LOCUS       NM_006300               4104 bp    mRNA    linear   PRI 30-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 230 (ZNF230), mRNA.
ACCESSION   NM_006300
VERSION     NM_006300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4104)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 4104)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4104)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4104)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., He,X., Chanock,S. and Lan,Q.
  TITLE     PTEN identified as important risk factor of chronic obstructive
            pulmonary disease
  JOURNAL   Respir Med 103 (12), 1866-1870 (2009)
   PUBMED   19625176
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4104)
  AUTHORS   Trevino,L.R., Yang,W., French,D., Hunger,S.P., Carroll,W.L.,
            Devidas,M., Willman,C., Neale,G., Downing,J., Raimondi,S.C.,
            Pui,C.H., Evans,W.E. and Relling,M.V.
  TITLE     Germline genomic variants associated with childhood acute
            lymphoblastic leukemia
  JOURNAL   Nat Genet 41 (9), 1001-1005 (2009)
   PUBMED   19684603
REFERENCE   6  (bases 1 to 4104)
  AUTHORS   Dong,J.T., Zhang,S.Z., Ma,Y.X., Yang,K.X., Huang,M.K., Sun,Y.,
            He,G.P., Li,Y., Zhang,W. and Peng,Y.
  TITLE     Screening for ZNF230 gene mutation and analysis of its correlation
            with azoospermia
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22 (3), 258-260 (2005)
   PUBMED   15952109
  REMARK    GeneRIF: ZNF230 gene may be associated with azoospermia, and the
            A316G mutation may be correlated with the serum FSH level.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4104)
  AUTHORS   Xu,W.M., Zhang,S.Z., Qiu,W.M., He,G.P., Liu,Y.Q., Ma,Y.X. and
            Sun,Y.
  TITLE     [Construction of recombinant ZNF230/GFP fused plasmids and their
            expression and cellular localization]
  JOURNAL   Yi Chuan 26 (4), 451-454 (2004)
   PUBMED   15640038
REFERENCE   8  (bases 1 to 4104)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   9  (bases 1 to 4104)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   10 (bases 1 to 4104)
  AUTHORS   Zhang,S., Qiu,W., Wu,H., Zhang,G., Huang,M., Xiao,C., Yang,J.,
            Kamp,C., Huang,X., Huellen,K., Yue,Y., Pan,A., Lebo,R., Milunsky,A.
            and Vogt,P.H.
  TITLE     The shorter zinc finger protein ZNF230 gene message is transcribed
            in fertile male testes and may be related to human spermatogenesis
  JOURNAL   Biochem J 359 (Pt 3), 721-727 (2001)
   PUBMED   11672448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006213.1, AC018725.1 and AC067968.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006300.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.255809.1, BC050340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429154.7/ ENSP00000409318.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC006213.1         7548-7698           c
            152-234             AC006213.1         3562-3644           c
            235-361             AC006213.1         1739-1865           c
            362-448             AC006213.1         1485-1571           c
            449-834             AC006213.1         1-386               c
            835-1706            AC018725.1         37144-38015
            1707-4104           AC067968.1         2272-4669
FEATURES             Location/Qualifiers
     source          1..4104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..4104
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="zinc finger protein 230"
                     /db_xref="GeneID:7773"
                     /db_xref="HGNC:HGNC:13024"
                     /db_xref="MIM:620998"
     exon            1..151
