LOCUS       NM_014518               4956 bp    mRNA    linear   PRI 15-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 229 (ZNF229), transcript variant
            1, mRNA.
ACCESSION   NM_014518 XM_371175
VERSION     NM_014518.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Thye,T., Vannberg,F.O., Wong,S.H., Owusu-Dabo,E., Osei,I.,
            Gyapong,J., Sirugo,G., Sisay-Joof,F., Enimil,A., Chinbuah,M.A.,
            Floyd,S., Warndorff,D.K., Sichali,L., Malema,S., Crampin,A.C.,
            Ngwira,B., Teo,Y.Y., Small,K., Rockett,K., Kwiatkowski,D.,
            Fine,P.E., Hill,P.C., Newport,M., Lienhardt,C., Adegbola,R.A.,
            Corrah,T., Ziegler,A., Morris,A.P., Meyer,C.G., Horstmann,R.D. and
            Hill,A.V.S.
  CONSRTM   African TB Genetics Consortium; Wellcome Trust Case Control
            Consortium
  TITLE     Genome-wide association analyses identifies a susceptibility locus
            for tuberculosis on chromosome 18q11.2
  JOURNAL   Nat Genet 42 (9), 739-741 (2010)
   PUBMED   20694014
  REMARK    Erratum:[Nat Genet. 2011 Oct;43(10):1040]
REFERENCE   3  (bases 1 to 4956)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   4  (bases 1 to 4956)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF192979.1, AC245748.2 and BM663713.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014518.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.105737.1,
                                           SRR1660805.135560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614049.5/ ENSP00000479884.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AF192979.1         6-43
            39-276              AF192979.1         45-282
            277-411             AC245748.2         113084-113218       c
            412-895             AF192979.1         418-901
            896-4952            AC245748.2         96476-100532        c
            4953-4956           BM663713.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..4956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..4956
                     /gene="ZNF229"
                     /note="zinc finger protein 229"
                     /db_xref="GeneID:7772"
                     /db_xref="HGNC:HGNC:13022"
                     /db_xref="MIM:620827"
     exon            1..164
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     exon            165..252
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     exon            253..463
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2907
                     /gene="ZNF229"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 229 isoform 1"
                     /protein_id="NP_055333.3"
                     /db_xref="CCDS:CCDS42574.1"
                     /db_xref="GeneID:7772"
                     /db_xref="HGNC:HGNC:13022"
                     /db_xref="MIM:620827"
                     /translation="METLTSRHEKRALHSQASAISQDREEKIMSQEPLSFKDVAVVFT
                     EEELELLDSTQRQLYQDVMQENFRNLLSVGERNPLGDKNGKDTEYIQDEELRFFSHKE
                     LSSCKIWEEVAGELPGSQDCRVNLQGKDFQFSEDAAPHQGWEGASTPCFPIENFLDSL
                     QGDGLIGLENQQFPAWRAIRPIPIQGSWAKAFVNQLGDVQERCKNLDTEDTVYKCNWD
                     DDSFCWISCHVDHRFPEIDKPCGCNKCRKDCIKNSVLHRINPGENGLKSNEYRNGFRD
                     DADLPPHPRVPLKEKLCQYDEFSEGLRHSAHLNRHQRVPTGEKSVKSLERGRGVRQNT
                     HIRNHPRAPVGDMPYRCDVCGKGFRYKSVLLIHQGVHTGRRPYKCEECGKAFGRSSNL
                     LVHQRVHTGEKPYKCSECGKGFSYSSVLQVHQRLHTGEKPYTCSECGKGFCAKSALHK
                     HQHIHPGEKPYSCGECGKGFSCSSHLSSHQKTHTGERPYQCDKCGKGFSHNSYLQAHQ
