LOCUS       NM_001306089           10157 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 236 (ZNF236), transcript variant
            1, mRNA.
ACCESSION   NM_001306089 XM_006722541
VERSION     NM_001306089.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10157)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 10157)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   3  (bases 1 to 10157)
  AUTHORS   McDonough,C.W., Bostrom,M.A., Lu,L., Hicks,P.J., Langefeld,C.D.,
            Divers,J., Mychaleckyj,J.C., Freedman,B.I. and Bowden,D.W.
  TITLE     Genetic analysis of diabetic nephropathy on chromosome 18 in
            African Americans: linkage analysis and dense SNP mapping
  JOURNAL   Hum Genet 126 (6), 805-817 (2009)
   PUBMED   19690890
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 10157)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 10157)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 10157)
  AUTHORS   Halama,N., Yard-Breedijk,A., Vardarli,I., Akkoyun,I., Yard,B.,
            Janssen,B. and van der Woude,F.J.
  TITLE     The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced
            and excluded as susceptibility gene for diabetic nephropathy
  JOURNAL   Genomics 82 (3), 406-411 (2003)
   PUBMED   12906866
REFERENCE   7  (bases 1 to 10157)
  AUTHORS   Holmes,D.I., Wahab,N.A. and Mason,R.M.
  TITLE     Cloning and characterization of ZNF236, a glucose-regulated
            Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23
  JOURNAL   Genomics 60 (1), 105-109 (1999)
   PUBMED   10458916
REFERENCE   8  (bases 1 to 10157)
  AUTHORS   Holmes,D.I., Abdel Wahab,N. and Mason,R.M.
  TITLE     Identification of glucose-regulated genes in human mesangial cells
            by mRNA differential display
  JOURNAL   Biochem Biophys Res Commun 238 (1), 179-184 (1997)
   PUBMED   9299475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027575.13 and AC093330.25.
            
            On Apr 22, 2020 this sequence version replaced NM_001306089.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648028.1, SRR11853559.15940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320610.14/ ENSP00000322361.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC027575.13        71713-71818
            107-249             AC027575.13        98682-98824
            250-414             AC027575.13        100931-101095
            415-593             AC027575.13        117841-118019
            594-718             AC027575.13        120857-120981
            719-891             AC027575.13        124648-124820
            892-1035            AC027575.13        127165-127308
            1036-1239           AC027575.13        129269-129472
            1240-1468           AC027575.13        130440-130668
            1469-1741           AC027575.13        144169-144441
            1742-1945           AC027575.13        148175-148378
            1946-2087           AC027575.13        153536-153677
            2088-2348           AC027575.13        154311-154571
            2349-2602           AC027575.13        157476-157729
            2603-2704           AC027575.13        159224-159325
            2705-2856           AC027575.13        159816-159967
            2857-2960           AC027575.13        161400-161503