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..234
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1644
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="zinc finger protein FDZF2"
                     /codon_start=1
                     /product="zinc finger protein 230"
                     /protein_id="NP_006291.2"
                     /db_xref="CCDS:CCDS33044.1"
                     /db_xref="GeneID:7773"
                     /db_xref="HGNC:HGNC:13024"
                     /db_xref="MIM:620998"
                     /translation="MTTFKEAVTFKDVAVFFTEEELGLLDPAQRKLYQDVMLENFTNL
                     LSVGHQPFHPFHFLREEKFWMMETATQREGNSGGKTIAEAGPHEDCPCQQIWEQTASD
                     LTQSQDSIINNSHFFEQGDVPSQVEAGLSIIHTGQKPSQNGKCKQSFSDVAIFDPPQQ
                     FHSGEKSHTCNECGKSFCYISALRIHQRVHLREKLSKCDMRGKEFSQSSCLQTRERVH
                     TGEKPFKCEQCGKGFRCRAILQVHCKLHTGEKPYICEKCGRAFIHDFQLQKHQIIHTG
                     EKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEECGKGFTDSLDLHKHQIIHTGQK
                     PYNCKECGKSFRWSSYLLIHQRIHSGEKPYRCEECGKGYISKSGLNLHQRVHTGERPY
                     NCKECGKSFSRASSILNHKKLHCRKKPFKCEDCGKRLVHRSFCKDQQGDHNGENSSKC
                     EDCGKRYKRRLNLDIILSLFLNDM"
     exon            235..361
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..448
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..4104
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: AATAAA"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: ATTATA"
     polyA_site      1825
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="major polyA site"
     polyA_site      1847
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: AATAAG"
     polyA_site      3732
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
     regulatory      3770..3775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: AATAAA"
     polyA_site      3801
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: AATAAA"
     polyA_site      4041
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
     regulatory      4082..4087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
                     /note="hexamer: AATAAA"
     polyA_site      4104
                     /gene="ZNF230"
                     /gene_synonym="FDZF2"
ORIGIN      
        1 gtgtgagcct gcggttgcta cataaccgcg tagtttgagc catttctgcg tctggcgggt
       61 ccttctgaac ttgtcacctt cgcttggggt cgcaacgacc cgatgatcga tgatccaagc
      121 aagggaaaag aagccttggc ggagagcgga ggcacaattc caccttcctt tgtgctccat
      181 tactcaagac actgaagact ccaaaaagta gtaggaaaaa tgaccacatt caaggaggca
      241 gtgaccttca aggatgtggc tgtgttcttc actgaggagg aactggggct actggaccct
      301 gcccagagga agctgtacca agacgtgatg cttgagaact tcacgaacct gctgtcagtg
      361 gggcatcaac cattccaccc tttccacttc ctaagggaag aaaagttttg gatgatggag
      421 acagcaaccc aaagagaagg aaattcaggc ggcaagacta ttgcggaagc aggaccacat
      481 gaagactgcc cttgccagca aatctgggaa caaactgcaa gtgacttaac ccagtctcaa
      541 gactccatca taaataattc tcacttcttt gaacaaggtg atgtcccctc ccaggttgag
      601 gcaggactat ctataattca tacaggacag aaaccttcac agaatgggaa gtgtaaacag
      661 tccttcagtg atgttgccat ctttgatcct cctcagcagt tccactcagg agagaagtct
      721 catacatgca atgagtgtgg aaaaagcttc tgttacatct cagctcttcg tattcaccag
      781 agagttcact tgagagagaa actctctaag tgtgacatgc gtggtaagga attcagtcag
      841 agctcatgtc tgcaaactcg tgagagagtc cacactggag agaaaccatt caaatgtgag
      901 caatgtggga aaggcttcag atgtagagcg atacttcaag ttcactgcaa attacacaca
      961 ggagagaaac cttatatttg tgagaaatgt gggagggcct tcattcacga tttccagctt
     1021 cagaaacatc agataattca tactggggag aagccgttca aatgtgaaat atgtggtaag
     1081 agcttctgcc ttaggtcaag tcttaatagg cattgcatgg tccacacagc agagaaactg
