LOCUS       NM_001207005            2757 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 233 (ZNF233), transcript variant
            2, mRNA.
ACCESSION   NM_001207005
VERSION     NM_001207005.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Xie,W., Qiao,X., Shang,L., Dou,J., Yang,X., Qiao,S. and Wu,Y.
  TITLE     Knockdown of ZNF233 suppresses hepatocellular carcinoma cell
            proliferation and tumorigenesis
  JOURNAL   Gene 679, 179-185 (2018)
   PUBMED   30179682
  REMARK    GeneRIF: Study shows that manipulation of ZNF233 expression in
            hepatocellular carcinoma (HCC) cells affected cell growth through
            regulating cell cycle progression. Tumorigenicity assay further
            found that silencing ZNF233 suppressed HCC cell proliferation in
            vivo, suggesting an oncogenic role of ZNF233 in HCC development.
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055310.1, DB071795.1, BC136734.1 and CR743367.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001207005.1.
            
            Transcript Variant: This variant (2) has a different 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1843777.1,
                                           SRR18074967.388931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683810.1/ ENSP00000507588.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK055310.1         7-10
            5-554               DB071795.1         1-550
            555-2321            BC136734.1         476-2242
            2322-2757           CR743367.1         146-581
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2757
                     /gene="ZNF233"
                     /note="zinc finger protein 233"
                     /db_xref="GeneID:353355"
                     /db_xref="HGNC:HGNC:30946"
     exon            1..53
                     /gene="ZNF233"
                     /inference="alignment:Splign:2.1.0"
     exon            54..115
                     /gene="ZNF233"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2113
                     /gene="ZNF233"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 233 isoform 1"
                     /protein_id="NP_001193934.1"
                     /db_xref="CCDS:CCDS33047.1"
                     /db_xref="GeneID:353355"
                     /db_xref="HGNC:HGNC:30946"
                     /translation="MTKFQEMVTFKDVAVVFTREELGLLDLAQRKLYQDVMLENFRNL
                     LSVGYQPFKLDVILQLGKEDKLRMMETEIQGDGCSGHKNQNEIDTLQEVRLRFLSYED
                     LICWQIWEQFTSKLTSNQDLIINLQGKRSKLLKQGDSPCQVWTGESSQVSEDENYVIK
                     LQGESSNSIKNQELPLRTTWDFWRKMYLREPQNYQSRCQQIDVKNKLCKCDHCVRQRI
                     AHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELH
                     QQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQR
                     VSTGENLYRCQVYARSSNQNSCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDS
                     AGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQRVHTGEK
                     PYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPY
                     KCDTCGKDFSQISHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDHQQVHTGENPYKC
                     DVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGM
                     CGKSFSQTSHLQAHQRVHTGEKPYKCFVCGKGFSKSSLSSDSSESP"
     exon            116..242
                     /gene="ZNF233"
                     /inference="alignment:Splign:2.1.0"
     exon            243..338
                     /gene="ZNF233"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2757
                     /gene="ZNF233"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF233"
