LOCUS       NM_003414               3268 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 267 (ZNF267), transcript variant
            1, mRNA.
ACCESSION   NM_003414
VERSION     NM_003414.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Long,X., Liu,X., Deng,T., Chen,J., Lan,J., Zhang,S., Zhou,M.,
            Guo,D. and Zhou,J.
  TITLE     LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 33 (2023)
   PUBMED   36691044
  REMARK    GeneRIF: LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Schnabl,B., Valletta,D., Kirovski,G. and Hellerbrand,C.
  TITLE     Zinc finger protein 267 is up-regulated in hepatocellular carcinoma
            and promotes tumor cell proliferation and migration
  JOURNAL   Exp Mol Pathol 91 (3), 695-701 (2011)
   PUBMED   21840307
  REMARK    GeneRIF: ZNF267 promotes proliferation and migration of
            hepatocellular carcinoma cells in vitro
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Schnabl,B., Czech,B., Valletta,D., Weiss,T.S., Kirovski,G. and
            Hellerbrand,C.
  TITLE     Increased expression of zinc finger protein 267 in non-alcoholic
            fatty liver disease
  JOURNAL   Int J Clin Exp Pathol 4 (7), 661-666 (2011)
   PUBMED   22076166
  REMARK    GeneRIF: Report increased expression of zinc finger protein 267 in
            non-alcoholic fatty liver disease.
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Schnabl,B., Hu,K., Muhlbauer,M., Hellerbrand,C., Stefanovic,B.,
            Brenner,D.A. and Scholmerich,J.
  TITLE     Zinc finger protein 267 is up-regulated during the activation
            process of human hepatic stellate cells and functions as a negative
            transcriptional regulator of MMP-10
  JOURNAL   Biochem Biophys Res Commun 335 (1), 87-96 (2005)
   PUBMED   16054593
  REMARK    GeneRIF: ZNF267 as a negative transcriptional regulator of matrix
            metallopeptidase 10 might promote liver fibrogenesis
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Hu,K., Fink,M., Froh,M., Gabele,E., Hellerbrand,C., Muhlbauer,M.,
            Wiest,R., Scholmerich,J. and Schnabl,B.
  TITLE     Characterization of the human zinc finger protein 267 promoter:
            essential role of nuclear factor Y
  JOURNAL   Biochim Biophys Acta 1729 (1), 14-23 (2005)
   PUBMED   15814297
  REMARK    GeneRIF: The binding site for NF-Y is critical for ZNF267 gene
            regulation and, herewith, the activation of this transcriptional
            factor plays an important role in the activation process of hepatic
            stellate cells and in liver fibrosis
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Schafer,U., Schneider,A. and Neugebauer,E.
  TITLE     Identification of a nitric oxide-regulated zinc finger containing
            transcription factor using motif-directed differential display
  JOURNAL   Biochim Biophys Acta 1494 (3), 269-276 (2000)
   PUBMED   11121585
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034105.7.