                     RVHMGQHLYKCNVCGKSFSYSSGLLMHQRLHTGEKPYKCECGKSFGRSSDLHIHQRVH
                     TGEKPYKCSECGKGFRRNSDLHSHQRVHTGERPYVCDVCGKGFIYSSDLLIHQRVHTG
                     EKPYKCAECGKGFSYSSGLLIHQRVHTGEKPYRCQECGKGFRCTSSLHKHQRVHTGKK
                     PYTCDQCGKGFSYGSNLRTHQRLHTGEKPYTCCECGKGFRYGSGLLSHKRVHTGEKPY
                     RCHVCGKGYSQSSHLQGHQRVHTGEKPYKCEECGKGFGRNSCLHVHQRVHTGEKPYTC
                     GVCGKGFSYTSGLRNHQRVHLGENPYK"
     exon            464..522
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     exon            523..667
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     exon            668..4956
                     /gene="ZNF229"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF229"
                     /note="hexamer: ATTAAA"
     polyA_site      4956
                     /gene="ZNF229"
                     /note="major polyA site"
ORIGIN      
        1 accttgattg cttcttaggc agtggtgagg cgtcttagag acgtgcatct ccatgcggtt
       61 gtactgtcag gccatgggaa ttaggatcgg ctctatagga ccagtgtgaa gggacaacgt
      121 gcggcggagg gtcgaagccc acggatttcc atgagctcgg cctggcttcc ttcttggaat
      181 tgttcgtttc tcggagataa ttgtataaaa gaaggagaaa taaccccaca tctcttgaca
      241 ctagagctcc aggtcccctg accatgggaa gcagtcgcgc tctggacagt aaaggtggag
      301 acaggaactt gtcagagctt ggagagtttc cggaatgaaa aaggcctgga tcttctgcgt
      361 ctccagctta ggaaaaccag agaataaata cagttgctgc tgctcgcaga gaacctagca
      421 gaagagacca tggagacttt gacctcaagg catgagaaaa gagctcttca ttctcaagcc
      481 tcagccattt cccaagatag ggaggagaag atcatgtctc aggagccatt gagcttcaag
      541 gacgtggctg tggtcttcac tgaggaggag ctagagctgc tggactctac ccagaggcag
      601 ctgtaccaag atgtgatgca ggagaatttc aggaacctac tctcagtggg tgagaggaat
      661 cctctgggag acaagaatgg aaaggatacg gagtatattc aagatgaaga attaaggttc
      721 ttttcacaca aagagctctc ctcatgcaaa atctgggaag aggtggcagg tgaattacct
      781 gggagccaag actgtagagt aaatctgcaa ggaaaagact tccagttctc agaagatgct
      841 gctccccatc aagggtggga aggagcatct acgccgtgtt ttccaattga gaatttcctg
      901 gacagtctac aaggggatgg gcttatcggt ctagaaaatc aacagtttcc agcctggaga
      961 gctataagac caatccccat tcaaggatct tgggcaaaag cgtttgtgaa ccagttaggg
     1021 gatgttcaag aaagatgtaa aaatctcgac acagaagaca cagtatataa atgtaactgg
     1081 gatgatgaca gcttttgctg gatatcttgt catgttgatc acagattccc tgaaatagac
     1141 aagccgtgtg gttgcaataa atgcagaaaa gactgcatta aaaactctgt acttcatcgc
     1201 attaaccctg gagagaatgg cttgaaaagt aacgaataca gaaatggctt cagggacgat
     1261 gcagaccttc ccccgcatcc aagagtacct ttgaaagaga aactctgtca atatgatgag
     1321 tttagtgagg gcttgaggca cagtgcccat cttaacagac atcaaagagt tcccacagga
     1381 gagaaatctg ttaagagtct tgagcgtggt cggggcgtca gacagaacac gcacatacgt
     1441 aaccacccca gagcccctgt gggagacatg ccctatagat gtgatgtctg tggaaagggg
     1501 ttcaggtata aatcggttct tcttattcat caaggggtgc acacaggaag gagaccctat
     1561 aaatgtgagg agtgtgggaa ggcatttggt cgaagttcaa acctgcttgt ccatcagagg
     1621 gtccacactg gagagaaacc atataaatgc agcgagtgtg ggaagggctt cagttacagc
     1681 tcagtgcttc aagtccatca gaggctgcac acaggggaga agccctacac ctgcagcgag
     1741 tgtggcaaag gcttctgtgc caagtctgca ctgcacaaac accagcacat tcaccctgga
     1801 gaaaagccct acagctgtgg cgagtgtgga aagggattca gctgcagctc ccacctcagc
     1861 agtcatcaga agacacacac cggcgagagg ccctaccagt gtgacaagtg tggcaaaggt
     1921 ttcagtcaca actcgtacct tcaagctcac cagagagttc acatggggca gcatctgtac
     1981 aaatgtaacg tgtgtggtaa gagtttcagt tacagctcag ggcttctcat gcatcagaga
     2041 ctgcacacag gagagaaacc ctacaaatgc gagtgcggga agagctttgg ccggagctcc
