LOCUS       NM_001099282            2069 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 239 (ZNF239), transcript variant
            2, mRNA.
ACCESSION   NM_001099282
VERSION     NM_001099282.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2069)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2069)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2069)
  AUTHORS   Lei,S.F., Papasian,C.J. and Deng,H.W.
  TITLE     Polymorphisms in predicted miRNA binding sites and osteoporosis
  JOURNAL   J Bone Miner Res 26 (1), 72-78 (2011)
   PUBMED   20641033
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2069)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 2069)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2069)
  AUTHORS   Dreuillet,C., Tillit,J., Kress,M. and Ernoult-Lange,M.
  TITLE     In vivo and in vitro interaction between human transcription factor
            MOK2 and nuclear lamin A/C
  JOURNAL   Nucleic Acids Res 30 (21), 4634-4642 (2002)
   PUBMED   12409453
  REMARK    GeneRIF: In this study, we identify a novel interaction between
            lamin A/C and hsMOK2 by using the yeast two-hybrid system
REFERENCE   7  (bases 1 to 2069)
  AUTHORS   Arranz,V., Dreuillet,C., Crisanti,P., Tillit,J., Kress,M. and
            Ernoult-Lange,M.
  TITLE     The zinc finger transcription factor, MOK2, negatively modulates
            expression of the interphotoreceptor retinoid-binding protein gene,
            IRBP
  JOURNAL   J Biol Chem 276 (15), 11963-11969 (2001)
   PUBMED   11278819
REFERENCE   8  (bases 1 to 2069)
  AUTHORS   Arranz,V., Harper,F., Florentin,Y., Puvion,E., Kress,M. and
            Ernoult-Lange,M.
  TITLE     Human and mouse MOK2 proteins are associated with nuclear
            ribonucleoprotein components and bind specifically to RNA and DNA
            through their zinc finger domains
  JOURNAL   Mol Cell Biol 17 (4), 2116-2126 (1997)
   PUBMED   9121460
REFERENCE   9  (bases 1 to 2069)
  AUTHORS   Arranz,V., Kress,M. and Ernoult-Lange,M.
  TITLE     Localization of zinc finger Mok2 gene to mouse chromosome 6, a new
            region of homology with human chromosome 19
  JOURNAL   Mamm Genome 7 (1), 77-78 (1996)
   PUBMED   8903737
REFERENCE   10 (bases 1 to 2069)
  AUTHORS   Ernoult-Lange,M., Arranz,V., Le Coniat,M., Berger,R. and Kress,M.
  TITLE     Human and mouse Kruppel-like (MOK2) orthologue genes encode two
            different zinc finger proteins
  JOURNAL   J Mol Evol 41 (6), 784-794 (1995)
   PUBMED   8587123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450326.30 and BC026030.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001099282.1.
            
            Summary: MOK2 proteins are DNA- and RNA-binding proteins that are
            mainly associated with nuclear RNP components, including the
            nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed
            9121460]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-9 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026030.1, SRR5189664.51774.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374446.7/ ENSP00000363569.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL450326.30        172127-172181       c
            56-2041             BC026030.1         1-1986
            2042-2043           AL450326.30        153935-153936       c
            2044-2069           BC026030.1         1989-2014
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..2069
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /note="zinc finger protein 239"
                     /db_xref="GeneID:8187"
                     /db_xref="HGNC:HGNC:13031"
                     /db_xref="MIM:601069"
     exon            1..77
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /inference="alignment:Splign:2.1.0"
     exon            78..118
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..241
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..2069
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1710