            
            On Nov 23, 2018 this sequence version replaced NM_003414.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP284515.1, SRR1660809.186339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300870.15/ ENSP00000300870.10
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AC034105.7         56477-56639
            164-290             AC034105.7         67168-67294
            291-386             AC034105.7         67831-67926
            387-3268            AC034105.7         97146-100027
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3268
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="zinc finger protein 267"
                     /db_xref="GeneID:10308"
                     /db_xref="HGNC:HGNC:13060"
                     /db_xref="MIM:604752"
     exon            1..163
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2392
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger (C2H2); zinc finger protein 2; zinc finger protein
                     HZF2"
                     /codon_start=1
                     /product="zinc finger protein 267 isoform 1"
                     /protein_id="NP_003405.4"
                     /db_xref="CCDS:CCDS32440.1"
                     /db_xref="GeneID:10308"
                     /db_xref="HGNC:HGNC:13060"
                     /db_xref="MIM:604752"
                     /translation="MGLLTFRDVAVEFSLEEWEHLEPAQKNLYQDVMLENYRNLVSLG
                     LVVSKPDLITFLEQRKEPWNVKSEETVAIQPDVFSHYNKDLLTEHCTEASFQKVISRR
                     HGSCDLENLHLRKRWKREECEGHNGCYDEKTFKYDQFDESSVESLFHQQILSSCAKSY
                     NFDQYRKVFTHSSLLNQQEEIDIWGKHHIYDKTSVLFRQVSTLNSYRNVFIGEKNYHC
                     NNSEKTLNQSSSPKNHQENYFLEKQYKCKEFEEVFLQSMHGQEKQEQSYKCNKCVEVC
                     TQSLKHIQHQTIHIRENSYSYNKYDKDLSQSSNLRKQIIHNEEKPYKCEKCGDSLNHS
                     LHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQIDTGENLYKCKACSKSFTRS
                     SNLIVHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSC
                     LTQHQTTHTGEKLYKCKVCSKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLT
                     QHRKIHTGENLYKCKVCAKPFTCFSNLIVHERIHTGEKPYKCKECGKAFPYSSHLIRH
                     HRIHTGEKPYKCKACSKSFSDSSGLTVHRRTHTGEKPYTCKECGKAFSYSSDVIQHRR
                     IHTGQRPYKCEECGKAFNYRSYLTTHQRSHTGERPYKCEECGKAFNSRSYLTTHRRRH
                     TGERPYKCDECGKAFSYRSYLTTHRRSHSGERPYKCEECGKAFNSRSYLIAHQRSHTR
                     EKL"
     exon            164..290
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..386
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..3268
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="hexamer: AATAAA"
     polyA_site      2752
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
     regulatory      3193..3198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="hexamer: AATAAA"
     polyA_site      3219
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="major polyA site"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
                     /note="hexamer: ATTAAA"
     polyA_site      3268
                     /gene="ZNF267"
                     /gene_synonym="HZF2"
ORIGIN      
        1 agttagagct cgggtctcct cgccacagct ccgagtcttt cgttctggga ggcccaggcg
       61 gcttcgcgtt ctgagaataa acagaacctc tgttgctctg cgacttgcag gcactgggag
      121 attcgtagct aagacgccag ggcatcccgg aagctgggaa atgggactgt tgacattcag
      181 ggatgtggcc gtagaattct ctttggagga gtgggaacac ctggaaccag ctcagaagaa
      241 tttgtatcag gatgtgatgt tagaaaacta cagaaacctg gtctctctgg gtcttgttgt
      301 ctctaagccg gacctgatca cctttttgga acaaaggaaa gagccttgga atgtgaagag
