LOCUS       NM_021047               3542 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 253 (ZNF253), transcript variant
            1, mRNA.
ACCESSION   NM_021047
VERSION     NM_021047.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3542)
  AUTHORS   Inoue,M., Takahashi,K., Niide,O., Shibata,M., Fukuzawa,M. and Ra,C.
  TITLE     LDOC1, a novel MZF-1-interacting protein, induces apoptosis
  JOURNAL   FEBS Lett 579 (3), 604-608 (2005)
   PUBMED   15670815
REFERENCE   2  (bases 1 to 3542)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011477.5 and BC014148.2.
            
            On May 17, 2019 this sequence version replaced NM_021047.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.257461.1,
                                           SRR1660803.183962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589717.2/ ENSP00000468720.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC011477.5         41368-41390         c
            24-2352             BC014148.2         1-2329
            2353-3542           AC011477.5         12598-13787         c
FEATURES             Location/Qualifiers
     source          1..3542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3542
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="zinc finger protein 253"
                     /db_xref="GeneID:56242"
                     /db_xref="HGNC:HGNC:13497"
                     /db_xref="MIM:606954"
     exon            1..118
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1615
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 411; DNA-binding protein; bone marrow zinc
                     finger 1"
                     /codon_start=1
                     /product="zinc finger protein 253 isoform 1"
                     /protein_id="NP_066385.2"
                     /db_xref="CCDS:CCDS42532.1"
                     /db_xref="GeneID:56242"
                     /db_xref="HGNC:HGNC:13497"
                     /db_xref="MIM:606954"
                     /translation="MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRDVMLENYRNLVFLG
                     IVVSKPDLVTCLEQGKKPLTMERHEMIAKPPVMSSHFAQDLWPENIQNSFQIGMLRRY
                     EECRHDNLQLKKGCKSVGEHKVHKGGYNGLNQCLTTTQKEIFQCDKYGKVFHKFSNSN
                     TYKTRHTGINLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTH
                     KRIHTGEKPYRCEECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTHKI
                     VHTGEKPYKCEECGKAFKHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIH
                     TGEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTG
                     EKPYKCDECGKTFTWPSILSKHKRTHTGEKPYKCEECGKSFTASSTLTTHKRIHTGEK
                     PYKCEECGKAFNWSSDLNKHKKIHIERKPYIVKNVTDLLNVPPLLISIR"
     exon            119..245
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /inference="alignment:Splign:2.1.0"
     exon            246..341
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /inference="alignment:Splign:2.1.0"
     exon            342..3542
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="hexamer: AATACA"
     polyA_site      2516
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="major polyA site"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="hexamer: AATAAA"
     polyA_site      2582
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="major polyA site"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="hexamer: ATTAAA"
     polyA_site      3323
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="major polyA site"
     polyA_site      3503
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
                     /note="hexamer: AATGAA"
     polyA_site      3530
                     /gene="ZNF253"
                     /gene_synonym="BMZF-1; BMZF1; ZNF411"
ORIGIN      
        1 gtttatcctc agtgttctgt gtcctgtgct tatagaggcc cgtcctctgt ggccgtgtga
       61 cctgcaagta ttgggagagc cacagctaaa ccccgggacc cctggaagcc tagaaatggg
      121 accattgcaa tttagagatg tggccataga attctctctg gaggagtggc attgcctgga
      181 cactgcacag cggaatttat atagggatgt gatgttagag aactacagaa acttggtctt
      241 ccttggtatt gttgtctcta agccagacct ggttacctgt ctggagcaag gaaaaaaacc
