LOCUS       NM_145011               4152 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 25 (ZNF25), transcript variant 4,
            mRNA.
ACCESSION   NM_145011
VERSION     NM_145011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Twine,N.A., Harkness,L., Kassem,M. and Wilkins,M.R.
  TITLE     Transcription factor ZNF25 is associated with osteoblast
            differentiation of human skeletal stem cells
  JOURNAL   BMC Genomics 17 (1), 872 (2016)
   PUBMED   27814695
  REMARK    GeneRIF: This study shows that the uncharacterized transcription
            factor, ZNF25, is associated with differentiation of hMSC to
            osteoblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Guy,J., Hearn,T., Crosier,M., Mudge,J., Viggiano,L., Koczan,D.,
            Thiesen,H.J., Bailey,J.A., Horvath,J.E., Eichler,E.E.,
            Earthrowl,M.E., Deloukas,P., French,L., Rogers,J., Bentley,D. and
            Jackson,M.S.
  TITLE     Genomic sequence and transcriptional profile of the boundary
            between pericentromeric satellites and genes on human chromosome
            arm 10p
  JOURNAL   Genome Res 13 (2), 159-172 (2003)
   PUBMED   12566394
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Guy,J., Spalluto,C., McMurray,A., Hearn,T., Crosier,M.,
            Viggiano,L., Miolla,V., Archidiacono,N., Rocchi,M., Scott,C.,
            Lee,P.A., Sulston,J., Rogers,J., Bentley,D. and Jackson,M.S.
  TITLE     Genomic sequence and transcriptional profile of the boundary
            between pericentromeric satellites and genes on human chromosome
            arm 10q
  JOURNAL   Hum Mol Genet 9 (13), 2029-2042 (2000)
   PUBMED   10942432
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Tunnacliffe,A., Liu,L., Moore,J.K., Leversha,M.A., Jackson,M.S.,
            Papi,L., Ferguson-Smith,M.A., Thiesen,H.J. and Ponder,B.A.
  TITLE     Duplicated KOX zinc finger gene clusters flank the centromere of
            human chromosome 10: evidence for a pericentric inversion during
            primate evolution
  JOURNAL   Nucleic Acids Res 21 (6), 1409-1417 (1993)
   PUBMED   8464732
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Rousseau-Merck,M.F., Tunnacliffe,A., Berger,R., Ponder,B.A. and
            Thiesen,H.J.
  TITLE     A cluster of expressed zinc finger protein genes in the
            pericentromeric region of human chromosome 10
  JOURNAL   Genomics 13 (3), 845-848 (1992)
   PUBMED   1639412
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP229986.1 and AL117337.26.
            
            On Nov 22, 2018 this sequence version replaced NM_145011.3.
            
            Transcript Variant: This variant (4) encodes isoform b, as do
            variants 5-9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.96318.1,
                                           SRR1660803.32271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302609.8/ ENSP00000302222.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               BP229986.1         10-582
            574-4152            AL117337.26        60118-63696         c
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.21"
     gene            1..4152
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /note="zinc finger protein 25"
                     /db_xref="GeneID:219749"
                     /db_xref="HGNC:HGNC:13043"
                     /db_xref="MIM:194528"
     exon            1..142
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     exon            143..242
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1598
