LOCUS       NM_001370374            3544 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 266 (ZNF266), transcript variant
            3, mRNA.
ACCESSION   NM_001370374 XM_017026154
VERSION     NM_001370374.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Gamsjaeger,R., Liew,C.K., Loughlin,F.E., Crossley,M. and
            Mackay,J.P.
  TITLE     Sticky fingers: zinc-fingers as protein-recognition motifs
  JOURNAL   Trends Biochem Sci 32 (2), 63-70 (2007)
   PUBMED   17210253
  REMARK    Review article
REFERENCE   6  (bases 1 to 3544)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011451.6.
            
            On May 7, 2019 this sequence version replaced XM_017026154.1.
            
            Summary: This gene encodes a protein containing many tandem
            zinc-finger motifs. Zinc fingers are protein or nucleic
            acid-binding domains, and may be involved in a variety of
            functions, including regulation of transcription. This gene is
            located in a cluster of similar genes encoding zinc finger proteins
            on chromosome 19. Alternative splicing results in multiple
            transcript variants for this gene. [provided by RefSeq, Sep 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2136377.1,
                                           SRR1803616.190485.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592904.7/ ENSP00000466714.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC011451.6         34320-34609
            291-376             AC011451.6         34700-34785
            377-438             AC011451.6         35034-35095
            439-599             AC011451.6         35658-35818
            600-718             AC011451.6         36107-36225
            719-872             AC011451.6         49675-49828
            873-955             AC011451.6         50594-50676
            956-1082            AC011451.6         51262-51388
            1083-1163           AC011451.6         51985-52065
            1164-1252           AC011451.6         54151-54239
            1253-3544           AC011451.6         55173-57464
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3544
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /note="zinc finger protein 266"
                     /db_xref="GeneID:10781"
                     /db_xref="HGNC:HGNC:13059"
                     /db_xref="MIM:604751"
     exon            1..290
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..376
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..438
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..599
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..718
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..872
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             848..2698
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /note="isoform 2 is encoded by transcript variant 3; zinc
                     finger protein 1; zinc finger protein HZF1"
                     /codon_start=1
                     /product="zinc finger protein 266 isoform 2"
                     /protein_id="NP_001357303.1"
                     /db_xref="CCDS:CCDS92507.1"
                     /db_xref="GeneID:10781"
                     /db_xref="HGNC:HGNC:13059"
                     /db_xref="MIM:604751"
                     /translation="MAATDLSYGLYRDPVCLQEKTEVERVVADCLTNCYQDSVTFDDL
                     AVDFTPEEWTLLDPTQRNLYRDVMLENYKNLATVGYQLFKPSLISWLEQEESRTVQRG
                     DFQASEWKVQLKTKELALQQDVLGEPTSSGIQMIGSHNGGEVSDVKQCGDVSSEHSCL
                     KTHVRTQNSENTFECYLYGVDFLTLHKKTSTGEQRSVFSQCGKAFSLNPDVVCQRTCT
                     GEKAFDCSDSGKSFINHSHLQGHLRTHNGESLHEWKECGRGFIHSTDLAVRIQTHRSE
                     KPYKCKECGKGFRYSAYLNIHMGTHTGDNPYECKECGKAFTRSCQLTQHRKTHTGEKP
                     YKCKDCGRAFTVSSCLSQHMKIHVGEKPYECKECGIAFTRSSQLTEHLKTHTAKDPFE
                     CKICGKSFRNSSCLSDHFRIHTGIKPYKCKDCGKAFTQNSDLTKHARTHSGERPYECK
                     ECGKAFARSSRLSEHTRTHTGEKPFECVKCGKAFAISSNLSGHLRIHTGEKPFECLEC
                     GKAFTHSSSLNNHMRTHSAKKPFTCMECGKAFKFPTCVNLHMRIHTGEKPYKCKQCGK
                     SFSYSNSFQLHERTHTGEKPYECKECGKAFSSSSSFRNHERRHADERLSA"
     exon            873..955
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1082
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1163
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1252
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..3544
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3355..3360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /note="major polyA site"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