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /note="isoform a is encoded by transcript variant 2; zinc
                     finger protein (C2H2) homologous to mouse MOK-2; zinc
                     finger protein MOK-2; zinc finger protein HOK-2"
                     /codon_start=1
                     /product="zinc finger protein 239 isoform a"
                     /protein_id="NP_001092752.1"
                     /db_xref="CCDS:CCDS41502.1"
                     /db_xref="GeneID:8187"
                     /db_xref="HGNC:HGNC:13031"
                     /db_xref="MIM:601069"
                     /translation="MASTITGSQDCIVNHRGEVDGEPELDISPCQQWGEASSPISRNR
                     DSVMTLQSGCFENIESETYLPLKVSSQIDTQDSSVKFCKNEPQDHQESRRLFVMEEST
                     ERKVIKGESCSENLQVKLVSDGQELASPLLNGEATCQNGQLKESLDPIDCNCKDIHGW
                     KSQVVSCSQQRAHTEEKPCDHNNCGKILNTSPDGHPYEKIHTAEKQYECSQCGKNFSQ
                     SSELLLHQRDHTEEKPYKCEQCGKGFTRSSSLLIHQAVHTDEKPYKCDKCGKGFTRSS
                     SLLIHHAVHTGEKPYKCDKCGKGFSQSSKLHIHQRVHTGEKPYECEECGMSFSQRSNL
                     HIHQRVHTGERPYKCGECGKGFSQSSNLHIHRCIHTGEKPYQCYECGKGFSQSSDLRI
                     HLRVHTGEKPYHCGKCGKGFSQSSKLLIHQRVHTGEKPYECSKCGKGFSQSSNLHIHQ
                     RVHKKDPR"
     polyA_site      2069
                     /gene="ZNF239"
                     /gene_synonym="HOK-2; MOK2"
                     /note="major polyA site"
ORIGIN      
        1 gtatttcggg gccctaggcg cgcgagcggt cagcatccgg aatctggccc ctgcaggcgt
       61 ggggttccac gtgggaggaa tccatcccct ctgggagtaa gaaatgacca gggtccggga
      121 accagttaca ttcaaggatg cctctgtggc cttcaccgag gaggagtgag gtcacctgga
      181 ctctgctccc aggaagctgt gcggagctgt gatgctgggc aactacagaa acttggtctt
      241 ggagacttga atgaaaattc tgtggagaat cttcagcaga aaacacttca ggatctgtta
      301 catgagcttt cctcctggct agttttggaa ggcatggcca gtacaattac tggaagtcag
      361 gattgtattg tgaatcatcg aggggaagtg gatggggagc ctgaactaga tatttcccct
      421 tgtcaacagt ggggagaagc atcttctcct atttccagaa acagggacag tgtgatgact
      481 cttcaaagtg gttgtttcga aaacattgaa agtgaaacat atttgccttt gaaagtctca
      541 agccaaatag acacacaaga ctcttcagtg aagttctgta agaatgagcc tcaggatcat
      601 caggaaagca gacgtctctt tgtaatggaa gaaagcactg agagaaaagt gataaagggg
      661 gaaagttgtt cagagaacct tcaagttaaa ctggtgtctg atggacaaga actggcctcg
      721 ccattgttaa atggtgaggc aacttgccag aatggccagt taaaagaatc tttggatccc
      781 attgactgta actgcaaaga cattcatgga tggaaatcac aggtggtcag ttgtagtcag
      841 cagagagctc atacagagga gaaaccctgt gaccataata actgtgggaa aatacttaac
      901 accagcccag atggtcatcc atatgagaaa atccacactg cagagaaaca atacgaatgt
      961 agtcagtgtg gtaagaactt cagtcaaagc tcagagctac tacttcatca gagagaccac
     1021 acagaagaaa aaccctacaa atgtgagcaa tgtgggaagg gcttcacaag gagctcgagt
     1081 ctgcttatcc atcaggcagt ccacacagat gagaagcctt ataagtgtga caagtgtggg
     1141 aagggcttca ccaggagctc aagtctgctc atccatcatg ccgtccatac aggcgaaaaa
     1201 ccttataaat gtgacaagtg tgggaagggc tttagtcaga gctccaaact gcacatccac
     1261 cagcgagtcc acactggaga gaagccctat gagtgtgagg agtgtggtat gagcttcagt
     1321 cagcgctcaa acctgcacat ccaccagcga gtacacacag gagagaggcc ctacaagtgt
     1381 ggtgagtgtg ggaagggctt cagtcagagc tcgaaccttc acattcaccg gtgcatccac
     1441 acaggagaga agccttacca atgctatgag tgtgggaagg gtttcagcca gagctcggat
     1501 cttcgcatcc atctcagagt ccacactgga gagaagccct atcactgtgg caagtgtggg
     1561 aagggattta gccagagttc caaactcctc atccaccaga gagtacatac tggagagaag
     1621 ccctatgagt gcagcaagtg tgggaagggc ttcagccaga gctccaacct tcacatccac
     1681 cagcgggttc acaagaaaga tcctcgctaa ctgacattag cccattcagg tcttcacagc
     1741 gctcatactg taaaaactgt taaatattta gtatcactct tactttatat tctacaaagg
     1801 agagagatgt aagggttatt tagatatgtt ccctcactga aaaatcactc attcaaaata
     1861 tttaagtatc aagcactttg ttatgctgta caatgaatgg attgttcttg tttctcagat
     1921 gggtagagta aaagtgtctg tactttacaa ttcaactaca tgttctaccc agcattttaa
     1981 cggcaagaac tttatattta ttctcaagca gggcatgttt ccctttgttc acattctctg
     2041 agaaattgaa actctggttt ctcttcaaa
//