            2961-3112           AC027575.13        162903-163054
            3113-3325           AC027575.13        164803-165015
            3326-3608           AC093330.25        36617-36899
            3609-3712           AC093330.25        39912-40015
            3713-4078           AC093330.25        42030-42395
            4079-4224           AC093330.25        43878-44023
            4225-4465           AC093330.25        44118-44358
            4466-4645           AC093330.25        44768-44947
            4646-4833           AC093330.25        53997-54184
            4834-4965           AC093330.25        64362-64493
            4966-5163           AC093330.25        72826-73023
            5164-5293           AC093330.25        76528-76657
            5294-5470           AC093330.25        77520-77696
            5471-10157          AC093330.25        85056-89742
FEATURES             Location/Qualifiers
     source          1..10157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..10157
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="zinc finger protein 236"
                     /db_xref="GeneID:7776"
                     /db_xref="HGNC:HGNC:13028"
                     /db_xref="MIM:604760"
     exon            1..106
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5595
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulated by glucose"
                     /codon_start=1
                     /product="zinc finger protein 236 isoform 1"
                     /protein_id="NP_001293018.1"
                     /db_xref="CCDS:CCDS77201.1"
                     /db_xref="GeneID:7776"
                     /db_xref="HGNC:HGNC:13028"
                     /db_xref="MIM:604760"
                     /translation="MPRGRPPKPRESKARGDSDGVLTLNAENTNYAYQVPNFHKCEIC
                     LLSFPKESQFQRHMRDHERNDKPHRCDQCPQTFNVEFNLTLHKCTHSGEDPTCPVCNK
                     KFSRVASLKAHIMLHEKEENLICSECGDEFTLQSQLAVHMEEHRQELAGTRQHACKAC
                     KKEFETSSELKEHMKTHYKIRVSSTRSYNRNIDRSGFTYSCPHCGKTFQKPSQLTRHI
                     RIHTGERPFKCSECGKAFNQKGALQTHMIKHTGEKPHACAFCPAAFSQKGNLQSHVQR
                     VHSEVKNGPTYNCTECSCVFKSLGSLNTHISKMHMGGPQNSTSSTETAHVLTATLFQT
                     LPLQQTEAQATSASSQPSSQAVSDVIQQLLELSEPAPVESGQSPQPGQQLSITVGINQ
                     DILQQALENSGLSSIPAAAHPNDSCHAKTSAPHAQNPDVSSVSNEQTDPTDAEQEKEQ
                     ESPEKLDKKEKKMIKKKSPFLPGSIREENGVRWHVCPYCAKEFRKPSDLVRHIRIHTH
                     EKPFKCPQCFRAFAVKSTLTAHIKTHTGIKAFKCQYCMKSFSTSGSLKVHIRLHTGVR
                     PFACPHCDKKFRTSGHRKTHIASHFKHTELRKMRHQRKPAKVRVGKTNIPVPDIPLQE
                     PILITDLGLIQPIPKNQFFQSYFNNNFVNEADRPYKCFYCHRAYKKSCHLKQHIRSHT
                     GEKPFKCSQCGRGFVSAGVLKAHIRTHTGLKSFKCLICNGAFTTGGSLRRHMGIHNDL
                     RPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQQAASIDDSTVDQQSMQASTQM
                     QVEIESDELPQTAEVVAANPEAMLDLEPQHVVGTEEAGLGQQLADQPLEADEDGFVAP
                     QDPLRGHVDQFEEQSPAQQSFEPAGLPQGFTVTDTYHQQPQFPPVQQLQDSSTLESQA
                     LSTSFHQQSLLQAPSSDGMNVTTRLIQESSQEELDLQAQGSQFLEDNEDQSRRSYRCD
                     YCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKSHEKTHTGVKAFSCSVC
                     NASFTTNGSLTRHMATHMSMKPYKCPFCEEGFRTTVHCKKHMKRHQTVPSAVSATGET
                     EGGDICMEEEEEHSDRNASRKSRPEVITFTEEETAQLAKIRPQESATVSEKVLVQSAA
                     EKDRISELRDKQAELQDEPKHANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGK
                     SFTVKSTLDCHVKTHTGQKLFSCHVCSNAFSTKGSLKVHMRLHTGAKPFKCPHCELRF
                     RTSGRRKTHMQFHYKPDPKKARKPMTRSSSEGLQPVNLLNSSSTDPNVFIMNNSVLTG
                     QFDQNLLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQLAANLVGPNVQIS
                     GIDAASINNITLQIDPSILQQTLQQGNLLAQQLTGEPGLAPQNSSLQTSDSTVPASVV
                     IQPISGLSLQPTVTSANLTIGPLSEQDSVLTTNSSGTQDLTQVMTSQGLVSPSGGPHE
                     ITLTINNSSLSQVLAQAAGPTATSSSGSPQEITLTISELNTTSGSLPSTTPMSPSAIS
                     TQNLVMSSSGVGGDASVTLTLADTQGMLSGGLDTVTLNITSQGQQFPALLTDPSLSGQ
                     GGAGSPQVILVSHTPQSASAACEEIAYQVAGVSGNLAPGNQPEKEGRAHQCLECDRAF
                     SSAAVLMHHSKEVHGRERIHGCPVCRKAFKRATHLKEHMQTHQAGPSLSSQKPRVFKC
                     DTCEKAFAKPSQLERHSRIHTGERPFHCTLCEKAFNQKSALQVHMKKHTGERPYKCAY
                     CVMGFTQKSNMKLHMKRAHSYAGALQESAGHPEQDGEELSRTLHLEEVVQEAAGEWQA
                     LTHVF"
     exon            107..249
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            250..414
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            415..593
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            594..718
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            719..891
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1035
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1239
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1468
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1741
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1945
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2087
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2348
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2602
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2704
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2856
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2960
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3112
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3325
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3608
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3712
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..4078
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4224
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4465
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..4645
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4646..4833
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4965
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5163
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..5293
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            5294..5470
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..10157
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7152..7157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="hexamer: AATAAT"
     polyA_site      7174
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="major polyA site"
     regulatory      7495..7500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="hexamer: ATTAAA"
     polyA_site      7524
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