                     /note="hexamer: AATAAA"
     polyA_site      3544
                     /gene="ZNF266"
                     /gene_synonym="HZF1"
ORIGIN      
        1 gctgtgtttt ccggcgcttt ctccgcgccg ccaaacccgt tttcttcctg gtggcgtttg
       61 ggcttaatac agctttggcg aggtcggatg acgggtggga gccagcggtg gaaggggtgg
      121 cgaaagtacc ggtttgcccc aggccgccga ggggcctcct tagagagacc ttgcctgctc
      181 cgctcgcgtc cgccggggcc gcgcgggtcc tcctggcgcc gccaggttca aaaagccact
      241 cgagttgtca ctgcgacggc cctgggccag gagccgtttc gggatctgtc aaacaacgag
      301 ttttcgtcgt tcgaatcagg ttgactggtc cttcatcccc ccaatctccc gtacctggcg
      361 agtccagctc gtcgcggcct gtacctcccc acagagcttc aaaacgggct tttaggaaga
      421 aggaatggag gctttgaagc aatgctaaga aaagagtgat atgcaagctg agaccaaaaa
      481 tatggtatga tttagccata ctgaagggga aggaaataag agctgggcaa agcattctgt
      541 gaattggctg actccacttc tatggtgaga gagaggagtg catcaaagat tactcccagt
      601 agagatggtt tcagcatgtt ggccagtctg gtctcagact cctgacctca agtgatccac
      661 ccacctcggc ctcccaaaat gctgggatta caggtataag ccactgtgcc tggccaaaga
      721 taccgttaac cctggataaa gagaatggag gttacctctg tccgtgtaga ttcctaagct
      781 gtcctggagt gatccttgga gtaaaggaaa ggtgctttga agcacattca gccatcagcc
      841 ctgtgggatg gcagccactg atttgtccta tggtctttac agggacccag tctgccttca
      901 agaaaagaca gaagtagaaa gggtggtggc tgactgtctg acaaattgtt atcaggattc
      961 agtgactttt gatgatctgg ctgtggactt caccccagaa gaatggactt tactggaccc
     1021 aactcagaga aacctctaca gagatgtgat gctggagaac tacaagaatt tggccacagt
     1081 aggatatcag ctcttcaaac ccagtctgat ctcttggctg gaacaagaag agtctaggac
     1141 agtgcagaga ggtgatttcc aagcttcaga atggaaagtg caacttaaaa ccaaagagtt
     1201 agcccttcag caggatgttt tgggggagcc aacctccagt gggattcaaa tgataggaag
     1261 ccacaacgga ggggaggtca gtgatgttaa gcaatgtgga gatgtctcca gtgaacactc
     1321 atgccttaag acacatgtga gaactcaaaa tagtgagaac acatttgagt gttatctgta
     1381 tggagtagac ttccttactc tgcacaagaa aacctctact ggagagcaac gttctgtatt
     1441 tagtcagtgt ggaaaagcct tcagcctgaa cccagatgtt gtttgccaga gaacgtgcac
     1501 aggagagaaa gcttttgatt gcagtgactc tgggaaatcc ttcattaatc attcacacct
     1561 tcagggacat ttaagaactc acaatggaga aagtctccat gaatggaagg aatgtgggag
     1621 aggctttatt cactccacag accttgctgt gcgtatacaa actcacaggt cagaaaaacc
     1681 ctacaaatgt aaggaatgtg gaaaaggatt tagatattct gcatacctta atattcacat
     1741 gggaacccac actggagaca atccctatga gtgtaaggag tgtgggaaag ccttcaccag
     1801 gtcttgtcaa cttactcagc acagaaaaac tcacactgga gagaaacctt ataaatgtaa
     1861 ggattgtggg agagccttca ctgtttcctc ttgcttaagt caacatatga aaatccatgt
     1921 gggtgagaag ccttatgaat gcaaggaatg tgggatagcc ttcactagat cttctcaact
     1981 tactgaacat ttaaaaactc acactgcaaa ggatcccttt gaatgtaaga tatgtggaaa
     2041 atcctttaga aattcctcat gcctcagtga tcactttcga attcacactg gaataaaacc
     2101 ctataaatgt aaggattgtg ggaaagcctt cactcagaac tcagacctta ctaagcatgc
     2161 acgaactcac agtggagaga ggccctatga atgtaaggaa tgtggaaagg cctttgccag
     2221 atcctctcgc cttagtgaac atacaagaac tcacactgga gagaagcctt ttgaatgtgt
     2281 caaatgtggg aaagcctttg ctatttcttc aaatcttagt ggacatttga gaattcacac
     2341 tggagagaag ccctttgagt gcctggaatg tggtaaagca tttacgcatt cctccagtct
     2401 taataatcac atgcggaccc acagcgccaa aaaaccattc acgtgtatgg aatgtggcaa
     2461 agcttttaag tttcccacgt gtgttaacct tcacatgcgg atccacactg gagaaaaacc
     2521 ctacaaatgt aaacagtgtg ggaaatcctt cagttactcc aattcgtttc agttacatga
     2581 acgaactcac actggagaga aaccctatga atgtaaggag tgcgggaaag ccttcagttc
     2641 ttccagttcc tttcgaaatc atgaaagaag gcatgcggat gagagactgt cagcataagg
     2701 aatgtgggaa aacctaaagg tgtccctgtt ctctctgaag acatgaaaac tcactgggga
     2761 gaaaccctat gaatgtaaaa atgtggaagc aactttgtat ctcaggtctt aatgaacaca
     2821 tatgaattca cagtggagaa gaccctgcat cagggaatgt ggaaatgact ttgctgaatt
     2881 ctcaagcctt accaaacaca tcagaaatct cactggagag aaactgtatg aatgtagaga
     2941 atctgggaat acctttctga atcccacaaa ccttaatgtg tgtatgtgaa ctcacattgg
     3001 agagaaaccc tgcaatttaa atggtatggt ctggatgatg ccccactcca tatttgtaag
     3061 ccctaagtcc tagttcctta cactataact gtatttggac atagggtttt caaacaggtg
     3121 agtaacttca aatgaggttg ttgggttcga tccctaatct gacatcactg gtgtccctat
     3181 aagggaaact gaaggaagga tacacatgga gaagactgtg tggatccacc agaagatggc
     3241 catctacaag ccaaggacag agacctggaa cagatgcttt cattatggcc tccagaggaa
     3301 accaaccctg tctccacctt gatattgcac ttccaggctc cagaactgtg aggcaataaa
     3361 tttctcttgg ttaaatcatt cagtctgtta ttttgtacag caaccctagg aaactaatac
     3421 tgtgaggaac ttgggaaaag ctttagatca agcttgtcca acccgcaggc caggatggct
     3481 ttgaatgcag accaacacaa atttttaagc tttcttcaaa cataataaaa tttttttgtg
     3541 atta
//