     2101 gacctccaca tccatcagag ggtccacaca ggagagaaac cctataaatg cagtgagtgt
     2161 gggaagggct tccggcggaa ttcagacctt cacagccacc agagggtcca cacgggagag
     2221 aggccctacg tgtgtgacgt gtgtgggaag ggtttcatct acagctccga cctccttatc
     2281 catcagaggg tccacactgg agagaaaccc tataaatgtg ctgagtgtgg caaaggcttc
     2341 agttacagct cagggcttct cattcaccag agagtccaca caggcgagaa accttacaga
     2401 tgccaagagt gcggaaaggg ctttaggtgc acatcaagcc ttcacaaaca tcagcgagtc
     2461 cacacgggaa aaaagcccta tacgtgtgat cagtgtggca agggattcag ttatggctct
     2521 aatcttcgca cccaccagag gttgcacaca ggagagaaac cctacacttg ttgtgaatgt
     2581 gggaagggtt tcagatatgg ctcaggtctc cttagtcata agagagtgca cactggcgag
     2641 aagccataca gatgccacgt gtgtgggaag ggctatagtc agagctcaca tcttcaaggt
     2701 catcagaggg tccacactgg tgagaaaccc tataaatgtg aggagtgtgg gaagggcttt
     2761 ggccgcaact cctgtcttca tgttcatcag agagtccaca ctggagagaa gccctatacg
     2821 tgtggtgtgt gtgggaaagg cttcagttat acctcaggtc tgcggaacca ccaaagagtg
     2881 catttaggcg agaaccctta taagtagatg tacatagagg attccatctg ggactcagag
     2941 ctttctatcc atctgagagc caacacagga gaaaaaccat aggaaagtga catgtaggag
     3001 ggctatagga gaaactgatg attttacatt ttctagtctg cataggaagg gaacacctgg
     3061 atgtgtgata aataggttag cacttcagtt acaaacttca gtctttaaga gtctgttgtg
     3121 cagcggagta ggctttaaag aaacagtgca gcagtggttt cagtaataat cctcacttcc
     3181 atcagaatct gcctgggagg gagcttttac aatgtacaag tggtgagaat gtttccaagg
     3241 tgctaattat ggacatagat tctttgtgtg ggttgatagc taccaatggg acagtgtaga
     3301 aacaagtttc cacctttcta aaaccagttt ggtacatatc tttttaaaga tcgctttata
     3361 aaaacaaaaa gataacatta acatttattg aaacaagtca ctctgagaag accaggaaca
     3421 aagttctctt ggcagatctg ggtgatgtgt gtgtctcaca tttttatcat gtttttatga
     3481 ctgttttatc ttgcaggtaa gctttacagc tttcagagga gttgtagtac actacagaaa
     3541 tatgtcttct ttccaggttc aaaaagcaaa atctgattgg cattgcattg aattattaat
     3601 taaataaatt tattaattgg cattgcattg aatttatagg ttaattttga aagaatgtgg
     3661 cgtctttgaa atgctgattt tttttcactt taaaaaaatg actttttttt taccactgat
     3721 agtatttcat atggtccctc agtaatattt cttagagatg gttaaaaata ggttctgagt
     3781 catcttaagc atatttctag gaatttgttt tattgctgtc atgaatataa tggttttgct
     3841 ccagttcatt tcatagttta acatatcaaa tattaggtat cttaaaaatc acaaatgcta
     3901 tttcaccctg caggttagca gtattaaaat agaatcatca aatcccccat cagtgggggc
     3961 gggggggggg gttgtagaaa cagtctgata tggtttggct cttgtcccca cccaaatctc
     4021 atctcaattt taatccccac gtgtcagagg agggccttgg tgggagatga ttggatcacg
     4081 agggcagatt tctcccttgc tgttctcatg atagtgagtt ctcatgagag ctgatggttt
     4141 taaggtgtag cccttcctcg ctgtctctct cctgtcccct tgtgaagaag gtccttattt
     4201 ctcttttgcg ttctgccatg actaagtttt cggaggcctc cccagccatg tggaactgtg
     4261 tgtgagttaa acctctttcc tttgcaaatt acctagtctc aggtagttct ttatagcagt
     4321 gcaaaaatgg acgtaataag tcttatgtac ttattggtga gagagaaaat ccgtgcattg
     4381 ttttcaaaag aattcattaa cgtatcaatt caatttctat aacctttgaa gtggcagtaa
     4441 atatgtagta attgatactt gggagatagt tgcccacttg ggcaaaaacg catgcagaag
     4501 gtggagtttt taaatttaaa acatttttaa aatagcaaat gttaatattc cagtttccat
     4561 tggtaggaaa ttttttagat aagttcaggc atatgtatgc aatggaaagc cactagaaat
     4621 cttcaggcac acagataatg acaatgcagg ttgctcatga agtatttagt gaaccaggag
     4681 agttttagaa caacaattat agcatgaccc cattttgtta gtatgttttt ctgtgtgtat
     4741 gtttagagca acagagaaaa aaagatgtgg gagaggacat ataactactt atctctagtg
     4801 gtgggattct gaatgtataa tacatatgtt gtacttttat gtattttact ttgtaacaaa
     4861 gtatctttca gttttataat aacagtagag ctatttttta taaattagcc tgatggaaca
     4921 atcccttatg attaaagatt catgttgtaa cctcta
//
