LOCUS       NM_004234               3190 bp    mRNA    linear   PRI 05-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 235 (ZNF235), transcript variant
            1, mRNA.
ACCESSION   NM_004234
VERSION     NM_004234.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3190)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 3190)
  AUTHORS   Shannon,M. and Stubbs,L.
  TITLE     Analysis of homologous XRCC1-linked zinc-finger gene families in
            human and mouse: evidence for orthologous genes
  JOURNAL   Genomics 49 (1), 112-121 (1998)
   PUBMED   9570955
REFERENCE   3  (bases 1 to 3190)
  AUTHORS   Shannon,M., Ashworth,L.K., Mucenski,M.L., Lamerdin,J.E.,
            Branscomb,E. and Stubbs,L.
  TITLE     Comparative analysis of a conserved zinc finger gene cluster on
            human chromosome 19q and mouse chromosome 7
  JOURNAL   Genomics 33 (1), 112-120 (1996)
   PUBMED   8617494
REFERENCE   4  (bases 1 to 3190)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138473.1, AC092477.1 and
            AC138470.1.
            
            On Jun 18, 2008 this sequence version replaced NM_004234.3.
            
            Summary: This gene product belongs to the zinc finger protein
            superfamily, members of which are regulatory proteins characterized
            by nucleic acid-binding zinc finger domains. The encoded protein is
            a member of the Kruppel family of zinc finger proteins, and
            contains Kruppel-associated box (KRAB) A and B domains and 15
            tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the
            mouse Zfp93 protein. This gene is located in a cluster of zinc
            finger genes on 19q13.2. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300317.1, SRR1660803.83228.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291182.9/ ENSP00000291182.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC138473.1         17857-17911         c
            56-118              AC138473.1         16276-16338         c
            119-245             AC138473.1         12492-12618         c
            246-341             AC138473.1         11694-11789         c
            342-1064            AC138473.1         1360-2082           c
            1065-2417           AC092477.1         1113-2465           c
            2418-3190           AC138470.1         1-773
FEATURES             Location/Qualifiers
     source          1..3190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..3190
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /note="zinc finger protein 235"
                     /db_xref="GeneID:9310"
                     /db_xref="HGNC:HGNC:12866"
                     /db_xref="MIM:604749"
     exon            1..55
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /inference="alignment:Splign:2.1.0"
     exon            56..118
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2320
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein homologous to Zfp93 in mouse; zinc finger
                     protein homologous to mouse Zfp93; zfp-93; zinc finger
                     protein 6; zinc finger protein 270; zinc finger protein
                     HZF6; zinc finger protein 93 homolog"
                     /codon_start=1
                     /product="zinc finger protein 235 isoform 1"
                     /protein_id="NP_004225.3"
                     /db_xref="CCDS:CCDS33048.1"
                     /db_xref="GeneID:9310"
                     /db_xref="HGNC:HGNC:12866"
                     /db_xref="MIM:604749"
                     /translation="MTKFQEAVTFKDVAVAFTEEELGLLDSAQRKLYRDVMLENFRNL
                     VSVGHQSFKPDMISQLEREEKLWMKELQTQRGKHSGDRNQNEMATLHKAGLRCFSLGE
                     LSCWQIKRHIASKLARSQDSMINIEGKSSQFPKHHDSPCQVGAGESIQASVDDNCLVN
                     HIGDHSSIIENQEFPTGKVPNSWSKIYLNETQNYQRSCKQTQMKNKLCIFAPYVDIFS
                     CISHHHDDNIVHKRDKVHSNSDCGKDTLKVSPLTQRSIHTGQKTYQGNECEEAFNDSS
                     SLELHKQVHLGKKSPACSTHEKDTSYSSGIPVQQSVRTGKKRYWCHECGKGFSQSSNL
                     QTHQRVHTGEKPYTCHECGKSFNQSSHLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNI
                     HCRVHTGEKPYKCEVCGKGFTQRSHLQAHERIHTGEKPYKCGDCGKRFSCSSNLHTHQ
                     RVHTEEKPYKCDECGKCFSLSFNLHSHQRVHTGEKPYKCEECGKGFSSASSFQSHQRV
                     HTGEKPFRCNVCGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHT
                     GEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCDACQKRFSQASHLQAHQRVHTGE
                     KPYKCDTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKP
