LOCUS       NM_006965               6256 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 24 (ZNF24), transcript variant 1,
            mRNA.
ACCESSION   NM_006965
VERSION     NM_006965.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6256)
  AUTHORS   Meng,F., Ai,C., Yan,G. and Wang,G.
  TITLE     Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes
            colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt
            pathway and activating the p53 signaling
  JOURNAL   Exp Cell Res 433 (1), 113796 (2023)
   PUBMED   37774763
  REMARK    GeneRIF: Tumor-suppressive zinc finger protein 24 (ZNF24)
            sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting
            the Wnt pathway and activating the p53 signaling.
REFERENCE   2  (bases 1 to 6256)
  AUTHORS   Liu,Y., Cheng,H., Cheng,C., Zheng,F., Zhao,Z., Chen,Q., Zeng,W.,
            Zhang,P., Huang,C., Jiang,W., Liu,X. and Liu,G.
  TITLE     ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in
            hepatoma cells via transcriptional regulation of DNMT1
  JOURNAL   Cancer Med 11 (5), 1269-1280 (2022)
   PUBMED   35092191
  REMARK    GeneRIF: ZNF191 alters DNA methylation and activates the PI3K-AKT
            pathway in hepatoma cells via transcriptional regulation of DNMT1.
REFERENCE   3  (bases 1 to 6256)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6256)
  AUTHORS   Liu,Y., Wu,D., Cheng,H., Chen,L., Zhang,W., Zou,L., Gao,Q.,
            Zhao,Z., Chen,Q., Zeng,W., Zhang,Z., Jiang,W., Huang,C. and Liu,G.
  TITLE     Wnt8B, transcriptionally regulated by ZNF191, promotes cell
            proliferation of hepatocellular carcinoma via Wnt signaling
  JOURNAL   Cancer Sci 112 (2), 629-640 (2021)
   PUBMED   33197287
  REMARK    GeneRIF: Wnt8B, transcriptionally regulated by ZNF191, promotes
            cell proliferation of hepatocellular carcinoma via Wnt signaling.
REFERENCE   5  (bases 1 to 6256)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6256)
  AUTHORS   Albanese,V., Biguet,N.F., Kiefer,H., Bayard,E., Mallet,J. and
            Meloni,R.
  TITLE     Quantitative effects on gene silencing by allelic variation at a
            tetranucleotide microsatellite
  JOURNAL   Hum Mol Genet 10 (17), 1785-1792 (2001)
   PUBMED   11532988
REFERENCE   7  (bases 1 to 6256)
  AUTHORS   Han,Z.G., Zhang,Q.H., Ye,M., Kan,L.X., Gu,B.W., He,K.L., Shi,S.L.,
            Zhou,J., Fu,G., Mao,M., Chen,S.J., Yu,L. and Chen,Z.
  TITLE     Molecular cloning of six novel Kruppel-like zinc finger genes from
            hematopoietic cells and identification of a novel transregulatory
            domain KRNB
  JOURNAL   J Biol Chem 274 (50), 35741-35748 (1999)
   PUBMED   10585455
REFERENCE   8  (bases 1 to 6256)
  AUTHORS   Williams,A.J., Blacklow,S.C. and Collins,T.
  TITLE     The zinc finger-associated SCAN box is a conserved oligomerization
            domain
  JOURNAL   Mol Cell Biol 19 (12), 8526-8535 (1999)
   PUBMED   10567577
REFERENCE   9  (bases 1 to 6256)
  AUTHORS   Rousseau-Merck,M.F., Huebner,K., Berger,R. and Thiesen,H.J.
  TITLE     Chromosomal localization of two human zinc finger protein genes,
            ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12,
            respectively
  JOURNAL   Genomics 9 (1), 154-161 (1991)
   PUBMED   2004757
REFERENCE   10 (bases 1 to 6256)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116447.10.