     regulatory      7962..7967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="hexamer: AATAAA"
     polyA_site      7983
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
     regulatory      10128..10133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
                     /note="hexamer: AATAAA"
     polyA_site      10157
                     /gene="ZNF236"
                     /gene_synonym="ZNF236A; ZNF236B"
ORIGIN      
        1 gagtgtgagt gtgagtgtga gtgggtgtgg gtgcgagccg ggccgccgac gatgccgcgg
       61 ggccgccccc cgaagcccag ggagagcaag gcgcgcggcg actccgatgg agttttaaca
      121 ttgaatgcgg agaacactaa ttatgcctat caagttccaa acttccataa atgtgaaatc
      181 tgtctactat cttttccaaa agaatcccag tttcaacgcc acatgaggga tcacgagcga
      241 aatgacaagc cacatcgatg tgaccagtgc ccccaaacat ttaatgttga attcaacctg
      301 acacttcata aatgcaccca cagcggggaa gatcctacct gccctgtgtg taacaagaaa
      361 ttctccagag tggctagtct caaagcgcat attatgctac atgaaaagga agagaatctc
      421 atctgttctg agtgtgggga tgagtttact ctgcagagtc agctggccgt gcacatggag
      481 gagcaccgcc aggagctggc tggaacccgg cagcatgcct gcaaggcctg caagaaagag
      541 ttcgagacct cctcggagct gaaggaacac atgaagactc attacaaaat tagggtatca
      601 agtacaaggt cttataaccg gaatatcgac agaagtggat tcacgtattc gtgtccgcac
      661 tgtggaaaga cgtttcaaaa gccaagccag ttaacgcgac acattaggat acacacaggt
      721 gaaaggccgt tcaaatgtag tgaatgtgga aaggctttta accagaaggg ggcactgcag
      781 acccacatga tcaagcacac aggtgaaaaa ccccatgcct gtgccttctg tcctgccgcc
      841 ttctctcaga aagggaatct tcagtcgcac gtgcagcgag tccactcaga ggtcaagaat
      901 ggtcctacct ataactgtac agaatgtagt tgtgtattta aaagtttagg cagcttaaac
      961 acgcatatca gcaagatgca tatgggtggg ccacagaatt caacaagttc tacagagact
     1021 gctcatgttt taacggccac actttttcag acgttacctc ttcaacagac ggaagcccaa
     1081 gccacgtcgg cctcaagcca gccgagctcc caggcggtga gcgacgtcat ccagcagctc
     1141 ctggagctct cagagccggc gccggtggag tcggggcagt ccccgcagcc tgggcagcag
     1201 ctgagcatca cagtgggcat caaccaggac attttacagc aagccttaga aaacagtggg
     1261 ctgtcttcaa ttccagctgc agcacatcct aatgactcct gccatgccaa gacctctgca
     1321 ccacacgctc aaaacccaga tgtttccagc gtttcaaatg agcagacgga ccccacagac
     1381 gcagagcaag aaaaagaaca ggaaagcccg gagaaactgg ataaaaaaga aaaaaaaatg
     1441 ataaagaaga agtcaccgtt tctacctggc tccatccgcg aggagaacgg cgtgcgctgg
     1501 catgtgtgtc cctactgcgc caaggagttc cgcaagccca gcgacctggt ccgccacatc
     1561 cgcatccaca cccacgagaa gcccttcaag tgcccgcagt gcttccgcgc cttcgccgtg
     1621 aagagcacgc tgacagcgca catcaagacg cacaccggca tcaaggcgtt caagtgccag
     1681 tactgcatga agagcttctc cacctctggc agcctcaagg tgcacattcg cctgcacaca
     1741 ggagttagac cttttgcttg tcctcactgt gacaaaaaat ttcgaacctc aggccatagg
     1801 aagactcaca ttgcttccca ctttaaacat acggaattaa ggaaaatgag gcaccagcgt
     1861 aaacctgcaa aggtccgtgt tggcaagacg aatattccag tccctgatat tcctttgcag
     1921 gaaccaatcc tcataactga cttaggtctc atccagccca ttccaaaaaa ccagtttttc
     1981 caaagctatt tcaataataa ttttgtcaat gaagcagata gaccatacaa gtgtttttac
     2041 tgtcatcgtg catataaaaa atcttgccac cttaaacaac acatcagatc ccatacaggt
     2101 gaaaaacctt ttaaatgttc tcagtgtgga agaggctttg tttctgcagg cgtgctcaaa
     2161 gcacacatca gaacacacac aggactgaaa tctttcaagt gtctgatatg taatggggct
     2221 ttcactactg gtggcagctt acggcgacac atgggtatcc acaacgacct tcgtccctat