                     YTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGNL"
     exon            119..245
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /inference="alignment:Splign:2.1.0"
     exon            246..341
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /inference="alignment:Splign:2.1.0"
     exon            342..3190
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /note="hexamer: AGTAAA"
     polyA_site      3190
                     /gene="ZNF235"
                     /gene_synonym="ANF270; HZF6; ZFP93; ZNF270"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcactt ccgctccagg aaggcgaggt cggatctgag atatctccca gggaggttca
       61 cttccccgga actctgcctt ttcccagaag gaggagggga aaaatgacca agttccagga
      121 ggcagtgaca ttcaaggatg tggctgtggc cttcactgag gaggagctgg ggctgctgga
      181 ctctgcccag aggaagctgt accgagatgt gatgctggag aactttagga acctggtttc
      241 agtgggacat cagtccttca aaccagatat gatatcccag ttggagaggg aagaaaagct
      301 ttggatgaag gagcttcaaa cccaaagagg taagcattca ggagacagga atcaaaatga
      361 gatggcaact cttcacaaag caggattaag gtgcttttca ctgggagagc tttcatgctg
      421 gcaaatcaag agacacattg cgagcaaatt agccagaagt caagactcca tgataaatat
      481 tgaaggaaag agctctcagt tccccaagca ccatgattcc ccctgtcaag tgggagcagg
      541 agaatctatt caagcttctg tggatgacaa ctgtctagtg aatcacatag gggatcattc
      601 cagtatcatt gaaaatcaag aatttccaac tgggaaagtt ccgaattctt ggagtaaaat
      661 atatctgaat gagacacaga attatcagag aagttgtaag cagactcaga tgaaaaacaa
      721 actatgtata tttgctccat atgttgacat tttcagttgt atttcacacc accatgatga
      781 taatatagtg cacaaaagag ataaagttca tagcaatagt gattgtggta aagataccct
      841 aaaggtatca cctcttaccc agcgtagtat tcacacagga cagaaaacct accagggtaa
      901 tgaatgtgaa gaagccttca atgatagctc cagtcttgaa cttcataaac aggtacactt
      961 gggaaagaag tctccagcgt gtagtacaca tgagaaggac accagttata gctcaggtat
     1021 tcctgttcaa caaagtgttc gtactgggaa aaaacgctat tggtgtcatg aatgtggtaa
     1081 aggtttcagt cagagctcaa atctgcaaac tcatcagaga gtccacacag gggagaaacc
     1141 ctatacatgc cacgagtgtg gtaagagctt taatcagagc tcacatcttt atgctcattt
     1201 gcctattcac acaggagaga agccctatag atgtgacagt tgtgggaagg gcttcagtcg
     1261 tagcacagat cttaacattc attgcagagt tcacactgga gagaaacctt ataaatgtga
     1321 ggtgtgtggg aagggcttca ctcagagatc acatcttcag gcccatgaaa gaattcacac
     1381 tggagagaaa ccatataaat gtggggattg tggtaaacgc tttagttgta gctcaaatct
     1441 tcatacccat cagagagtcc acactgaaga aaaaccatac aaatgtgatg agtgtggtaa
     1501 gtgctttagt ttgagcttta atcttcatag tcatcaacga gtccacacag gagaaaaacc
     1561 atataaatgt gaagagtgtg gtaagggttt tagttcagcc tcaagtttcc agagccatca
     1621 gagggtccat acaggagaga aaccatttcg atgcaacgtg tgtgggaaag gcttcagtca
     1681 gagttcatac tttcaagcac atcagagagt ccacactgga gaaaaaccat acaaatgtga
     1741 agtgtgtggg aagcgcttca attggagctt gaatcttcac aatcatcaga gagtccacac
     1801 cggagagaaa ccctacaaat gtgaagagtg tggtaagggt ttcagtcagg cttcaaatct
     1861 tcaagcccat cagagcgtcc acactgggga aaaaccattc aagtgtgatg catgtcagaa
     1921 gcgattcagt caggcctcac accttcaagc ccatcagaga gtccacaccg gagagaaacc
     1981 atataaatgt gacacttgtg gtaaggcctt cagccagagg tcaaatcttc aagtccatca
     2041 gataattcac actggagaga aaccatttaa atgtgaggaa tgtgggaaag aattcagttg
     2101 gagtgctggt ctcagtgccc atcagagggt ccacacagga gagaaaccct atacgtgtca
     2161 gcagtgtggg aagggcttca gtcaggcctc acattttcac acacaccaga gagtccacac
     2221 tggagagagg ccttacatat gtgatgtctg ttgtaagggc ttcagtcaga ggtcacatct
     2281 catctaccat cagagagtcc acactggagg gaatctgtag aaatgagagg tgtggttcag
     2341 ccttcagtta gagctcacat ctttgtctcc gttgggaagt ccatgctgat gattgtgaaa
     2401 agttccttta aaactagaag cttcaaagaa tcttgacagg aaagaagtct ctcaaatgct
     2461 gtgttttaga cttggttagg acatgaattc tttacaaacg tcatatttca cagatgcgag
     2521 aaaactttgt tctgtaaata tgatcagtgt ttatatcaga gtaccaggtg tcccggttct
     2581 caagatgtaa cacagcagaa aagtcttgtc ggagtctgca caggagagag gccttccttt
     2641 aacaaaagta tgattgacag aaaaaatgga tgtcaactaa aatgtaacct ctatgtaagg
     2701 aggtgttttt caccactcta tctctaccat gtagaattgt gcttggctca taatagggcc
     2761 cagcaattac tgaagaaagt gaagaaaata cctataatta ggacaaatac ttgaaaattc
     2821 tagtctgttt tctactctaa atttatatta atttatattc aaaaggaatc ctgcaagtag
     2881 ccttaataac gttagtttca gtaagtactg aaaagtatat aatactgcca tccatactaa
     2941 cacaaatttg gaaaaaagac atgaatggct cccatccttc agccttagtt ctttgtacag
     3001 tgtatcatca gttgtgtaca gtatgatttt tagtgtcagt ttatagactg aacaatactg
     3061 tttttatcta atgtgaccct gcaatttaca tgattagaat ttttggacac taagctgtac
     3121 tgtaactctg aaagtgttaa aagtagttac tgatgacaaa aagtttctta gtaaacttga
     3181 attgttaata
//
