LOCUS       NM_013362               4447 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 225 (ZNF225), transcript variant
            1, mRNA.
ACCESSION   NM_013362
VERSION     NM_013362.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4447)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4447)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 4447)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EG328378.1, AK223477.1, BQ373092.1, AC021092.1 and BU633034.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013362.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA337224.1, SRR1803611.63785.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262894.11/ ENSP00000262894.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                EG328378.1         446-489             c
            45-2407             AK223477.1         1-2363
            2408-2727           BQ373092.1         2-321               c
            2728-3753           AC021092.1         25620-26645
            3754-4441           BU633034.1         18-705              c
            4442-4447           AC021092.1         27334-27339
FEATURES             Location/Qualifiers
     source          1..4447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..4447
                     /gene="ZNF225"
                     /note="zinc finger protein 225"
                     /db_xref="GeneID:7768"
                     /db_xref="HGNC:HGNC:13018"
     exon            1..171
                     /gene="ZNF225"
                     /inference="alignment:Splign:2.1.0"
     exon            172..254
                     /gene="ZNF225"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2360
                     /gene="ZNF225"
                     /codon_start=1
                     /product="zinc finger protein 225"
                     /protein_id="NP_037494.2"
                     /db_xref="CCDS:CCDS46100.1"
                     /db_xref="GeneID:7768"
                     /db_xref="HGNC:HGNC:13018"
                     /translation="MTTLKEAVTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNL
                     LSVGHQSLHRDTFHFLKEEKFWMMETATQREGNLGGKIQMEMETVSESGTHEGLFSHQ
                     TWEQISSDLTRFQDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEGRTCKKSFSDV
                     SVLDLHQQLQSREKSHTCDECGKSFCYSSALRIHQRVHMGEKLYNCDVCGKEFNQSSH
                     LQIHQRIHTGEKPFKCEQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFIHDSQLQ
                     EHQRIHTGEKPFKCDICCKSFRSRANLNRHSMVHMREKPFRCDTCGKSFGLKSALNSH
                     RMVHTGEKRYKCEECGKRFIYRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVR
                     VHSGETTFKCEECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKGYKRRLDLDFHQRVH
                     RGEKPYNCKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQLYTHRRVHSG
                     EKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGKGFNSKFNLDMHQRVHTGER
                     PYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPY
                     KCEKCGKSFRWASTHLTHQRLHSREKLLQCEDCGKSIVHSSCLKDQQRDQSGEKTSKC
                     EDCGKRYKRRLNLDTLLSLFLNDT"
     exon            255..381
                     /gene="ZNF225"
                     /inference="alignment:Splign:2.1.0"
     exon            382..474
                     /gene="ZNF225"
