LOCUS       NM_203282               4089 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 254 (ZNF254), transcript variant
            4, mRNA.
ACCESSION   NM_203282
VERSION     NM_203282.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4089)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 4089)
  AUTHORS   Dooley,T.P., Reddy,S.P., Wilborn,T.W. and Davis,R.L.
  TITLE     Biomarkers of human cutaneous squamous cell carcinoma from tissues
            and cell lines identified by DNA microarrays and qRT-PCR
  JOURNAL   Biochem Biophys Res Commun 306 (4), 1026-1036 (2003)
   PUBMED   12821146
REFERENCE   3  (bases 1 to 4089)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
REFERENCE   4  (bases 1 to 4089)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF054180.1, BC043147.1, BC139749.1, DB340394.1, CN395850.1,
            BU783464.1, BM876253.1 and BM976089.1.
            
            On Jun 2, 2019 this sequence version replaced NM_203282.3.
            
            Summary: Zinc finger proteins have been shown to interact with
            nucleic acids and to have diverse functions. The zinc finger domain
            is a conserved amino acid sequence motif containing 2 specifically
            positioned cysteines and 2 histidines that are involved in
            coordinating zinc. Kruppel-related proteins form 1 family of zinc
            finger proteins. See ZFP93 (MIM 604749) for additional information
            on zinc finger proteins.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region and uses an alternate start codon, compared to
            variant 1. The encoded isoform (b) has a distinct and longer
            N-terminus compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.225149.1,
                                           SRR1803615.230936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357002.5/ ENSP00000349494.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AF054180.1         15-113
            100-398             BC043147.1         99-397
            399-2197            BC139749.1         357-2155
            2198-2502           DB340394.1         1-305               c
            2503-2971           CN395850.1         21-489
            2972-3395           BU783464.1         172-595
            3396-3923           BM876253.1         17-544              c
            3924-4089           BM976089.1         12-177              c
FEATURES             Location/Qualifiers
     source          1..4089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..4089
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /note="zinc finger protein 254"
                     /db_xref="GeneID:9534"
                     /db_xref="HGNC:HGNC:13047"
                     /db_xref="MIM:604768"
     exon            1..151
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2101
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /note="isoform b is encoded by transcript variant 4; zinc
                     finger protein 539; bone marrow zinc finger 5;
                     hematopoietic cell-derived zinc finger protein 1;
                     CTD-2017D11.1"
                     /codon_start=1
                     /product="zinc finger protein 254 isoform b"
                     /protein_id="NP_975011.3"
                     /db_xref="CCDS:CCDS32983.1"
                     /db_xref="GeneID:9534"
                     /db_xref="HGNC:HGNC:13047"
                     /db_xref="MIM:604768"
                     /translation="MPGPPRSLEMGLLTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLE
                     NYRNLAFLGIAVSKPDLITCLEQGKEPWNMKRHEMVDEPPGMCPHFAQDLWPEQGMED
                     SFQKAILRRYGKYGHENLQLRKGCKSVDEYKVNKEGYNGLNQCFTTAQSKVFQCDKYL
                     KVFYKFLNSNRPKIRHTEKKSFKCKKRVKLFCMLSHKTQHKSIYHREKSYKCKECGKT
                     FNWSSTLTNHRKIYTEEKPYKCEEYNKSPKQLSTLTTHEIIHAGEKLYKCEECGEAFN
                     RSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLTEHKKIHTRKKPYKCEECGKAFIWS
                     STLTRHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKRYKCLECGKAFKQLST
                     LTTHKIIHVGEKLYKCEECGKGFNRSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLT
                     KHKRIHTREKPYKCEECGKAFIWSSTLTRHKRMHTGEKPYKCEECGKSFSQSSTLTTH
                     KIIHTGEKPYKCEECGKAFNWSSTLTKHKIIHTEEKPYKCEKCGKAFKQSSILTNHKR
                     IHTGEKPYKCEECGKSFNRSSTFTKHKVIHTGVKPYKCEECGKAFFWSSTLTKHKRIH
                     TGEQPYKWEKFGKAFNRSSHLTTDKITHWREILQV"
     exon            152..278
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /inference="alignment:Splign:2.1.0"
     exon            279..374
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /inference="alignment:Splign:2.1.0"
     exon            375..4089
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /note="hexamer: AATAAA"
     polyA_site      3973
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /note="major polyA site"
     regulatory      4067..4072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
                     /note="hexamer: GATAAA"
     polyA_site      4089
                     /gene="ZNF254"
                     /gene_synonym="BMZF-5; HD-ZNF1; ZNF539; ZNF91L"
ORIGIN      
        1 gcctttgtct ctcgctgtcg ccggagtccc aggtctgtct tcactgctct gtgtcctctg
       61 ctcctagagg cccagcctct gtggcgctgt taccagcagg tattggagat ccacagctaa
      121 gatgccagga ccccctagaa gcctagaaat gggactgttg acatttaggg atgtggccat
      181 agaattctct ctggaggagt ggcaacacct ggacattgca cagcagaatt tatatagaaa
      241 tgtgatgtta gagaactaca gaaacctggc cttcctgggt attgctgtct ctaagccaga
      301 cctgatcacc tgtctggaac aagggaaaga gccctggaat atgaagcgac atgagatggt
      361 ggatgaaccc ccaggtatgt gtcctcattt tgctcaagac ctttggccag agcagggcat
      421 ggaagattct tttcaaaaag caatactgag aagatatgga aaatatggac atgagaattt
      481 acagttaaga aaaggctgta aaagtgtgga tgagtataag gtgaacaaag aaggttataa
      541 tggacttaac cagtgtttca caactgccca gagcaaagta tttcaatgtg ataaatattt
      601 gaaagtcttc tataaatttt taaattcaaa cagacctaag ataagacata ctgaaaagaa
      661 atctttcaaa tgtaaaaaac gtgtcaaatt attttgcatg ctttcacata aaacccaaca
      721 caaaagcatt tatcatagag agaagtccta caaatgtaaa gaatgtggaa aaacctttaa
      781 ttggtcctca acccttacta atcataggaa aatttatact gaagagaaac cttacaaatg
      841 tgaagaatat aacaaatctc ctaagcaact ctcaaccctt actacacatg aaataattca
      901 tgctggagag aaactctaca aatgtgaaga atgtggtgaa gcttttaatc gatcctcaaa
      961 tcttactaca cataagataa ttcatactgg agagaaacct tacaagtgtg aagaatgtgg
     1021 caaagcattt atctggtcct caacccttac tgagcataag aaaattcata ctagaaagaa
     1081 accctacaag tgtgaagaat gtggcaaagc atttatatgg tcctcaacac taactagaca
     1141 taagaggatg cacactggag agaaacccta caaatgtgaa gaatgtggca aagcttttag
     1201 ccagtcctca acccttacta cacataagat aattcatact ggagagaaac gctacaaatg
     1261 cttagaatgt ggcaaagctt ttaagcaact ctcaactctt actacacata aaataattca
     1321 tgttggagag aaactctaca aatgtgaaga atgcggcaaa ggttttaatc gatcttcaaa
