LOCUS       NM_001381984            2627 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 23 (ZNF23), transcript variant 22,
            mRNA.
ACCESSION   NM_001381984
VERSION     NM_001381984.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2627)
  AUTHORS   Wei,P., Wang,H., Li,Y. and Guo,R.
  TITLE     Nucleolar small molecule RNA SNORA75 promotes endometrial
            receptivity by regulating the function of miR-146a-3p and ZNF23
  JOURNAL   Aging (Albany NY) 13 (11), 14924-14939 (2021)
   PUBMED   34030136
  REMARK    GeneRIF: Nucleolar small molecule RNA SNORA75 promotes endometrial
            receptivity by regulating the function of miR-146a-3p and ZNF23.
REFERENCE   2  (bases 1 to 2627)
  AUTHORS   Cai,L., Zhang,Q., Du,L. and Zheng,F.
  TITLE     Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in
            Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23
            Transcription
  JOURNAL   Cytogenet Genome Res 161 (10-11), 488-500 (2021)
   PUBMED   34923485
  REMARK    GeneRIF: Silencing of miR-1246 Induces Cell Cycle Arrest and
            Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting
            ZNF23 Transcription.
REFERENCE   3  (bases 1 to 2627)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2627)
  AUTHORS   Zhang,X., Ding,C., Tian,H., Dong,X., Meng,X., Zhu,W., Liu,B.,
            Wang,L., Huang,M. and Li,C.
  TITLE     ZNF23 Suppresses Cutaneous Melanoma Cell Malignancy via
            Mitochondria-Dependent Pathway
  JOURNAL   Cell Physiol Biochem 43 (1), 147-157 (2017)
   PUBMED   28848158
  REMARK    GeneRIF: Ectopic expression of ZNF23 induced cell apoptosis by
            activation of caspase-3, p27, p53 expression and down-regulation of
            Bcl-2 through mitochondria-dependent pathway.
REFERENCE   6  (bases 1 to 2627)
  AUTHORS   Huang,C., Jia,Y., Yang,S., Chen,B., Sun,H., Shen,F. and Wang,Y.
  TITLE     Characterization of ZNF23, a KRAB-containing protein that is
            downregulated in human cancers and inhibits cell cycle progression
  JOURNAL   Exp Cell Res 313 (2), 254-263 (2007)
   PUBMED   17137575
  REMARK    GeneRIF: ZNF23 is a new member of KRAB-ZNF superfamily with
            growth-inhibitory ability and its downregulation may contribute to
            carcinogenesis
REFERENCE   7  (bases 1 to 2627)
  AUTHORS   Zhou,L., Zhu,C., Luo,K., Li,Y., Pi,H., Yuan,W., Wang,Y., Huang,C.,
            Liu,M. and Wu,X.
  TITLE     Identification and characterization of two novel zinc finger genes,
            ZNF359 and ZFP28, in human development
  JOURNAL   Biochem Biophys Res Commun 295 (4), 862-868 (2002)
   PUBMED   12127974
  REMARK    GeneRIF: Characterization of ZNF359 and its role in human
            development
REFERENCE   8  (bases 1 to 2627)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
REFERENCE   9  (bases 1 to 2627)
  AUTHORS   Cannizzaro,L.A., Aronson,M.M. and Thiesen,H.J.
  TITLE     Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene
            cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region
            10q23-q24
  JOURNAL   Hum Genet 91 (4), 383-385 (1993)
   PUBMED   8500793
REFERENCE   10 (bases 1 to 2627)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010547.9.
            
            Transcript Variant: This variant (22) encodes the longest isoform
            (g).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.683012.1,
                                           SRR14038197.658279.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647773.2/ ENSP00000497736.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC010547.9         68137-68174         c
            39-103              AC010547.9         62691-62755         c
            104-230             AC010547.9         59969-60095         c
            231-338             AC010547.9         59170-59277         c
            339-2627            AC010547.9         53524-55812         c
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..2627
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /note="zinc finger protein 23"
                     /db_xref="GeneID:7571"
                     /db_xref="HGNC:HGNC:13023"
                     /db_xref="MIM:194527"
     exon            1..38
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /inference="alignment:Splign:2.1.0"
     exon            39..103
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2131
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /note="isoform g is encoded by transcript variant 22; zinc
                     finger protein 359; zinc finger protein 32; kruppel-like
                     zinc finger factor X31; zinc finger protein 23 (KOX 16);
                     zinc finger protein 612"
                     /codon_start=1
                     /product="zinc finger protein 23 isoform g"
                     /protein_id="NP_001368913.1"
                     /db_xref="CCDS:CCDS92194.1"
                     /db_xref="GeneID:7571"
                     /db_xref="HGNC:HGNC:13023"
