LOCUS       NM_138367               2953 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 251 (ZNF251), mRNA.
ACCESSION   NM_138367 XM_001127489 XM_937814
VERSION     NM_138367.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA811573.1, AK000435.1, DA775010.1, BX509447.1, BC006258.2 and
            BU674002.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA933103.1, SRR1660807.209917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148, SAMN03267768
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292562.12/ ENSP00000292562.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               DA811573.1         55-563
            510-811             AK000435.1         448-749
            812-1104            DA775010.1         282-574
            1105-1541           BX509447.1         208-644
            1542-2639           BC006258.2         207-1304
            2640-2953           BU674002.1         18-331              c
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2953
                     /gene="ZNF251"
                     /note="zinc finger protein 251"
                     /db_xref="GeneID:90987"
                     /db_xref="HGNC:HGNC:13045"
     exon            1..127
                     /gene="ZNF251"
                     /inference="alignment:Splign:2.1.0"
     exon            128..235
                     /gene="ZNF251"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2218
                     /gene="ZNF251"
                     /codon_start=1
                     /product="zinc finger protein 251"
                     /protein_id="NP_612376.1"
                     /db_xref="CCDS:CCDS47944.1"
                     /db_xref="GeneID:90987"
                     /db_xref="HGNC:HGNC:13045"
                     /translation="MAATFQLPGHQEMPLTFQDVAVYFSQAEGRQLGPQQRALYRDVM
                     LENYGNVASLGFPVPKPELISQLEQGKELWVLNLLGAEEPDILKSCQKDSEVGTKKEL
                     SILNQKFSEEVKTPEFVSRRLLRDNAQAAEFREAWGREGKLKERVGNSAGQSLNKPNI
                     HKRVLTEATVGRERSLGERTQECSAFDRNLNLDQNVVRLQRNKTGERVFKCDICSKTF
                     KYNSDLSRHQRSHTGEKPYECGRCGRAFTHSSNLVLHHHIHTGNKPFKCDECGKTFGL
                     NSHLRLHRRIHTGEKPFGCGECGKAFSRSSTLIQHRIIHTGEKPYKCNECGRGFSQSP
                     QLTQHQRIHTGEKPHECSHCGKAFSRSSSLIQHERIHTGEKPHKCNQCGKAFSQSSSL
                     FLHHRVHTGEKPYVCNECGRAFGFNSHLTEHVRIHTGEKPYVCNECGKAFRRSSTLVQ
                     HRRVHTGEKPYQCVECGKAFSQSSQLTLHQRVHTGEKPYDCGDCGKAFSRRSTLIQHQ
                     KVHSGETRKCRKHGPAFVHGSSLTADGQIPTGEKHGRAFNHGANLILRWTVHTGEKSF
                     GCNEYGKAFSPTSRPTEDQIMHAGEKPYKCQECGNAFSGKSTLIQHQVTHTGQKPCHC
                     SVYGKAFSQSSQLTPPQQTRVGEKPALNDGSKRYFIHIKKIFQERHF"
     exon            236..365
                     /gene="ZNF251"
                     /inference="alignment:Splign:2.1.0"
     exon            366..479
                     /gene="ZNF251"
                     /inference="alignment:Splign:2.1.0"
     exon            480..2953
                     /gene="ZNF251"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2369..2374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF251"
                     /note="hexamer: AGTAAA"
     polyA_site      2396
                     /gene="ZNF251"
                     /note="major polyA site"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF251"
                     /note="hexamer: AATAAA"
     polyA_site      2953
                     /gene="ZNF251"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcatcc tagcccgccc cctccccggc tctggacccg gttctgtggg agggtccgtt
       61 ccgggctcgg tgcgactgcg cagctcctcg gcgcttcctc ggtggcttcc ccgggtcgag