            
            On Nov 22, 2018 this sequence version replaced NM_006965.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.15229.1,
                                           SRR1660805.7258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261332.11/ ENSP00000261332.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC116447.10        12325-12385
            62-564              AC116447.10        16012-16514
            565-712             AC116447.10        16769-16916
            713-6256            AC116447.10        18975-24518
FEATURES             Location/Qualifiers
     source          1..6256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..6256
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="zinc finger protein 24"
                     /db_xref="GeneID:7572"
                     /db_xref="HGNC:HGNC:13032"
                     /db_xref="MIM:194534"
     exon            1..61
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            62..564
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1251
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 191; zinc finger protein 24 (KOX 17); zinc
                     finger protein KOX17; retinoic acid suppression protein A;
                     zinc finger and SCAN domain-containing protein 3"
                     /codon_start=1
                     /product="zinc finger protein 24 isoform 1"
                     /protein_id="NP_008896.2"
                     /db_xref="CCDS:CCDS11912.1"
                     /db_xref="GeneID:7572"
                     /db_xref="HGNC:HGNC:13032"
                     /db_xref="MIM:194534"
                     /translation="MSAQSVEEDSILIIPTPDEEEKILRVKLEEDPDGEEGSSIPWNH
                     LPDPEIFRQRFRQFGYQDSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVA
                     ILPKELQTWVRDHHPENGEEAVTVLEDLESELDDPGQPVSLRRRKREVLVEDMVSQEE
                     AQGLPSSELDAVENQLKWASWELHSLRHCDDDGRTENGALAPKQELPSALESHEVPGT
                     LNMGVPQIFKYGETCFPKGRFERKRNPSRKKQHICDECGKHFSQGSALILHQRIHSGE
                     KPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSGLINHQRIHTGEKP
                     YECVQCGKSYSQSSNLFRHQRRHNAEKLLNVVKV"
     exon            565..712
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..6256
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="hexamer: AATAAA"
     polyA_site      3258
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="major polyA site"
     regulatory      6096..6101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="hexamer: AATAAA"
     polyA_site      6123
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
     regulatory      6231..6236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="hexamer: AATAAA"
     polyA_site      6256
                     /gene="ZNF24"
                     /gene_synonym="KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3"
                     /note="major polyA site"
ORIGIN      
        1 gtttctgcgt ctgccgtgga cagcgaagct gctgcggttc ctgagccgga ggtttgcgcc
       61 ggagtgcctg tgaagaaaac ggggtattgc cctgaggctt atattctgcc tcagttgtct
      121 tttcttgaaa tattataaat cagaatgtct gcacagtcag tggaagaaga ttcaatactt
      181 atcatcccaa ctccagatga agaggaaaaa attctgagag tgaagttgga ggaggatcct
      241 gatggcgaag agggatcaag tatcccctgg aaccatctcc cagacccaga gattttccga
      301 cagcgattca ggcagtttgg ataccaggat tcacctgggc cccgtgaggc tgtgagccag
      361 ctccgagaac tttgccgtct gtggctcagg ccagagacgc acacaaaaga acaaatcttg
      421 gagctggtag tgctggagca gtttgttgcc atcctaccca aagagctaca gacttgggtt
      481 cgagatcatc atccagagaa tggagaggag gcagtgacag tgctggagga tttggagagt
