gctgggtgtg gtggctcacg cctgtaattc cagcactttg
    12001 ggaggccaag gtgggaggat cacttgaggt caggagtgcg agaccagcct ggttaacttg
    12061 gtgaaaccac gtctctacta aaaataaaaa aaaagagaaa aaaaaaagcc gggtgtggtg
    12121 gcatgtgcct gtaatcccag caactcagga agctgaggca ggaggatcgc ttgaagctgt
    12181 gaggtggagg ttgcagtgag ccgagatcat gctactgcac tccagcccag gtgacagagc
    12241 aagaaagcaa aattccatct caaaaaaaaa aaaaaggccg ggtgtggtgg ctcacgcctg
    12301 taatcctagc actttgggag gctgaggcag gtggatcacg aggtcaggag atcgaaacca
    12361 tcctggctaa tgtggtgaaa ccctgtctct acaaaaaaat acaaaaaatt agccaggctg
    12421 gtagtggaag cctgtagtcc cagctacttg ggaggctgag gaaggagaat ggcgtgaacc
    12481 tggaaccagt gagcccagat ctcaccactg cactccagcc tgggcgacag agcgagactc
    12541 cgtctcaaaa aaaaaaaagg tgaatatagg agaaaagaca ctgtaaaata atatacctga
    12601 taagggtcta gtatccagaa catataaaga actcttacaa cccaacaaca aaaagacaac
    12661 ccaatatcaa aatgggcaga ggacttgaag agacttttct gtaaagaaga tatgcaaata
    12721 gcatatgaaa cgatactcaa catcactagc catcatggaa atataaatca aaaatacaat
    12781 gagataacac tccataccca tcagaatgtc ttattatttt aaaaacaaac cagaaacaag
    12841 tattgacaaa gaagtggaga aatgtgaaca ccgctgtaaa atggtaaagc tgctatgact
    12901 gacccttgct acaacgtgga ggaacctcag aaacattgtg ctgagaaccc agcacaaggc
    12961 cacacacctg taatcccagc tactcgggag gctgaggtgg gagggtcgct tgagcctggg
    13021 agttcaagtc cagtctgggc agcatagcaa gactccatgt ctacaaagat aaaaataaaa
    13081 gcaatgtgca gaaagaggct ggccacaaaa aggtcacata ctgtatgata ccacttatat
    13141 gaaataccca gaatgggtaa atccaaagag agcatattgg tggttgtcaa gggtcggagg
    13201 gaggatgaaa tgtgtgacag ctgcttaatg gatggaggat ttcctttggg gtgatgaaac
    13261 tattttggaa ctaagaggtg gtggctgcac aatgttgtgc atggactaaa tgtcacagaa
    13321 atgtacattt ttaaaagtta attttatatt gtgtaaattt tacctcaata aaaaaatcta
    13381 gtccacagca
//