                     /inference="alignment:Splign:2.1.0"
     exon            475..4447
                     /gene="ZNF225"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2747..2752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF225"
                     /note="hexamer: AATATA"
     polyA_site      2773
                     /gene="ZNF225"
                     /note="major polyA site"
     regulatory      2927..2932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF225"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="ZNF225"
     regulatory      4281..4286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF225"
                     /note="hexamer: ATTAAA"
     polyA_site      4302
                     /gene="ZNF225"
                     /note="major polyA site"
     regulatory      4415..4420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF225"
                     /note="hexamer: ATTAAA"
     polyA_site      4447
                     /gene="ZNF225"
                     /note="major polyA site"
ORIGIN      
        1 agtggagtag cgggccactt ccgctccgtt actgtgaggt tgctgcagtt ttgtccctgg
       61 tagtttgggt cagttccgcg agacccttct gaatttcctg gacctacgca ttggatcctt
      121 aacgaactgg tgatcgaatt aggggaaaag aaacctcgtc ggagagcaga ggcaggattc
      181 tgctttccct tggactgtat cactcaggac tctgaatatt ccctgaaata ggaggaaaaa
      241 tgaccacgtt gaaggaggca gtgaccttca aggacgtggc tgtggtcttc actgaggaag
      301 agctgaggct gctggacctt gcccagagga aactgtaccg agaagtgatg ctggagaact
      361 tcaggaacct gctctcagtg gggcatcaat cactccacag agatactttc cacttcctaa
      421 aggaagaaaa gttttggatg atggagacag caacccaaag agaagggaat ttaggaggca
      481 agatccaaat ggagatggag actgtttcag aatcaggaac acatgaaggc ttgttcagtc
      541 atcaaacctg ggaacaaatt tcaagtgact taaccaggtt tcaagactcc atggtaaaca
      601 gctttcagtt ctccaaacaa gatgatatgc cctgccaggt tgatgcagga ctatctataa
      661 ttcacgtaag acagaaacct tctgagggta ggacgtgtaa aaagtccttt agtgatgtct
      721 ccgtccttga tcttcatcaa caactacagt caagagagaa gtctcataca tgtgatgaat
      781 gtggaaagag tttctgttat agctcagctc ttcgtattca tcagagagtt cacatggggg
      841 agaaactcta taattgtgat gtgtgtggta aggaattcaa tcagagctca catctgcaaa
      901 ttcatcagag aatccacact ggagagaaac cattcaaatg tgagcagtgt gggaaaggct
      961 ttagtcgtag atcaggactt tatgttcatc gtaaattaca cacaggagtg aaacctcata
     1021 tttgtgagaa atgtgggaag gccttcattc atgattccca gcttcaggaa catcaaagaa
     1081 tccatactgg ggagaagcca ttcaaatgtg atatatgttg taagagcttc cgtagtagag
     1141 caaatcttaa taggcattcc atggttcaca tgcgagagaa accattcaga tgtgatacat
     1201 gtggtaagag ctttggtctg aaatcagcac ttaatagtca tcgcatggtc cacacaggag
     1261 agaaacggta caaatgtgag gaatgtggaa aacgcttcat ttataggcaa gatctttata
     1321 agcatcagat agaccacaca ggggagaagc catataattg taaagaatgt ggaaagagct
     1381 tcagatgggc ctcaggtctt tcaagacatg tgcgagtcca cagtggagag acaacattca
     1441 aatgtgaaga atgtgggaag ggattttata caaattcaca acgttattct caccagagag
     1501 cgcacagtgg agaaaagcca tatagatgtg aggagtgtgg gaagggctac aaaaggaggt
     1561 tggatcttga ctttcatcag agggtccaca gaggagagaa accctataat tgtaaggaat
     1621 gtgggaagag ctttggctgg gcctcgtgtc ttttgaatca tcagagaatc cacagtggag
     1681 aaaaaccatt taaatgtgaa gaatgtggga aaagatttac tcagaattca caactttata
     1741 cccatcgtag agtccacagt ggagaaaaac cattcaaatg tgaagagtgt gggaaaagat