     1141 tacaaatctg aggagtgtgg aaaaggcttc actgatagcc tagatttgca taagcatcag
     1201 ataattcaca caggacagaa accgtacaat tgtaaagaat gtgggaagag cttcagatgg
     1261 tcctcatatc ttttgatcca tcagcgaatc cacagtggag aaaaaccata cagatgtgag
     1321 gagtgtggga agggctacat tagtaagtca ggtcttaact tgcaccagag ggtccatact
     1381 ggagagagac cttataattg taaggaatgt gggaagagct ttagccgggc ttcaagtatt
     1441 ttgaatcata agaaactcca ctgccggaaa aaacccttca aatgtgagga ttgtggaaag
     1501 aggcttgtac accggtcttt ctgtaaagac caacaaggag accacaatgg agaaaactca
     1561 tccaaatgtg aggactgtgg gaagcgctac aagaggcgct tgaatctgga tataatttta
     1621 tcattatttt taaatgatat gtaagttgta catatatatg ggatatggta tgaaatttta
     1681 atatgtgtat ataatacgta atgatcaaat tgatgtaatt agtgtattac cttaaacaat
     1741 taacatttct ttgttttggg aaaattcaaa atccattgtt ctagcgattt gaaaagaaac
     1801 aataaattat tgttgattat agtcaccttt ggtgctttag aacactagaa tgtatttctc
     1861 ctatctagca gtacttatgt atcttgttac ccaatctttg gctatctcac ctaaccccta
     1921 cacttccctg cttctagaac cactgtttta ctcactaatt ctatgaaatc aactttttta
     1981 gcttccatat gtgtgtgagg acagttagta tttatcttac cttgcttagc ttatattgtt
     2041 taacatgtcc tccaaagctc atctatgttg ccacaaatga cacaattttg ttttcttttt
     2101 atgcccaaag agtattctat tgtgtatata tgccaccttt tcttcattta tctattgatg
     2161 gacacatagg tgggttccat atcttaacta ttgtgaagaa tagtgctcca atgaacatgg
     2221 tagtgtagat atctgatcca catactgatt tcctttgctt tggatatact caatagtggg
     2281 attgctagat cactcgaatc ttatgcctca gaggcttgac acaagagcaa aactatggaa
     2341 gtgtggctag ggtgatatgg cttcatacca cctcaggcct caagtcctca actgcaccag
     2401 agtgtccacg ttggacagaa tccttagtaa tgaggtgtgt gataaagtct ctgctcagtt
     2461 gtctataatc tcatttgaga gttcacaaag gggcaaaaca ttaaaaagag gcatatggta
     2521 agcacttcag tgtgtgttta tatcataatt tatcacagtc catactgata atatatttca
     2581 tccaggcttg taggacagaa aacatttgtt taagttaaat tcagtgtttc accatagctc
     2641 agcattctcc catcatccta ggaccatcgt agtagagaac tcttgtaaat tgtgcagtag
     2701 ggttgcaaac agaacttacg cttgtcattc aggagacagg ccttagaata agagtttgtt
     2761 cacacattta caaaacccta atgatgaaca tgtcaaaagt ggtgaccact agaatgtcaa
     2821 ctacaggtac cttgttttct gcatcctcag gaccttaaca ctgattagca cttacatgtt
     2881 tagtatgtgt taaatgactc aaaaggagaa aatatgatat tttaaaattg catctaggag
     2941 agaaaatcta caaaaaataa ttcagggaca cgagttaaaa tgcagaatac actcagttct
     3001 gcaatccaaa gcattatttt gggtaatctt accctgttgc acttggctgc tggcttcccc
     3061 tcatcctctg ttctgaagtt tactactagt ggctttgtct aatgctccat tggttgcata
     3121 caatataaat tcaacaatca tttgtaactc ttctcacact acaggctgaa aatggtttgt
     3181 taacttgtca ataacagtcc actgcatata tcacaattac atttttttca acagtgttaa
     3241 ggcaaaattt atagtaatac tttttacgtg gcagatgtag ttacgttgga aaaaacttcc
     3301 ttagttctga attctcatga ttgcttctgt atttccatgc aggccttgat ataatggcct
     3361 tctaattgtg gtagcattta ttttatcaaa caactcaggt agaagctatg ccaatttgac
     3421 aatttttgga aacctaacct aatattctct tcctatctct atgaaatacc aagagaaacc
     3481 tatcggagtt tggtaatttc atgaaatgta tccatgattg gggtaggagt gacatttaca
     3541 tgctcttctt tattgttggc agtaaaaata agtcttttgt aagcagtgta tatcagaatg
     3601 tataaggtac aagtgtttta cctggaaatg atgggatagg aaattatgat tatgatgtta
     3661 aaactgtgaa aagtagaaaa ccacatggat gatatcaccc cattttaaaa tggaataagt
     3721 attcaacaag aatttgtgtg aaatgcattt attcctataa cataagacca ataaaatgag
     3781 ggaaccagac atacagtaaa aggagaaaaa cataatgtga gctttgtgaa atctgactgt
     3841 aaccttcata acataatcaa atatctttgt gtgtttctgg gactttttaa tgtgtatata
     3901 cgtaatttgt gaacaactat tctttcctct ggcaatgaat atttgctggt atttttccat
     3961 tttataattt tatgcatttt ttctcagtga acatcagttt tatcaaagca gtaaatttag
     4021 tgcaataaat ttgcaaactt attaacgtta atcacttacc taccaggact cagaatctca
     4081 gaataaaatt gctctatatt gtca
//
