LOCUS       NM_001032373            2563 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 226 (ZNF226), transcript variant
            2, mRNA.
ACCESSION   NM_001032373
VERSION     NM_001032373.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF596130.1, CD700800.1 and BC024197.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001032373.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023091.1, AK314554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337433.10/ ENSP00000336719.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                CF596130.1         19-61
            44-375              CD700800.1         74-405
            376-2563            BC024197.2         416-2603
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2563
                     /gene="ZNF226"
                     /note="zinc finger protein 226"
                     /db_xref="GeneID:7769"
                     /db_xref="HGNC:HGNC:13019"
     exon            1..43
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            44..94
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            95..155
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2552
                     /gene="ZNF226"
                     /note="isoform a is encoded by transcript variant 2;
                     Kruppel-associated box protein"
                     /codon_start=1
                     /product="zinc finger protein 226 isoform a"
                     /protein_id="NP_001027545.1"
                     /db_xref="CCDS:CCDS46102.1"
                     /db_xref="GeneID:7769"
                     /db_xref="HGNC:HGNC:13019"
                     /translation="MNMFKEAVTFKDVAVAFTEEELGLLGPAQRKLYRDVMVENFRNL
                     LSVGHPPFKQDVSPIERNEQLWIMTTATRRQGNLGEKNQSKLITVQDRESEEELSCWQ
                     IWQQIANDLTRCQDSMINNSQCHKQGDFPYQVGTELSIQISEDENYIVNKADGPNNTG
                     NPEFPILRTQDSWRKTFLTESQRLNRDQQISIKNKLCQCKKGVDPIGWISHHDGHRVH
                     KSEKSYRPNDYEKDNMKILTFDHNSMIHTGQKSYQCNECKKPFSDLSSFDLHQQLQSG
                     EKSLTCVERGKGFCYSPVLPVHQKVHVGEKLKCDECGKEFSQGAHLQTHQKVHVIEKP
                     YKCKQCGKGFSRRSALNVHCKVHTAEKPYNCEECGRAFSQASHLQDHQRLHTGEKPFK
                     CDACGKSFSRNSHLQSHQRVHTGEKPYKCEECGKGFICSSNLYIHQRVHTGEKPYKCE
                     ECGKGFSRPSSLQAHQGVHTGEKSYICTVCGKGFTLSSNLQAHQRVHTGEKPYKCNEC
                     GKSFRRNSHYQVHLVVHTGEKPYKCEICGKGFSQSSYLQIHQKAHSIEKPFKCEECGQ
                     GFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVF
                     RQASNLLAHQRVHSGEKPFKCEECGKSFGRSAHLQAHQKVHTGDKPYKCDECGKGFKW
                     SLNLDMHQRVHTGEKPYKCGECGKYFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSS
                     QLQSHQRVHTGEKPYKCEICGKSFSWRSNLTVHHRIHVGDKSYKSNRGGKNIRESTQE
                     KKSIK"
     exon            156..282
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            283..375
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            376..2563
                     /gene="ZNF226"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2543..2548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF226"
                     /note="hexamer: TATAAA"
     polyA_site      2563
                     /gene="ZNF226"
                     /note="major polyA site"