     1801 ttactcagaa ttcacaactt tattctcatc gcagagtcca cactggagta aagccataca
     1861 aatgtgaaga gtgtgggaag ggcttcaaca gtaagtttaa tcttgacatg caccagaggg
     1921 tccacaccgg agagagacct tataattgta aagaatgtgg gaagagcttt agccgggcct
     1981 caagtatttt gaatcataag agactccatg gtgatgaaaa gccattcaaa tgtgaagagt
     2041 gtgggaagag atttactgag aattcacagc ttcattccca tcagagggtt cacactgggg
     2101 aaaagccata caaatgtgag aagtgtggaa agagcttcag atgggcctca actcatctaa
     2161 cccatcagag actccacagt agagaaaaac tacttcaatg tgaggactgt gggaagagca
     2221 ttgtgcacag ttcatgcctt aaagaccaac aaagagacca aagtggagag aaaacatcta
     2281 aatgtgagga ctgtgggaag cgctacaaga ggcgcttgaa tcttgatacg cttttgtcat
     2341 tatttttaaa tgacacataa ctgttgtact catttatggg gtacagtgtg atagttaatg
     2401 caagtataca atgtgtaatg atcaaatcag tgtaattaac atacctatca cctcaaacat
     2461 ttatcattta tttatgttgg gaacccttaa aattcactgt cctagctatt tgaaaataat
     2521 acgttgttaa ttactgtcac cctgtagtgg tgtaaaacac tagaacttat tcctcctacc
     2581 tgcctgtatt tctgtattca ttaaccaacc tttggctacc accctgcctc ctcacctcta
     2641 agaactacta ttctactctc tacttctatg aagttaactt tttgagcttc cacatatgtg
     2701 tgagaacatg tggtatgtat ctttctgtgc ctggcatata tcacttaata taatgccctg
     2761 taagtctcat tcactttgct gtgagtgata gaattttgtt gtttttcatg gctaaatagt
     2821 actctgatgt gtatatttgc cccattttct ttattcattc atccagtgga cacttaggtt
     2881 gattacatac cttggcctat ttcttggcta tcgtgaatgg tgctgcaata aacatggggg
     2941 ggtggagata acactttaac atactgattt ccttttcttt ggatatgtac caagtatcat
     3001 ataatagtat gacatgactc aaaattaagg aataagattg tggaaattgg ttttcaaaaa
     3061 aaaattctct agtttgaata tagagaaaaa ttggtgagtg tcttcagctg tcctcataca
     3121 taatgcatgt gagctcgctt taagcataag tgaaggagtg gaaaaatcct ggagatagaa
     3181 atcaaggggt atacatgtgg atgtaaaaaa tcaacaaaga ttcttttaag aaaaggtgtg
     3241 tatgggtagg gaacaatagc atgacagcag tgcggcctct aacagtctgg aaccagttag
     3301 gacaaagagc aggattgagc gccattccat tcatagacac cgtggtgata ttttgagtac
     3361 attaggttaa aaggctttct tcagcaaaat ctatctctag agatagattt gatttttata
     3421 atcaaatcta ctagagatag atttgatttt tataatcaaa tctaccagag atagatttga
     3481 tttttataat caaatctact agagatagat ttgattttta taatcaaatc tactagagat
     3541 agatttgatt tttatactta atgttctaga ctgtatcttt tcaggatgct aggtacttta
     3601 tgaagatcca tgctgtctca atttgcatag tgggttggag gtccctaaga caatctctcc
     3661 agattctatg atttgctaag aggactcaga atatagttgt actcatgact atattatagt
     3721 gacaggatac aaataatcag caaagggaaa aggttcttgt ataatatctg gagggaatca
     3781 gatgtaaatt tgtaaagatc ctttgtgcat ggagtaacag gtctcaattc ctccagtatt
     3841 gaattgtgac tgtacttgtg aaatgtctac aatggaaatt aattatcaac ccgtaccaaa
     3901 ggttcttatt ggaactaatc atgtaggtac catccctctg gtacatatca agattctaga
     3961 ctccaagaag gggagcaagt gttcagaata acttgaacca tgcctaccag ttatggaatg
     4021 gtggcaaccc tctcaaactc cgtgtttcct aacaccagct aaaggccagt cttataagca
     4081 gtcctttcta agatttgcag tctcaggcct gttatattaa ctttttgtgc acatagtact
     4141 agaaaactgt tggctcagtc ttctttttgt tttgtgtgtt ttggttttta actgtcaccg
     4201 ataccagaat agctcatctc caaggtaact gtaacagaac actcagcaga ttaaacagaa
     4261 aatacttgct tattataatt attaaaagtt tggtagggtc tatgtctgct ctctggtgtg
     4321 tcctggatca tcaacttggt tacaacatgg tgttaacatg tgggactgat tgtgtttctt
     4381 gttaatattt ctgtttctcc caaccacgct gaatattaaa tacctagttc tatatctagt
     4441 accctga
//