      541 gaacttgatg accctggaca accggtttct ctccgtcgac gaaaacggga agtactagta
      601 gaagacatgg tatctcaaga agaagctcag ggattaccaa gttctgagct tgatgctgtg
      661 gagaaccagc tcaagtgggc atcctgggag ctccattccc taaggcactg tgatgatgat
      721 ggtaggactg aaaatggagc actagctcca aagcaggagc ttccttcagc attagaatcc
      781 catgaagttc ctggcactct caatatgggt gttcctcaaa tttttaaata tggagaaacc
      841 tgtttcccca agggcaggtt tgaaagaaag agaaatccct ctcgaaagaa acaacatata
      901 tgtgatgaat gtggaaaaca cttcagtcag ggctcagccc ttattcttca tcaaagaatt
      961 cacagtgggg agaaacctta tggatgtgtt gagtgtggga aagcattcag ccgaagttcc
     1021 attcttgtgc aacaccagag agtccacact ggagaaaaac cttacaaatg tcttgaatgt
     1081 gggaaagcct ttagccagaa ttcggggctt attaatcatc agagaatcca tactggggag
     1141 aaaccttatg aatgcgttca gtgtgggaaa tcgtatagtc aaagctcaaa tctttttaga
     1201 catcagagaa gacacaatgc agaaaaactt ctgaatgttg tgaaagttta agaaattgaa
     1261 aaaaaaaaaa gaatcagcac tcaggtcttt ttcttcagaa atgaagacaa aatttaaaat
     1321 atgaaatgat gcagaatagt tttttcccta ttgactgtca gaaaatccac tgggaaatgt
     1381 aaaaatcttc actcaccatt atgatattta tcttgaaaga aatggtgtca tacctgccta
     1441 gaaactgaaa ttttaaactt aattcaggtc ttaatgccta aattttccat gtgatgttta
     1501 tagtctgtat tacttctcca aataatgaac tacctgattc attgtccctt tcttgaaagt
     1561 ttctttttta agacaaatac attatttctg cattgatcat tgaaatgttc tttatatgga
     1621 tacattccct tatatattaa aaggcaacag gaattacaaa gtctgaaaac cattttaaac
     1681 catcttttaa aaatttaccc ttatttcctt ttacctaatt tgaatatgca tttgagaaaa
     1741 taagaggata aaggatggct aagagcctca aaatgaacca taagatctca gataagaagt
     1801 gatggtgata aaacatcaaa aagtgaatgg aacaccttga ttggggaaga tatgcaaata
     1861 ctttgatcta agaattgaaa tgtatcaaga atttatattt tgcctgcagg aaaattcaaa
     1921 agctactcat cctctctata atttggagtc atcttactaa tgaaaataat gttttcccat
     1981 atattattaa aaagcataca gtctaaataa taaacagttg taaaataatg aaggtagaaa
     2041 ttataacact agggaaaaat ttgtagcgga tggcagtgtt gaaggcaaat gtaaacataa
     2101 gggtaatggt ctgtcatggc ttttagaaaa agatgataga gttcatcatt attttgcctt
     2161 catctttgtt aaggacagaa aattccctga caggtgggca agtatcaggt tacctatttt
     2221 ttattccttt ggtacaaaag ggttgaacgt caggctaaaa aagcagccat gcatttatta
     2281 ttaaacattt tctaccgaca aggcactgtg ctaggtactg taatcctacc ataagtaggt
     2341 aggtatttct tccactgtaa atcatagggg tttgctgttt tatgtgagtt agcctcttcc
     2401 ccttgtctga gcattcctca ggggaggtca cctgtgaggt tcccagaact gtagtttttt
     2461 ttaccagggt gttgtatttg gagggggagg aggactcggc tcaaaagagc tagctggctc
     2521 tccagtgttc agaggtgagt ccacgatact cttaccacaa tttggaagtt tgtgaatctt
     2581 tttaaagaac taatcaatct ctaatagcat tgaggttgta cctacatatt aagttgaatg
     2641 gactgttcta tttaaaaaat aaacaactag acaattaact agtttattaa cctatcacaa
     2701 ttgaattttt ttttaatttt cagtcttaac acatttttta aaatgtatta aagtaataca
     2761 ttgtagtagt aggattatat actccttggc tgagaattcc aagtactgtg gttctactgt
     2821 ttagtggaaa actctggaag ttaaaatata gaatatgaga ggaggctttt ttataatggg
     2881 catcattgtg tggaaaatga cccatgtgaa tacaaatatt tcctagttca gagattttgg
     2941 ttatatctgg tgcttggatc aagtttaaaa atggaaggtg agattttgca tgagcctatt
     3001 aaaaagcata gtaataaatg caaggccagc tggtggaaaa gtgaggcaga atggagcttg
     3061 tttataggtt ttctgataac aattataaaa aatgtgcttt atagattaag atttattgaa
     3121 gtataaatat gtagtaatga tataatgtat tttaagttat acaagaaaat gtagggactt
     3181 ttgtttgggt ctttttctct ttgtggctga ggggaaacaa gtcagtgtcc aataaagctg
     3241 taaactcctc tgctctaaga taaatgatgt gatttattta tttataactg gcttctttcc
     3301 aagtaggttt tcaggtggca tatttggaag acggctggaa tgacagaatt cttgtatcag
     3361 agtaggtaag aagggagcaa cctctcaatg gctattatgt catgcttttt aagatcgtat