      361 tgaggagaca gtagccatcc agccagatgt gttttcgcat tataacaagg acctgttgac
      421 agagcactgc acagaagctt cattccaaaa agtgatatcg aggagacatg ggagctgtga
      481 tcttgagaat ttacatttaa gaaaaaggtg gaaaagggag gagtgtgaag ggcacaatgg
      541 atgttatgat gaaaagactt ttaaatatga tcaatttgat gaatcctctg ttgaaagttt
      601 gtttcaccag caaatacttt cttcttgtgc caaaagctat aactttgatc aatataggaa
      661 ggtctttact cattcatcat tgcttaatca acaagaggaa atagatattt ggggaaaaca
      721 tcacatatat gataaaactt cagtgttatt taggcaggtc tctactctaa atagttaccg
      781 aaatgttttt attggagaga aaaattatca ttgcaataat tctgaaaaaa ccttgaacca
      841 aagctcaagc cctaaaaatc atcaggaaaa ttattttcta gaaaaacaat acaaatgtaa
      901 agaatttgag gaagtctttc ttcagagtat gcatgggcaa gagaaacaag aacagtctta
      961 caaatgtaat aaatgtgtag aagtttgtac ccagtcatta aaacatattc aacatcagac
     1021 catccatatc agagaaaact catatagcta taacaaatat gataaagatc ttagtcagtc
     1081 atcaaatctt agaaagcaga taatccataa tgaagagaaa ccatacaaat gtgaaaaatg
     1141 tggggatagc ttaaaccata gtttgcacct tactcaacat cagatcattc ctaccgaaga
     1201 gaaaccctgt aaatggaaag aatgtggcaa ggtctttaac cttaactgta gtttatacct
     1261 tactaaacag cagcaaattg atactggaga aaacctttac aaatgtaaag catgtagcaa
     1321 atcttttact cgttcctcca atcttattgt gcatcagaga attcacactg gagagaaacc
     1381 atacaaatgt aaagaatgtg gcaaagcctt tcgctgtagt tcatacctta ctaaacataa
     1441 gcgaattcat actggagaga aaccttataa atgtaaagaa tgtggaaaag cttttaaccg
     1501 tagttcatgc cttactcaac atcagacaac tcatacagga gaaaaacttt acaaatgtaa
     1561 agtatgtagc aaatcttatg ctcgttcttc aaatcttatt atgcatcaga gagttcatac
     1621 tggagagaag ccttataaat gtaaagaatg tggcaaagtc tttagccgta gttcttgcct
     1681 tactcaacat cggaaaattc atactggaga aaatctttac aaatgcaaag tatgtgctaa
     1741 accttttact tgtttctcaa atcttattgt gcatgagaga attcatactg gagagaaacc
     1801 ctataaatgt aaagaatgtg gcaaagcctt tccttatagt tcacacctta ttcgacatca
     1861 tcgaattcat actggagaaa aaccatacaa atgtaaagca tgtagcaaat cttttagtga
     1921 ctcctcaggt cttactgtgc atcggcgaac tcatactgga gagaaaccct atacatgtaa
     1981 agaatgtggc aaagccttta gttatagttc agatgttatt cagcatcgga gaattcatac
     2041 tggccagaga ccctacaaat gtgaagaatg tggcaaagcc ttcaactata ggtcatacct
     2101 cactacacat cagagaagtc atactggaga gagaccctac aaatgtgaag aatgtggcaa
     2161 agccttcaac tctaggtcat acctcactac acatcggaga agacatactg gagagagacc
     2221 ctacaaatgt gatgaatgtg gtaaagcctt cagctatagg tcatacctca ctacacatcg
     2281 gagaagtcat agtggagaga gaccctacaa atgtgaagaa tgtggcaaag cctttaactc
     2341 taggtcatac ctcattgcac atcagagaag tcatactaga gaaaaacttt aaaaatgtaa
     2401 aacatggagc agatttttta cttgttaccc atgtcttatt gtgcatcaga taatttatat
     2461 gggagtgaaa ccctacaaat gttaagaatg tggcataacc tttaactatt ttcaagcctt
     2521 acacaatagc agagaatata aactgaaaaa atccatacaa atattaaaaa tgtggcaaat
     2581 tattttaaac tgtgctcaac ccttactcaa gataatccat actagagaaa cactatagat
     2641 gtaaaaatgt gaaaagtttt attcaaaata tcaaacttat gagtcaccta ggggttcata
     2701 gaaaaaggaa gtttgcagat gcaataaatg tgaggaagta tttaataaaa aatgaagtct
     2761 aaatgtgtca gagaatttat gtgagaaagg actaaagcac agacactttc agcctttata
     2821 ctaaataaga gtattttttg tacagaataa tctaaaggca aaataattag ataatttatt
     2881 tgcttatatg ttttaaagta gcaagaacat tgatgttttg acaggtatat ttcatagata
     2941 cttcatttgt atttacagta tttgaggttt ttggaaagca aatattattt atataattca
     3001 gctttcaaat ctgttgctgc ttttccttaa tccgtggtgt tcatgtgaaa atatgtgttc
     3061 tgtttttttt tctgcatcag aacaatgtga ggtcattcta cgttaatatc attaatatca
     3121 gcatttttca tggaagttta atgccaaatg taaaacacat gaaaattttt aaaaatatgc
     3181 tctttgtgtt tgaataaagt agtaatgcat gtaaacatat acgtgtttag agctcttttc
     3241 tatattaaag taagagggat attctgaa
//