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /note="isoform b is encoded by transcript variant 4; zinc
                     finger protein 25 (KOX 19); zinc finger protein KOX19"
                     /codon_start=1
                     /product="zinc finger protein 25 isoform b"
                     /protein_id="NP_659448.1"
                     /db_xref="CCDS:CCDS7195.1"
                     /db_xref="GeneID:219749"
                     /db_xref="HGNC:HGNC:13043"
                     /db_xref="MIM:194528"
                     /translation="MNKFQGPVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHL
                     VSVGYHVNKPNAVFKLKQGKEPWILEVEFPHRGFPEDLWSIHDLEARYQESQAGNSRN
                     GELTKHQKTHTTEKACECKECGKFFCQKSALIVHQHTHSKGKSYDCDKCGKSFSKNED
                     LIRHQKIHTRDKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLT
                     EHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVH
                     QRMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSALTVHQR
                     THTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECGKSFAVNSVLRLHQRTH
                     TGEKPYACKECGKSFSQKSHFIIHQRKHTGEKPYECQECGETFIQKSQLTAHQKTHTK
                     KRNAEK"
     exon            243..369
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     exon            370..465
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     exon            466..529
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     exon            530..4152
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /note="hexamer: AATAAA"
     polyA_site      3860
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /note="major polyA site"
     regulatory      4135..4140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="ZNF25"
                     /gene_synonym="KOX19; Zfp9"
ORIGIN      
        1 gtcttctttc tggcattggc gtttttttgg tcttacgccc tagggtgggg agaggactcc
       61 ggtgcctccg ggtctgggct gggccgcaaa gggcggggcc tgggcccggc gcgggccggg
      121 agcagaggcc gagaccctgc aggtgattcc tggggctgcc agctaaggtc ccttatgatt
      181 tctgctctgg ctttgcagtt ttcagccttt cccaagagca gcagaaaatg aacaagttcc
      241 agggacccgt gacattaaag gatgttattg tggaattcac caaggaagaa tggaagttac
      301 tgacccctgc tcagaggact ctgtataagg atgtgatgct ggaaaactat agtcaccttg
      361 tctcagtggg ttaccatgtg aataagccaa atgcagtctt caagttgaag caaggaaaag
      421 agccatggat attagaagta gaatttccac atcggggctt ccctgaagac ctatggagca
      481 ttcatgatct agaagcaaga taccaggaaa gccaagctgg aaattcaagg aatggagaac
      541 tcacaaaaca tcagaaaact cataccacag agaaagcctg tgaatgtaag gaatgtggga
      601 agttcttctg ccagaagtct gccctcatag tacatcagca tactcactca aagggcaaat
      661 cctatgactg tgataaatgt gggaaatctt tctctaaaaa tgaagacctc ataagacatc
      721 agaaaattca cacgagagat aaaacctatg agtgtaaaga atgtaagaaa atattttacc
      781 acctatcatc tctcagtaga catctgagaa cccatgcagg agagaaaccc tatgaatgta
      841 atcagtgtga aaaatccttc taccagaaac cacatctcac agaacatcag aaaacacaca
      901 caggggagaa accttttgaa tgtactgaat gtgggaagtt cttctatgtg aaggcatacc
      961 tcatggtaca tcagaaaaca cacacagggg agaaacccta tgagtgtaag gagtgtggga
     1021 aagccttttc ccagaagtca cacctcacag tacatcagag aatgcacaca ggggagaaac
     1081 cctataaatg taaggaatgt gggaaattct tctctaggaa ttcacacctc aaaactcatc
     1141 agagaagtca cacaggagag aaaccctatg aatgtaagga atgtaggaaa tgcttctacc
     1201 agaagtcagc cctcacagta catcagcgaa ctcacacagg ggagaaaccc tttgaatgta
     1261 ataaatgtgg gaaaacattt tactataaat cagacctcac taaacatcag agaaaacaca