      301 tttaactatg gaaagacatg agatgattgc caaaccccca gttatgagtt ctcattttgc
      361 ccaagacctt tggccagaga acatacaaaa ttctttccaa atagggatgc tgagaagata
      421 tgaagaatgc agacatgaca atttacagtt aaaaaaaggc tgtaaaagcg tgggtgagca
      481 taaggtgcac aaaggaggtt ataatggact taaccaatgt ttgacaacta cccagaaaga
      541 aatatttcaa tgtgataaat atggaaaagt ctttcataag ttttcaaatt caaacacata
      601 taagacaaga catactggaa taaatctttt caaatgtata atatgtggca aagcttttaa
      661 acggtcctca acccttacta cacataagaa aattcatact ggagagaaac cttacagatg
      721 tgaagaatgt ggcaaagctt ttaaccaatc tgcaaacctt actacacata agagaattca
      781 taccggagag aaaccctaca gatgtgaaga atgtggcaaa gcctttaagc agtcctcaaa
      841 ccttactaca cataagaaaa ttcatactgg agagaaaccc tacaaatgtg aagaatgtgg
      901 caaagccttc aaccgatcca cagaccttac tacacataag atagttcata ctggagagaa
      961 accctacaaa tgtgaagaat gtggcaaagc ctttaagcac ccctcacacg ttaccacaca
     1021 taagaaaatt catactagag ggaaacccta caactgtgaa gaatgtggca aatcctttaa
     1081 gcactgctct aaccttacta tacataagag aattcataca ggagagaaac cctacaaatg
     1141 tgaagaatgt ggcaaagcct ttcacctatc ctcacacctt actacacata agatacttca
     1201 tactggagag aaaccctaca gatgtagaga atgtggcaaa gcttttaacc attccacaac
     1261 ccttttttca catgagaaaa ttcatactgg agagaaaccc tacaaatgtg atgaatgtgg
     1321 caaaaccttt acctggccct caatcctctc caaacataaa agaactcata ctggagagaa
     1381 accctacaaa tgtgaagaat gtggcaaatc ctttactgca tcctcaactc taactacaca
     1441 taagagaatt catactggag agaaacctta caaatgtgaa gaatgtggca aagcttttaa
     1501 ctggtcctca gaccttaata aacataagaa aattcatatt gaacgaaaac cctacatagt
     1561 gaagaatgtg acagatcttt taaatgttcc tccactttta attagcataa gataattcat
     1621 actggagaga aaccctatga atgtgatgaa tgtgggaaag cctttaacca gccctcgact
     1681 cttagtaaat ttgagagttt atatggaaca caaaccctac aaatataaag aatgtgacaa
     1741 agctttttaa ggaagttctc aacccttatt acacataatt cataccaaac agaagcccta
     1801 caagtgtgaa gaatgtggca aaacctataa acctataaca agttctcaat tccttttttt
     1861 ttgagatgga gtttcactct tgtcaccgag gctggagtgc aatgacatga tctccgttca
     1921 ctgcaatctc tgcctcctgg gtttaagcca ttcttctgcc tcagcctccc aagtagctgg
     1981 gattacaggt gcccaacacc acgcctggct aatttttgga tttttagtag agatggggtt
     2041 tcacaatgtt ggccaggctg gtctcgaact cctgacctca ggtgatccac ctgccttggc
     2101 cttccaaagt gctggggtta caggcgtgag ccaccatgcc tggctacaag ttcttaattc
     2161 ttaagagaca ccatgcctgg ctacaagttc ttaattctta agagacatgg cgataattca
     2221 tgctgaagag gaaatctgga aacctgaaag atgcgacatt gcttttacca acacctccac
     2281 atttcctata cataaaaata aattatacta gtgtaatacc ctagaaatgt ataaaatgtg
     2341 acaaagcctt tatatgattg tcatacatga ttgtaggtga tagaagtcat actgccaaaa
     2401 ctcctgtaag tgtgaagaat gtggcaaaat attttattag tgcttatacc ttatttcaca
     2461 ggaaagctct tatccttgag aaaaattgtg caaatacaaa gaatatggaa aaaccattaa
     2521 tgcctactca catcttactg aacagaagaa ggttcatagt taataaagca ttaaaagtgc
     2581 aattactgtc aaaaaatctt tcagaaaata gaagtcttta aagtgaagaa tatttattct
     2641 gaagacagcc attacaaata taaagggggt tgtagtgcct ttacttgtgt cacagatctt
     2701 agtgcacaca tgtagtacta gaggaaaacc ctgaagcagt tgctcaagct ttgtttcagg
     2761 gaatcaaggg aatttatatt gagaatagta ctgcaaatgt aatgaatgga aagacttttc
     2821 ttttccaaaa atgacagctt agaaaacacc agagggttta taccaaaata tatttttgca
     2881 gatgcagtaa atatcaaaaa atatttaatt caaaattgat tctatgtaaa tatcagagaa
     2941 ttttccatag aataattaag gcactgacac ttcagacatt acactaaatc agaatgttca
     3001 gtataaaaac taatccacag ctacagctgt tagataaatt atttctatat aattttttaa
     3061 aaagtggatt tttgaagcac tgtaattaca ttgaaagtat acttgttttc ttgaaaaaat
     3121 ttttttgaaa agtgaataat gatataatac agctttcaca ttgctttatg ctattttatt
     3181 cctattatat tcacatgtga aagcatgtga tcaattgttg ctgcattaga gatattagag
     3241 attgtttttt attagttggg cattatgtat gaccttttct ataaaagagt aaggacatta
     3301 aaatgtaaga tgcatgatga aaatataagt ggagaggctc tttgtagtta actgatatta
     3361 agtaatgtgt aaggtggggg ttcatgttct catttctata atcctagcca atgacttaat
     3421 gttgatgctt tgaatgtctt ttggatggtc taacctacat taacatgtat gcggaacatc
     3481 ttaaaacttt ttttcaaaaa tcataatgaa ttattttatt aataagcaaa gataaaaaat
     3541 aa
//