     1381 tcttactaca cataagataa ttcatactgg agagaaacct tacaagtgtg aagaatgtgg
     1441 caaagcattt atctggtcct caacccttac taaacataag agaattcata ctagagagaa
     1501 accctacaaa tgtgaagaat gtggcaaggc atttatatgg tcctcaaccc taactagaca
     1561 taagaggatg cacactggag agaaacccta caaatgtgaa gaatgtggca aatcttttag
     1621 ccaatcctca acccttacta cacataagat aattcatact ggagagaaac cctacaaatg
     1681 tgaagaatgt ggcaaagcct ttaactggtc ctcaactctt actaaacata agataattca
     1741 tactgaagag aaaccctaca aatgtgaaaa atgtggcaaa gcctttaagc agtcttcaat
     1801 ccttactaac cataagagaa ttcatactgg agagaaaccc tataaatgtg aagaatgtgg
     1861 caaatctttt aaccggtctt caacttttac taaacataag gtaattcata ctggagtaaa
     1921 accctacaaa tgtgaagaat gtggcaaagc atttttctgg tcctcaaccc taactaaaca
     1981 taagagaatt catactggag agcaacccta caaatgggaa aaatttggca aagcctttaa
     2041 tcggtcctcg cacctcacca cagataagat aactcattgg agagaaatct tacaagtatg
     2101 aataatgtgc caaagcctaa gaaaaccctc aattcttaat agatataaga ttattcctac
     2161 tggagagaaa ctacaaacct gagagaggcg ctaatgcttt tgacagtacc taaaacttta
     2221 aagaaaatca ttctgctgaa aaatcctaga aatgtgaaga atgtgaaaaa gcctttaaat
     2281 gattgtcaca cttgattgta ggtaagataa ttcatactgg agaaaactac cagtgtgaac
     2341 aacgtggcca agcttcgaca atgctcacac cctattgcac aggaaagcat ttatacttga
     2401 gaagaaatgt acaaatattg gcaaagtaaa aaatccatta acacctgctc acatcttact
     2461 caaaattgta gagttcatag taaataaaag cattaaaatt ctaattactc tcagaagatc
     2521 tgtcagaaag tatgtcttta aagtatagaa gagcatttat tttgaaaaaa acattacaca
     2581 tatgaagagg attgtaatat ctttacttgt accacagatc ttattgtaca cattttatac
     2641 tagagaaaaa ccctcaggca gttgttaaaa ttttgttgaa catcagggag tttaagaaaa
     2701 ccctgcaagt ataatgaatt tggaaaaaca ttttttcaaa aactacaaat tataaaacac
     2761 caaagtgttc atactaaaat atatttttgc agatacatta aatatgaaag atattcaatc
     2821 caaaattaag tctatgtaaa tatcagggaa taattcacag tagaaatatc tagggcattc
     2881 aagctttaga cattacacta aatcagagtg ctgagtatag aaaataatac aaacagattt
     2941 gtctaaacat ttgtatataa ctttaaaaat agaatatttt ttggagggtt ataattacat
     3001 tcaaagtact tttttttgaa aatacagatt ttttttaaaa gtgaataatg tgttcaactc
     3061 ttaaattcat gctgtttcat cattgctggt gtattcatat gtgaaagcat gtgactaatt
     3121 gttgctgcat aaaagatatg agattctttt ttattaggca ttatttatga ccttttctat
     3181 gaaaagataa ggacattaaa atgtaagatg cgtgaggaaa atttaggtag agaggctctt
     3241 tgtggttaac ttataatatt gagtgatgca tgaggtaggt gttcagaata atattcctct
     3301 gcattattat gaatgaaaag cattcttaat tttagttaaa attaagttag tcatatgtta
     3361 ttttattaat tgtacttcta tgaaataata tgcagtctat ttttaaatta taaattatgt
     3421 gtgaacttag cttttcaatt caacattttt aacatattaa atactattgt gaattcaatg
     3481 aagtgttctt atgccactaa ctttaaccta ttcccttact caaggatgta ggtaaaagat
     3541 ggtaacaata cactatttgg taagataatg tactgacatc tctagcaatc ttttttgcca
     3601 gtggctttaa attgccaata agttaaagaa tattgttcct atgggttaaa tttttattct
     3661 tattttcaca tttaaattta tttttcttaa tttttgtgga tacataatat gtgtatatat
     3721 gtatgccata tatggtatat tttgatgcag gcatactcta tataataatc acattagagg
     3781 aaatgagata tccattacct ctagcattta ttctttttat tacaagcaat tcaattgtac
     3841 acttttagtt atttttaaat ttacaatgtt attgattaca gggtcatttt tatggtcata
     3901 ataaaaaatt ttatacaaac gtgtaaaatc tatacatttc tgagttctga ataaatattt
     3961 ttaaaaattt taatatattt ttctttgaat atgtgacctt tgcctgcaag cacatatgga
     4021 ctcttagaat tgatttacat aaaattaaat atatacttct attaaagata aaccttaggt
     4081 gtaaataaa
//