                     /note="hexamer: ATTAAA"
     polyA_site      2757
                     /gene="ZNF233"
                     /note="major polyA site"
ORIGIN      
        1 gtgtacttcc gctgcaggag ggcgaagcag ccgtcatcta tcccctctgg gagttctgcc
       61 ttcccaggac cctgcccttc cccagaagga gcaggagaaa atgaccaagt ttcaggagat
      121 ggtgacattc aaggatgtgg ctgtggtctt caccagggag gagctggggt tgctggacct
      181 tgcccagaga aagctgtacc aagatgtgat gctggagaac ttcaggaacc tgctgtcagt
      241 gggctatcaa cccttcaaac tagatgtgat attacagttg ggaaaagaag acaagcttcg
      301 gatgatggag acagaaatcc aaggagatgg gtgttcagga cacaagaatc aaaatgagat
      361 agataccctt caagaagtaa gattaagatt cctttcatat gaagacctta tatgctggca
      421 aatatgggaa caatttacaa gtaaattaac cagtaatcaa gacctaataa taaatcttca
      481 aggcaagagg tccaagttgc taaaacaagg tgattccccc tgtcaggtgt ggacaggaga
      541 atctagtcag gtctctgaag atgagaacta tgtaataaag ctacaagggg agagttcaaa
      601 tagcataaaa aatcaagagc ttccattgag gaccacctgg gatttctgga ggaaaatgta
      661 tctgagagaa ccacagaatt atcagagtag gtgtcagcaa attgatgtaa aaaataagct
      721 ctgtaaatgt gatcattgtg ttaggcaaag aattgctcat caacatgatg atcatggagt
      781 acacaaaaga gagaaagctt ttagccacaa taattgtgga aaagactgtg tgaaggaatc
      841 atcccagcat agcataatcc aatcaggaga gcaaacctct gatgaaaatg gaaaaggctt
      901 aagtgttggc tctaatcttg aacttcacca gcaactacac ttaagagaca agcctcatgt
      961 aaatgttgag tacgggaagg gcataggtta cagctcaggg cttcccaggc atcagtgttt
     1021 ccacatagga gagaaatgct ataggaatgg tgacagtggt gagggcttca gtcagggctc
     1081 acatctgcaa cctcatcaga gagtcagcac aggagagaac ctctacagat gtcaggtata
     1141 tgcccggagc tccaaccaga actcctgtct tccctctcat gagcttactc acccaggaga
     1201 gaagttgtgt acatgtggca ggtgtgggaa gggcttccat catagcttag attttgacat
     1261 tcactgtgta gacagtgctg gagagagagc ctgtaaatgt gatgtatatg ataaaggctt
     1321 cagtcagaca tcacaacttc aagcccatca gagaggtcac tctagagaca agacatacaa
     1381 atgggaagta agtgacagga tatttaatag gaattctggt cttcaccaga gagttcacac
     1441 tggagagaaa ccatataaat gtgaggtatg tgataagggc ttcagtaagg cctcaaatct
     1501 tcaagcccat cagagaatcc acactggaga gaaaccctac aaatgtgatg tgtgtgataa
     1561 gaacttcagc cgtaattccc accttcaggc ccatcagaga gtccatacag gagagaaacc
     1621 ctacaaatgt gacacatgtg ggaaggactt cagtcagatc tctcatcttc aggcccatca
     1681 gagagttcac aaaggagaga agccatacaa atgtgagaca tgtgggaagg gctttagtca
     1741 gagttcgcat ctccaagacc atcagcaagt ccatactgga gagaatccct acaaatgtga
     1801 tgtgtgtggg aaaggcttca gttggagttc acatcttcaa gcccatcaga gagtccacac
     1861 aggagagaaa ccatacaaat gtgaagaatg taggaaaggc ttcatctgga actcatatct
     1921 tcatgttcat cagaggatcc acacgggaga gaaaccctat aaatgtggca tgtgtggtaa
     1981 gagcttcagt cagacttcac atcttcaagc ccatcagaga gtccatactg gagagaaacc
     2041 atacaaatgt tttgtgtgtg gtaagggctt tagtaagagt tcgttgtctt cagattcatc
     2101 agagagtcca tgatggtgat gaatctatta atcatgatga gtgtgatagg ggtgctcttc
     2161 aagacttaga cttcccattt tcctcagaaa atccacacag cacagaatat ttataaaatg
     2221 tcatgtttta agaattcatg agctgagttt ttatagttat ctgaattcca ttgaagaaaa
     2281 cctatttttg tatgaatatg accagtttca agcagagccc aaaatgtcac agttgtcaag
     2341 agaacacaca acagagaaac cctataaaga atgatacaat atgtttcaat cagaaccttc
     2401 acatccaata agcaatatgc aggagtgaag ccttcaaaat gataagtaag gtcagaattt
     2461 agcaaaagta taatgaggga catgacaaaa tctgtgtcca ctagaatcta agctccatgc
     2521 aggaacattg tttactgctg catgatcgtg accttgaaca agtacctaag aaatagtggc
     2581 ttccctggaa ttgtttaact tgataggaaa aatctatcat atataggaca tatatttgaa
     2641 tattttagtg agctcagccc caattcgtca ttataattgt actgggaaaa ggattcttgc
     2701 aagaagcctt aaaatgaatt caaggaaatg acatttaatt aaaacacata aaaccaa
//
