LOCUS       NM_033468               3879 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 257 (ZNF257), transcript variant
            1, mRNA.
ACCESSION   NM_033468
VERSION     NM_033468.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Puig,M., Castellano,D., Pantano,L., Giner-Delgado,C., Izquierdo,D.,
            Gaya-Vidal,M., Lucas-Lledo,J.I., Esko,T., Terao,C., Matsuda,F. and
            Caceres,M.
  TITLE     Functional Impact and Evolution of a Novel Human Polymorphic
            Inversion That Disrupts a Gene and Creates a Fusion Transcript
  JOURNAL   PLoS Genet 11 (10), e1005495 (2015)
   PUBMED   26427027
  REMARK    GeneRIF: one of the breakpoints disrupts the transcription factor
            gene ZNF257, causing a significant reduction in the total
            expression level of this gene in lymphoblastoid cell lines
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB001158.1, BC036446.1 and AC011482.4.
            
            On May 17, 2019 this sequence version replaced NM_033468.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.17050.1,
                                           SRR1803614.151304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000594947.6/ ENSP00000470209.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               DB001158.1         1-562
            563-950             BC036446.1         714-1101
            951-951             AC011482.4         71763-71763         c
            952-1211            BC036446.1         1103-1362
            1212-1212           AC011482.4         71502-71502         c
            1213-2349           BC036446.1         1364-2500
            2350-2350           AC011482.4         70364-70364         c
            2351-3502           BC036446.1         2502-3653
            3503-3879           AC011482.4         68835-69211         c
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..3879
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /note="zinc finger protein 257"
                     /db_xref="GeneID:113835"
                     /db_xref="HGNC:HGNC:13498"
                     /db_xref="MIM:606957"
     exon            1..152
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1841
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /note="isoform a is encoded by transcript variant 1; bone
                     marrow zinc finger 4"
                     /codon_start=1
                     /product="zinc finger protein 257 isoform a"
                     /protein_id="NP_258429.2"
                     /db_xref="CCDS:CCDS46030.1"
                     /db_xref="GeneID:113835"
                     /db_xref="HGNC:HGNC:13498"
                     /db_xref="MIM:606957"
                     /translation="MGPLTIRDVTVEFSLEEWHCLDTAQQNLYRDVMLENYRNLVFLG
                     IAVSKPDLITCLEQGKEPCNMKRHEMVAKPPVMCSHIAEDLCPERDIKYFFQKVILRR
                     YDKCEHENLQLRKGCKSVDECKVCKGGYNGLNQCLITTQSKMYQCDKYVKVFYKFSNS
                     DRHKIRHTEKKTCKCKECGKSFCMLSQLTRHKRIHIRENSHKCEECGKAFNQSSALTR
                     HKMTHTGEKPYKCEECGKAFNRSSHLTQHKVIHTREKPYKCEECGKAFNRSSHITQHK
                     RIHNREKPFKYDECCKAFKWSSALTTLTQHKRIHTGEKPYKCEECGKAFNQSSALTRH
                     KMIHTGEKPFQCEECGKAFNRSSHLTQHKIIHTKEKPYKCEECGKAFNRSSHLTKHKR
                     IHTREKAYKCDEYCKAFNWSSALTTLTQHKIIHTGEKPYKCEECGKAFNRSSYLIRHK
                     IIHTGEKPYKCEECGKAFNQSSHLTQHKIIHTGEKPYKCEECGKAFNRSSHLSQHKII
                     HTGEKPYKCEECGKPFNRFSYLTVHKRIHAGENPNKYEECGKACNHSSNLTKHNS"
     exon            153..279
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /inference="alignment:Splign:2.1.0"
     exon            280..375
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..3879
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /note="hexamer: AATAAA"
     polyA_site      2597
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /note="major polyA site"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
                     /note="hexamer: AATAAA"
     polyA_site      3508
                     /gene="ZNF257"
                     /gene_synonym="BMZF-4; BMZF4"
ORIGIN      
        1 actttgtctc tcgctctagc ccgagctgca ggtctcgtct tccctggtct gtgtcctctt
       61 ctcctagggg cccagcctct gtggccctgt gacctgcagg tattgggaga tccccagcta
      121 agacgccagg tcctcctgga agcctagaaa tgggaccact gacaattagg gatgtgactg
      181 tagaattctc tctggaggag tggcattgcc tggacactgc acagcagaat ttatataggg
      241 atgtgatgtt agagaactac agaaacctgg tcttcctggg tattgctgtc tctaagccag