     2281 atgtgtccct attgccaaaa aacatttaag acttcactaa attgcaaaaa gcacatgaaa
     2341 acccacagat atgagcttgc ccagcagctc caacagcatc agcaggcagc ctcgatagat
     2401 gacagcactg tagaccagca gagcatgcag gcctccactc aaatgcaggt ggagatcgag
     2461 agcgacgagc tgccgcagac ggcagaggtg gtcgcagcga accccgaggc catgctggac
     2521 ctggagcctc agcatgtggt gggcacggag gaagcagggc tgggccagca gttggcagat
     2581 cagcccctgg aagcagatga agatgggttt gtggctccac aggaccctct gcgagggcac
     2641 gtagaccagt ttgaagagca gagccctgcg caacagtcct tcgaaccagc agggctaccc
     2701 caaggtttta cagtgactga tacgtaccat cagcagcctc agtttccacc tgtccaacag
     2761 ctacaggatt ccagcacact tgagtctcag gccctctcca caagcttcca ccagcagagc
     2821 ttgctgcagg ctcccagctc tgatgggatg aatgtaacaa ctcgcttgat tcaggagtca
     2881 tcccaagagg aactggacct gcaggcacaa ggttcccagt ttctggagga caacgaggac
     2941 cagagcaggc gctcttacag gtgtgactat tgcaacaaag gctttaagaa gtccagccac
     3001 ctgaagcagc atgtgcggtc gcacaccggg gaaaagccct acaagtgcaa gctctgtgga
     3061 cgcggctttg tttcctctgg ggtcctcaag tcccacgaga agacacacac aggagtgaag
     3121 gcgttcagct gcagtgtgtg caatgcttcc ttcaccacca atggcagcct cacccggcac
     3181 atggccacac atatgagcat gaagccttat aagtgtccgt tttgtgagga gggtttccga
     3241 actacagtgc attgtaaaaa gcacatgaag agacaccaaa cagtcccctc tgctgtgtca
     3301 gccactggag agacagaagg aggagacatt tgtatggagg aagaggaaga acattctgac
     3361 agaaatgcat cacggaagtc tcgtcctgag gtcatcactt tcacggagga ggagacagcc
     3421 cagttagcca agatccggcc gcaggagagc gccacggtgt cagagaaggt cctggtgcag
     3481 tccgcggcag aaaaggaccg catcagtgag ctgagggaca agcaggcgga gctgcaggac
     3541 gagcccaagc acgccaactg ctgcacatac tgccccaaga gcttcaagaa acctagcgac
     3601 ctggtgaggc atgttcgaat ccatactgga gaaaagccat acaaatgtga tgaatgtgga
     3661 aagagtttta ctgtgaaatc cactctcgat tgtcatgtga agactcacac aggtcagaag
     3721 ctcttcagct gtcacgtctg cagcaacgcc ttctccacga agggaagtct gaaggtccac
     3781 atgcgcctgc acacgggagc caagcccttc aaatgcccgc attgcgagct gcgtttccgt
     3841 acctcgggta gaagaaagac acacatgcag tttcattata aaccagaccc aaagaaggcc
     3901 agaaagccta tgactcgaag ctcatcggaa ggactgcagc ctgtaaacct cctcaactcc
     3961 tcctctactg acccaaacgt gtttatcatg aacaactctg ttctaacagg acagtttgat
     4021 cagaatctgc tgcaaccagg actggtgggc caagctattc tccctgcctc tgtgtcagct
     4081 gggggtgacc tgaccgtgtc tctgacagat gggagcctgg ctaccctaga aggcatccag
     4141 ttacagttgg ctgctaactt ggttggacca aatgtacaga tttctggaat cgatgctgcc
     4201 agcattaata acattacgtt gcagattgat ccaagcattc tgcagcagac gctacagcag
     4261 ggcaacctat tggctcagca gctcacgggg gagcctggcc tggccccaca gaacagctct
     4321 ctccagacat cggacagcac ggtccctgcc agtgttgtca tccagcccat ctcaggcctg
     4381 tccttacagc ccacagtgac ctctgcgaac ctgaccatag gcccgctgtc tgagcaggat
     4441 tcagtgctga ccactaacag cagtgggacc caagacctca ctcaagtgat gacttcgcaa
     4501 ggtctagtgt ccccctccgg cggtccccac gagatcaccc tgaccattaa caactccagc
     4561 ctgagccagg tcctggcaca ggccgctggg cccactgcca cgtcttcctc ggggtctcca
     4621 caggaaatta ccctgactat ctccgaactt aacactacaa gcggaagcct tccttcaaca
     4681 acaccgatgt ctccatcggc catctcgact cagaacctgg tcatgtcctc gtcgggcgtg
     4741 ggaggtgacg ctagtgtcac gctgacgctg gccgatactc agggtatgct atctggaggc
     4801 ctggacactg tcacactcaa catcacctct cagggtcagc agttcccagc gctcctcacg
     4861 gatccctctc tctcgggcca gggtggagca ggctcgccgc aagtcatact agtgagccac