ORIGIN      
        1 agacgacgta gcagccatct tttccctggc tttggtgatt cagccctgac ttctcaaaaa
       61 gcactgcaca gaggaggagg cagcagaacc ccatttcagc ttcttaggac tctgcacttc
      121 cccagaagga agaattaaaa atgaatatgt tcaaggaagc agtgaccttc aaggacgtgg
      181 ctgtggcctt cacggaggag gaattggggc tgctgggccc tgcccagagg aagctgtacc
      241 gagatgtgat ggtggagaac tttaggaacc tgctgtcagt ggggcatcca cccttcaaac
      301 aagatgtatc acctatagaa agaaatgagc agctttggat aatgacgaca gcaacccgaa
      361 gacagggaaa tttaggagag aaaaatcaaa gtaagttaat tactgttcaa gacagagaat
      421 cagaagaaga gctttcttgt tggcaaatct ggcaacaaat tgcaaatgac ttaaccaggt
      481 gtcaagactc catgatcaat aattctcagt gtcacaaaca aggtgatttc ccttaccagg
      541 tagggacaga actgtctatt caaatttctg aagatgagaa ctatatagta aataaagcag
      601 atggtcccaa taatactggg aatccagagt ttcctatctt gagaacccag gattcttgga
      661 ggaaaacatt cctgactgag tcacagagat tgaacagaga tcagcaaatt tccataaaaa
      721 ataaattatg tcaatgtaag aagggtgttg atcccatcgg ttggatttca catcatgatg
      781 gtcatagagt acacaaaagt gaaaaatctt atagacccaa tgattatgaa aaagacaaca
      841 tgaagatttt gacatttgat cacaatagca tgattcacac aggacagaaa tcgtaccagt
      901 gtaatgagtg taaaaaaccc ttcagtgatc tctccagctt tgatcttcat cagcagttac
      961 aatcaggaga gaagtctctt acatgtgttg agcgtggaaa aggcttctgt tacagcccag
     1021 ttcttcctgt tcatcagaaa gtacatgtgg gagaaaaact taagtgtgat gagtgtggta
     1081 aggaattcag tcagggcgct catctacaga cccatcagaa agtccacgtg atagagaaac
     1141 catacaaatg taagcaatgt gggaaaggtt tcagtcgtag atcagcactt aatgttcatt
     1201 gcaaggtcca cacggcagag aaaccttata attgtgagga gtgtgggagg gccttcagtc
     1261 aggcctctca tcttcaggac catcagagac tccacactgg ggagaagcca ttcaaatgtg
     1321 atgcatgtgg taagagcttc agtcggaatt cacatcttca atcccatcaa agagttcata
     1381 caggagagaa accatacaaa tgtgaggagt gtggtaaggg cttcatttgt agctcaaatc
     1441 tttacattca tcagagagtc cacacaggag aaaaacccta taaatgtgag gaatgtggta
     1501 aaggctttag tcggccttca agtcttcagg cccatcaggg agttcacact ggagagaagt
     1561 catacatatg tactgtatgt gggaaaggct ttactctgag ttcaaatctt caagcccatc
     1621 agagagtcca cactggagag aagccataca aatgcaatga gtgtgggaag agcttcagga
     1681 ggaattccca ttatcaagtt catctagtgg tccacacagg agagaaaccc tataaatgtg
     1741 agatatgtgg gaagggcttc agtcaaagtt cgtatcttca aatccatcag aaggcccaca
     1801 gtatagagaa accttttaag tgtgaggagt gtgggcaggg tttcaatcag agctcacgac
     1861 ttcagattca ccagctgatc catacgggtg agaaaccata caaatgtgaa gagtgtggca
     1921 agggatttag tcgtagagca gatcttaaaa ttcactgtag gatccacaca ggagagaaac
     1981 catataattg tgaggagtgt gggaaggtct tcaggcaggc ctcaaatctt ttggcccatc
     2041 agagagtcca cagtggagaa aaaccattca aatgtgaaga atgtgggaag agtttcggtc
     2101 ggagtgcaca tcttcaagcc catcaaaaag tccacactgg agataagcca tacaaatgtg
     2161 atgagtgtgg gaagggcttc aagtggagct tgaaccttga catgcatcag agggtgcaca
     2221 caggagaaaa accatataaa tgtggggagt gtggtaagta cttcagtcag gcctcaagtc
     2281 ttcaacttca tcagagtgtc cacacaggag agaaaccata caaatgtgat gtgtgtggta
     2341 aagtcttcag tcggtcttca caactacagt ctcatcagcg agttcacact ggggagaaac
     2401 cttataaatg tgagatatgt ggtaagagct tcagttggcg atcaaatctt acagttcatc
     2461 acagaatcca tgttggtgat aaatcctata aaagtaatag gggtggtaag aacatcagag
     2521 aatccacaca ggaaaaaaaa tctataaaat gattctttgt gaa
//