      301 acctgatcac ctgtctggag caaggaaaag agccctgtaa tatgaagaga catgagatgg
      361 tagccaaacc cccagttatg tgttctcata ttgctgaaga cctttgccca gagcgagaca
      421 taaaatattt tttccaaaaa gtcatactga ggagatatga taaatgtgaa catgagaatt
      481 tacaattaag aaagggctgt aaaagtgtgg atgagtgtaa ggtgtgcaaa ggaggttata
      541 atggacttaa ccaatgtctg ataactaccc agagcaaaat gtatcaatgt gataaatatg
      601 taaaagtctt ctataagttt tcaaattcag atagacataa gataagacat actgaaaaga
      661 aaacttgcaa atgtaaagaa tgtggcaaat cattttgcat gctttcacaa ctaactcgac
      721 ataagagaat tcatattaga gagaattccc acaaatgtga agaatgtggc aaagccttta
      781 accagtcctc agctcttact cgacataaga tgactcatac tggagagaaa ccctacaaat
      841 gtgaagagtg tggaaaagct tttaaccggt cttcacacct tactcaacat aaggtaattc
      901 atactagaga gaaaccctac aaatgtgaag agtgtggcaa agcctttaac cggtcttcac
      961 acattactca acataagaga attcataata gagagaagcc cttcaaatat gatgaatgtt
     1021 gcaaagcctt taagtggtcc tcagctctta ctacccttac tcaacataag agaattcata
     1081 ctggagagaa accctacaaa tgtgaagagt gtggcaaagc ctttaaccag tcctcagccc
     1141 ttactcgaca taagatgatt catactggag agaaaccctt ccaatgtgaa gagtgtggca
     1201 aagcttttaa ccggtcttca caccttactc aacataagat aattcatact aaagagaaac
     1261 cctacaaatg tgaagagtgt ggaaaagcct ttaaccggtc ttcacacctt actaaacata
     1321 agagaattca tactagagag aaggcctaca aatgtgatga atattgcaaa gcttttaact
     1381 ggtcctcagc tcttactacc cttactcagc ataagataat tcatactgga gagaaaccct
     1441 acaaatgtga agagtgtggc aaagccttta accggtcttc ataccttatt cgacataaga
     1501 taattcatac tggagagaaa ccctacaaat gtgaagagtg tggcaaagcc tttaaccagt
     1561 cttcacacct tactcaacat aaaataattc atactgggga gaagccctac aaatgtgaag
     1621 aatgtggcaa agcctttaac cggtcttcac acctttctca acataagata attcatactg
     1681 gagagaaacc ctacaaatgt gaagaatgtg gcaagccttt taatcgtttc tcatacctta
     1741 ccgtacataa gagaattcat gctggagaga accccaacaa atatgaagaa tgtggcaaag
     1801 cttgtaacca ttcctcaaac cttactaaac ataattcata atggagaaaa accctacaaa
     1861 tgtgaagaat gtgtcaaagc ttttaactgt tcctcaatcc ttactaaaca taagggaatt
     1921 cataatagag aaaccctaca aatgtgaaga acgtggcctg gcttttaaca aatcctcaac
     1981 atttactaag cataaaataa ttcatgctgg agagaaactc ttgaaatgtg atgaatgtgg
     2041 catagcctct tcccagttct caactcttac taaacatgag aacacatgtg gaagataaag
     2101 cctacaaata tgaagaatgt gacaaggcct ttaaaagttc tcaaccctta ttacacataa
     2161 tttatactgg acagaaatcc taaagtgtga agaatgtcac aaagccctta ataagtcctc
     2221 aattcttaac agatataaga tgtttcatac tggagcgaaa ctacaatcct gaatgatgtc
     2281 acagtgcttt taacaatacc tcaaactttt ctaaacataa aaaaaaatta tactagtgcg
     2341 aaactctaga aatataaaga acatgaaaaa cttttaaatg gttttcacac ttgattgcag
     2401 gtaaaataat ttataccgga gaaaactcca agtgtgaaga atataacttt taaccagtgt
     2461 tcacaactta ttgtacagga aagcatttat agttgagaaa tggtgtacaa atataaagaa
     2521 tgtggaaaag tcattaatat ttgctcacat attacacatc agagagttca tacttaataa
     2581 aagtattata aatacaatta ctgtcaaatg atctttcaga aatataaacc tttaaagtga
     2641 agaagagttc attctaaaga caaacattac aaatataaag gggtttgtag tgcttttact
     2701 tgtatcacag attttattgt acacattttg tactagagaa taaccctgaa gcagttgcta
     2761 aaattttgtt cagcattagg aaatttatgt tggagaagaa ttcagcaagt gtgattaatt
     2821 tggaaaaaca ttttttccat aactatagct tagaaaatgc cagagagctc atactaaaat
     2881 atacttttgc agatgcaata aatacaaaga aatatttaat tcaaattgag tttatataat
     2941 tatcagagaa ttaacagtag aaatagctaa ggcactgaca cttcagacat tacactaaat
     3001 cagattgctg agtatagaaa atccaaaact acagttggta agtaaattaa ttttatgtaa
     3061 ctttaaaatg agtagacatt tctttgagaa gtcataatta aattcaagta tacttttttg
     3121 ataaaattat aaagcttttt aaaagtaaat aatgatgtaa gtcaactctc aaattacttc
     3181 atgctgtttc ttcatttcta ttgtattcac ctgtgaaagc atgtgatcaa ctattgctgc
     3241 atcagagata tgagagatac tttattaggt gggaattata tacgacctct tctataaaat
     3301 agtaaggaca ctgaaatata agatgcataa gagtctaagt gaagaggttc tttgtggtta
     3361 acttagtgat gtatgaagta gttgctcatg ttatgagaga aaaacatttt taattttagt
     3421 taaatgtaag ttaaaattaa aatagtacca tataatgtta gtgattgtac ttttatttaa
     3481 taaaatgcag tacattttaa aatttttaga ttatttgtgg acttaattta taattaaata
     3541 ttttctttta ccacgttaag actattgtac gttcaggccg ggcacagtag ctcacgcctg
     3601 taatcccaac actttgggag gctgaggcgg gcggatcaat tgaggccagg agtttgaaac
     3661 cagcctggcc aacatggtga aaccctgtct ctactgaaaa tacaaaaaat tagccaggca
     3721 tggtggtggg tgcctgaaat cccagctatt tgggagattg aggcaagaga atcacgtgta
     3781 cccaggaggc agaggttgca gtgagccaag atcacgacat tgcactccag cctaggcaac
     3841 aagagcaaga cttcgtctca aaaaaaaaaa aaaaaaaaa
//