     4921 acgccacagt cagcgtctgc tgcttgtgaa gaaatagcct accaggtagc tggcgtctct
     4981 gggaacctgg ccccgggcaa ccagccagag aaggagggcc gggcgcacca gtgcctggag
     5041 tgtgaccgcg ccttctcatc ggcggcggtg ctcatgcacc acagcaagga ggtgcatggc
     5101 cgggagcgca tccacggctg ccccgtgtgc aggaaggcct tcaagcgcgc cacgcacctc
     5161 aaggagcaca tgcagacaca ccaggccggc ccctctttga gctcccagaa gccaagagtg
     5221 tttaaatgtg acacttgtga gaaggcattt gccaaaccaa gccagctgga gcgccacagc
     5281 cgcatacata caggggagcg gccgttccat tgcacgcttt gtgagaaagc cttcaaccag
     5341 aagagtgcgc tgcaggtgca catgaagaag cacacggggg agcggcccta caagtgtgcc
     5401 tactgcgtca tgggcttcac gcagaagagc aacatgaagc tgcacatgaa gcgggcgcac
     5461 agctatgctg gagctctgca ggagtctgca ggtcacccgg agcaggacgg ggaggagctg
     5521 agccggaccc tccacctgga ggaggtggtg caggaggccg ccggcgagtg gcaggccctc
     5581 acccacgtct tctgatgcga gttggaagta cacctttaag aatgtttctg aagttacgtt
     5641 ttgtgaagag caaagcactt ggaatctccg ttttaaagct tcaagtgtta aaaatgctac
     5701 aatagttttt tatctataaa attatctaaa gaatcattgt ctttcagaga ctcataggaa
     5761 aaaaaaacta ggaaaagtgt caccgcattg ttctcttttg tctacaaatc actgaactca
     5821 ggtactactg taggcagttt cctcctcagt ctcctccgtg gctagtgtgt ctagttcacg
     5881 aagcaattaa ctgggtctta ctatcattgt agtgtgattt ctttgtatta gcaaagacaa
     5941 aaacgctaac attgaaaaag tatgtcagat tttccttcat gtttctggtt ataagaagca
     6001 tagcttacaa agcaagcgta agattgaggc atgaagttca gaaaaaaaag tgttacaaca
     6061 cacagggaag ttttttccac tcttttctct gtgcattttg aaaattagtc aaaatggact
     6121 cttttcagtc taccataagt taatataact gataccttga gagatggctg gaccaattct
     6181 ctccatgaca aatgtttaat cattagttac aagaatgcag tatctggggc gtcaacatgg
     6241 ggactcgagt aaacctgacc caccaataag gattcagctg tccacacggg ctggcgacac
     6301 acttaccgca tcaatctgtg ttcaggtcca gggttacata attgcagaag cacaagccat
     6361 acatcgcagg taggaaacca cagaaccgtc tgcaaggagc aagcaacggt ggccctgtcc
     6421 accccagcaa ataagaagca tatctgtagc ttaaggccac gaatccgtaa aaaccccatg
     6481 actttctctt cgtgcataaa cagatgtatt tttgatttca gggaattctt tagtatcgtc
     6541 aatggtgcca cataaaacat gtcccaaacc aaatcccacc cgtgctgggc agagtgcgtg
     6601 cacgccattc ctacagcatt ccaaagatgg aaggttcttt acttcatgtt aatttttcct
     6661 ttgaaattat ttatatgttc tatatataaa tacatatgta catagatata tgggcctctg
     6721 tgtggctgaa cagtatattt tgtaaatata agtactagtc ctaattgcag aaagagcgtc
     6781 agtttcacct ccccacgagc acttcagatc agtattgtat tcattttatt cataaatgga
     6841 tatctttttc attgtcatat aaagctgggt tttatttttt tttcctgaaa aataattgcc
     6901 tttattttct ctcgttgcct ccttggtttc agaagagagt agttttatta taaatattgt
     6961 atggactttg tatattaaga gaggagctca tttcagattc ctaaagaaat agacatttta
     7021 ctgttatttt gaaagggcat cttttgattt ttttgttgtt gttgttcact tttggcatat
     7081 gtatataagt aatattgacg gtgatatgaa aacttttgtt atgtgaagat atttaagtca
     7141 gaaaattgtt aaataatatt acttcttttc caaactgctt tgtgtattgt atattttttt
     7201 aagaaaaaga aaagccttat ttgacttatg cttgtgatac tggacttctt accaatccgg
     7261 aggtttcctt ccttgaatgt cagtgtgtaa acctggctgt agccgcatat gcagaataac
     7321 tgtaattgtg ctagagtttt aaaggttctg cttttaatgc actttttatt ttataatttt
     7381 gtattgaaat attttagaaa tgttgattaa ttttggtgaa aaaatatccc caaagtggaa
     7441 attattggaa ttttaaactt ttgttcttgc tgggttattt attttgattt tagcattaaa
     7501 tgtcatctca ggacatctct aaaaggggtt gtttaattcc taattgtata gaaagctagt