     1321 caggggagaa gccctatgaa tgcacagaat gtggcaaatc ttttgctgtg aattcagtcc
     1381 tcagattaca tcaaaggact cacacaggag agaagcccta tgcatgcaag gaatgtggga
     1441 agtccttttc tcagaagtca cattttatta tacatcagag aaaacacaca ggggagaagc
     1501 cctatgagtg tcaggagtgt ggggaaacct ttatccagaa gtcacaactc actgcacatc
     1561 agaagacaca cacaaagaag aggaatgctg agaagtaaga tgagttggga aattctcttg
     1621 actgaattaa tccttcaaaa caatcagata attcacacaa gaggtacacc ttatgaatcg
     1681 catcaataga gggaaatttt cagctacaat ctttgctctc tctgtgtatc agcaaataca
     1741 tagagagatt ctgtacattt atttgggaga aaattttatc atattttagg cttttctaaa
     1801 tattagataa tatagatggc agaagtcatg caaattgtaa aacaggaagg aaacctttca
     1861 gaagtcatac ttttgttttg caacatagaa gtcacacagg agaaaaatcc tgtaagtaaa
     1921 acgaatgtca agacattttc tgtcagggca gccagctgta gacatccaaa agctcacaaa
     1981 tgagaagctc cttgagtatc tagaaatctc tttacacaat tggagctcat gtactagaga
     2041 attcaaaggg ataactgcaa agacactggt agatatagaa gcctttatta agaattgatg
     2101 tttcattcaa tttcagatca ctggtacttg gatagatatt ttaaatattt ggaaggtgtt
     2161 caataaaaat tcaaataatt tgtactgagg gaaacagtta tactacaaat catgttgcag
     2221 atctgatgcc gagattgctc tattttaaaa ggaaacctgc aaatgtctac atatatgaag
     2281 cttttaaaaa gcacaagtta tcaggcaaca tcattaaaca tacattaaat gtctgttagc
     2341 atataggatt ttgtgcgtat gtgagtgtgc tataacatgt aacttgcgga tgttcagcgt
     2401 gcatgtggaa tccatccata atggtacata gcgaaataat ataatcttag ttcagtaact
     2461 attatgtgta tgaagatgtt gcacattaag tctcagtagt gactctggtt gttaatattt
     2521 gtattgtaag tgtaatattc cttttaaatt ataaggcatc tttttatcct tttttgtgtt
     2581 tgtaaatgga tatagacagt ggtaataact aatccttcaa aaataagtta aaatgttttt
     2641 gtaaaatttt caaatgtcag tcaagttttg cattagggac acatttatat atagcaaaag
     2701 cctgagctgt ttttaaacag ctaaaaacag tagtatttat tacaatctcc acaatgaaaa
     2761 caaatagtgc aatgtaagaa atattatgta tcttactgtt gatgtgtgag cagggagcag
     2821 agctatctgc atttgtattt agtgtgagag tcctaaatgt tcttcaccaa ctttttcttc
     2881 ctcatagaag caacatggca tagttaaggg tgtggactct gggctcctgc tgcctgggcc
     2941 ccgattccag catggggcat gctacttaat atctctgtgc ctcagttccc atcccataaa
     3001 agagtagtga tagtgacaac atcttaggat tgctttgagg tctaaatgag ttaacatttt
     3061 caaagcactt agaatagtgt ctgagacaca agagctatat gttagaggtt atcatcatta
     3121 tttgtatttt gtgaattacg ctgcaaaaaa aaaaaaaatg ttggctaccc aacattcatt
     3181 ccccaccttc ttgctgccag tgccttgatt tggttgtttg ttgtttgttt gttttcctac
     3241 aagtgattta ggggcagatc ctgactacac taagtcaggg tttgacaaat gacagtccat
     3301 cagacagatc tggcccacta cccatttttg tatcctgcaa gctaagaatg gttttatatt
     3361 tctaaatggt tgaaagaatc aaagaatatt gtgacacatg aaaattatat gatattcaaa
     3421 tttcagtgtc cataaataaa gttttgaaaa catgaataca aacaaaaaac acctatttat
     3481 gtttgacctg tggctgtctt tgcactaccc cagcagagtt gagtagttgt agcagacacc
     3541 acatgccctt gagcctaaga tctagcactt tacaaagtaa gtttttctgt tacttagagc
     3601 tgaaaataaa agcaatgtag agttacgctt ttataagtat ttcatgtttc agaaatgatg
     3661 catacagcaa tttgtaggtg ggtggttttt tgcagtatat ttattttgtg cattatattt
     3721 atatgttaag agcctgagct tagaagtatt tttttcaaag aaatgtgttt tttacttgct
     3781 aaattgtcat aacatcaaaa caagaaattt cttgatggaa tgtagcagta aacatatgaa
     3841 ataaacattg tctaaattaa gtcgaattgt tcattgatac tgccccacag tattcctttg
     3901 ttttctccca aatcaatggc cagttttccc tgtatcattt tataattttc tttctatccc
     3961 ataagatacc attggtaagt catacttagc taacgtaacc caataacaaa aaacttacaa
     4021 tacccaattc catcagctac attactagta atctataaaa ttattgcctg cacttcatgt
     4081 aattgtcata tgctgctaca atctaaacct gccagcgtct tacttcccct tcctaataaa
     4141 gactttcatt ga
//