     3421 gcggttccta tatacaagga agcttccctg tggtagattt gtcataaatg ccaaagatat
     3481 ttggtaatgt gagtgtagaa aaagtagtat gagggttggc aaatactgtt tttgtcttgg
     3541 cagctctaat atctgcattg ttcagaaagg attctgaggc taaggcaaag ctctgtggga
     3601 aaaagggact ggaccaaaaa aaactggatg gtggcacaca agaagaggaa atgatgagat
     3661 gtgtactttc tatctctggt taggcttagt ccccactaga caaattgatt ttaaatacta
     3721 tgtagtgatt tttaaattcc atccacacat tcattaccca cacagataat catagaaatt
     3781 tgggggagtg cctagcttct gatgaagtgg tgatatggca gtgccaagca gtggcatcgc
     3841 cagagtatct gtttggttag caaatgagca gtcattttag gtcatgcaga ttgctgatat
     3901 ctgcccagta gccactgagc atttgctggt tttttcttct ggctttcttg gaggttaagc
     3961 tctctgtagt catacccagt tggtacttga tctttagcaa tatgtctcat attcatgtaa
     4021 attgaaggga gggttacatg tactgaaata atctgcatgc taggcattgg cttagacacc
     4081 gtacctatct cacttagatt tgtggactag gaaagcaaga ttcagagatc atgtgacttg
     4141 catgtggcct agagataaaa ttcaaatctg gttctgtaga ctccagggac atattcacca
     4201 tgccatgggt ggtggctatt aaaccttgat aaatttgtgt ttatggttaa caaatgtgaa
     4261 agctattaaa cattgctggt ttgaattttt tacagtgcag aaatgtaaaa tgaaaaagga
     4321 tatttccttt cacagtgtta ccgagaagtc atgataattt cgtttgttct tccagattta
     4381 ggcatatact tatttaatca ataatgtgtt aacagctgac acctgtggtt gctgtgacag
     4441 gcactatttg aagtgcttta tcatggatta actcttaatc ctcagctacc gtataaagta
     4501 ggacataacc ccatttcaca tgcactacac tgagacttgc ctcctctccc cccacattga
     4561 agatgttctt ttttcataac tatatactat tccattgcat gaatattctg taatttattt
     4621 aatcccctat ggattgataa ttaggttcat tatagataga agtgtaatta acattcctgt
     4681 acatgtattt tgctacttgt gtgggtattt ctgtaggatg aataactaga aatttattgg
     4741 atcaggtttc acatttgcag ttttgaaaac tactaccaaa aagatttcac caatttacaa
     4801 ctccatcatt agtaagaatg cctgtttgcc tatagtctgc caaccctgaa tccttaaaaa
     4861 tttttgccaa tctggtaggc aaaatttctt tcttttcttt gaatattaat gaggaggaac
     4921 atcttttcat gtttcttggc catttgcatt tcctattatg aattgctttt gcccattttc
     4981 ctttttttaa ttatgaaagt ctaatgacta ccttctcatt gtataaaaaa cacagttctt
     5041 tgaatagaga gacccttttc tccaatgcta ccaatcacat tccacttacc acagtttaac
     5101 atacatcctc tagtcacctt tccgtacgaa tatacataca cataaaaaca ctttttacat
     5161 aaataggatc tcatattctg tagcttttta aaattttggt ctcaaaaaaa gataacaggt
     5221 ctttaaattt ctttaatggt tgaatatgat taaatactat gaaaatgcca ttatttattc
     5281 ccttaatttt tttcctctcg ctattacatt gccaaagtaa acatcctatt cagatgtctt
     5341 tgtgcatgtg tgtgaatatt tctttagtct ggagtccagt aaggtggatt tttggatcaa
     5401 agggtttgtt ctctgtccac cttcagtctt cccaaaggcc ttcataactg tattttcacc
     5461 aagtgtatgg agaatgttca tttccccata taaccatacc tacacttgat agtttttatc
     5521 tgttgggcga aaaagaacct tttcttattt tgcatttccc tgattataaa aaaaaatggt
     5581 gagattgggg ttattttcat gtttattggc catttatagt ttactgtgga ttgtttgtat
     5641 cccttacctg ctttctattg ggttatgtgt ggatatattg tttttatttg ttcagcatct
     5701 ccttccccat cttctggtaa cacaaccttt atttatttgt ggggaaccta ttccctgtgg
     5761 cttaggtgag catgtgacca ggcctggcct cctgagtccc acagcttcct agccacagtg
     5821 ataaaagaat gggtatataa cttaagccag gctaaggaaa gcccttaaca gaacttctgc
     5881 tggaactact ggaaagaagg ctttatggag atcccaggaa ccaaggacca tgtaagcctg
     5941 aatttgtgcc atgtggagag agtctgtctg aggagaaact cggatgctag cagaaatgga
     6001 aagagaacta agttctgatg tcatttttct ggaggcccta gatccagctg tgcctaaagc
     6061 ctgccctacc tccggacttt aaagttttgt gagccaataa agtccctttc ttgtttaaga
     6121 taattgaatt gagtttctgt tctgattaat ataggttatt tgtattttct tattgatttg
     6181 tagaaaacct ttgtaatttt aaattctaga ctttatgcac tatataagtt aataaaatta
     6241 gcatggcctt ccatga
//