                     /db_xref="MIM:194527"
                     /translation="MAAMHLTAWPQKSVTFEDVAVYFTQAEWDGLSPAQRTLYRDVML
                     ENYGNVASLGFPLLKPAVISQLEGGSELGGSSPLAAGTGLQGLQTVDIQTDNDLTKEM
                     YEGKENVSFELQRDFSQETDFSEASLLEKQQEVHSAGNIKKEKSNTIDGTVKDETSPV
                     EECFFSQSSNSYQCHTITGEQPSGCTGLGKSISFDTKLVKHEIINSEERPFKCEELVE
                     PFRCDSQLIQHQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSF
                     SYSSHYITHQTIHSGEKPYQCKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECGNGFSC
                     SSAYITHQRVHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECNECGKGFRCSS
                     QLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKL
                     IQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRIHTGEKPYECNECGKAFSVNGKLMR
                     HQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQ
                     RIHTGEKPFKCMECEKAFSCSSNYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRS
                     HTGEKPFRCVECGKGFSFSSDYIIHQTVHTWKKPYMCSVCGKAFRFSFQLSQHQSVHS
                     EGKS"
     exon            104..230
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /inference="alignment:Splign:2.1.0"
     exon            231..338
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2627
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /note="hexamer: AACAAG"
     polyA_site      2592
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /note="hexamer: AATAAA"
     polyA_site      2627
                     /gene="ZNF23"
                     /gene_synonym="KOX16; Zfp612; ZNF359; ZNF612"
                     /note="major polyA site"
ORIGIN      
        1 gcacttccgg cagcgccggg gagcagtccg ctacggagct ccagcccttc tctgagacgg
       61 ggaccagggg atggcagcca tgcacctgac agcctggccc cagaagtcgg tgacctttga
      121 ggacgtggct gtgtacttca cccaggcgga atgggatggc ctgtcccctg cacagaggac
      181 cctgtacagg gatgtgatgc tggagaatta tgggaatgtg gcctccctgg gatttccact
      241 tctcaaacct gctgtgatct cacaactgga gggaggaagt gagctggggg gctcatctcc
      301 actggctgca ggaacaggcc tccagggcct ccagactgta gatattcaga ctgacaatga
      361 tttgacaaag gaaatgtatg aaggaaaaga gaatgtatca tttgaacttc aaagagactt
      421 ttcccaggaa acagactttt cagaagcctc tcttctagag aaacaacagg aagtccactc
      481 agcaggaaat ataaagaagg agaagagcaa caccattgat ggaacagtga aagatgagac
      541 aagccccgtg gaggagtgtt tttttagtca aagttcaaac tcatatcagt gtcataccat
      601 cactggagag cagccctctg ggtgtacagg attggggaaa tccatcagct ttgatacaaa
      661 actcgtgaag catgaaataa ttaattctga ggaaagacct ttcaaatgtg aagaattagt
      721 agagcccttt aggtgtgact ctcaacttat tcaacatcaa gagaacaaca ctgaggaaaa
      781 gccttatcag tgttcggagt gtggcaaagc tttcagcatt aatgagaaat taatttggca
      841 tcagagactt cacagtgggg agaaaccctt caaatgtgtg gagtgtggga aaagcttcag
      901 ctacagttcc cattatatca cacatcagac aatccacagt ggggagaagc cctatcagtg
      961 taagatgtgt gggaaggcct tcagtgttaa tggaagccta agtaggcatc agagaatcca
     1021 tacgggagag aagccctatc agtgcaagga atgtggaaat ggcttcagct gtagttctgc
     1081 atatattaca catcagagag tccacactgg agagaaacct tacgagtgta atgactgtgg
     1141 gaaagcgttc aatgttaatg caaaattaat tcaacatcag agaatccata ctggagagaa
     1201 accttatgaa tgtaatgaat gtggaaaagg cttcaggtgc agctcccagc ttaggcagca
     1261 tcagagcatc cacacaggag aaaagcccta tcagtgtaaa gagtgtggaa aaggcttcaa
     1321 taataataca aaactcattc agcatcagag aatccacaca ggtgagaaac cctatgaatg
     1381 cactgaatgt ggaaaagcct tcagtgtcaa agggaagtta atccaacacc agagaattca
     1441 cacaggcgag aaaccctatg agtgtaatga atgcgggaaa gccttcagat gtaactccca
     1501 atttcggcag catctgagaa ttcacactgg ggagaagccc tatgagtgta atgagtgtgg
     1561 aaaggccttc agcgttaatg ggaaactaat gcggcatcag agaattcaca ctggggagaa
     1621 accttttgaa tgtaatgagt gtgggagatg ctttacttct aaaagaaacc tacttgatca
     1681 tcaccgaatc catactggag aaaagcccta tcaatgtaag gaatgtggga aagccttcag
     1741 tatcaatgcc aaactaacta ggcatcagag gatacatact ggggagaaac ctttcaaatg
     1801 tatggaatgt gagaaagcat tcagctgtag ttctaactat attgtgcacc agagaatcca
     1861 tacaggagag aaaccctttc agtgtaagga gtgtggaaaa gccttccatg ttaatgccca
     1921 tttaattcgg catcagagaa gccacactgg ggagaaaccc ttcagatgtg tggaatgtgg
     1981 caaaggcttc agctttagtt ctgactacat tatacatcag acagtccaca cttggaagaa
     2041 accctatatg tgtagtgtgt gtgggaaagc attcaggttt agcttccagc tcagtcagca
     2101 tcagagtgtc catagtgaag gaaaatccta ataatgagaa agatatagaa aactcttaag
     2161 gttaatgcca aaatggatca agtatcatca gattcatcca ttgaaaaacc tccaagaggg
     2221 catgaatatg gcagagtctt catatggaaa cagtttttat tctattcagt ttaaatcagg
     2281 aaaggatgac cagttaaaga gaaacatcca aaaatagctt tgttttgtac caacaggaat
     2341 tagaaaatat aatgaaaaga tttcgttccc agcagcatca agaaaagtag attttctaga
     2401 aataaacagt tatggaggac ttgtatggag aaatttaagt cttcactgag ggccacttta
     2461 caaaggaaat ttgaataaat ggagagagag agaagccttg ttgttggata ggaaaacccg
     2521 tactaaagat actctaccta cattaattta tttgtttaat ttttgacaac aagcatgtat
     2581 tacttttgaa aagatgaaaa ataaagattt atttaaaaaa ggaaaaa
//