      121 caaacaggta agttcgggga gacttcaggc cagggcagtc tcctgtcttc tcttggaaac
      181 cacagcagcc catgcacaca gaatggcagc cacattccag cttccagggc accaggagat
      241 gccgctgacc ttccaggatg tggccgtgta cttctctcag gcggaggggc ggcagctggg
      301 cccccagcag cgggcgctct accgggatgt gatgctggag aactatggga acgtggcctc
      361 tctgggattc cctgtcccta agccggagtt gatctcccag ctggagcagg ggaaggaact
      421 ttgggtcctg aatcttctgg gagctgagga accagatatc ttgaaaagct gccagaaaga
      481 ttctgaggtt gggaccaaga aggaactatc tattttaaac caaaaatttt ccgaagaagt
      541 aaaaacccca gaatttgtat caagaagact cttaagggat aatgcacagg ccgctgagtt
      601 tcgggaagca tggggccgtg agggcaaact caaagagcgc gtgggaaatt ctgccgggca
      661 gagtttgaac aaacccaata ttcacaagag agttttaaca gaagctaccg tgggcaggga
      721 aagatctttg ggagaaagaa cccaagagtg tagtgcattt gatagaaact tgaatctgga
      781 ccaaaatgtt gttagacttc aaagaaataa aacaggagag agggtcttta aatgtgatat
      841 atgcagcaaa accttcaaat ataattcaga cctaagtaga caccagagaa gtcacactgg
      901 ggagaagccg tacgaatgtg gccggtgtgg gcgagccttt actcacagct caaatcttgt
      961 tctgcaccat cacattcaca ctggaaataa accatttaaa tgtgatgaat gtgggaaaac
     1021 ttttggactc aattctcacc tccgtcttca tcggagaatt cacactggag aaaaaccctt
     1081 tggctgtggt gagtgtggga aggctttcag tcgaagctca actcttattc aacatcggat
     1141 cattcacaca ggagagaaac cctacaagtg taatgaatgt ggaagaggct ttagccagag
     1201 cccccagtta actcagcatc agagaattca cactggagag aagccgcatg aatgcagtca
     1261 ctgtgggaag gccttcagtc gaagctccag ccttattcag catgagagaa ttcacactgg
     1321 agagaagccc cataaatgca atcagtgtgg gaaggccttc agtcagagct caagcctttt
     1381 cctccatcat cgggttcata ctggagagaa accctatgta tgtaatgaat gcggcagagc
     1441 ctttggtttt aactctcatc ttactgaaca cgtaaggatt cacacaggag aaaaacccta
     1501 tgtttgtaat gagtgcggca aagcctttcg tcggagttcc actcttgttc agcatcgaag
     1561 agttcacact ggggagaagc cctaccagtg cgttgaatgt gggaaagctt tcagccagag
     1621 ctcccagctc accctacatc agcgagttca cactggagag aagccctatg actgtggtga
     1681 ctgtgggaag gccttcagcc ggaggtcaac cctcattcag catcagaaag ttcacagcgg
     1741 agagactcgt aagtgcagaa aacatggtcc agcctttgtt catggctcca gcctcacagc
     1801 agatggacag attcccactg gagagaagca cggcagagcc tttaaccatg gtgcaaatct
     1861 cattctgcgc tggacagttc acactggtga gaaatccttt ggatgtaatg aatatggaaa
     1921 agctttcagt cccacctcac gacccactga agatcagata atgcatgctg gggaaaagcc
     1981 ctataaatgt caagaatgtg gaaacgcctt cagtggaaag tcaaccctta ttcaacatca
     2041 ggtaactcac actggtcaga aaccatgtca ttgcagtgtg tatgggaaag ccttcagcca
     2101 gagttcacag ctcacaccac ctcagcagac tcgtgttgga gagaaacctg ctttaaatga
     2161 tggctctaaa agatacttta ttcatatcaa gaagattttc caagaaagac atttttaatg
     2221 tgataaatgc agaagacagt ttagcaactg ttcacttgac attagaagat aagatggcat
     2281 aatgaaagat atataaggtc taaatattac tggcaaagta aaataaatag ttcagatgac
     2341 tactaaagtc aaagtcatta aatctggaag taaacacgag aattcattct gggaaatcag
     2401 gctgtctgtg taaaggttac tgctgtgctc aggagttgaa ccgtgtggtg ctgtatccgg
     2461 atactcatga cgaatggatg gagggcgtga aaagtgagcc cagctggtgc tctgggtcta
     2521 ccctacctga catccttcca gtcttatcct ttgtttccta tccaggccca ggcttgtggc
     2581 tgagaacatc cactttcagt cccatatacc tgcctccaag tgtggtacag agaacttggg
     2641 cctgctgggg gcgcttagcc ttactctctc caccacctct cccaccaacc cccagatgaa
     2701 ctgcaggtag acgtttcttc cttgcttgga gccccagttt ttgcatttca ttttcattaa
     2761 aatgaaaggt ggtttggttt tggttctaag gagctctaca gtttaacaga gagagggacc
     2821 ttaggggcca agaaagcagg ggcctaccaa gtatctccac ttttgaaaat tgtaattact
     2881 gataaaaaat tttttaaagg caggtttatt gaagcataat ttataaacaa taaaatttac
     2941 tctttttagt gta
//