     7561 ttggtgaatt gtattggtta attgactgtt taaggcctta acaggtgaat ctagagccta
     7621 cttttatttt ggttaaagaa aaagaaaata tcaataattc aattttgtgt cttttctcaa
     7681 tttattagca aacacaagac attttatgta ttatttcgat ttacttccta attataaaag
     7741 ctgctttttt gcagaacatt ccttgaaaat ataaggtttt gaaaagacat aattttactt
     7801 gaatctttgt ggggtacagg ttgatcttta tattttactg gttgttttaa aaattctaga
     7861 aaagagattt ctaggcctca tgtataacca gggttttgag gataaagaac tgtattttta
     7921 gaactatctc atcatagcat atctgctttg gaataactat aaataaaaga tgaagttagg
     7981 aaatgtgatt aatttttttc gtttgaaaat atttaagata aaacagtttg gcatgtaaat
     8041 taatttcaag ttcagatatt tttaagagaa aactttagtg gtattttcct ttacctctgt
     8101 gaagttcaga ggcgtttacc cctgcagtgt ccactggaaa ggcttcagac tttcaaaatc
     8161 agggcatggc tccgcgacag cgagccgtgg gcgtcagcac agtgccctgt gcatgtgtca
     8221 gaactgttcc tgttcccttt catttgctgc tttattcaac ggcacccagt cattgaggaa
     8281 ccttttgaaa gttcctaagt gttttgatcc tgcttgtgtg ctcaagtaac catgaagcac
     8341 tgaagctgaa agaatgaatt gcctttgcaa agataccaaa cgtgaaggtg gggtgcaggt
     8401 actgaggaag caggaggcat gtagcatgtg tggagtccca cctgctagat aatgcccaag
     8461 cggctgcgtt tccatagaat ggcaatagat gaaaatgaag acatgttttc aaacatgcag
     8521 attgaaatgc taccccaccc ccatcaagct ctactttttc ccctttgaaa aacttgaggc
     8581 acttagaaag tatctaaata gaggaaatgc tatgacatgg catctgacag cttgcagcca
     8641 ggtcagtggg aggctcatca aatgccactc tcctcttcct gacagtgttc tgctggtggg
     8701 acatgaacat cagtgcttgt ctggcactta actaggggat gtttccttcg tgcatatttt
     8761 ctactcccct gttgtaatat tttaaggaaa cttgatcttt gaaattatag ctagtgttct
     8821 gtgtcttcct ttgaactcat atcacattta ttacaagaga cgcatgtgtt agcacagcta
     8881 cacaattttt agaagtagaa gtggatttct tgtcttgctg tgggttttcc tcattttaga
     8941 agaatatttg taactcatta agatacacat tttaacatga aatgaccatc acacagattt
     9001 atgtttggaa atattcaaga taaaatagtt tggcatgtaa atcaatttca agatttatgt
     9061 acataagatt tttaaaggaa ataggtaaga tatatagaac tgctttctag tgtatattaa
     9121 ggctatctca tgcctgcttc ttacattttt ttctgaagct tatttcagaa ttaataccgt
     9181 gcccttccct gactaaaaaa agttaatcca aggattgatc gttgcgaatg tatccctttt
     9241 ccaagaccta ctgcatagga agtaagtgag gcagagatga gattatgcgg cggatacttc
     9301 tgaaggaagc gttctttttg tgtcacttaa tctgtgttca cgtaacttag gcactttgga
     9361 ttttttagaa tgaaatttca aaagcgccta cacgcaccac ccaatttaat gtcgtatctg
     9421 tacttggggc ctctacacct ttcccatatt ctaatgaaaa gatcgtacgc caaaggccac
     9481 tgagctggca tcttcttcat tgtggagaaa gtgggaacca cagagctttt cgtgggccag
     9541 atgcccacat attcctagca gagacatgtt ctttgtcatg gtgtggcttg ccacaacatg
     9601 tcctgtttgg tggctggccc tctccgaacg gattcccctc ctcagacccc catgcacgga
     9661 tgagcacata gctcaccctc accctcacac actcacccac acactcaccc tcacactcac
     9721 ccacacaccc tcacactcac cctccctaca caggcatcgg ggcagttctt tatatggatg
     9781 actaacaact aagaaaaaat gaagattagt atgaatggca ggagcaacag gcagtcagaa
     9841 gagatttttc tatttaatct tttatgtgta acactttaca gcatgaagac gtattctatc
     9901 aatatttgta tcataattga caaattctca agtgacatag ggatttgttc ttgattcacc
     9961 actaaagaaa atttttaaag ttaatttttt ttaattacag aagaattctc tttttatctt
    10021 cacaattgtt tcatgatcta tttatacatt ggatgatatt tatttaatcc agttttgtat
    10081 tagaaatgga tagtgatgcc aaaagccacc gtgctggctt taaaaataat aaaaatagtt
    10141 tttgtattat tttaaaa
//
