LOCUS       NM_182490               3049 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 227 (ZNF227), transcript variant
            2, mRNA.
ACCESSION   NM_182490
VERSION     NM_182490.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA494064.1, BC047570.1 and AL833012.1.
            
            On Nov 24, 2018 this sequence version replaced NM_182490.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047570.1, SRR1803616.105700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313040.12/ ENSP00000321049.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA494064.1         5-10
            7-930               BC047570.1         1-924
            931-3049            AL833012.1         693-2811
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..3049
                     /gene="ZNF227"
                     /note="zinc finger protein 227"
                     /db_xref="GeneID:7770"
                     /db_xref="HGNC:HGNC:13020"
     exon            1..54
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     exon            55..209
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     exon            210..271
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2611
                     /gene="ZNF227"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 227 isoform a"
                     /protein_id="NP_872296.1"
                     /db_xref="CCDS:CCDS12636.1"
                     /db_xref="GeneID:7770"
                     /db_xref="HGNC:HGNC:13020"
                     /translation="MPSQNYDLPQKKQEKMTKFQEAVTFKDVAVVFSREELRLLDLTQ
                     RKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWMMETETQRSSKHQNKMETLQ
                     KFALKYLSNQELSCWQIWKQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDS
                     SIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPFHEHIK
                     TDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEK
                     CFSQSSHLRTHQRIHPGEKLNRCHESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFS
                     SSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWS
                     VNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSP
                     LICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQ
                     VHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLH
                     QVIHTGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQR
                     VHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIYHQRGH
                     TGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTR
                     EKLFKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTYHQKVHTGKK
                     L"
     exon            272..398
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     exon            399..482
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     exon            483..3049
                     /gene="ZNF227"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF227"
                     /note="hexamer: AATAAA"
     polyA_site      3049
                     /gene="ZNF227"
                     /note="major polyA site"
ORIGIN      
        1 agagccactt ccgccccgga aagcgaggcc gccaccatct tttgggtccg ggaggattga
       61 gtcatcgggc tccaatgcgt ggggatgttt accgccgttt atccgggata gagactccat
      121 cgtgctgaca gcatcctttt attcaccgcc tccgaatttg caaagaggag gaaggaggga
      181 cttcttggct tctcccagca tagccccagt tatgccatct cagaactatg accttcccca
      241 gaagaagcag gagaaaatga ccaagtttca ggaggctgtg acattcaagg atgtggctgt
      301 ggtcttctcc agggaggaac tgcgactgct cgatcttacc cagaggaagc tgtaccgaga
      361 tgtcatggtg gagaacttca agaacctggt tgcagtgggg catcttccct tccaaccaga
      421 tatggtatcc caattggaag cagaagaaaa gctttggatg atggaaacag aaacccaaag
      481 aagcagcaag catcaaaata agatggaaac actccaaaaa tttgcattaa aatacctttc
      541 aaatcaagag ctgtcctgct ggcaaatctg gaaacaggtt gcaagtgaat taaccaggtg
      601 tcttcagggg aagagttccc agttattaca aggtgactct attcaggttt ctgaaaatga
      661 gaacaatata atgaacccta aaggagatag ctctatttat attgaaaatc aagagtttcc
      721 attttggaga acccagcatt cttgcgggaa tacatatctg agtgagtcac agattcagag
      781 tagaggtaag caaattgatg tgaaaaataa cctgcaaata catgaagact tcatgaagaa
      841 atcaccattt catgagcata ttaaaactga cacagaacca aaaccctgca aaggtaatga
      901 atatggcaaa atcattagtg atggctccaa tcagaaatta cccttaggag agaaacccca
      961 tccatgtggt gagtgtggaa ggggcttcag ttatagccca aggcttcccc ttcatccgaa
     1021 tgttcataca ggagaaaaat gcttcagtca aagctcacat ctgcgaactc atcagagaat
     1081 tcacccagga gagaaactca atagatgtca tgaatctggt gattgcttca ataagagctc
     1141 ttttcattct tatcaatcta atcatacagg agagaagtct tatagatgcg acagttgcgg
     1201 caagggattc agtagcagca cgggtcttat cattcattac agaactcata ctggagagaa
     1261 accctataaa tgcgaggaat gtggtaaatg ctttagtcaa agttcaaatt ttcagtgcca
     1321 tcagagagtc cacactgaag aaaaaccata caaatgcgaa gagtgtggta agggcttcgg
     1381 ttggagtgtt aatctccgtg ttcaccagag ggtccacagg ggtgagaagc cctataaatg
     1441 tgaggaatgt ggtaagggct tcactcaggc tgcacatttt cacatccatc agagagtcca
     1501 cactggagag aaaccctaca agtgtgatgt gtgtggtaag ggcttcagcc acaattcacc
     1561 attaatatgc catcggagag tccacacagg agagaagcca tacaagtgtg aggcgtgtgg
     1621 gaaaggcttt acccgtaata cagatctgca tattcatttc agagttcaca cgggagagaa
     1681 accctataaa tgtaaggagt gtggtaaggg cttcagtcag gcttcaaatc ttcaagtcca
     1741 tcagaatgtc cacactgggg agaaacgatt caagtgtgaa acgtgtggga agggcttcag
     1801 tcagtcctca aagcttcaaa cccatcagcg agtccacact ggagagaaac catatagatg
     1861 tgatgtgtgt ggtaaggact tcagttatag ttcaaatctt aaactacacc aagtaattca
     1921 cactggagaa aaaccatata aatgtgagga atgtgggaag ggcttcagtt ggagatcaaa
     1981 tcttcatgca catcaaagag ttcactcagg agaaaaaccc tataaatgtg agcagtgtga
     2041 taagagcttc agtcaggcca tagattttcg ggtacatcag agagtccata ctggagagaa
     2101 gccatacaaa tgtggtgtct gtggtaaggg cttcagtcag tcctctggtc ttcaatccca
     2161 tcagagagtc cacacggggg aaaagccata caaatgtgat gtgtgtggaa agggctttag
     2221 atacagttcg cagtttatat accatcagag aggccacact ggagaaaaac cttacaaatg
     2281 tgaagagtgt gggaaaggct ttggtaggag cttgaatctt cgccatcatc agagggtcca
     2341 cacgggagag aaaccccata tatgtgagga gtgtggtaag gccttcagtc tcccctcaaa
     2401 tcttcgagtc cacctgggtg ttcacaccag ggaaaaactc tttaaatgtg aagagtgtgg
     2461 taaaggcttc agtcagagtg cacgtcttga agcccatcag agagtccaca ctggagaaaa
     2521 accatacaaa tgtgacatat gtgataagga cttccgtcac cgttcacgtc ttacatatca
     2581 tcagaaagtc catactggta aaaagcttta gaaatgagaa atgtgttacc aacttttgtc
     2641 tgaatgcaca tcttcaagtt tttggctagt ccatgctggt ggtaaaccct gtaaaactac
     2701 tgagagtgga agggggtttg ttcacacttg gaatctttct aacaaatcca tcaagatgat
     2761 aacacagaac catgaacagg aatagaactc gtatttaggg gagaaatagg gctggtggct
     2821 ctcttggtaa gatctagtta atataaatga tcacctttca ttgtgaatat atgcctgaag
     2881 ataatgtgtg gaaggatatt tgccatatgc taactggttt tttggccagg gagagttttg
     2941 ggttattatc ccttttcttt aattttcatt ttatacttac agtgatcatt attttcataa
     3001 aagctgtaaa gctatgaaaa atgaataaaa ttactaaaaa ttttctgta
//
